Effects of betahistine at histamine H3 receptors: Mixed inverse agonism/agonism in vitro and partial inverse agonism in vivo

Journal of Pharmacology and Experimental Therapeutics

Volumn 334, Issue 3, 2010, Pages 945-954

  Gbahou, F ^a   Davenas, E ^a   Morisset, S ^a   Arrang, Jean Michel ^a  

^a INSERM   (France)

Author keywords

[No Author keywords available]

Indexed keywords

ARACHIDONIC ACID; BETAHISTINE; CIPROXIFAN; CYCLIC AMP; HISTAMINE; HISTAMINE H3 RECEPTOR; IODOPROXYFAN; PERTUSSIS TOXIN; RECOMBINANT RECEPTOR; TELE METHYLHISTAMINE; THIOPERAMIDE; HISTAMINE AGONIST; HISTAMINE DERIVATIVE; HISTAMINE H2 RECEPTOR ANTAGONIST; HISTAMINE H3 RECEPTOR ANTAGONIST; IMIDAZOLE DERIVATIVE; RECOMBINANT PROTEIN; TELE-METHYLHISTAMINE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRAIN NERVE CELL; CHO CELL; DOSE RESPONSE; DRUG EFFECT; DRUG RECEPTOR BINDING; DRUG TOLERABILITY; FIRST PASS EFFECT; IN VITRO STUDY; IN VIVO STUDY; INVERSE AGONISM; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; ANIMAL; BIOSYNTHESIS; BRAIN; BRAIN LEVEL; CHO CELL LINE; CRICETULUS; CYTOLOGY; DRUG EFFECTS; GENETICS; HAMSTER; HUMAN; INTRAPERITONEAL DRUG ADMINISTRATION; METABOLISM; NERVE CELL; ORAL DRUG ADMINISTRATION; PHYSIOLOGY; RAT;

ADMINISTRATION, ORAL; ANIMALS; ARACHIDONIC ACID; BETAHISTINE; BRAIN; BRAIN CHEMISTRY; CHO CELLS; CRICETINAE; CRICETULUS; CYCLIC AMP; HISTAMINE; HISTAMINE AGONISTS; HISTAMINE H2 ANTAGONISTS; HISTAMINE H3 ANTAGONISTS; HUMANS; IMIDAZOLES; INJECTIONS, INTRAPERITONEAL; METHYLHISTAMINES; MICE; NEURONS; PERTUSSIS TOXIN; RATS; RECEPTORS, HISTAMINE H3; RECOMBINANT PROTEINS;

EID: 77956255306     PISSN: 00223565     EISSN: 15210103     Source Type: Journal    
DOI: 10.1124/jpet.110.168633     Document Type: Article

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