The melanocytic protein Melan-A/MART-1 has a subcellular localization distinct from typical melanosomal proteins

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Volumn 3, Issue 9, 2002, Pages 678-693

  De Mazière, Ann M ^a   Muehlethaler, Katja ^b   Van Donselaar, Elly ^a   Salvi, Suzanne ^b   Davoust, Jean ^c   Cerottini, Jean Charles ^b   Lévy, Frédéric ^b   Slot, Jan W ^a   Rimoldi, Donata ^b  

^a UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

^b UNIVERSITY OF LAUSANNE   (Switzerland)

^c INSTITUT GUSTAVE ROUSSY   (France)

Author keywords

Endosome; Immunoelectron microscopy; Melan 1 MART 1; Melanoma; Melanosome

Indexed keywords

MELAN A; MART1 ANTIGEN; TUMOR ANTIGEN; TUMOR PROTEIN;

ACYLATION; ARTICLE; BIOCHEMISTRY; BIOGENESIS; CELL COMPARTMENTALIZATION; CELL LABELING; CELL LINE; CELL LINEAGE; CELL MATURATION; CELL MEMBRANE; CELL NUCLEUS MEMBRANE; CELL ORGANELLE; CELL STRUCTURE; CELL VACUOLE; CELL WALL; CELLULAR DISTRIBUTION; CONTROLLED STUDY; ENDOPLASMIC RETICULUM; ENDOSOME; GOLGI COMPLEX; HUMAN; HUMAN CELL; IMMUNOELECTRON MICROSCOPY; IMMUNOFLUORESCENCE MICROSCOPY; MELANOCYTE; MELANOMA CELL; MELANOSOME; PIGMENTATION; PRIORITY JOURNAL; PROTEIN CONTENT; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN METABOLISM; PROTEIN PROCESSING; QUANTITATIVE ANALYSIS; STEM CELL; TRANS GOLGI NETWORK; CELL FRACTIONATION; CONFOCAL MICROSCOPY; FLUORESCENCE MICROSCOPY; METABOLISM; POLYACRYLAMIDE GEL ELECTROPHORESIS; SKIN;

ELECTROPHORESIS, POLYACRYLAMIDE GEL; GOLGI APPARATUS; HUMAN; MELANOSOMES; MICROSCOPY, CONFOCAL; MICROSCOPY, FLUORESCENCE; NEOPLASM PROTEINS; SKIN; SUBCELLULAR FRACTIONS; SUPPORT, NON-U.S. GOV'T; ANTIGENS, NEOPLASM; HUMANS;

EID: 0036707868     PISSN: 13989219     EISSN: None     Source Type: Journal    
DOI: 10.1034/j.1600-0854.2002.30909.x     Document Type: Article

References (46)

1. A new gene coding for a differentiation antigen recognized by autologous cytolytic T lymphocytes on HLA-A2 melanomas
2. Cloning of the gene coding for a shared human melanoma antigen recognized by autologous T cells infiltrating into tumor
3. Cloning and characterization of the genes encoding the murine homologues of the human melanoma antigens MART1 and gp100
4. Identification of the immunodominant peptides of the MART-1 human melanoma antigen recognized by the majority of HLA-A2-restricted tumor infiltrating lymphocytes
5. Cytolytic T lymphocyte recognition of the immunodominant HLA-A*0201-restricted Melan-A/MART-1 antigenic peptide in melanoma
6. The use of melanosomal proteins in the immunotherapy of melanoma
7. + T cells after vaccination with antigenic peptide
8. Subcellular localization of the melanoma-associated protein Melan-AMART-1 influences the processing of its HLA-A2-restricted epitope
9. Production of recombinant MART-1 proteins and specific antiMART-1 polyclonal and monoclonal antibodies: Use in the characterization of the human melanoma antigen MART-1
10. Chemical composition and terminology of specialized organelles (melanosomes and melanin granules) in mammalian melanocytes
11. The melanosome membrane dynamics in black and white
12. Distinct protein sorting and localization to premelanosomes, melanosomes, and lysosomes in pigmented melanocytic cells
13. Characterization and subcellular localization of human Pmel 17/silver, a 110-kDa (pre) melanosomal membrane protein associated with 5, 6,-dihydroxyindole-2-carboxylic acid (DHICA) converting activity
14. The Pmel 17/silver locus protein. Characterization and investigation of its melanogenic function
15. Sorting and targeting of melanosomal membrane proteins: Signals, pathways, and mechanisms
16. Assembly, target-signaling and intracellular transport of tyrosinase gene family proteins in the initial stage of melanosome biogenesis
17. Signalling functions of protein palmitoylation
18. Serological analysis of Melan-A (MART-1), a melanocyte-specific protein homogeneously expressed in human melanomas
19. Subcellular localization of melanin biosynthesis
20. Syntaxin 13 mediates cycling of plasma membrane proteins via tubulovesicular recycling enclosomes
21. The Hermansky-Pudlak syndrome (HPS) protein is part of a high molecular weight complex involved in biogenesis of early melanosomes
22. Lysosome-related organelles
23. Intracellular sorting and targeting of melanosomal membrane proteins: Identification of signals for sorting of the human brown locus protein, gp75
24. Intracellular trafficking of lysosomal membrane proteins
25. A cytoplasmic sequence in human tyrosinase defines a second class of di-leucine-based sorting signals for late endosomal and lysosomal delivery
26. Di-leucine signals mediate targeting of tyrosinase and synaptotagmin to synaptic-like microvesicles within PC12 cells
27. A di-leucine-based motif in the cytoplasmic tail of LIMP-II and tyrosinase mediates selective binding of AP-3
28. AP-3 mediates tyrosinase but not TRP-1 trafficking in human melanocytes
29. The tyrosinase tail mediates sorting to the lysosomal compartment in MDCK cells via a di-leucine and a tyrosine-based signal
30. The tyrosine-based lysosomal targeting signal in lamp-1 mediates sorting into Golgi-derived clathrin-coated vesicles
31. The mammalian AP-3 adaptor-like complex mediates the intracellular transport of lysosomal membrane glycoproteins
32. Differential roles of syntaxin 7 and syntaxin 8 in enclosomal trafficking
33. Bi-layered clathrin coats on endosomal vacuoles are involved in protein sorting towards lysosomes
34. Multivesicular endosomes containing internalized EGF-EGF receptor complexes mature and then fuse directly with lysosomes
35. Hrs recruits clathrin to early endosomes
36. Pmel17 initiates premelanosome morphogenesis within multivesicular bodies
37. A model for melanosome biogenesis based on the purification and analysis of early melanosomes
38. Interaction of melanosomal proteins with melanin
39. Aberrant retention of tyrosinase in the endoplasmic reticulum mediates accelerated degradation of the enzyme and contributes to the dedifferentiated phenotype of amelanotic melanoma cells
40. Reversible palmitoylation of signaling proteins
41. Palmitoylation-dependent control of degradation, life span, and membrane expression of the CCR5 receptor
42. Palmitoylation of the canine histamine H2 receptor occurs at Cys (305) and is important for cell surface targeting
43. Cysteine34 of the cytoplasmic tail of the cation-dependent mannose 6-phosphate receptor is reversibly palmitoylated and required for normal trafficking and lysosomal enzyme sorting
44. Dual palmitoylation of PSD-95 mediates its vesiculotubular sorting, postsynaptic targeting, and ion channel clustering
45. A monoclonal antibody specific for cells of the melanocyte lineage
46. Immunolocalization of the insulin regulatable glucose transporter in brown adipose tissue of the rat