메뉴 건너뛰기




Volumn 30, Issue 5, 2010, Pages 675-682

Neuroprotective actions of the synthetic estrogen 17α- Ethynylestradiol in the hippocampus

Author keywords

Estrogens; Excitotoxicity; Kainic acid; Neurodegeneration; Quinolinic acid; Reactive astroglia

Indexed keywords

ETHINYLESTRADIOL; QUINOLINIC ACID; VIMENTIN;

EID: 77956265551     PISSN: 02724340     EISSN: None     Source Type: Journal    
DOI: 10.1007/s10571-009-9490-3     Document Type: Article
Times cited : (17)

References (62)
  • 2
    • 0032517113 scopus 로고    scopus 로고
    • Estradiol prevents kainic acid-induced neuronal loss in the rat dentate gyrus
    • Azcoitia I, Sierra A, Garcia-Segura LM (1998) Estradiol prevents kainic acid-induced neuronal loss in the rat dentate gyrus. Neuroreport 9:3075-3079
    • (1998) Neuroreport , vol.9 , pp. 3075-3079
    • Azcoitia, I.1    Sierra, A.2    Garcia-Segura, L.M.3
  • 3
    • 0033298546 scopus 로고    scopus 로고
    • Gonadal hormones affect neuronal vulnerability to excitotoxininduced degeneration
    • Azcoitia I, Fernandez-Galaz C, Sierra A, Garcia-Segura LM (1999a) Gonadal hormones affect neuronal vulnerability to excitotoxininduced degeneration. J Neurocytol 28:699-710
    • (1999) J. Neurocytol , vol.28 , pp. 699-710
    • Azcoitia, I.1    Fernandez-Galaz, C.2    Sierra, A.3    Garcia-Segura, L.M.4
  • 4
    • 0033573273 scopus 로고    scopus 로고
    • Neuroprotective effects of estradiol in the adult rat hippocampus: Interaction with insulin-like growth factor-I signalling
    • Azcoitia I, Sierra A, Garcia-Segura LM (1999b) Neuroprotective effects of estradiol in the adult rat hippocampus: interaction with insulin-like growth factor-I signalling. J Neurosci Res 58:815-822
    • (1999) J. Neurosci. Res. , vol.58 , pp. 815-822
    • Azcoitia, I.1    Sierra, A.2    Garcia-Segura, L.M.3
  • 6
    • 0038657688 scopus 로고    scopus 로고
    • Estrogen can protect neurons: Modes of action
    • Behl C (2002) Estrogen can protect neurons: modes of action. J Steroid Biochem Mol Biol 83:195-197
    • (2002) J. Steroid Biochem. Mol. Biol. , vol.83 , pp. 195-197
    • Behl, C.1
  • 8
    • 0034333266 scopus 로고    scopus 로고
    • Kainate, a double agent that generates seizures: Two decades of progress
    • Ben-Ari Y, Cossart R (2000) Kainate, a double agent that generates seizures: two decades of progress. Trends Neurosci 23:580-587
    • (2000) Trends Neurosci. , vol.23 , pp. 580-587
    • Ben-Ari, Y.1    Cossart, R.2
  • 10
    • 0032755173 scopus 로고    scopus 로고
    • Chemical and anatomical changes in the striatum and substantia nigra following quinolinic acid lesions in the striatum of the rat: A detailed time course of the cellular and GABA (A) receptor changes
    • Brickell KL, Nicholson LFB, Waldvogel HJ, Faull RLM (1999) Chemical and anatomical changes in the striatum and substantia nigra following quinolinic acid lesions in the striatum of the rat: a detailed time course of the cellular and GABA (A) receptor changes. J Chem Neuroanat 17:75-97
    • (1999) J. Chem. Neuroanat. , vol.17 , pp. 75-97
    • Brickell, K.L.1    Nicholson, L.F.B.2    Waldvogel, H.J.3    Faull, R.L.M.4
  • 11
    • 0030773376 scopus 로고    scopus 로고
    • Neuron loss, granule cell axon reorganization, and functional changes in the dentate gyrus of epileptic kainite-treated rats
    • Buckmaster PS, Dudek FE (1997) Neuron loss, granule cell axon reorganization, and functional changes in the dentate gyrus of epileptic kainite-treated rats. J Comp Neurol 385:385-404
    • (1997) J. Comp. Neurol. , vol.385 , pp. 385-404
    • Buckmaster, P.S.1    Dudek, F.E.2
  • 12
    • 73349128704 scopus 로고    scopus 로고
    • Selective estrogen receptor modulators decrease the production of interleukin-6 and interferon-gamma-inducible protein-10 by astrocytes exposed to inflammatory challenge in vitro
    • Cerciat M, Unkila M, Garcia-Segura LM, Arevalo MA (2010) Selective estrogen receptor modulators decrease the production of interleukin-6 and interferon-gamma-inducible protein-10 by astrocytes exposed to inflammatory challenge in vitro. Glia 58:93-102
    • (2010) Glia , vol.58 , pp. 93-102
    • Cerciat, M.1    Unkila, M.2    Garcia-Segura, L.M.3    Arevalo, M.A.4
  • 13
    • 33749824242 scopus 로고    scopus 로고
    • Dose and temporal pattern of estrogen exposure determines neuroprotective outcome in hippocampal neurons: Therapeutic implications
    • Chen S, Nilsen J, Brinton RD (2006) Dose and temporal pattern of estrogen exposure determines neuroprotective outcome in hippocampal neurons: therapeutic implications. Endocrinology 147:5303-5313
    • (2006) Endocrinology , vol.147 , pp. 5303-5313
    • Chen, S.1    Nilsen, J.2    Brinton, R.D.3
  • 14
    • 7044231160 scopus 로고    scopus 로고
    • Selective estrogen receptor modulators protect hippocampal neurons from kainic acid excitotoxicity: Differences with the effect of estradiol
    • Ciriza I, Carrero P, Azcoitia I, Lundeen SG, Garcia-Segura LM (2004) Selective estrogen receptor modulators protect hippocampal neurons from kainic acid excitotoxicity: differences with the effect of estradiol. J Neurobiol 61:209-221
    • (2004) J. Neurobiol. , vol.61 , pp. 209-221
    • Ciriza, I.1    Carrero, P.2    Azcoitia, I.3    Lundeen, S.G.4    Garcia-Segura, L.M.5
  • 16
    • 33845590845 scopus 로고    scopus 로고
    • Role of astrocytes in estrogenmediated neuroprotection
    • Dhandapani KM, Brann DW (2007) Role of astrocytes in estrogenmediated neuroprotection. Exp Gerontol 42:70-75
    • (2007) Exp. Gerontol. , vol.42 , pp. 70-75
    • Dhandapani, K.M.1    Brann, D.W.2
  • 19
    • 0027314268 scopus 로고
    • Molecular profile of reactive astrocytes-implications for their role in neurologic disease
    • Eddleston M, Mucke L (1993) Molecular profile of reactive astrocytes-implications for their role in neurologic disease. Neuroscience 54:15-36
    • (1993) Neuroscience , vol.54 , pp. 15-36
    • Eddleston, M.1    Mucke, L.2
  • 21
    • 51849168176 scopus 로고    scopus 로고
    • Neuronmicroglia crosstalk up-regulates neuronal FGF-2 expression which mediates neuroprotection against excitotoxicity via JNK1/2
    • Figueiredo C, Pais TF, Gomes JR, Chatterjee S (2008) Neuronmicroglia crosstalk up-regulates neuronal FGF-2 expression which mediates neuroprotection against excitotoxicity via JNK1/2. J Neurochem 107:73-85
    • (2008) J. Neurochem. , vol.107 , pp. 73-85
    • Figueiredo, C.1    Pais, T.F.2    Gomes, J.R.3    Chatterjee, S.4
  • 25
    • 0031404546 scopus 로고    scopus 로고
    • Phenolic A ring requirement for the neuroprotective effects of steroids
    • Green PS, Gordon K, Simpkins JW (1997) Phenolic A ring requirement for the neuroprotective effects of steroids. J Steroid Biochem Mol Biol 63:229-235
    • (1997) J. Steroid Biochem. Mol. Biol. , vol.63 , pp. 229-235
    • Green, P.S.1    Gordon, K.2    Simpkins, J.W.3
  • 27
    • 9644289380 scopus 로고    scopus 로고
    • Chronic temporal lobe epilepsy is associated with severely declined dentate neurogenesis in the adult hippocampus
    • Hattiangady B, Rao MS, Shetty AK (2004) Chronic temporal lobe epilepsy is associated with severely declined dentate neurogenesis in the adult hippocampus. Neurobiol Dis 17:473-490
    • (2004) Neurobiol. Dis. , vol.17 , pp. 473-490
    • Hattiangady, B.1    Rao, M.S.2    Shetty, A.K.3
  • 28
    • 0033612565 scopus 로고    scopus 로고
    • Analysis of cell death in the trochlear nucleus of the chick embryo: Calibration of the optical dissector counting method reveals systematic bias
    • Hatton WJ, von Bartheld CS (1999) Analysis of cell death in the trochlear nucleus of the chick embryo: calibration of the optical dissector counting method reveals systematic bias. J Comp Neurol 409:169-186
    • (1999) J. Comp. Neurol. , vol.409 , pp. 169-186
    • Hatton, W.J.1    Von Bartheld, C.S.2
  • 29
    • 0034747419 scopus 로고    scopus 로고
    • 17Beta-estradiol attenuates quinolinic acid insult in the rat hippocampus
    • Heron P, Daya S (2001) 17Beta-estradiol attenuates quinolinic acid insult in the rat hippocampus. Metab Brain Dis 16:187-198
    • (2001) Metab. Brain Dis. , vol.16 , pp. 187-198
    • Heron, P.1    Daya, S.2
  • 30
    • 0004187685 scopus 로고    scopus 로고
    • Unbiased stereology. Three-dimensional measurement in microscopy
    • Oxford
    • Howard CV, Redd MG (1998) Unbiased stereology. Three-dimensional measurement in microscopy. Bios Scientific, Oxford
    • (1998) Bios Scientific
    • Howard, C.V.1    Redd, M.G.2
  • 32
    • 33750942277 scopus 로고    scopus 로고
    • Estrogen and the development and protection of nigrostriatal dopaminergic neurons: Concerted action of a multitude of signals, protective molecules, and growth factors
    • Kipp M, Karakaya S, Pawlak J, Araujo-Wright G, Arnold S, Beyer C (2006) Estrogen and the development and protection of nigrostriatal dopaminergic neurons: concerted action of a multitude of signals, protective molecules, and growth factors. Front Neuroendocrinol 27:376-390
    • (2006) Front Neuroendocrinol , vol.27 , pp. 376-390
    • Kipp, M.1    Karakaya, S.2    Pawlak, J.3    Araujo-Wright, G.4    Arnold, S.5    Beyer, C.6
  • 33
    • 34548572072 scopus 로고    scopus 로고
    • Oestrogen and progesterone reduce lipopolysaccharide-induced expression of tumour necrosis factor-alpha and interleukin-18 in midbrain astrocytes
    • Kipp M, Karakaya S, Johann S, Kampmann E, Mey J, Beyer C (2007) Oestrogen and progesterone reduce lipopolysaccharide-induced expression of tumour necrosis factor-alpha and interleukin-18 in midbrain astrocytes. J Neuroendocrinol 19:819-822
    • (2007) J. Neuroendocrinol , vol.19 , pp. 819-822
    • Kipp, M.1    Karakaya, S.2    Johann, S.3    Kampmann, E.4    Mey, J.5    Beyer, C.6
  • 34
    • 0035136594 scopus 로고    scopus 로고
    • Neuroprotection by estrogen via extracellular signal-regulated kinase against quinolinic acid-induced cell death in the rat hippocampus
    • Kuroki Y, Fukushima K, Kanda Y, Mizuno K, Watanabe Y (2001) Neuroprotection by estrogen via extracellular signal-regulated kinase against quinolinic acid-induced cell death in the rat hippocampus. Eur J Neurosci 13:472-476
    • (2001) Eur. J. Neurosci. , vol.13 , pp. 472-476
    • Kuroki, Y.1    Fukushima, K.2    Kanda, Y.3    Mizuno, K.4    Watanabe, Y.5
  • 35
    • 0036253035 scopus 로고    scopus 로고
    • Estradiol, but not raloxifene, improves aspects of spatial working memory in aged ovariectomized rhesus monkeys
    • Lacreuse A, Wilson ME, Herndon JG (2002) Estradiol, but not raloxifene, improves aspects of spatial working memory in aged ovariectomized rhesus monkeys. Neurobiol Aging 23:589-600
    • (2002) Neurobiol. Aging , vol.23 , pp. 589-600
    • Lacreuse, A.1    Wilson, M.E.2    Herndon, J.G.3
  • 36
    • 33748681724 scopus 로고    scopus 로고
    • Estrogen receptor protein interaction with phosphatidylinositol 3-kinase leads to activation of phosphorylated Akt and extracellular signal-regulated kinase 1/2 in the same population of cortical neurons: A unified mechanism of estrogen action
    • Mannella P, Brinton RD (2006) Estrogen receptor protein interaction with phosphatidylinositol 3-kinase leads to activation of phosphorylated Akt and extracellular signal-regulated kinase 1/2 in the same population of cortical neurons: a unified mechanism of estrogen action. J Neurosci 26:9439-9447
    • (2006) J. Neurosci. , vol.26 , pp. 9439-9447
    • Mannella, P.1    Brinton, R.D.2
  • 37
    • 33644534495 scopus 로고    scopus 로고
    • From structural biochemistry to expression profiling: Neuroprotective activities of estrogen
    • Manthey D, Behl C (2006) From structural biochemistry to expression profiling: neuroprotective activities of estrogen. Neuroscience 138:845-850
    • (2006) Neuroscience , vol.138 , pp. 845-850
    • Manthey, D.1    Behl, C.2
  • 38
    • 0033529941 scopus 로고    scopus 로고
    • The antioxidant neuroprotective effects of estrogens and phenolic compounds are independent from their estrogenic properties
    • Moosmann B, Behl C (1999) The antioxidant neuroprotective effects of estrogens and phenolic compounds are independent from their estrogenic properties. Proc Natl Acad Sci USA 96:8867-8872
    • (1999) Proc. Natl. Acad. Sci. USA , vol.96 , pp. 8867-8872
    • Moosmann, B.1    Behl, C.2
  • 40
    • 51649127553 scopus 로고    scopus 로고
    • Estradiol and neurodegenerative oxidative stress
    • Nilsen J (2008) Estradiol and neurodegenerative oxidative stress. Front Neuroendocrinol 29:463-475
    • (2008) Front Neuroendocrinol , vol.29 , pp. 463-475
    • Nilsen, J.1
  • 41
    • 0037087099 scopus 로고    scopus 로고
    • Dual action of estrogen on glutamate-induced calcium signaling: Mechanisms requiring interaction between estrogen receptors and src/mitogen activated protein kinase pathway
    • Nilsen J, Chen S, Brinton RD (2002) Dual action of estrogen on glutamate-induced calcium signaling: mechanisms requiring interaction between estrogen receptors and src/mitogen activated protein kinase pathway. Brain Res 930:216-234
    • (2002) Brain Res. , vol.930 , pp. 216-234
    • Nilsen, J.1    Chen, S.2    Brinton, R.D.3
  • 43
    • 14744293013 scopus 로고    scopus 로고
    • Neuroprotective effects of an estratriene analog are estrogen receptor independent in vitro and in vivo
    • Perez E, Liu R, Yang SH, Cai ZY, Covey DF, Simpkins JW (2005) Neuroprotective effects of an estratriene analog are estrogen receptor independent in vitro and in vivo. Brain Res 1038:216-222
    • (2005) Brain Res. , vol.1038 , pp. 216-222
    • Perez, E.1    Liu, R.2    Yang, S.H.3    Cai, Z.Y.4    Covey, D.F.5    Simpkins, J.W.6
  • 44
    • 0141884323 scopus 로고    scopus 로고
    • Neuroprotective and neurotoxic effects of estrogens
    • Picazo O, Azcoitia I, García-Segura LM (2003) Neuroprotective and neurotoxic effects of estrogens. Brain Res 990:20-27
    • (2003) Brain Res. , vol.990 , pp. 20-27
    • Picazo, O.1    Azcoitia, I.2    García-Segura, L.M.3
  • 45
    • 38649109472 scopus 로고    scopus 로고
    • Mechanistic investigations on the antioxidant action of a neuroprotective estrogen derivative
    • Prokai-Tatrai K, Perjesi P, Rivera-Portalatin NM, Simpkins JW, Prokai L (2008) Mechanistic investigations on the antioxidant action of a neuroprotective estrogen derivative. Steroids 73:280-288
    • (2008) Steroids , vol.73 , pp. 280-288
    • Prokai-Tatrai, K.1    Perjesi, P.2    Rivera-Portalatin, N.M.3    Simpkins, J.W.4    Prokai, L.5
  • 46
    • 0034003210 scopus 로고    scopus 로고
    • Neuroprotective effects of chronic estradiol benzoate treatment on hippocampal cell loss induced by status epilepticus in the female rat
    • Reibel S, André V, Chassagnon S, André G, Marescaux C, Nehlig A, Depaulis A (2000) Neuroprotective effects of chronic estradiol benzoate treatment on hippocampal cell loss induced by status epilepticus in the female rat. Neurosci Lett 281:79-82
    • (2000) Neurosci. Lett. , vol.281 , pp. 79-82
    • Reibel, S.1    André, V.2    Chassagnon, S.3    André, G.4    Marescaux, C.5    Nehlig, A.6    Depaulis, A.7
  • 47
    • 33747757721 scopus 로고    scopus 로고
    • Estrogens are potentially the only steroids with an antioxidant role in pregnancy: In vitro evidence
    • Reyes MR, Sifuentes-Alvarez A, Lazalde B (2006) Estrogens are potentially the only steroids with an antioxidant role in pregnancy: in vitro evidence. Acta Obstet Gynecol Scand 85:1090-1093
    • (2006) Acta Obstet. Gynecol. Scand. , vol.85 , pp. 1090-1093
    • Reyes, M.R.1    Sifuentes-Alvarez, A.2    Lazalde, B.3
  • 48
    • 0030697366 scopus 로고    scopus 로고
    • Reactive astrocytes: Cellular and molecular cues to biological function
    • Ridet JL, Malhotra SK, Privat A, Gage FH (1997) Reactive astrocytes: cellular and molecular cues to biological function. Trends Neurosci 20:570-577
    • (1997) Trends Neurosci. , vol.20 , pp. 570-577
    • Ridet, J.L.1    Malhotra, S.K.2    Privat, A.3    Gage, F.H.4
  • 49
    • 0028867902 scopus 로고
    • Effects of estrogens on the redox chemistry of iron: A possible mechanism of the antioxidant action of estrogens
    • Ruiz-Larrea B, Leal A, Martin C, Martinez R, Lacort M (1995) Effects of estrogens on the redox chemistry of iron: a possible mechanism of the antioxidant action of estrogens. Steroids 60:780-783
    • (1995) Steroids , vol.60 , pp. 780-783
    • Ruiz-Larrea, B.1    Leal, A.2    Martin, C.3    Martinez, R.4    Lacort, M.5
  • 51
    • 0036882077 scopus 로고    scopus 로고
    • Effects of 17betaestradiol and xenoestrogens on the neuronal survival in an organotypic hippocampal culture
    • Sato K, Matsuki N, Ohno Y, Nakazawa K (2002) Effects of 17betaestradiol and xenoestrogens on the neuronal survival in an organotypic hippocampal culture. Neuroendocrinology 76:223-234
    • (2002) Neuroendocrinology , vol.76 , pp. 223-234
    • Sato, K.1    Matsuki, N.2    Ohno, Y.3    Nakazawa, K.4
  • 52
    • 0032838951 scopus 로고    scopus 로고
    • Vulnerability of the dentate gyrus to aging and intracerebroventricular administration of kainic acid
    • Shetty AK, Turner DA (1999) Vulnerability of the dentate gyrus to aging and intracerebroventricular administration of kainic acid. Exp Neurol 158:491-503
    • (1999) Exp. Neurol. , vol.158 , pp. 491-503
    • Shetty, A.K.1    Turner, D.A.2
  • 54
    • 0036549257 scopus 로고    scopus 로고
    • Estrogen regulates the development of brain-derived neurotrophic factor mRNA and protein in the rat hippocampus
    • Solum DT, Handa RJ (2002) Estrogen regulates the development of brain-derived neurotrophic factor mRNA and protein in the rat hippocampus. J Neurosci 22:2650-2659
    • (2002) J. Neurosci. , vol.22 , pp. 2650-2659
    • Solum, D.T.1    Handa, R.J.2
  • 55
    • 0037307839 scopus 로고    scopus 로고
    • Oral feeding with ethinyl estradiol suppresses and treats experimental autoimmune encephalomyelitis in SJL mice and inhibits the recruitment of inflammatory cells into the central nervous system
    • Subramanian S, Matejuk A, Zamora A, Vandenbark AA, Offner H (2003) Oral feeding with ethinyl estradiol suppresses and treats experimental autoimmune encephalomyelitis in SJL mice and inhibits the recruitment of inflammatory cells into the central nervous system. J Immunol 170:1548-1555
    • (2003) J. Immunol. , vol.170 , pp. 1548-1555
    • Subramanian, S.1    Matejuk, A.2    Zamora, A.3    Vandenbark, A.A.4    Offner, H.5
  • 56
    • 33746216297 scopus 로고    scopus 로고
    • Mechanisms of neuroprotection by estrogen
    • Suzuki S, Brown CM, Wise PM (2006) Mechanisms of neuroprotection by estrogen. Endocrine 29:209-215
    • (2006) Endocrine , vol.29 , pp. 209-215
    • Suzuki, S.1    Brown, C.M.2    Wise, P.M.3
  • 57
    • 37448999687 scopus 로고    scopus 로고
    • Neuroprotective effects of lactation against kainic acid treatment in the dorsal hippocampus of the rat
    • Vanoye-Carlo A, Morales T, Ramos E, Mendoza-Rodríguez A, Cerbón M (2008) Neuroprotective effects of lactation against kainic acid treatment in the dorsal hippocampus of the rat. Horm Behav 53:112-123
    • (2008) Horm Behav. , vol.53 , pp. 112-123
    • Vanoye-Carlo, A.1    Morales, T.2    Ramos, E.3    Mendoza-Rodríguez, A.4    Cerbón, M.5
  • 58
    • 0033816050 scopus 로고    scopus 로고
    • Neuroprotective effects of estrogens on hippocampal cells in adult female rats after status epilepticus
    • Velísková J, Velísek L, Galanopoulou AS, Sperber EF (2000) Neuroprotective effects of estrogens on hippocampal cells in adult female rats after status epilepticus. Epilepsia 41 (Suppl 6): S30-S35
    • (2000) Epilepsia , vol.41 , Issue.6 SUPPL.
    • Velísková, J.1    Velísek, L.2    Galanopoulou, A.S.3    Sperber, E.F.4
  • 59
    • 0027164617 scopus 로고
    • Regionally specific loss of neurons in the aging human hippocampus
    • West MJ (1993) Regionally specific loss of neurons in the aging human hippocampus. Neurobiol Aging 14:287-293
    • (1993) Neurobiol. Aging , vol.14 , pp. 287-293
    • West, M.J.1
  • 60
    • 0035663680 scopus 로고    scopus 로고
    • Estradiol is a protective factor in the adult and aging brain: Understanding of mechanisms derived from in vivo and in vitro studies
    • Wise PM, Dubal DB, Wilson ME, Rau SW, Böttner M, Rosewell KL (2001) Estradiol is a protective factor in the adult and aging brain: understanding of mechanisms derived from in vivo and in vitro studies. Brain Res Rev 37:313-319
    • (2001) Brain Res. Rev. , vol.37 , pp. 313-319
    • Wise, P.M.1    Dubal, D.B.2    Wilson, M.E.3    Rau, S.W.4    Böttner, M.5    Rosewell, K.L.6
  • 61
    • 0027504537 scopus 로고
    • Carcinogenic antioxidants. Diethylstilboestrol, hexoestrol and 17 alpha-ethynyloestradiol
    • Wiseman H, Halliwell B (1993) Carcinogenic antioxidants. Diethylstilboestrol, hexoestrol and 17 alpha-ethynyloestradiol. FEBS Lett 332:159-163
    • (1993) FEBS Lett. , vol.332 , pp. 159-163
    • Wiseman, H.1    Halliwell, B.2
  • 62
    • 40849094517 scopus 로고    scopus 로고
    • Estrogen receptorindependent neuroprotection via protein phosphatase preservation and attenuation of persistent extracellular signal-regulated kinase 1/2 activation
    • Yi KD, Cai ZY, Covey DF, Simpkins JW (2008) Estrogen receptorindependent neuroprotection via protein phosphatase preservation and attenuation of persistent extracellular signal-regulated kinase 1/2 activation. J Pharmacol Exp Ther 324:1188-1195
    • (2008) J. Pharmacol. Exp. Ther. , vol.324 , pp. 1188-1195
    • Yi, K.D.1    Cai, Z.Y.2    Covey, D.F.3    Simpkins, J.W.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.