-
1
-
-
9244224723
-
Intrinsic tumour suppression
-
Lowe SW, Cepero E, Evan G. Intrinsic tumour suppression. Nature 2004;432:307-15.
-
(2004)
Nature
, vol.432
, pp. 307-315
-
-
Lowe, S.W.1
Cepero, E.2
Evan, G.3
-
2
-
-
72949096792
-
Senescence in tumours: Evidence from mice and humans
-
Collado M, Serrano M. Senescence in tumours: evidence from mice and humans. Nat Rev Cancer 2010;10:51-7.
-
(2010)
Nat Rev Cancer
, vol.10
, pp. 51-57
-
-
Collado, M.1
Serrano, M.2
-
3
-
-
34548186667
-
Cellular senescence: When bad things happen to good cells
-
Campisi J, d'Adda di Fagagna F. Cellular senescence: when bad things happen to good cells. Nat Rev Mol Cell Biol 2007;8:729-40.
-
(2007)
Nat Rev Mol Cell Biol
, vol.8
, pp. 729-740
-
-
Campisi, J.1
D'Adda Di Fagagna, F.2
-
5
-
-
77952576753
-
The Yin and Yang functions of the Myc oncoprotein in cancer development and as targets for therapy
-
Larsson LG, Henriksson MA. The Yin and Yang functions of the Myc oncoprotein in cancer development and as targets for therapy. Exp Cell Res 2010;316:1429-37.
-
(2010)
Exp Cell Res
, vol.316
, pp. 1429-1437
-
-
Larsson, L.G.1
Henriksson, M.A.2
-
6
-
-
0032145569
-
Myc signaling via the ARF tumor suppressor regulates p53-dependent apoptosis and immortalization
-
Zindy F, Eischen CM, Randle DH, et al. Myc signaling via the ARF tumor suppressor regulates p53-dependent apoptosis and immortalization. Genes Dev 1998;12:2424-33.
-
(1998)
Genes Dev
, vol.12
, pp. 2424-2433
-
-
Zindy, F.1
Eischen, C.M.2
Randle, D.H.3
-
7
-
-
0030944985
-
Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a
-
Serrano M, Lin AW, McCurrach ME, Beach D, Lowe SW. Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a. Cell 1997;88:593-602.
-
(1997)
Cell
, vol.88
, pp. 593-602
-
-
Serrano, M.1
Lin, A.W.2
McCurrach, M.E.3
Beach, D.4
Lowe, S.W.5
-
8
-
-
0020520516
-
Tumorigenic conversion of primary embryo fibroblasts requires at least two cooperating oncogenes
-
Land H, Parada LF, Weinberg RA. Tumorigenic conversion of primary embryo fibroblasts requires at least two cooperating oncogenes. Nature 1983;304:596-602. (Pubitemid 13035496)
-
(1983)
Nature
, vol.304
, Issue.5927
, pp. 596-602
-
-
Land, H.1
Parada, L.F.2
Weinberg, R.A.3
-
9
-
-
76249101395
-
Phosphorylation by Cdk2 is required for Myc to repress Ras-induced senescence in cotransformation
-
Hydbring P, Bahram F, Su Y, et al. Phosphorylation by Cdk2 is required for Myc to repress Ras-induced senescence in cotransformation. Proc Natl Acad Sci U S A 2010;107:58-63.
-
(2010)
Proc Natl Acad Sci U S A
, vol.107
, pp. 58-63
-
-
Hydbring, P.1
Bahram, F.2
Su, Y.3
-
10
-
-
56149126490
-
C-MYC overexpression is required for continuous suppression of oncogene-induced senescence in melanoma cells
-
Zhuang D, Mannava S, Grachtchouk V, et al. C-MYC overexpression is required for continuous suppression of oncogene-induced senescence in melanoma cells. Oncogene 2008;27:6623-34.
-
(2008)
Oncogene
, vol.27
, pp. 6623-6634
-
-
Zhuang, D.1
Mannava, S.2
Grachtchouk, V.3
-
11
-
-
8644219655
-
Living with or without cyclins and cyclindependent kinases
-
Sherr CJ, Roberts JM. Living with or without cyclins and cyclindependent kinases. Genes Dev 2004;18:2699-711.
-
(2004)
Genes Dev
, vol.18
, pp. 2699-2711
-
-
Sherr, C.J.1
Roberts, J.M.2
-
12
-
-
32444444938
-
C-Myc phosphorylation is required for cellular response to oxidative stress
-
Benassi B, Fanciulli M, Fiorentino F, et al. c-Myc phosphorylation is required for cellular response to oxidative stress. Mol Cell 2006;21:509-19.
-
(2006)
Mol Cell
, vol.21
, pp. 509-519
-
-
Benassi, B.1
Fanciulli, M.2
Fiorentino, F.3
-
13
-
-
77949730783
-
Cdk2 suppresses cellular senescence induced by the c-myc oncogene
-
1-14
-
Campaner S, Doni M, Hydbring P, et al. Cdk2 suppresses cellular senescence induced by the c-myc oncogene. Nat Cell Biol 2010;12:54-9, 1-14.
-
(2010)
Nat Cell Biol
, vol.12
, pp. 54-59
-
-
Campaner, S.1
Doni, M.2
Hydbring, P.3
-
14
-
-
0037663490
-
Werner syndrome protein limits MYC-induced cellular senescence
-
Grandori C, Wu KJ, Fernandez P, et al. Werner syndrome protein limits MYC-induced cellular senescence. Genes Dev 2003;17:1569-74.
-
(2003)
Genes Dev
, vol.17
, pp. 1569-1574
-
-
Grandori, C.1
Wu, K.J.2
Fernandez, P.3
-
16
-
-
34548771087
-
Cellular senescence is an important mechanism of tumor regression upon c-Myc inactivation
-
DOI 10.1073/pnas.0701953104
-
Wu CH, van Riggelen J, Yetil A, Fan AC, Bachireddy P, Felsher DW. Cellular senescence is an important mechanism of tumor regression upon c-Myc inactivation. Proc Natl Acad Sci U S A 2007;104:13028-33. (Pubitemid 351737587)
-
(2007)
Proceedings of the National Academy of Sciences of the United States of America
, vol.104
, Issue.32
, pp. 13028-13033
-
-
Wu, C.-H.1
Van Riggelen, J.2
Yetil, A.3
Fan, A.C.4
Bachireddy, P.5
Felsher, D.W.6
-
17
-
-
33748069123
-
Cyclin-dependent kinase 2 functions in normal DNA repair and is a therapeutic target in BRCA1-deficient cancers
-
Deans AJ, Khanna KK, McNees CJ, Mercurio C, Heierhorst J, McArthur GA. Cyclin-dependent kinase 2 functions in normal DNA repair and is a therapeutic target in BRCA1-deficient cancers. Cancer Res 2006;66:8219-26.
-
(2006)
Cancer Res
, vol.66
, pp. 8219-8226
-
-
Deans, A.J.1
Khanna, K.K.2
McNees, C.J.3
Mercurio, C.4
Heierhorst, J.5
McArthur, G.A.6
-
18
-
-
77949274487
-
p53-dependent senescence delays Emu-myc-induced B-cell lymphomagenesis
-
Post SM, Quintas-Cardama A, Terzian T, Smith C, Eischen CM, Lozano G. p53-dependent senescence delays Emu-myc-induced B-cell lymphomagenesis. Oncogene 2010;29:1260-9.
-
(2010)
Oncogene
, vol.29
, pp. 1260-1269
-
-
Post, S.M.1
Quintas-Cardama, A.2
Terzian, T.3
Smith, C.4
Eischen, C.M.5
Lozano, G.6
-
19
-
-
69149108005
-
Inactivation of CDK2 is synthetically lethal to MYCN over-expressing cancer cells
-
Molenaar JJ, Ebus ME, Geerts D, et al. Inactivation of CDK2 is synthetically lethal to MYCN over-expressing cancer cells. Proc Natl Acad Sci U S A 2009;106:12968-73.
-
(2009)
Proc Natl Acad Sci U S A
, vol.106
, pp. 12968-12973
-
-
Molenaar, J.J.1
Ebus, M.E.2
Geerts, D.3
-
20
-
-
0041327168
-
Proliferation of cancer cells despite CDK2 inhibition
-
DOI 10.1016/S1535-6108(03)00053-9
-
Tetsu O, McCormick F. Proliferation of cancer cells despite CDK2 inhibition. Cancer Cell 2003;3:233-45. (Pubitemid 37443879)
-
(2003)
Cancer Cell
, vol.3
, Issue.3
, pp. 233-245
-
-
Tetsu, O.1
McCormick, F.2
-
21
-
-
10944228764
-
Critical role of CDK2 for melanoma growth linked to its melanocyte-specific transcriptional regulation by MITF
-
Du J, Widlund HR, Horstmann MA, et al. Critical role of CDK2 for melanoma growth linked to its melanocyte-specific transcriptional regulation by MITF. Cancer Cell 2004;6:565-76.
-
(2004)
Cancer Cell
, vol.6
, pp. 565-576
-
-
Du, J.1
Widlund, H.R.2
Horstmann, M.A.3
-
22
-
-
77949741498
-
Skp2 targeting suppresses tumorigenesis by Arf-p53-independent cellular senescence
-
Lin HK, Chen Z, Wang G, et al. Skp2 targeting suppresses tumorigenesis by Arf-p53-independent cellular senescence. Nature 2010;464:374-9.
-
(2010)
Nature
, vol.464
, pp. 374-379
-
-
Lin, H.K.1
Chen, Z.2
Wang, G.3
-
23
-
-
34447137342
-
Inhibition of CDK1 as a potential therapy for tumors over-expressing MYC
-
Goga A, Yang D, Tward AD, Morgan DO, Bishop JM. Inhibition of CDK1 as a potential therapy for tumors over-expressing MYC. Nat Med 2007;13:820-7.
-
(2007)
Nat Med
, vol.13
, pp. 820-827
-
-
Goga, A.1
Yang, D.2
Tward, A.D.3
Morgan, D.O.4
Bishop, J.M.5
-
24
-
-
77649295810
-
Tumor stroma-derived TGF-beta limitsmyc-driven lymphomagenesis via Suv39h1-dependent senescence
-
Reimann M, Lee S, Loddenkemper C, et al. Tumor stroma-derived TGF-beta limitsmyc-driven lymphomagenesis via Suv39h1-dependent senescence. Cancer Cell2010;17:262-72.
-
(2010)
Cancer Cell
, vol.17
, pp. 262-272
-
-
Reimann, M.1
Lee, S.2
Loddenkemper, C.3
|