Potential analgesic and anti-inflammatory activities of Panax ginseng head butanolic fraction in animals

Food and Chemical Toxicology

Volumn 46, Issue 12, 2008, Pages 3749-3752

  Lee, Je Hyuk ^a   Lee, Jung Hun ^a   Lee, Yu Mi ^a   Kim, Pit Na ^a   Jeong, Choon Sik ^a  

^a Duksung Women's University   (South Korea)

Author keywords

Acute toxicity; Anti inflammation; IL 6; Panax ginseng; Paw edema; Vascular permeability

Indexed keywords

ACETIC ACID; ACETYLSALICYLIC ACID; BUTANOL; CARRAGEENAN; EVANS BLUE; GINSENG EXTRACT; IBUPROFEN; INTERLEUKIN 6;

ACUTE TOXICITY; ANALGESIC ACTIVITY; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIINFLAMMATORY ACTIVITY; ARTHRITIS; ARTICLE; BLOOD LEVEL; CONTROLLED STUDY; EXTRAVASATION; GINSENG; LD 50; MOUSE; NONHUMAN; PAW EDEMA; RAT; WRITHING TEST;

ACETIC ACID; ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; BODY WEIGHT; BUTANOLS; CAPILLARY PERMEABILITY; CARRAGEENAN; EDEMA; INTERLEUKIN-6; LETHAL DOSE 50; MALE; MICE; MICE, INBRED ICR; ORGAN SIZE; PAIN MEASUREMENT; PANAX; PLANT EXTRACTS; PLANT ROOTS; RATS; RATS, SPRAGUE-DAWLEY; SOLVENTS; SPLEEN;

ANIMALIA; MUS; PANAX GINSENG;

EID: 55949120431     PISSN: 02786915     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.fct.2008.09.055     Document Type: Article

References (30)

1. 9-tetrahydrocannabinol administration. J. Pharmacol. Exp. Ther. 303 (2002) 340-346
2. Corsini E., Di Paola R., Viviani B., Genovese T., Mazzon E., Lucchi L., Marinovich M., Galli C.L., and Cuzzocrea S. Increased carrageenan-induced acute lung inflammation in old rats. Immunology 115 (2005) 253-261
3. Cuzzocrea S., Mazzon E., Di Paola R., Peli A., Bonato A., Britti D., Genovese T., Muià C., Crisafulli C., and Caputi A.P. The role of the peroxisome proliferator-activated receptor-α (PPAR-α) in the regulation of acute inflammation. J. Leukoc. Biol. 79 (2006) 999-1010
4. Di Rosa M., Papadimitrion J.P., and Willoughby D.A. Studies on the mediators of the acute inflammatory response induced in rats in different sites by carrageenan and turpentine. J. Pathol. 104 (1971) 15-29
5. Franzotti E.M., Santos C.V., Rodrigues H.M., Mourao R.H., Andrade M.R., and Antoniolla A.R. Anti-inflammatory, analgesic activity and acute toxicity of Sida cordifolia L. (Malva-branca). J. Ethnopharmacol. 72 (2000) 273-277
6. Fries J.F., Ramey D.R., Singh G., Morfeld D., Bloch D.A., and Raynauld J.P. A reevaluation of aspirin therapy in rheumatoid arthritis. Arch. Intern. Med. 153 (1993) 1465-1472
7. Fuzzati N., Gabetta B., Jagaker K., Pace R., and Peterlongo F. Liquid chromatography-electrospray mass spectrometric identification of ginsenosides in Panax ginseng roots. J. Chromatogr. A 854 (1999) 69-79
8. Harris J.M., and Spencer P.S.J. A modified plethysmography apparatus for recording volume changes in rat paw. J. Pharm. Pharmacol. 14 (1962) 464-466
9. Jeong C.S. General pharmacology of head of Panax ginseng butanol fraction. Kor. J. Pharmacogn. 33 (2002) 151-155
10. Koster R., Anderson M., and Beer E.J. Acetic acid for analgesic and screening. Fed. Proc. 18 (1959) 412-416
11. Lee Y.C., Kim S.H., Roh S.S., Choi H.Y., and Seo Y.B. Suppressive effects of Chelidonium majus methanol extract in knee joint, regional lymph nodes, and spleen on collagen-induced arthritis in mice. J. Ethnopharmacol. 112 (2007) 40-48
12. Lorke D. A new approach to practical acute toxicity testing. Arch. Toxicol. 54 (1983) 275-287
13. Madhok R., Crilly A., Watson J., and Capell H.A. Serum IL-6 levels in rheumatoid arthritis: correlations with clinical and laboratory indices of disease activity. Ann. Rheum. Dis. 52 (1993) 232-234
14. Malfait A.M., Gallily R., Sumariwalla P.F., Malik A.S., Andreakos E., Mechoulam R., and Felmann M. The nonpsychoactive cannabis constituent cannabidiol is an oral anti-arthritic therapeutic in murine collagen-induced arthritis. Proc. Natl. Acad. Sci. U.S.A. 97 (2000) 9561-9566
15. Miles A.A., and Miles E.M. Vascular reactions to histamine, histamine-liberator and leukotaxine in the skin of guinea-pigs. J. Physiol. 118 (1952) 228-257
16. Nandakumar K.S., Backlund J., Vestberg M., and Holmdahl R. Collagen type II (CII)-specific antibodies induce arthritis in the absence of T or B cells but the arthritis progression is enhanced by CII-reactive T cells. Arthritis Res. Ther. 6 (2004) 544-550
17. Nantel F., Denis D., Gordon R., Northey A., Cirino M., Metters K.M., and Chan C.C. Distribution and regulation of cyclooxygenase-2 in carrageenan-induced inflammation. Br. J. Pharmacol. 128 (1999) 83-859
18. Ojewole J.A.O. Antinociceptive, anti-inflammatory and antidiabetic properties of Hypoxis hemerocallidea Fisch. and C.A. Mey. (Hypoxidaceae) corm ['African Potato'] aqueous extract in mice and rats. J. Ethnopharmacol. 103 (2006) 126-134
19. Pan M., Kang I., Craft J., and Yin Z. Resistance to development of collagen-induced arthritis in C57BL/6 mice is due to a defect in secondary, but not in primary, immune response. J. Clin. Immunol. 24 (2004) 481-491
20. Petkov V.D., and Mosharov A.H. Effects of standardized ginseng extract on learning memory and physical capabilities. Am. J. Chin. Med. 5 (1987) 19-29
21. Saito H., Yoshida Y., and Takagi K. Effect of Panax ginseng root on exhaustive exercise in mice. Jpn. J. Pharmacol. 24 (1974) 119-127
22. Spector W.G., and Willoughby D.A. The inflammatory response. Bacteriol. Rev. 27 (1963) 117-154
23. Trentham D.E., Townes A.S., and Kang A.S. Autoimmunity to type II collagen: an experimental model of arthritis. J. Exp. Med. 146 (1977) 857-868
24. Ueno A., Naraba H., Ikeda Y., Ushikubi F., Murata T., Naramiya S., and Ohishi S. Intrinsic prostacyclin contributes to exudation induced by bradikinin or carrageenan: a study on the paw edema induced in ip-receptor-deficient mice. Life Sci. 66 (2000) 155-160
25. Van Snick J. Interleukin-6 an overview. Annu. Rev. Immunol. 8 (1990) 253-278
26. Vogel H.G., and Vogel W.H. Drug Discovery and Evaluation, Pharmacological Assays (1997), Springer, Berlin
27. Wang H.C., Chen C.R., and Chang C.J. Carbon dioxide extraction of ginseng root hair oil and ginsenosides. Food Chem. 72 (2001) 505-509
28. Whittle B.A. The use of changes in capillary permeability in mice to distinguish between narcortic analgesics. Br. J. Pharmacol. 22 (1964) 246-253
29. Winter C.A., Risley E.A., and Nuss G.W. Carrageenan-induced edema in hind paw of the rat as an assay for anti-inflammatory drugs. Proc. Soc. Exp. Biol. Med. 111 (1962) 544-547
30. Yun T.K., and Choi S.Y. Non-organ specific cancer prevention of ginseng: a prospective study in Korea. Int. J. Epidemiol. 27 (1998) 359-364