Pediatric atopic dermatitis: A review of the medical management

Annals of Pharmacotherapy

Volumn 44, Issue 9, 2010, Pages 1448-1458

  Carbone, Antonia ^a   Siu, Anita ^b,c   Patel, Rupal ^b,d  

^a Saint Barnabas Health Care System   (United States)

^b RUTGERS UNIVERSITY   (United States)

^c JERSEY SHORE UNIVERSITY MEDICAL CENTER   (United States)

^d Pathmark Pharmacy   (United States)

Author keywords

Atopic dermatitis; Eczema; Emollients; Pediatrics

Indexed keywords

ALCLOMETASONE DIPROPIONATE; AMCINONIDE; ANTIHISTAMINIC AGENT; BETAMETHASONE DIPROPIONATE; BETAMETHASONE VALERATE; BLEACHING AGENT; CALCIUM; CLOBETASOL PROPIONATE; CLOBEX; CLOCORTOLONE PIVALATE; CORMAX; CORTICOSTEROID; DESONIDE; DESOXIMETASONE; DIFLORASONE DIACETATE; EMOLLIENT AGENT; FLUOCINOLONE ACETONIDE; FLUOCINONIDE; FLUTICASONE PROPIONATE; HALCINONIDE; HYDROCORTISONE BUTYRATE; HYDROCORTISONE VALERATE; IMMUNOGLOBULIN E; LUXIQ; MOMETASONE FUROATE; PALMIDROL; PIMECROLIMUS; PREDNICARBATE; PREDNISONE; RANBAXY; RETINOL; TACROLIMUS; TRIAMCINOLONE ACETONIDE; ULOBETASOL PROPIONATE; UNCLASSIFIED DRUG; UNINDEXED DRUG; VANOS; VITAMIN D;

ALLERGIC RHINITIS; ASTHMA; ATOPIC DERMATITIS; BACTERIAL INFECTION; BATH; CONJUNCTIVITIS; DIET; DRUG EFFICACY; DRY SKIN; ECZEMA; EYE DISEASE; FACE; FAMILY HISTORY; HUMAN; HYPERSENSITIVITY; KAPOSI VARICELLIFORM ERUPTION; LACTOBACILLUS; LICHENOID ERUPTION; LIMB; LITERATURE; LOTION; MEDICAL HISTORY; MONOTHERAPY; OINTMENT; PAPULOVESICULAR RASH; PEDIATRICS; PHOTOTHERAPY; PRIORITY JOURNAL; PRURITUS; QUALITY OF LIFE; REGULATORY T LYMPHOCYTE; REVIEW; SCAR FORMATION; SELF CARE; SKIN INFECTION; SKIN MANIFESTATION; TREATMENT DURATION; TREATMENT OUTCOME; XEROSIS;

EID: 77956251548     PISSN: 10600280     EISSN: None     Source Type: Journal    
DOI: 10.1345/aph.1P098     Document Type: Review

References (47)

1. Laughter D, Istvan JA, Tofte SJ, et al. The prevalence of atopic dermatitis in Oregon school children. J Am Acad Dermatol 2000;43:649-55.
2. Chamlin SL. The psychosocial burden of childhood atopic dermatitis. Dermatol Ther 2006;19:104-7. DOI 10.1111/j.1529-8019.2006.00060.x
3. Schultz-Larsen F, Hanifin JM. Epidemiology of atopic dermatitis. Immunol Allergy Clin N Am 2002;22:1-24. DOI 10.1016/S0889-8561(03)00066-3
4. von Mutius E. The environmental predictors of allergic disease. J Allergy Clin Immunol 2000;105:9-19. DOI 10.1016/S0091-6749(00)90171-4
5. Strachan DP. Hay fever, hygiene, and household size. BMJ 1989;299: 1259-60. DOI 10.1136/bmj.299.6710.1259
6. Krol A, Krafchik B. The differential diagnosis of atopic dermatitis in childhood. Dermatol Ther 2006;19:73-82.
7. Morar N, Willis-Owen SA, Moffatt MF, et al. The genetics of atopic dermatitis. J Allergy Clin Immunol 2006;118:24-34. DOI 10.1016/j.jaci.2006.03. 037
8. Guidelines of care for atopic dermatitis, developed in accordance with the American Academy of Dermatology (AAD)/American Academy of Dermatology Association "Administrative Regulations for Evidence-Based Clinical Practice Guidelines." J Am Acad Dermatol 2004;50:391-404.
9. National Collaborating Centre for Women's and Children's Health. Guidelines for the management of atopic eczema in children: management of atopic eczema in children from birth up to the age of 12 years. December 2007:1-220. www.nice.org.uk/nicemedia/pdf/CG057FullGuideline.pdf (accessed 2009 March 15).
10. Kipps TJ. Functions of B lymphocytes and plasma cells in immunoglobulin production. In: Lichtman MA, Beutler E, Kipps TJ, Seligsohn U, Kaushansky K, Prchal JT.Williams hematology. 7th ed. New York: McGraw-Hill Professional, 2006. www.accessmedicine.com/content.aspx?aID=2146806.
11. Ambruso DR, Hays T, Goldenberg NA. Hematologic disorders. In: Hay WW Jr, Levin MJ, Sondheimer JM, Deterding RR. Current diagnosis & treatment: pediatrics. 19th ed. New York: McGraw-Hill Professional, 2008. www.accessmedicine.com/content.aspx?aID=3406649.
12. Simon D, Braathen LR, Simon H-U. Eosinophils and atopic dermatitis. Allergy 2004:59;561-70. DOI 10.1111/j.1398-9995.2004.00476.x
13. Carmi E, Defossez-Tribout C, Ganry O, et al. Ocular complications of atopic dermatitis in children. Acta Derm Venereol 2006;86:515-7.
14. Lewis-Jones S. Quality of life and childhood atopic dermatitis: the misery of living with childhood eczema. Int J Clin Pract 2006;60:984-92. (Pubitemid 44082290)
15. Laitinen K, Kalliomaki M, Poussa T, et al. Evaluation of diet and growth in children with and without atopic eczema: follow-up study from birth to 4 years. Brit J Nutr 2005;94:565-74. DOI 10.1079/BJN20051503
16. Berardi RR, Kroon LA, McDermott JH, et al. Handbook of nonprescription drugs: an interactive approach to self care. In: Newton GD, ed. Dermatologic disorders: atopic dermatitis and dry skin. 16th ed. Washington, DC: APhA, 2009:627-41.
17. Sugarman JL, Parish LC. Efficacy of a lipid base barrier repair formulation in moderate to severe pediatric atopic dermatitis. J Drugs Dermatol 2009;8:1106-11.
18. Bergstrom KG. Topical devices for atopic dermatitis: what is the data behind these new products? J Drugs Dermatol 2007;6:956-8.
19. Eberlein B, Eicke C, Reinhardt HW, et al. Adjuvant treatment of atopic eczema: assessment of an emollient containing N-palmitoylethanolamine (ATOPA study). J Eur Acad Dermatol Venereol 2008;22:73-82. DOI 10.1111/j.1468-3083. 2007.02351.x
20. Package insert. EpiCeram skin barrier emulsion. Bridgewater, NJ: Promius Pharma, 2008.
21. Abramowicz M, Zuccotti G, Pflomm JM, et al. Drugs for allergic disorders. Treat Guidel Med Lett 2010;8:9-17.
22. Taketomo CK, Hodding JH, Kraus DM. Pediatric dosage handbook. 16th ed. Houston: Lexi-Comp Inc., 2009.
23. Hanifin JM, Hebert AA, Mays SR, et al. Effects of a low-potency corticosteroid lotion plus a moisturizing regimen in the treatment of atopic dermatitis. Curr Ther Res 1998;59:227-33. DOI 10.1016/S0011-393X(98)85076-5
24. Grimalt R, Mengeaud V, Cambazard F, et al. The steroid-sparing effect of an emollient therapy in infants with atopic dermatitis: a randomized controlled study. Dermatol 2007;214:61-7. (Pubitemid 46033003)
25. Lassus A. Alclometasone dipropionate cream 0.05% versus clobetasone butyrate cream 0.05%. A controlled clinical comparison in the treatment of atopic dermatitis in children. Int J Dermatol 1984;23:565-6. (Pubitemid 14019560)
26. Kirkup ME, Birchall NM, Weinberg EG, et al. Acute and maintenance treatment of atopic dermatitis in children - two comparative studies with fluticasone propionate (0.05%) cream. J Dermatolog Treat 2003;14:141-8. DOI 10.1080/09546630310013388
27. Smitt JHS, Winterburg DH, Oosting J. Treatment of atopic dermatitis with topical corticosteroids in children. Efficacy and systemic effects of triamcinolone acetonide and alclometasone diproprionate. Eur J Dermatol 1993;3:549-52. (Pubitemid 24033437)
28. Rafanelli A, Rafanelli S, Stanganelli I, et al. Mometasone furoate in the treatment of atopic dermatitis in children. J Eur Acad Dermatol Venereol 1993;2:225-30.
29. Wolkerstorfer A, Strobos MA, Glazenburg EJ, et al. Fluticasone propionate 0.05% cream once daily versus clobetasone butyrate 0.05% cream twice daily in children with atopic dermatitis. J Am Acad Dermatol 1998;39:226-31. DOI 10.1016/S0190-9622(98)70080-5
30. Lassus A. Clinical comparison of alclometasone dipropionate cream 0.05% with hydrocortisone butyrate cream 0.1% in the treatment of atopic dermatitis in children. J Int Med Res 1983;11:315-9. (Pubitemid 13012698)
31. Koo JYM, Fleischer AB Jr, Abramovits W, et al. Tacrolimus ointment is safe and effective in the treatment of atopic dermatitis: results in 8000 patients. J Am Acad Dermatol 2005;53:S195-205. DOI 10.1016/j.jaad.2005.04.063
32. Hanifin JM, Paller AS, Eichenfield L, et al. Efficacy and safety of tacrolimus ointment treatment for up to 4 years in patients with atopic dermatitis. J Am Acad Dermatol 2005;53:S186-94. DOI 10.1016/j.jaad.2005.04.062
33. Kempers S, Boguniewicz M, Carter E, et al. A randomized investigator-blinded study comparing pimecrolimus 1% cream with tacrolimus ointment 0.03% in the treatment of pediatric patients with moderate atopic dermatitis. J Am Acad Dermatol 2004;51:515-25. DOI 10.1016/j.jaad.2004.01.051
34. Duff G, Kendall M, Raine J, et al. Topical tacrolimus (protopic) and pimecrolimus (elidel): reports of malignancies. Curr Probl Pharmacovigilance 2006;31:1-2.
35. Reitamo S, Harper J, Dbos J, et al. 0.03% Tacrolimus ointment applied once or twice daily is more efficacious than 1% hydrocortisone acetate in children with moderate to severe atopic dermatitis: results of a randomized double-blind controlled trial. Br J Dermatol 2004;150:554-62. (Pubitemid 38446313)
36. Reitamo S, Van Leent EJ, Ho V, et al. Efficacy and safety of tacrolimus ointment compared with that of hydrocortisone acetate ointment in children with atopic dermatitis. J Allergy Clin Immunol 2002;109:539-46.
37. Forte WC, Sumits JM, Rodrigues AG, et al. Rebound phenomenon to systemic corticosteroid in atopic dermatitis. Allergol Immunopath 2005; 33:301-11.
38. Sonenthal KR, Grammer LC, Patterson R. Do some patients with atopic dermatitis require long-term oral steroid therapy? J Allergy Clin Immunol 1993;91:971-3.
39. Ricci G, Dondi A, Patrizi A, et al. Systemic therapy of atopic dermatitis in children. Drugs 2009;69:297-306.
40. Hindley D, Galloway G, Murray J, et al. A randomized study of "wet wraps" versus conventional treatment for atopic eczema. Arch Dis Child 2006;91:164-8. DOI 10.1136/adc.2004.050831
41. Ibbotson SH, Bilsland D, Cox NH, et al. An update and guidance on narrowband ultraviolet B phototherapy: a British photodermatology group workshop report. Br J Dermatol 2004;151:283-97.
42. Leung DYM. Infection in atopic dermatitis. Curr Opin Pediatr 2003; 15:399-404.
43. Boguniewicz M, Sampson H, Leung SB, et al. Effects of cefuroxime axetil on Staphylococcus aureus colonization and superantigen production in atopic dermatitis. J Allergy Clin Immunol 2001;108:651-2.
44. Breuer K, Haussler S, Kapp A, et al. Staphylococcus aureus: colonizing features and influence of an antibacterial treatment in adults with atopic dermatitis. Br J Dermatol 2002;147:55-61. DOI 0.1046/j.1365-2133.2002.04872.x
45. Krakowski AC, Eichenfield LF, Dohil MA. Management of atopic dermatitis in the pediatric population. Pediatrics 2008;122;812-24. DOI 10.1542/peds.2007-2232
46. Metry D, Browning J, Rousseau, et al. Sodium hypochlorite (bleach) baths: a potential measure to reduce the incidence of recurrent, cutaneous Staphylococcus aureus superinfection among susceptible populations. Poster presented at the Society for Pediatric Dermatology Annual Meeting, July 12-15, 2007, Chicago, IL.
47. Huang JT, Abrams M, Tlougan B, et al. Treatment of Staphylococcus aureus colonization in atopic dermatitis decreases disease severity. Pediatrics 2009;123:e 808-14.