Characterization of the Raf kinase inhibitory protein (RKIP) binding pocket: NMR-based screening identifies small-molecule ligands

PLoS ONE

Volumn 5, Issue 5, 2010, Pages

  Shemon, Anne N ^a   Heil, Gary L ^b   Granovsky, Alexey E ^a   Clark, Mathew M ^a,b   McElheny, Dan ^b   Chimon, Alexander ^a   Rosner, Marsha R ^a,b   Koide, Shohei ^b  

^a UNIVERSITY OF CHICAGO   (United States)

^b UNIVERSITY OF CHICAGO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4 [[4 [(2,4 DINITROPHENYL)AMINOL]PHENYL]AMINO] 4 OXO 2 BUTENOIC ACID; 9 (2,3 DIHYDROXYPROPYL)ADENINE; EPIDERMAL GROWTH FACTOR; LOCOSTATIN; MITOGEN ACTIVATED PROTEIN KINASE; N [[(2 BROMO 4 NITROPHENYL)AMINO]CARBONOTHIOYL] 3 (2 THIENYL)ACRYLAMIDE; N' (2,4 DINITROPHENYL) 2,3,4,5,6 PENTAFLUOROBENZOHYDRAZIDE; PHOSPHATIDYLETHANOLAMINE; PHOSPHATIDYLETHANOLAMINE BINDING PROTEIN; PROTEIN KINASE INHIBITOR; RAF PROTEIN; UNCLASSIFIED DRUG; LIGAND; PEBP1 PROTEIN, HUMAN;

ARTICLE; BINDING AFFINITY; BINDING SITE; CONTROLLED STUDY; DRUG IDENTIFICATION; DRUG PROTEIN BINDING; DRUG SCREENING; DRUG STRUCTURE; HELA CELL; HETERONUCLEAR NUCLEAR MAGNETIC RESONANCE; HUMAN; HUMAN CELL; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; ANIMAL; BIOASSAY; CELL SURVIVAL; CHEMISTRY; DRUG EFFECT; ENZYME INDUCTION; METABOLISM; MOLECULAR LIBRARY; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PH; PHOSPHORYLATION; PROTEIN BINDING; RAT;

ANIMALS; BINDING SITES; BIOLOGICAL ASSAY; CELL SURVIVAL; ENZYME INDUCTION; EPIDERMAL GROWTH FACTOR; HELA CELLS; HUMANS; HYDROGEN-ION CONCENTRATION; LIGANDS; MAGNETIC RESONANCE SPECTROSCOPY; MITOGEN-ACTIVATED PROTEIN KINASES; PHOSPHATIDYLETHANOLAMINE BINDING PROTEIN; PHOSPHORYLATION; PROTEIN BINDING; RAF KINASES; RATS; SMALL MOLECULE LIBRARIES;

EID: 77956270130     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0010479     Document Type: Article

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