Parkinson's disease-related protein, α-synuclein, in Malignant Melanoma

PLoS ONE

Volumn 5, Issue 5, 2010, Pages

  Matsuo, Yasuhiro ^a   Kamitani, Tetsu ^a  

^a MEDICAL COLLEGE OF GEORGIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA SYNUCLEIN; BIOLOGICAL MARKER; MELANIN; MART1 ANTIGEN; TUMOR ANTIGEN; TUMOR MARKER; TUMOR PROTEIN;

AGED; ARTICLE; BRAIN TUMOR; CANCER CELL; CONTROLLED STUDY; FEMALE; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; MALE; MELANOMA; MELANOMA CELL; NEVUS CELL; PARKINSON DISEASE; PROTEIN DETERMINATION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; RETINOBLASTOMA; ADULT; METABOLISM; MIDDLE AGED; NEVUS; PATHOLOGY; PIGMENTATION; SKIN TUMOR; TUMOR CELL LINE;

ADULT; AGED; ALPHA-SYNUCLEIN; ANTIGENS, NEOPLASM; BRAIN NEOPLASMS; CELL LINE, TUMOR; FEMALE; HUMANS; MALE; MELANINS; MELANOMA; MIDDLE AGED; NEOPLASM PROTEINS; NEVUS; PARKINSON DISEASE; PIGMENTATION; RETINOBLASTOMA; SKIN NEOPLASMS; TUMOR MARKERS, BIOLOGICAL;

EID: 77956276535     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0010481     Document Type: Article

References (19)

1. Thompson JF, Scolyer RA, Kefford RF (2005) Cutaneous melanoma. Lancet 365: 687-701.
2. Batistatou A, Cook MG, Massi D (2009) Histopathology report of cutaneous melanoma and sentinel lymph node in Europe: a web-based survey by the Dermatopathology Working Group of the European Society of Pathology. Virchows Arch 454: 505-511.
3. Larson AR, Konat E, Alani RM (2009) Melanoma biomarkers: current status and vision for the future. Nat Clin Pract Oncol 6: 105-117.
4. Zubovits J, Buzney E, Yu L, Duncan LM (2004) HMB-45, S-100, NK1/C3, and MART-1 in metastatic melanoma. Hum Pathol 35: 217-223.
5. Cormier JN, Abati A, Fetsch P, Hijazi YM, Rosenberg SA, et al. (1998) Comparative analysis of the in vivo expression of tyrosinase, MART-1/Melan- A, and gp100 in metastatic melanoma lesions: implications for immunotherapy. J Immunother 21: 27-31.
6. Clarkson KS, Sturdgess IC, Molyneux AJ (2001) The usefulness of tyrosinase in the immunohistochemical assessment of melanocytic lesions: a comparison of the novel T311 antibody (anti-tyrosinase) with S-100, HMB45, and A103 (antimelan- A). J Clin Pathol 54: 196-200.
7. Fetsch PA, Marincola FM, Filie A, Hijazi YM, Kleiner DE, et al. (1999) Melanoma-associated antigen recognized by T cells (MART-1): the advent of a preferred immunocytochemical antibody for the diagnosis of metastatic malignant melanoma with fine-needle aspiration. Cancer 87: 37-42.
8. Yu LL, Flotte TJ, Tanabe KK, Gadd MA, Cosimi AB, et al. (1999) Detection of microscopic melanoma metastases in sentinel lymph nodes. Cancer 86: 617-627.
9. Shidham VB, Qi DY, Acker S, Kampalath B, Chang CC, et al. (2001) Evaluation of micrometastases in sentinel lymph nodes of cutaneous melanoma: higher diagnostic accuracy with Melan-A and MART-1 compared with S-100 protein and HMB-45. Am J Surg Pathol 25: 1039-1046.
10. Olsen JH, Friis S, Frederiksen K (2006) Malignant melanoma and other types of cancer preceding Parkinson disease. Epidemiology 17: 582-587.
11. Olsen JH, Friis S, Frederiksen K, McLaughlin JK, Mellemkjaer L, et al. (2005) Atypical cancer pattern in patients with Parkinson's disease. Br J Cancer 92: 201-205.
12. Gao X, Simon KC, Han J, Schwarzschild MA, Ascherio A (2009) Family history of melanoma and Parkinson disease risk. Neurology 73: 1286-1291.
13. Waxman EA, Giasson BI (2009) Molecular mechanisms of alpha-synuclein neurodegeneration. Biochim Biophys Acta 1792: 616-624.
14. Raposo G, Marks MS (2007) Melanosomes-dark organelles enlighten endosomal membrane transport. Nat Rev Mol Cell Biol 8: 786-797.
15. De Maziere AM, Muehlethaler K, van Donselaar E, Salvi S, Davoust J, et al. (2002) The melanocytic protein Melan-A/MART-1 has a subcellular localization distinct from typical melanosomal proteins. Traffic 3: 678-693.
16. Perez RG, Waymire JC, Lin E, Liu JJ, Guo F, et al. (2002) A role for alphasynuclein in the regulation of dopamine biosynthesis. J Neurosci 22: 3090-3099.
17. Peng X, Tehranian R, Dietrich P, Stefanis L, Perez RG (2005) Alpha-synuclein activation of protein phosphatase 2A reduces tyrosine hydroxylase phosphorylation in dopaminergic cells. J Cell Sci 118: 3523-3530.
18. Goridis C, Rohrer H (2002) Specification of catecholaminergic and serotonergic neurons. Nat Rev Neurosci 3: 531-541.
19. Gronskov K, Ek J, Brondum-Nielsen K (2007) Oculocutaneous albinism. Orphanet J Rare Dis 2: 43.