Colon OCTN2 gene expression is up-regulated by peroxisome proliferator-activated receptor γ in humans and mice and contributes to local and systemic carnitine homeostasis

Journal of Biological Chemistry

Volumn 285, Issue 35, 2010, Pages 27078-27087

  D'Argenio, Giuseppe ^a   Petillo, Orsolina ^b   Margarucci, Sabrina ^b   Torpedine, Angela ^b   Calarco, Anna ^b   Koverech, Angela ^c   Boccia, Angelo ^a   Paolella, Giovanni ^a   Peluso, Gianfranco ^b  

^a UNIVERSITY OF NAPLES FEDERICO II   (Italy)

^b INSTITUTE OF PROTEIN BIOCHEMISTRY   (Italy)

^c SAPIENZA UNIVERSITY OF ROME   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

CARNITINE; COMPUTATIONAL ANALYSIS; CONSTITUTIVELY ACTIVES; DOMINANT NEGATIVE; EPITHELIAL CELLS; IN-VITRO; IN-VIVO; INTESTINAL EPITHELIUM; ISOFORMS; LARGE INTESTINE; MICROBIOTAS; NULL MODEL; NUTRACEUTICALS; ORGANIC CATION TRANSPORTERS; OVER-EXPRESSION; PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR; PROTEIN EXPRESSIONS; REPORTER ASSAY; RESPONSE ELEMENTS; SELECTIVE MUTATION; SMALL INTESTINE; THIAZOLIDINEDIONES; TRANSCRIPTIONAL REGULATION;

ABSORPTION; ANIMALS; ASSAYS; BODY FLUIDS; CELL CULTURE; DRUG INTERACTIONS; MACHINERY;

GENE EXPRESSION;

2,4 THIAZOLIDINEDIONE DERIVATIVE; ADENOVIRUS VECTOR; CARNITINE; ISOPROTEIN; MESSENGER RNA; MUTANT PROTEIN; NUTRACEUTICAL; ORGANIC CATION TRANSPORTER 2; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA AGONIST; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA ANTAGONIST;

AMINO ACID BLOOD LEVEL; AMINO ACID METABOLISM; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; ASSAY; COLON ABSORPTION; COLON MUCOSA; CONTROLLED STUDY; DRUG ABSORPTION; GEL MOBILITY SHIFT ASSAY; GENE EXPRESSION; GENE EXPRESSION REGULATION; HOST; HUMAN; HUMAN CELL; HUMAN TISSUE; IN VITRO STUDY; IN VIVO STUDY; INTRON; LARGE INTESTINE; MALE; MICROFLORA; MUCOSA CELL; MUTATION; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; REPORTER GENE; TRANSCRIPTION REGULATION; UPREGULATION;

ANIMALS; CARNITINE; CELL LINE, TRANSFORMED; COLON; GENE EXPRESSION REGULATION; HOMEOSTASIS; HUMANS; HYPOGLYCEMIC AGENTS; INTESTINAL ABSORPTION; INTESTINE, SMALL; MICE; MICE, KNOCKOUT; ORGAN SPECIFICITY; ORGANIC CATION TRANSPORT PROTEINS; PPAR ALPHA; PPAR GAMMA; PROTEIN ISOFORMS; RESPONSE ELEMENTS; THIAZOLIDINEDIONES;

ADENOVIRIDAE; ANIMALIA; MUS;

EID: 77956254249     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M110.109678     Document Type: Article

References (45)

1. Rebouche, C. J., and Seim, H. (1998) Annu. Rev. Nutr. 18, 39-61
2. Rebouche, C. J. (2004) Ann. N.Y. Acad. Sci. 1033, 30-41
3. Lohninger, A., Pittner, G., and Pittner, F. (2005) Chem. Month. 136, 1255-1266
4. Steiber, A., Kerner, J., and Hoppel, C. L. (2004) Mol. Aspects Med. 25, 455-473
5. Lahjouji, K., Mitchell, G. A., and Qureshi, I. A. (2001) Mol. Genet. Metab. 73, 287-297
6. Tein, I. (2003) J. Inherit. Metab. Dis. 26, 147-169
7. Koepsell, H., Lips, K., and Volk, C. (2007) Pharm. Res. 24, 1227-1251
8. Wu, X., George, R. L., Huang, W., Wang, H., Conway, S. J., Leibach, F. H., and Ganapathy, V. (2000) Biochim. Biophys. Acta 1466, 315-327
9. Tamai, I., Ohashi, R., Nezu, J., Yabuuchi, H., Oku, A., Shimane, M., Sai, Y., and Tsuji, A. (1998) J. Biol. Chem. 273, 20378-20382
10. Alnouti, Y., Petrick, J. S., and Klaassen, C. D. (2006) Drug Metab. Dispos. 34, 477-482
11. Ohashi, R., Tamai, I., Yabuuchi, H., Nezu, J. I., Oku, A., Sai, Y., Shimane, M., and Tsuji, A. (1999) J. Pharmacol. Exp. Ther. 291, 778-784
12. Ohashi, R., Tamai, I., Nezu, Ji., J., Nikaido, H., Hashimoto, N., Oku, A., Sai, Y., Shimane, M., and Tsuji, A. (2001) Mol. Pharmacol. 59, 358-366
13. Wu, X., Huang, W., Prasad, P. D., Seth, P., Rajan, D. P., Leibach, F. H., Chen, J., Conway, S. J., and Ganapathy, V. (1999) J. Pharmacol. Exp. Ther. 290, 1482-1492
14. Slitt, A. L., Cherrington, N. J., Hartley, D. P., Leazer, T. M., and Klaassen, C. D. (2002) Drug Metab. Dispos. 30, 212-219
15. Xuan, W., Lamhonwah, A. M., Librach, C., Jarvi, K., and Tein, I. (2003) Biochem. Biophys. Res. Commun. 306, 121-128
16. Nezu, J., Tamai, I., Oku, A., Ohashi, R., Yabuuchi, H., Hashimoto, N., Nikaido, H., Sai, Y., Koizumi, A., Shoji, Y.., Takada, G., Matsuishi, T., Yoshino, M., Kato, H., Ohura, T., Tsujimoto, G., Hayakawa, J., Shimane, M., and Tsuji, A. (1999) Nat. Genet. 21, 91-94
17. Ringseis, R., Pösel, S., Hirche, F., and Eder, K. (2007) Pharmacol. Res. 56, 175-183
18. Koch, A., König, B., Stangl, G. I., and Eder, K. (2008) Exp. Biol. Med. 233, 356-365
19. Braissant, O., Foufelle, F., Scotto, C., Dauça, M., and Wahli, W. (1996) Endocrinology 137, 354-366
20. Meier, Y., Eloranta, J. J., Darimont, J., Ismair, M. G., Hiller, C., Fried, M., Kullak-Ublick, G. A., and Vavricka, S. R. (2007) Drug Metab. Dispos. 35, 590-594
21. D'Argenio, G., Calvani, M., Casamassimi, A., Petillo, O., Margarucci, S., Rienzo, M., Peluso, I., Calvani, R., Ciccodicola, A., Caporaso, N., and Peluso, G. (2006) FASEB J. 20, 2544-2546
22. Fujiya, M., Musch, M. W., Nakagawa, Y., Hu, S., Alverdy, J., Kohgo, Y., Schneewind, O., Jabri, B., and Chang, E. B. (2007) Cell. Host Microbe 1, 299-308
23. Auboeuf, D., Rieusset, J., Fajas, L., Vallier, P., Frering, V., Riou, J. P., Staels, B., Auwerx, J., Laville, M., and Vidal, H. (1997) Diabetes 46, 1319-1327
24. Kaiser, G. C., and Polk, D. B. (1997) Gastroenterology 112, 1231-1240
25. Corredor, J., Yan, F., Shen, C. C., Tong, W., John, S. K., Wilson, G., Whitehead, R., and Polk, D. B. (2003) Am. J. Physiol. Cell. Physiol. 284, C953-C961
26. Whitehead, R. H., VanEeden, P. E., Noble, M. D., Ataliotis, P., and Jat, P. S. (1993) Proc. Natl. Acad. Sci. U.S.A. 90, 587-591
27. Sahi, J., Goldstein, J. L., Layden, T. J., and Rao, M. C. (1994) Am. J. Physiol. Gastrointest. Liver Physiol. 266, 846-855
28. Laplante, M., Festuccia, W. T., Soucy, G., Gélinas, Y., Lalonde, J., Berger, J. P., and Deshaies, Y. (2006) Diabetes 55, 2771-2778
29. Diehl, K. H., Hull, R., Morton, D., Pfister, R., Rabemampianina, Y., Smith, D., Vidal, J. M., and van de Vorstenbosch, C. (2001) J. Appl. Toxicol. 21, 15-23
30. Rousseaux, C., Lefebvre, B., Dubuquoy, L., Lefebvre, P., Romano, O., Auwerx, J., Metzger, D., Wahli, W., Desvergne, B., Naccari, G. C., Chavatte, P., Farce, A., Bulois, P., Cortot, A., Colombel, J. F., and Desreumaux, P. (2005) J. Exp. Med. 201, 1205-1215
31. Sabatino, L., Casamassimi, A., Peluso, G., Barone, M. V., Capaccio, D., Migliore, C., Bonelli, P., Pedicini, A., Febbraro, A., Ciccodicola, A., and Colantuoni, V. (2005) J. Biol. Chem. 280, 26517-26525
32. Degenhardt, T., Matilainen, M., Herzig, K. H., Dunlop, T. W., and Carlberg, C. (2006) J. Biol. Chem. 281, 39607-39619
33. Heinäniemi, M., Uski, J. O., Degenhardt, T., and Carlberg, C. (2007) Genome Biol. 8, R147
34. Evans, A. M., and Fornasini, G. (2003) Clin Pharmacokinet. 42, 941-967
35. Ciacci, C., Peluso, G., Iannoni, E., Siniscalchi, M., Iovino, P., Rispo, A., Tortora, R., Bucci, C., Zingone, F., Margarucci, S., and Calvani, M. (2007) Dig. Liver Dis. 39, 922-928
36. Maeda, T., Wakasawa, T., Funabashi, M., Fukushi, A., Fujita, M., Motojima, K., and Tamai, I. (2008) Biol. Pharm. Bull. 31, 1230-1236
37. Mandard, S., Stienstra, R., Escher, P., Tan, N. S., Kim, I., Gonzalez, F. J., Wahli, W., Desvergne, B.,Müller, M., and Kersten, S. (2007) Cell. Mol. Life Sci. 64, 1145-1157
38. Schupp, M., Lefterova, M. I., Janke, J., Leitner, K., Cristancho, A. G., Mullican, S. E., Qatanani, M., Szwergold, N., Steger, D. J., Curtin, J. C., Kim, R. J., Suh, M. J., Suh, M., Albert, M. R., Engeli, S., Gudas, L. J., and Lazar, M. A. (2009) Proc. Natl. Acad. Sci. U.S.A. 106, 1105-1110
39. Hamilton, J. W., Li, B. U., Shug, A. L., and Olsen, W. A. (1986) Gastroenterology 91, 10-16
40. Shekhawat, P. S., Srinivas, S. R., Matern, D., Bennett, M. J., Boriack, R., George, V., Xu, H., Prasad, P. D., Roon, P., and Ganapathy, V. (2007) Mol. Genet. Metab. 92, 315-324
41. Dubuquoy, L., Rousseaux, C., Thuru, X., Peyrin-Biroulet, L., Romano, O., Chavatte, P., Chamaillard, M., and Desreumaux, P. (2006) Gut 55, 1341-1349
42. Desreumaux, P., Dubuquoy, L., Nutten, S., Peuchmaur, M., Englaro, W., Schoonjans, K., Derijard, B., Desvergne, B., Wahli, W., Chambon, P., Leibowitz, M. D., Colombel, J. F., and Auwerx, J. (2001) J. Exp. Med. 193, 827-838
43. Dubuquoy, L., Jansson, E. A., Deeb, S., Rakotobe, S., Karoui, M., Colombel, J. F., Auwerx, J., Pettersson, S., and Desreumaux, P. (2003) Gastroenterology 124, 1265-1276
44. Lewis, J. D., Lichtenstein, G. R., Deren, J. J., Sands, B. E., Hanauer, S. B., Katz, J. A., Lashner, B., Present, D. H., Chuai, S., Ellenberg, J. H., Nessel, L., and Wu, G. D. (2008) Gastroenterology 134, 688-695
45. Wang, K., and Wan, Y. J. Y. (2008) Exp. Biol. Med. 233, 496-506