Cortical lesions in multiple sclerosis

Nature Reviews Neurology

Volumn 6, Issue 8, 2010, Pages 438-444

  Calabrese, Massimiliano ^a   Filippi, Massimo ^b   Gallo, Paolo ^a  

^a UNIVERSITY OF PADOVA   (Italy)

^b SAN RAFFAELE HOSPITAL   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

BRAIN CORTEX LESION; COGNITIVE DEFECT; DEMYELINATING DISEASE; DISEASE CLASSIFICATION; ENCEPHALITIS; EPILEPSY; GRAY MATTER; HUMAN; MENINX DISORDER; MULTIPLE SCLEROSIS; NEUROIMAGING; NEUROPATHOLOGY; NUCLEAR MAGNETIC RESONANCE IMAGING; PRIORITY JOURNAL; REVIEW; THREE DIMENSIONAL IMAGING;

CEREBRAL CORTEX; HUMANS; MAGNETIC RESONANCE IMAGING; MULTIPLE SCLEROSIS;

EID: 77956265543     PISSN: 17594758     EISSN: 17594766     Source Type: Journal    
DOI: 10.1038/nrneurol.2010.93     Document Type: Review

References (60)

1. Charcot, J. M. Lectures on the Disease of the Nervous System Vol. 1 (The Sydenham Society, London, 1877).
2. Pirko, I., Lucchinetti, C. F., Sriram, S. & Bakshi, R. Gray matter involvement in multiple sclerosis. Neurology 68, 634-642 (2007).
3. Charil, A. & Filippi, M. Inflammatory demyelination and neurodegeneration in early multiple sclerosis. J. Neurol. Sci. 259, 7-15 (2007).
4. Chard, D. T. et al. Brain metabolite changes in cortical grey and normal-appearing white matter in clinically early relapsing-remitting multiple sclerosis. Brain 125, 2342-2352 (2002).
5. De Stefano, N. et al. Evidence of early cortical atrophy in MS: relevance to white matter changes and disability. Neurology 60, 1157-1162 (2003).
6. Dalton, C. M. et al. Early development of multiple sclerosis is associated with progressive grey matter atrophy in patients presenting with clinically isolated syndromes. Brain 127, 1101-1107 (2004).
7. Filippi, M. et al. Interferon beta-1a for brain tissue loss in patients at presentation with syndromes suggestive of multiple sclerosis: a randomised, double-blind, placebo-controlled trial. Lancet 364, 1489-1496 (2004).
8. Chard, D. T. et al. Progressive grey matter atrophy in clinically early relapsing-remitting multiple sclerosis. Mult. Scler. 10, 387-391 (2004).
9. Sailer, M. et al. Focal thinning of the cerebral cortex in multiple sclerosis. Brain 126, 1734-1744 (2003).
10. Sanfilipo, M. P., Benedict, R. H., Sharma, J., weinstock-Guttman, B. & Bakshi, R. The relationship between whole brain volume and disability in multiple sclerosis: a comparison of normalized gray vs white matter with misclassification correction. Neuroimage 26, 1068-1077 (2005).
11. Sanfilipo, M. P., Benedict, R. H., weinstock-Guttman, B. & Bakshi, R. Gray and white matter brain atrophy and neuropsychological impairment in multiple sclerosis. Neurology 66, 685-692 (2006).
12. Tiberio, M. et al. Gray and white matter volume changes in early RRMS: a 2-year longitudinal study. Neurology 64, 1001-1007 (2005).
13. Amato, M. P. et al. Neocortical volume decrease in relapsing-remitting MS patients with mild cognitive impairment. Neurology 63, 89-93 (2004).
14. Magliozzi, R. et al. Meningeal B-cell follicles in secondary progressive multiple sclerosis associate with early onset of disease and severe cortical pathology. Brain 130, 1089-1104 (2007).
15. Evangelou, N. et al. Regional axonal loss in the corpus callosum correlates with cerebral white matter lesion volume and distribution in multiple sclerosis. Brain 123, 1845-1849 (2000).
16. Kidd, D. et al. Cortical lesions in multiple sclerosis. Brain 122, 17-26 (1999).
17. Peterson, J. W., Bö, L., Mörk, S. J., Chang, A. & Trapp, B. D. Transected neurites, apoptotic neurons, and reduced inflammation in cortical multiple sclerosis lesions. Ann. Neurol. 50, 389-400 (2001).
18. Geurts, J. J. et al. Cortical lesions in multiple sclerosis: combined postmortem MR imaging and histopathology. AJNR Am. J. Neuroradiol. 26, 572-577 (2005).
19. Calabrese, M. et al. Detection of cortical inflammatory lesions by double inversion recovery magnetic resonance imaging in patients with multiple sclerosis. Arch. Neurol. 64, 1416-1422 (2007).
20. Brownell, B. & Hughes, J. T. The distribution of plaques in the cerebrum in multiple sclerosis. J. Neurol. Neurosurg. Psychiatry 25, 315-320 (1962).
21. Lumsden, C. E. The neuropathology of multiple sclerosis. In Handbook of Clinical Neurology Vol. 9 (eds Vinken, P. J. & Bruyn, G. W.) 217-309 (Elsevier, Amsterdam, 1970).
22. Bø, L., Vedeler, C. A., Nyland, H. I., Trapp, B. D. & Mørk, S. J. Subpial demyelination in the cerebral cortex of multiple sclerosis patients. J. Neuropathol. Exp. Neurol. 62, 723-732 (2003).
23. Kutzelnigg, A. et al. Cortical demyelination and diffuse white matter injury in multiple sclerosis. Brain 128, 2705-2712 (2005).
24. Vercellino, M. et al. Grey matter pathology in multiple sclerosis. J. Neuropathol. Exp. Neurol. 64, 1101-1107 (2005).
25. Gilmore, C. P. et al. Regional variations in the extent and pattern of grey matter demyelination in multiple sclerosis: a comparison between the cerebral cortex, cerebellar cortex, deep grey matter nuclei and the spinal cord. J. Neurol. Neurosurg. Psychiatry 80, 182-187 (2009).
26. Albert, M., Antel, J., Brück, W. & Stadelmann, C. Extensive cortical remyelination in patients with chronic multiple sclerosis. Brain Pathol. 17, 129-138 (2007).
27. Geurts, J. J. et al. Extensive hippocampal demyelination in multiple sclerosis. J. Neuropathol. Exp. Neurol. 66, 819-827 (2007).
28. Papadopoulos, D. et al. Substantial archaeocortical atrophy and neuronal loss in multiple sclerosis. Brain Pathol. 19, 238-253 (2009).
29. Wang, Q., Yu, S., Simonyi, A., Sun, G. Y. & Sun, A. Y. Kainic acid-mediated excitotoxicity as a model for neurodegeneration. Mol. Neurobiol. 31, 3-16 (2005).
30. Vallejo-Illarramendi, A., Domercq, M., Pérez-Cerdá, F., Ravid, R. & Matute, C. Increased expression and function of glutamate transporters in multiple sclerosis. Neurobiol. Dis. 21, 154-164 (2006).
31. Simon, J. H., Kinkel, R. P., Jacobs, L., Bub, L. & Simonian N. A wallerian degeneration pattern in patients at high risk for MS. Neurology 54, 1155-1160 (2000).
32. Fisher, E., Lee, J. C., Nakamura, K. & Rudick, R. A. Gray matter atrophy in multiple sclerosis: a longitudinal study. Ann. Neurol. 64, 255-265 (2008).
33. Calabrese, M. & Gallo, P. Magnetic resonance evidence of cortical onset of multiple sclerosis. Mult. Scler. 15, 933-941 (2009).
34. Van Horssen, J., Brink, B. P., De Vries, H. E., Van Der Valk, P. & Bø, L. The blood-brain barrier in cortical multiple sclerosis lesions. J. Neuropathol. Exp. Neurol. 66, 321-328 (2007).
35. Brink, B. P. et al. The pathology of multiple sclerosis is location-dependent: no significant complement activation is detected in purely cortical lesions. J. Neuropathol. Exp. Neurol. 64, 147-155 (2005).
36. Bø, L., Vedeler, C. A., Nyland, H., Trapp, B. D. & Mørk, S. J. Intracortical multiple sclerosis lesions are not associated with increased lymphocyte infiltration. Mult. Scler. 9, 323-331 (2003).
37. Peterson, J. W. et al. VCAM-1-positive microglia target oligodendrocytes at the border of multiple sclerosis lesions. J. Neuropathol. Exp. Neurol. 61, 539-546 (2002).
38. Gray, E., Thomas, T. L., Betmouni, S., Scolding, N. & Love, S. Elevated activity and microglial expression of myeloperoxidase in demyelinated cerebral cortex in multiple sclerosis. Brain Pathol. 18, 86-95 (2008).
39. Dal Bianco, A. et al. Multiple sclerosis and Alzheimer's disease. Ann. Neurol. 63, 174-183 (2008).
40. Serafini, B., Rosicarelli, B., Magliozzi, R., Stigliano, E. & Aloisi, F. Detection of ectopic, B-cell follicles with germinal centers in the meninges of patients with secondary progressive multiple sclerosis. Brain Pathol. 14, 164-174 (2004).
41. Guseo, A. & Jellinger, K. The significance of perivascular infiltrations in multiple sclerosis. J. Neurol. 211, 51-60 (1975).
42. Kooi, E. J., Geurts, J. J., Van Horssen, J., Bø, L. & Van Der Valk, P. Meningeal inflammation is not associated with cortical demyelination in chronic multiple sclerosis. J. Neuropathol. Exp. Neurol. 68, 1021-1028 (2009).
43. Willis, S. N. et al. Epstein-Barr virus infection is not a characteristic feature of multiple sclerosis brain. Brain 132, 3318-3328 (2009).
44. Serafini, B. et al. Dysregulated Epstein-Barr virus infection in the multiple sclerosis brain. J. Exp. Med. 204, 2899-2912 (2007).
45. Torkildsen, Ø. et al. Upregulation of immunoglobulin-related genes in cortical sections from multiple sclerosis patients. Brain Pathol. 20, 720-729 (2010).
46. Geurts, J. J. et al. Does high-field MR imaging improve cortical lesion detection in multiple sclerosis? J. Neurol. 255, 183-191 (2008).
47. Schmierer, K. et al. High field (9.4 Tesla) magnetic resonance imaging of cortical grey matter lesions in multiple sclerosis. Brain 133, 858-867 (2010).
48. Geurts, J. J. et al. Intracortical lesions in multiple sclerosis: improved detection with 3D double inversion-recovery MR imaging. Radiology 236, 254-260 (2005).
49. Bagnato, F. et al. In vivo detection of cortical plaques by MR imaging in patients with multiple sclerosis. AJNR Am. J. Neuroradiol. 27, 2161-2167 (2006).
50. Nelson, F. et al. Improved identification of intracortical lesions in multiple sclerosis with phase-sensitive inversion recovery in Combination with fast double inversion recovery MR imaging. AJNR Am. J. Neuroradiol. 28, 1645-1649 (2007).
51. Calabrese, M. et al. A 3-year magnetic resonance imaging study of cortical lesions in relapse-onset multiple sclerosis. Ann. Neurol. 67, 376-383 (2010).
52. Calabrese, M. et al. Cortical lesions in primary progressive multiple sclerosis: a 2-year longitudinal MR study. Neurology 72, 1330-1336 (2009).
53. Calabrese, M. et al. Evidence for relative cortical sparing in benign multiple sclerosis: a longitudinal magnetic resonance imaging study. Mult. Scler. 15, 36-41 (2009).
54. Rocca, M. A. et al. Preserved brain adaptive properties in patients with benign multiple sclerosis. Neurology 74, 142-149 (2010).
55. Calabrese, M. et al. Cortical lesions and atrophy associated with cognitive impairment in relapsing-remitting multiple sclerosis. Arch. Neurol. 66, 1144-1150 (2009).
56. Geurts, J. J. & Barkhof, F. Grey matter pathology in multiple sclerosis. Lancet Neurol. 7, 841-851 (2008).
57. Amato, M. P., Zipoli, V. & Portaccio, E. Multiple sclerosis-related cognitive changes: a review of cross-sectional and longitudinal studies. J. Neurol. Sci. 245, 41-46 (2006).
58. Rovaris, M., Comi, G. & Filippi, M. MRI markers of destructive pathology in multiple sclerosis-related cognitive dysfunction. J. Neurol. Sci. 245, 111-116 (2006).
59. Calabrese, M. et al. Extensive cortical inflammation is associated with epilepsy in multiple sclerosis. J. Neurol. 255, 581-586 (2008).
60. The Center for Information Technology. National Institutes of Health [online]. http://mipav.cit. nih.gov (2010).