메뉴 건너뛰기




Volumn 29, Issue 7, 2010, Pages 707-716

Off-label use of rituximab in systemic lupus erythematosus: A systematic review

Author keywords

B cell depletion; Rituximab; Systemic lupus erythematosus

Indexed keywords

ABATACEPT; AZATHIOPRINE; BELIMUMAB; CORTICOSTEROID; CYCLOPHOSPHAMIDE; EPRATUZUMAB; HYDROXYCHLOROQUINE; METHYLPREDNISOLONE; MYCOPHENOLIC ACID 2 MORPHOLINOETHYL ESTER; OCRELIZUMAB; OFATUMUMAB; PREDNISOLONE; RITUXIMAB; STEROID; MONOCLONAL ANTIBODY;

EID: 77956288032     PISSN: 07703198     EISSN: None     Source Type: Journal    
DOI: 10.1007/s10067-010-1387-5     Document Type: Review
Times cited : (58)

References (60)
  • 1
    • 1242307814 scopus 로고    scopus 로고
    • B cell abnormalities in systemic lupus erythematosus
    • Grammer AC, Lipsky PE (2003) B cell abnormalities in systemic lupus erythematosus. Arthritis Res Ther 5 (Suppl 4): S22-S27
    • (2003) Arthritis Res. Ther. , vol.5 , Issue.4 SUPPL.
    • Grammer, A.C.1    Lipsky, P.E.2
  • 2
    • 0032732329 scopus 로고    scopus 로고
    • High disease activity at baseline does not prevent a remission in patients with systematic lupus erythematosus
    • Formiga F, Moga I, Pc M, Mitjavila F, Rivera A, Pujol R (1999) High disease activity at baseline does not prevent a remission in patients with systematic lupus erythematosus. Rheumatology 38:724-727
    • (1999) Rheumatology , vol.38 , pp. 724-727
    • Formiga, F.1    Moga, I.2    Pc, M.3    Mitjavila, F.4    Rivera, A.5    Pujol, R.6
  • 3
    • 33744822178 scopus 로고    scopus 로고
    • Epidemiology of systemic lupus erythematosus: A comparison of worldwide disease burden
    • Danchenko N, Satia J, Satia J Athony M (2006) Epidemiology of systemic lupus erythematosus: a comparison of worldwide disease burden. Lupus 15:308-318
    • (2006) Lupus , vol.15 , pp. 308-318
    • Danchenko, N.1    Satia, J.2    Satia, J.3    Athony, M.4
  • 4
    • 33744819164 scopus 로고    scopus 로고
    • Predictors of survival in systemic lupus erythematosus
    • Kasitanon N, Magder L, Magder L, Ptri M (2006) Predictors of survival in systemic lupus erythematosus. Medicine 85(3):147-156
    • (2006) Medicine , vol.85 , Issue.3 , pp. 147-156
    • Kasitanon, N.1    Magder, L.2    Magder, L.3    Ptri, M.4
  • 5
    • 2942635727 scopus 로고    scopus 로고
    • Short-lived plasmablasts and long-lived plasma cells contribute to chronic humoral autoimmunity in NZB/W mice
    • Hoyer BF, Moser K, Moser K Huser AE et al (2004) Short-lived plasmablasts and long-lived plasma cells contribute to chronic humoral autoimmunity in NZB/W mice. J Exp Med 199:1577-1584
    • (2004) J. Exp. Med. , vol.199 , pp. 1577-1584
    • Hoyer, B.F.1    Moser, K.2    Moser, K.3    Huser, A.E.4
  • 6
    • 0004312115 scopus 로고    scopus 로고
    • Annex B: Key to evidence statements and grades of recommendations
    • SIGN 50: A guideline developer's handbook. Annex B: Key to evidence statements and grades of recommendations. http://www.sign. ac.uk/guidelines/ fulltext/50/annexb.html
    • SIGN 50: A Guideline Developer's Handbook
  • 7
    • 27444435887 scopus 로고    scopus 로고
    • How does B cell depletion therapy work, and how can it be improved?
    • Clark EA, Ledbetter JA (2005) How does B cell depletion therapy work, and how can it be improved? Ann Rheum Dis 64 (suppl 4): iv77-80
    • (2005) Ann. Rheum. Dis. , vol.64 , Issue.4 SUPPL.
    • Clark, E.A.1    Ledbetter, J.A.2
  • 8
    • 19944427673 scopus 로고    scopus 로고
    • Importance of cellular microenvironment and circulatory dynamics in B cell immunotherapy
    • Gong Q, Ou Q, Ye, S et al (2005) Importance of cellular microenvironment and circulatory dynamics in B cell immunotherapy. J Immunol 174:817-826
    • (2005) J. Immunol. , vol.174 , pp. 817-826
    • Gong, Q.1    Ou, Q.2    Ye, S.3
  • 9
    • 0037289807 scopus 로고    scopus 로고
    • The relationship of FcgammaRIIIa genotype to degree of B cell depletion by Rituximab in the treatment of systemic lupus erythematosus
    • Anolik JH, Campbell D, Campbell D Flgar RE, Young F, Sanz I, Rosenblatt J et al (2003) The relationship of FcgammaRIIIa genotype to degree of B cell depletion by Rituximab in the treatment of systemic lupus erythematosus. Arthritis Rheum 48(2):455-9
    • (2003) Arthritis Rheum. , vol.48 , Issue.2 , pp. 455-459
    • Anolik, J.H.1    Campbell, D.2    Campbell, D.3    Flgar, R.E.4    Young, F.5    Sanz, I.6    Rosenblatt, J.7
  • 11
    • 0033214474 scopus 로고    scopus 로고
    • B cells are required for lupus nephritis in the polygenic, Fas-intact MRL model of systemic autoimmunity
    • Chan O, Madaio MP, Slomchik MJ (1999) B cells are required for lupus nephritis in the polygenic, Fas-intact MRL model of systemic autoimmunity. J Immunol 163:3592-3596
    • (1999) J. Immunol. , vol.163 , pp. 3592-3596
    • Chan, O.1    Madaio, M.P.2    Slomchik, M.J.3
  • 12
    • 0033577903 scopus 로고    scopus 로고
    • A novel mouse with B cells but lacking serum antibody reveals an antibody-independent role for B cells in murine lupus
    • Chan OTM, Hannum LG, Hannum LG Hberman AM et al (1999) A novel mouse with B cells but lacking serum antibody reveals an antibody-independent role for B cells in murine lupus. J Exp Med 189:1639-1648
    • (1999) J. Exp. Med. , vol.189 , pp. 1639-1648
    • Chan, O.T.M.1    Hannum, L.G.2    Hannum, L.G.3    Hberman, A.M.4
  • 14
    • 33646198040 scopus 로고    scopus 로고
    • B cell Immunology in disease: Evolving concepts from the clinic
    • Martin F, Chan AC (2006) B cell Immunology in disease: evolving concepts from the clinic. Annual Rev Immunol 24:467-96
    • (2006) Annual Rev. Immunol. , vol.24 , pp. 467-496
    • Martin, F.1    Chan, A.C.2
  • 15
    • 70350525210 scopus 로고    scopus 로고
    • Clinical and immunological effects of rituximab in patients with lupus nephritis refractory to conventional therapy: A pilot study
    • Vigna-Perez M, Hernandez-Castro B, Predes-Saharopulos O et al (2006) Clinical and immunological effects of rituximab in patients with lupus nephritis refractory to conventional therapy: a pilot study. Arthritis Res Ther 8(3):R83
    • (2006) Arthritis Res. Ther. , vol.8 , Issue.3
    • Vigna-Perez, M.1    Hernandez-Castro, B.2    Predes-Saharopulos, O.3
  • 17
    • 34848912304 scopus 로고    scopus 로고
    • Delayed memeory B cell recovery in peripheral blood and lymphoid tissue in systematic lupus erythematosus after B cell depletion therapy
    • Anolik J, Barnard J, Barnard J, Oen T, Zheng B, Kemshetti S, Looney R, Sanz I (2007) Delayed memeory B cell recovery in peripheral blood and lymphoid tissue in systematic lupus erythematosus after B cell depletion therapy. Arthritis Rheum 56(9):3044-3056
    • (2007) Arthritis Rheum. , vol.56 , Issue.9 , pp. 3044-3056
    • Anolik, J.1    Barnard, J.2    Barnard, J.3    Oen, T.4    Zheng, B.5    Kemshetti, S.6    Looney, R.7    Sanz, I.8
  • 19
    • 44849100527 scopus 로고    scopus 로고
    • A doseescalation study of rituximab for treatment of systemic lupus erythematosus and Evans' syndrome: Immunological analysis of B cells, T cells and cytokines
    • Tamimoto Y, Horiuchi T, Horiuchi T, Tukamoto H et al (2008) A doseescalation study of rituximab for treatment of systemic lupus erythematosus and Evans' syndrome: immunological analysis of B cells, T cells and cytokines. Rheumatology 47:821-827
    • (2008) Rheumatology , vol.47 , pp. 821-827
    • Tamimoto, Y.1    Horiuchi, T.2    Horiuchi, T.3    Tukamoto, H.4
  • 20
    • 39549108298 scopus 로고    scopus 로고
    • Treatment of refractory SLE with rituximab plus cyclophosphamide: Clinical effects, serological changes, and predictors of response
    • Jonsdottir T, Gunnarsson I, Gunnarsson I, Rsselada A et al (2008) Treatment of refractory SLE with rituximab plus cyclophosphamide: clinical effects, serological changes, and predictors of response. Ann Rheum Dis 67(3):330-334
    • (2008) Ann. Rheum. Dis. , vol.67 , Issue.3 , pp. 330-334
    • Jonsdottir, T.1    Gunnarsson, I.2    Gunnarsson, I.3    Rsselada, A.4
  • 21
    • 62749091699 scopus 로고    scopus 로고
    • Effects of rituximab on resistant SLE disease including lung involvement
    • Reynolds A, Toescu V, Ye C (2009) Effects of rituximab on resistant SLE disease including lung involvement. Lupus 18(1):67-73
    • (2009) Lupus , vol.18 , Issue.1 , pp. 67-73
    • Reynolds, A.1    Toescu, V.2    Ye, C.3
  • 22
    • 2942537697 scopus 로고    scopus 로고
    • Efficacy of B-cell-targeted therapy with rituximab in patients with rheumatoid arthritis
    • Edwards JC, Szczepanski L, Szczepanski L Sechinski J et al (2004) Efficacy of B-cell-targeted therapy with rituximab in patients with rheumatoid arthritis. N Engl J Med 350(25):2572-81
    • (2004) N. Engl. J. Med. , vol.350 , Issue.25 , pp. 2572-2581
    • Edwards, J.C.1    Szczepanski, L.2    Szczepanski, L.3    Sechinski, J.4
  • 23
    • 0029020939 scopus 로고
    • Prevention of relapses in systemic lupus erythematosus
    • Bootsma H, Spronk P, Spronk P Drksen RH, et al (1995) Prevention of relapses in systemic lupus erythematosus. Lancet 345:1595-9
    • (1995) Lancet , vol.345 , pp. 1595-1599
    • Bootsma, H.1    Spronk, P.2    Spronk, P.3    Drksen, R.H.4
  • 24
    • 65249187242 scopus 로고    scopus 로고
    • A retrospective seven-year analysis of the use of B cell depletion therapy in systemic lupus erythematosus at university college london hospital: The first fifty patients
    • Lu TY-T, Ng KP, Ng KP Cmbridge G, Leandro MJ, Edwards JCW, Ehrenstein M, Isenberg DA (2009) A retrospective seven-year analysis of the use of B cell depletion therapy in systemic lupus erythematosus at University College London Hospital: the first fifty patients. Arthritis Rheum 61(4):482-487
    • (2009) Arthritis Rheum. , vol.61 , Issue.4 , pp. 482-487
    • Lu, T.Y.-T.1    Ng, K.P.2    Ng, K.P.3    Cmbridge, G.4    Leandro, M.J.5    Edwards, J.C.W.6    Ehrenstein, M.7    Isenberg, D.A.8
  • 25
    • 44349131653 scopus 로고    scopus 로고
    • Longterm clinical and immunological effects of anti-CD20 treatment in patients with refractory systemic lupus erythematosus
    • Lindholm C, Börjesson-Asp K (2008) Longterm clinical and immunological effects of anti-CD20 treatment in patients with refractory systemic lupus erythematosus. Rheumatol 35(5):826-33
    • (2008) Rheumatol. , vol.35 , Issue.5 , pp. 826-833
    • Lindholm, C.1    Börjesson-Asp, K.2
  • 26
    • 0026777352 scopus 로고
    • Derivation of the SLEDAI: A disease activity index for lupus patients
    • Committee on Prognosis Studies in SLE
    • Bombardier C, Gladman D, Gladman D Uowitz M, Caron D, Chang D, the Committee on Prognosis Studies in SLE (1992) Derivation of the SLEDAI: a disease activity index for lupus patients. Arthritis Rheum 35:630-40
    • (1992) Arthritis Rheum. , vol.35 , pp. 630-640
    • Bombardier, C.1    Gladman, D.2    Gladman, D.3    Uowitz, M.4    Caron, D.5    Chang, D.6
  • 27
    • 0027325557 scopus 로고
    • The BILAG index: A reliable and valid instrument for measuring clinical disease activity in systemic lupus erythematosus
    • Hay E, Bacon P, Bacon P Grdon C, Isenberg D, Maddison P, Snaith M et al (1993) The BILAG index: a reliable and valid instrument for measuring clinical disease activity in systemic lupus erythematosus. QJM 86:447-58
    • (1993) QJM , vol.86 , pp. 447-458
    • Hay, E.1    Bacon, P.2    Bacon, P.3    Grdon, C.4    Isenberg, D.5    Maddison, P.6    Snaith, M.7
  • 29
    • 77956286465 scopus 로고    scopus 로고
    • Trial design and baseline characteristics of patients in the randomised double-blind, placebo controlled phase III lupus nephritis assessment with rituximab study (LUNAR)
    • K. Furie et al (2009) Trial design and baseline characteristics of patients in the randomised double-blind, placebo controlled phase III lupus nephritis assessment with rituximab study (LUNAR). Ann Rheum Dis 2009 (suppl 3):253.
    • (2009) Ann. Rheum. Dis. 2009 , Issue.3 SUPPL. , pp. 253
    • Furie, K.1
  • 30
    • 77956272385 scopus 로고    scopus 로고
    • LUNAR Study of Rituxan rituximab in lupus nephritis misses primary endpoint. March
    • LUNAR Study of Rituxan (rituximab) in lupus nephritis misses primary endpoint. March 2009 23:13. http://www.news-medical.net/news/2009/03/11/46787. aspx. Sourced 24/05/09
    • (2009) Sourced 24/05/09 , vol.23 , pp. 13
  • 32
    • 33749331884 scopus 로고    scopus 로고
    • Long-term comparison of rituximab treatment for refractory systemic lupus erythematosus and vasculitis: Remission, relapse and retreatment
    • Smith K, Jones R, Jones R Brns S et al (2006) Long-term comparison of rituximab treatment for refractory systemic lupus erythematosus and vasculitis: remission, relapse and retreatment. Arthritis Rheum 54(9):2970-82
    • (2006) Arthritis Rheum. , vol.54 , Issue.9 , pp. 2970-2982
    • Smith, K.1    Jones, R.2    Jones, R.3    Brns, S.4
  • 34
    • 0142087478 scopus 로고    scopus 로고
    • Successful long-term treatment of systemic lupus erythematosus with rituximab maintenance therapy
    • Weide R, Heymanns J, Heymanns J Pndorf A, Köppler H (2003) Successful long-term treatment of systemic lupus erythematosus with rituximab maintenance therapy. Lupus 12:779-782
    • (2003) Lupus , vol.12 , pp. 779-782
    • Weide, R.1    Heymanns, J.2    Heymanns, J.3    Pndorf, A.4    Köppler, H.5
  • 37
    • 63249122739 scopus 로고    scopus 로고
    • Rituximab in the treatment of resistant systemic lupus erythematosus: Failure of therapy in rapidly progressive crescentic lupus nephritis
    • ACR/ARHP Abstrat
    • Sangle SR et al (2007) Rituximab in the treatment of resistant systemic lupus erythematosus: failure of therapy in rapidly progressive crescentic lupus nephritis. Arthritis Rheum 56. ACR/ARHP Abstrat 441
    • (2007) Arthritis Rheum. , vol.56 , pp. 441
    • Sangle, S.R.1
  • 38
    • 34247246405 scopus 로고    scopus 로고
    • Histopathological and clinical outcome of rituximab treatment in patients with cyclophosphamide-resistant proliferative lupus nephritis
    • Gunnarsson I, Sundelin B, Sundelin B Jnsdottir T, Jacobson S, Henriksson E, van Vollenhoven R (2007) Histopathological and clinical outcome of rituximab treatment in patients with cyclophosphamide-resistant proliferative lupus nephritis. Arthritis Rheum 56(4):1263-1272
    • (2007) Arthritis Rheum. , vol.56 , Issue.4 , pp. 1263-1272
    • Gunnarsson, I.1    Sundelin, B.2    Sundelin, B.3    Jnsdottir, T.4    Jacobson, S.5    Henriksson, E.6    Van Vollenhoven, R.7
  • 39
    • 34147193717 scopus 로고    scopus 로고
    • Efficacy of rituximab (anti-CD20) for refractory systemic lupus erythematosus involving the central nervous system
    • Tokunaga M, Saito K, Saito K Kwabata D et al (2007) Efficacy of rituximab (anti-CD20) for refractory systemic lupus erythematosus involving the central nervous system. Ann Rheum Dis 66:470-475
    • (2007) Ann. Rheum. Dis. , vol.66 , pp. 470-475
    • Tokunaga, M.1    Saito, K.2    Saito, K.3    Kwabata, D.4
  • 41
    • 34249702880 scopus 로고    scopus 로고
    • Clinical experience in using CD20 monoclonal antibody in treating severe systemic lupus erythematosus
    • Mohd Shahrir MS, Abdul Halim AG, Abdul Halim AG Sehardy Z, Norella Kong CT (2007) Clinical experience in using CD20 monoclonal antibody in treating severe systemic lupus erythematosus. APLAR J Rheumatol 10:112-116
    • (2007) APLAR J. Rheumatol. , vol.10 , pp. 112-116
    • Shahrir, M.S.M.1    Halim, A.G.A.2    Halim, A.G.A.3    Sehardy, Z.4    Kong, C.T.N.5
  • 42
    • 33947498428 scopus 로고    scopus 로고
    • Addition of rituximab to standard therapy improves response rate and progression-free survival in relapsed or refractory thrombotic thrombocytopenic purpura and autoimmune haemolytic anaemia
    • Heidel F, Lipka D, Lipka Dvn Auer C, Huber C, Scharrer I, Hess G (2007) Addition of rituximab to standard therapy improves response rate and progression-free survival in relapsed or refractory thrombotic thrombocytopenic purpura and autoimmune haemolytic anaemia. Thromb Haemost 97(2):228-33
    • (2007) Thromb. Haemost. , vol.97 , Issue.2 , pp. 228-233
    • Heidel, F.1    Lipka, D.2    Auer, L.D.C.3    Huber, C.4    Scharrer, I.5    Hess, G.6
  • 43
    • 13444252282 scopus 로고    scopus 로고
    • Remission of proliferative lupus nephritis following B cell depletion therapy is preceded by down-regulation of the T cell costimulatory molecule CD40 ligand: An open-label trial
    • Sfikakis PP, Boletis JN, Boletis JN Lonaki S et al (2005) Remission of proliferative lupus nephritis following B cell depletion therapy is preceded by down-regulation of the T cell costimulatory molecule CD40 ligand: an open-label trial. Arthritis Rheum 52:501-513
    • (2005) Arthritis Rheum. , vol.52 , pp. 501-513
    • Sfikakis, P.P.1    Boletis, J.N.2    Boletis, J.N.3    Lonaki, S.4
  • 44
    • 77956269804 scopus 로고    scopus 로고
    • Good safety profile of repeated b cell depletion therapy in patients with refractory systemic lupus erythematosus
    • Ceccarelli F, Perricone C, Perricone C Mssaro L et al (2009) Good safety profile of repeated b cell depletion therapy in patients with refractory systemic lupus erythematosus. Ann Rheum Dis 68 (Suppl 3):248
    • (2009) Ann. Rheum. Dis. , vol.68 , Issue.3 SUPPL. , pp. 248
    • Ceccarelli, F.1    Perricone, C.2    Perricone, C.3    Mssaro, L.4
  • 45
    • 21644469786 scopus 로고    scopus 로고
    • B cell non-Hodgkin's lymphoma: Rituximab safety experience
    • Mohrbacher A (2005) B cell non-Hodgkin's lymphoma: rituximab safety experience. Arthritis Res Ther 7 (Suppl 3): S19-S25
    • (2005) Arthritis Res. Ther. , vol.7 , Issue.3 SUPPL.
    • Mohrbacher, A.1
  • 46
    • 77956275438 scopus 로고    scopus 로고
    • Genentech, Inc. and Biogen Idec
    • Genentech, Inc. and Biogen Idec. http://www.news-medical.net/news/2009/ 03/11/46787.aspx
  • 50
    • 14044251596 scopus 로고    scopus 로고
    • Down-regulation of CD40 and CD80 on B cells in patients with life-threatening systemic lupus erythematosus after successful treatment with rituximab
    • Tokunaga M, Fujii K, Fujii K Sito K et al (2005) Down-regulation of CD40 and CD80 on B cells in patients with life-threatening systemic lupus erythematosus after successful treatment with rituximab. Rheumatology 44(2):176-182
    • (2005) Rheumatology , vol.44 , Issue.2 , pp. 176-182
    • Tokunaga, M.1    Fujii, K.2    Fujii, K.3    Sito, K.4
  • 51
    • 65249174511 scopus 로고    scopus 로고
    • EULAR points to consider in conducting clinical trials in systemic lupus erythematosus
    • Gordon C et al (2009) EULAR points to consider in conducting clinical trials in systemic lupus erythematosus. Ann Rheum Dis 68:470-6
    • (2009) Ann. Rheum. Dis. , vol.68 , pp. 470-476
    • Gordon, C.1
  • 52
    • 0034085623 scopus 로고    scopus 로고
    • Endpoints: Consensus recommendations from OMERACT IV. Outcome measures in rheumatology
    • Strand V, Gladman D, Gladman D Ienberg D, Petri M, Smolen J, Tugwell P (2000) Endpoints: consensus recommendations from OMERACT IV. Outcome measures in rheumatology. Lupus 9:322-7
    • (2000) Lupus , vol.9 , pp. 322-327
    • Strand, V.1    Gladman, D.2    Gladman, D.3    Ienberg, D.4    Petri, M.5    Smolen, J.6    Tugwell, P.7
  • 53
    • 34247613820 scopus 로고    scopus 로고
    • Increase of B cellactivating factor of the TNF family (BAFF) after rituximab treatment: Insights into a new regulating system of BAFF production
    • Lavie F, Miceli-Richard C, Itah M et al (2007) Increase of B cellactivating factor of the TNF family (BAFF) after rituximab treatment: insights into a new regulating system of BAFF production. Ann Rheum Dis 66(5):700-3
    • (2007) Ann. Rheum. Dis. , vol.66 , Issue.5 , pp. 700-703
    • Lavie, F.1    Miceli-Richard, C.2    Itah, M.3
  • 54
    • 21144438589 scopus 로고    scopus 로고
    • Tolerance and short-term efficacy of rituximab in 43 patients with systemic autoimmune diseases
    • Gottenberg J, Guillevin L, Guillevin L Lmbotte O et al (2005) Tolerance and short-term efficacy of rituximab in 43 patients with systemic autoimmune diseases. Ann Rheum Dis 64:913-920
    • (2005) Ann. Rheum. Dis. , vol.64 , pp. 913-920
    • Gottenberg, J.1    Guillevin, L.2    Guillevin, L.3    Lmbotte, O.4
  • 56
    • 77956289130 scopus 로고    scopus 로고
    • Rituximab (RTX) for refractory and relapsing SLE
    • 2008
    • Catapano et al (2008) Rituximab (RTX) for refractory and relapsing SLE. American Society of Nephrology, Renal Week, 4-9 2008, SA-PO2960
    • (2008) American Society of Nephrology, Renal Week , vol.4-9
    • Catapano1
  • 58
    • 77956280474 scopus 로고    scopus 로고
    • Rituximab therapy induces durable remissions in patients with refractory systemic lupus erythematosus (SLE)
    • Karpouzas G, Gogia M, Gogia M Mran R, Cooray D (2009) Rituximab therapy induces durable remissions in patients with refractory systemic lupus erythematosus (SLE). Ann Rheum Dis 68 (Suppl 3):248
    • (2009) Ann. Rheum. Dis. , vol.68 , Issue.3 SUPPL. , pp. 248
    • Karpouzas, G.1    Gogia, M.2    Gogia, M.3    Mran, R.4    Cooray, D.5
  • 59
    • 66149099305 scopus 로고    scopus 로고
    • Rituximab in severelupus nephritis: Early B cell depletion affects long-term renal outcome
    • Melander C et al (2009) Rituximab in severelupus nephritis: early B cell depletion affects long-term renal outcome. Clinical Journal of American Society of Nephrology 4:579-587
    • (2009) Clinical Journal of American Society of Nephrology , vol.4 , pp. 579-587
    • Melander, C.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.