A randomized investigator-blinded study comparing pimecrolimus cream 1% with tacrolimus ointment 0.03% in the treatment of pediatric patients with moderate atopic dermatitis

Journal of the American Academy of Dermatology

Volumn 51, Issue 4, 2004, Pages 515-525

  Kempers, Steven ^a   Boguniewicz, Mark ^a   Carter, Eric ^a   Jarratt, Michael ^a   Pariser, David ^a   Stewart, Dan ^a   Stiller, Matt ^a   Tschen, Eduardo ^a   Chon, Katie ^a   Wisseh, Steve ^a   Abrams, Beatrice ^a  

^a Minnesota Clinical Study Center   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PIMECROLIMUS; TACROLIMUS;

ADOLESCENT; ARTICLE; ATOPIC DERMATITIS; BACTERIAL INFECTION; BURNING SENSATION; CHILD; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CREAM; DISEASE DURATION; DRUG EFFICACY; DRUG FORMULATION; DRUG TOLERABILITY; ERYTHEMA; FEMALE; HEAT; HERPES SIMPLEX; HUMAN; IMPETIGO; INCIDENCE; MAJOR CLINICAL STUDY; MALE; MULTICENTER STUDY; OINTMENT; PEDIATRICS; PHASE 1 CLINICAL TRIAL; PRIORITY JOURNAL; PRURITUS; RANDOMIZED CONTROLLED TRIAL; RASH; SIDE EFFECT; SINGLE BLIND PROCEDURE; SKIN INFECTION; SKIN IRRITATION; SKIN MANIFESTATION; STAPHYLOCOCCUS INFECTION; TREATMENT OUTCOME; VIRUS INFECTION;

ADOLESCENT; CHILD; CHILD, PRESCHOOL; DERMATITIS, ATOPIC; DERMATITIS, IRRITANT; DERMATOLOGIC AGENTS; DRUG ADMINISTRATION SCHEDULE; DRUG COMBINATIONS; ERYTHEMA; FEMALE; HUMANS; MALE; OINTMENTS; PATIENT SATISFACTION; PRURITUS; TACROLIMUS;

EID: 20844459817     PISSN: 01909622     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jaad.2004.01.051     Document Type: Article

References (15)

1. Williams H.C. Inflammatory skin diseases I: Atopic dermatitis. Williams H.C., Strachan D.P. The Challenge of Dermato-epidemiology. 1997;131 CRC Press Inc, Boca Raton, FL
2. Larsen F.S., Holm N.V., Henningsen K. Atopic dermatitis: a genetic-epidemiologic study in a population-based twin sample. J Am Acad Dermatol. 15:1986;487-494
3. Williams H., Robertson C., Stewart A., Ait-Khaled N., Anabwani G., Anderson R., et al. Worldwide variations in the prevalence of symptoms of atopic eczema in the International Study of Asthma and Allergies in Childhood. J Allergy Clin Immunol. 103:1999;125-138
4. Laughter D., Istvan J.A., Tofte S.J., Hanifin J.M. The prevalence of atopic dermatitis in Oregon schoolchildren. J Am Acad Dermatol. 43:2000;649-655
5. Linnet J., Jemec G.D. An assessment of anxiety and dermatology life quality in patients with atopic dermatitis. Br J Dermatol. 140:1999;268-272
6. Fivenson D., Goldberg Arnold R.J., Kaniecki D.J., Cohen J.L., Frech F., Finlay A.Y. The effect of atopic dermatitis on total burden of illness and quality of life on adults and children in a large managed care organization. J Managed Care Pharm. 8:2002;333-342
7. Charman C.R., Morris A.D., Williams H.C. Topical corticosteroid phobia in patients with atopic eczema. Br J Dermatol. 142:2000;931-936
8. Meingassner J.G., Fahrngruber H., Bavandi A. Pimecrolimus inhibits the elicitation phase but does not suppress the sensitization phase in murine contact hypersensitivity, in contrast to tacrolimus and cyclosporin A. J Invest Dermatol. 121:2003;77-80
9. Stuetz A., Grassberger M., Meingassner J.G. Pimecrolimus (Elidel, SDZ ASM 981) - Preclinical pharmacological profile and skin selectivity. Semin Cutan Med Surg. 20:2001;233-241
10. Bernard L.A., Eichenfield L.F. Topical immunomodulators for atopic dermatitis. Curr Opin Pediatr. 14:2002;414-418
11. Gehan E.A., George W. Estimation of body surface area from height and weight. Cancer Chemother Reps. 54:1970;225-235
12. Charman C.R., Morris A.D., Williams H.C. Topical corticosteroid phobia in patients with atopic eczema. Br J Dermatol. 142:2000;931-936
13. Frosch P.J., Kligman A.M. A method for appraising the stinging capacity of topically applied substances. J Soc Cosmet Chem. 28:1977;197-209
14. Wahn U., Bos J.D., Goodfield M., Caputo R., Papp K., Manjra A., et al. Efficacy and safety of pimecrolimus cream in the long-term management of atopic dermatitis in children. Pediatrics. 110:2002;e2
15. Reitamo S., Van Leent E.J.M., Ho V., Harper J., Ruzicka T., Kalimo K., et al. Efficacy and safety of tacrolimus ointment compared with that of hydrocortisone acetate ointment in children with atopic dermatitis. J Allergy Clin Immunol. 109:2002;539-546