The role of the renin-angiotensin system in the regulation of erythropoiesis

American Journal of Kidney Diseases

Volumn 56, Issue 3, 2010, Pages 558-565

  Vlahakos, Demetrios V ^a   Marathias, Katerina P ^b   Madias, Nicolaos E ^c,d  

^a NATIONAL AND KAPODISTRIAN UNIVERSITY OF ATHENS   (Greece)

^b ONASSIS CARDIAC SURGERY CENTER   (Greece)

^c TUFTS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d ST ELIZABETH'S MEDICAL CENTER   (United States)

Author keywords

anemia; Angiotensin II; angiotensin II receptor blockers; angiotensin converting enzyme inhibitors; chronic kidney disease; chronic obstructive lung disease; diabetic kidney disease; dialysis; erythropoiesis; heart failure; hypertension; kidney transplantation; post transplant erythrocytosis

Indexed keywords

AMLODIPINE; ANGIOTENSIN II; ANGIOTENSIN RECEPTOR ANTAGONIST; BENAZEPRIL; CANDESARTAN; CAPTOPRIL; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; ENALAPRIL; ERYTHROPOIETIN; FENOTEROL; FOSINOPRILAT; FUROSEMIDE; GROWTH FACTOR; HYDRALAZINE; LOSARTAN; RAMIPRIL; RECOMBINANT ERYTHROPOIETIN; TEMOCAPRIL; VALSARTAN;

ANEMIA; BARTTER SYNDROME; CHRONIC KIDNEY DISEASE; CLINICAL TRIAL; CONTINUOUS AMBULATORY PERITONEAL DIALYSIS; DRUG MECHANISM; DRUG MEGADOSE; ERYTHROCYTE; ERYTHROID PRECURSOR CELL; ERYTHROPOIESIS; HEART FAILURE; HEMATOCRIT; HEMODIALYSIS; HUMAN; HYPERRENINEMIA; HYPERTENSION; KIDNEY TRANSPLANTATION; NONHUMAN; PATHOGENESIS; PATHOPHYSIOLOGY; POLYCYTHEMIA; PREVALENCE; REGULATORY MECHANISM; RENIN ANGIOTENSIN ALDOSTERONE SYSTEM; RENOVASCULAR HYPERTENSION; REVIEW; ANIMAL; PHYSIOLOGY;

ANIMALS; ERYTHROPOIESIS; HUMANS; RENIN-ANGIOTENSIN SYSTEM;

EID: 77956228093     PISSN: 02726386     EISSN: None     Source Type: Journal    
DOI: 10.1053/j.ajkd.2009.12.042     Document Type: Review

References (65)

1. H. Muoz-Ramrez, R.E. Chatelain, F.M. Bumpus, and P.A. Khairallah Development of two-kidney Goldblatt hypertension in rats under dietary sodium restriction Am J Physiol 238 6 1980 H889 H894
2. H. Kato, J. Ishida, and S. Imagawa Enhanced erythropoiesis mediated by activation of the renin-angiotensin system via angiotensin II type 1a receptor FASEB J 19 14 2005 2023 2025
3. A.B. Gould, and S.A. Goodman Effect of an angiotensin-converting enzyme inhibitor on blood pressure and erythropoiesis in rats Eur J Pharmacol 181 3 1990 225 234
4. T.N. Doan, N. Gletsu, J. Cole, and K.E. Bernstein Genetic manipulation of the renin-angiotensin system Curr Opin Nephrol Hypertens 10 4 2001 483 491
5. J. Cole, D. Ertoy, and H. Lin Lack of angiotensin II-facilitated erythropoiesis causes anemia in angiotensin-converting enzyme-deficient mice J Clin Invest 106 11 2000 1391 1398
6. S. Chien Blood rheology in hypertension and cardiovascular disease Cardiovasc Med 2 1977 356 360
7. R.C. Tarazi, E.D. Frohlich, H.P. Dustan, R.W. Gifford Jr, and I.H. Page Hypertension and high hematocrit Another clue to renal arterial disease Am J Cardiol 18 6 1966 855 858
8. B.R. Bacon, S.A. Rothman, E.S. Ricanati, and F.A. Rashad Renal artery stenosis with erythrocytosis after renal transplantation Arch Intern Med 140 9 1980 1206 1211
9. D.V. Vlahakos, C. Balodimos, and V. Papachristopoulos Renin-angiotensin system stimulates erythropoietin secretion in chronic hemodialysis patients Clin Nephrol 43 1995 53 59
10. D.V. Vlahakos, E.N. Kosmas, and I. Dimopoulou Association between activation of the renin-angiotensin system and secondary erythrocytosis in patients with chronic obstructive pulmonary disease Am J Med 106 1999 158 164
11. A. Yaren, I. Oztop, and S. Turgut Angiotensin-converting enzyme gene polymorphism is associated with anemia in non small-cell lung cancer Exp Biol Med (Maywood) 233 1 2008 32 37
12. M. Volpe, C. Tritto, and U. Testa Blood levels of erythropoietin in congestive heart failure and correlation with clinical, hemodynamic, and hormonal profile Am J Cardiol 74 1994 468 473
13. F. Hytten Blood volume changes in normal pregnancy Clin Haematol 14 3 1985 601 612
14. L.C. Remynse, F.P. Begun, S.C. Jacobs, and R.K. Lawson Juxtaglomerular cell tumor with elevation of serum erythropoietin J Urol 142 6 1989 1560 1562
15. D.W. Erkelens, and L.W. Statius van Eps Bartter's syndrome and erythrocytosis Am J Med 55 5 1973 711 719
16. G.T. Griffing, and J.C. Melby Enalapril (MK-421) and the white count and hematocrit Lancet 1 1982 1361
17. American Hospital Formulary Service Drug Information, 1988 1988 American Society of Pharmacists Bethesda, MD 906
18. L.H. Lindholm, M. Persson, and P. Alaupovic Metabolic outcome during 1 year in newly detected hypertensives: results of the Antihypertensive Treatment and Lipid Profile in a North of Sweden Efficacy Evaluation (ALPINE Study) J Hypertens 21 8 2003 1563 1574
19. M.H. Olsen, K. Wachtell, and G. Beevers Prognostic importance of hemoglobin in hypertensive patients with electrocardiographic left ventricular hypertrophy: the Losartan Intervention For End point reduction in hypertension (LIFE) Study Am Heart J 157 1 2009 177 184
20. A.L. Kamper, and O.J. Nielsen Effect of enalapril on haemoglobin and serum erythropoietin in patients with chronic nephropathy Scand J Clin Lab Invest 50 6 1990 611 618
21. C. Iodice, M.M. Balletta, and R. Minutolo Maximal suppression of renin-angiotensin system in nonproliferative glomerulonephritis Kidney Int 63 6 2003 2214 2221
22. B.I. Shand, R.R. Bailey, K.L. Lynn, and R.A. Robson Effect of enalapril on erythrocytosis in hypertensive patients with renal disease Blood Press 4 4 1995 238 240
23. E. Whl, O. Mehls, F. Schaefer ESCAPE Trial Group Antihypertensive and antiproteinuric efficacy of ramipril in children with chronic renal failure Kidney Int 66 2 2004 768 776
24. H. Hirakata, K. Onoyama, K. Iseki, H. Kumagai, S. Fujimi, and T. Omae Worsening of anemia induced by long-term use of captopril in hemodialysis patients Am J Nephrol 4 6 1984 355 360
25. A.R. Odabas, R. Cetinkaya, Y. Selcuk, S. Keles, and H. Bilen The effect of high dose losartan on erythropoietin resistance in patients undergoing haemodialysis Panminerva Med 45 1 2003 59 62
26. S. Ertrk, G. Nergizolu, and K. Ate The impact of withdrawing ACE inhibitors on erythropoietin responsiveness and left ventricular hypertrophy in haemodialysis patients Nephrol Dial Transplant 14 8 1999 1912 1916
27. E.J. Sharples, M. Varagunam, and P.J. Sinnott The effect of proinflammatory cytokine gene and angiotensin-converting enzyme polymorphisms on erythropoietin requirements in patients on continuous ambulatory peritoneal dialysis Perit Dial Int 26 1 2006 64 68
28. W.K. Loftus, F. Ierino, and T.H. Mathew Enalapril and anemia Med J Aust 148 1988 209 210
29. V.J. Canzanello, D.V. Vlahakos, M.P. Madaio, and N.E. Madias Enalapril-associated anemia in renal transplant recipients [abstract] Proc Am Soc Nephrol 22 1989 416A
30. P.C.B. Sizeland, R.R. Baily, K.L. Lynn, and R.A. Robson Anemia and angiotensin-converting enzyme inhibition in renal transplant recipients J Cardiovasc Pharmacol 16 suppl 7 1990 S117 S119
31. D.V. Vlahakos, V.J. Canzanello, M.P. Madaio, and N.E. Madias Enalapril-associated anemia in renal transplant recipients treated for hypertension Am J Kidney Dis 17 1991 199 205
32. D.V. Vlahakos, K.P. Marathias, B. Agroyannis, and N.E. Madias Posttransplant erythrocytosis Kidney Int 63 4 2003 1187 1194
33. D. Lorber, and D. Reddan Clinical characteristics of chronic kidney disease patients with and without diabetes: a subanalysis of the PAERI Study Clin Nephrol 66 1 2006 11 16
34. S. Kuriyama, H. Tomonari, and G. Tokudome Antiproteinuric effects of combined antihypertensive therapies in patients with overt type 2 diabetic nephropathy Hypertens Res 25 6 2002 849 855
35. P. Jacobsen, S. Andersen, B.R. Jensen, and H.H. Parving Additive effect of ACE inhibition and angiotensin II receptor blockade in type I diabetic patients with diabetic nephropathy J Am Soc Nephrol 14 4 2003 992 999
36. B. Herrlin, O. Nyquist, and C. Sylvn Induction of a reduction in haemoglobin concentration by enalapril in stable, moderate heart failure: a double blind study Br Heart J 66 3 1991 199 205
37. A. Ishani, E. Weinhandl, and Z. Zhao Angiotensin-converting enzyme inhibitor as a risk factor for the development of anemia, and the impact of incident anemia on mortality in patients with left ventricular dysfunction J Am Coll Cardiol 45 3 2005 391 399
38. D.V. Vlahakos, K.P. Marathias, and E.N. Kosmas Losartan reduces hematocrit in patients with chronic obstructive pulmonary disease and secondary erythrocytosis Ann Intern Med 134 2001 426 427
39. A. Fsun ger,.. Kumbasar, and. Karacan Effects of losartan on the renin-angiotensin-aldosterone system and erythrocytosis in patients with chronic obstructive pulmonary disease and systemic hypertension Clin Drug Invest 21 5 2001 337 343
40. R. Plata, A. Cornejo, and C. Arratia Angiotensin-converting-enzyme inhibition therapy in altitude polycythaemia: a prospective randomised trial Lancet 359 9307 2002 663 666
41. K. Savary, A. Michaud, and J. Favier Role of the renin-angiotensin system in primitive erythropoiesis in the chick embryo Blood 105 1 2005 103 110
42. M. Mrug, T. Stopka, and B.A. Julian Angiotensin II stimulates proliferation of normal early erythroid progenitors J Clin Invest 100 1997 2310 2314
43. M. Gupta, B.A. Miller, and N. Ahsan Expression of angiotensin II type I receptor on erythroid progenitors of patients with posttransplant erythrocytosis Transplantation 70 2000 1188 1194
44. D. Glicklich, L. Burris, and A. Urban Angiotensin-converting enzyme inhibition induces apoptosis in erythroid precursors and affects insulin-like growth factor-1 in posttransplantation erythrocytosis J Am Soc Nephrol 12 2001 1958 1964
45. P.H. Abbrecht, R.L. Malvin, and A.J. Vander Renal production of erythropoietin and renin after experimental kidney infarction Nature 211 1966 1318 1319
46. A.B. Gould, and S.A. Goodman Effect of an angiotensin-converting enzyme inhibitor on blood pressure and erythropoiesis in rats Eur J Pharmacol 181 3 1990 225 234
47. I. Naeshiro, K. Sato, F. Chatani, and S. Sato Possible mechanism for the anemia induced by candesartan cilexetil (TCV-116), an angiotensin II receptor antagonist, in rats Eur J Pharmacol 354 2-3 1998 179 187
48. J.J. Bourgoignie, N.I. Gallagher, and H.M. Perry Renin and erythropoietin in normotensive and in hypertensive patients J Lab Clin Med 71 1968 523 536
49. P. Grutzmacher, H.W. Radtke, N. Schwab, and W. Schoeppe Erythropoietin secretion in patients with renal artery stenosis Nephrol Dial Transplant 3 1988 496
50. S. Donnelly, and B.R. Shah Erythropoietin deficiency in hyporeninemia Am J Kidney Dis 33 5 1999 947 953
51. M. Labeeuw, N.F. Prost, and S. Daoub Renal venous erythropoietin concentrations in hypertensive patients with unilateral renal disease Nephrol Dial Transplant 7 1992 1190 1193
52. J.D. Jensen, H. Eiskjaer, J.P. Bagger, and E.B. Pedersen Elevated level of erythropoietin in congestive heart failure relationship to renal perfusion and plasma renin J Intern Med 233 2 1993 125 130
53. M.C. Pratt, N.J. Lewis-Barned, and R.J. Walker Effect of angiotensin converting enzyme inhibitors on erythropoietin concentrations in healthy volunteers Br J Clin Pharmacol 34 1992 363 365
54. A.L. Kamper, and O.J. Nielsen Effect of enalapril on hemoglobin and serum erythropoietin in patients with chronic nephropathy Scand J Clin Lab Invest 50 1990 611 618
55. T. Akpolat, T. Gumus, A. Bedir, and B. Adam Acute effect of trandolapril on serum erythropoietin in uremic and hypertensive patients J Nephrol 11 2 1998 94 97
56. Y.H. Huang Effect of angiotensin-converting enzyme inhibitors on serum levels of erythropoietin in patients on peritoneal dialysis Di Yi Jun Yi Da Xue Xue Bao 22 1 2002 74 75
57. F. Fyhrquist, K. Karppinen, T. Honkanen, O. Saijonmaa, and K. Rosenlf High serum erythropoietin levels are normalized during treatment of congestive heart failure with enalapril J Intern Med 226 4 1989 257 260
58. J. Gossmann, R. Burkhardt, and S. Harder Angiotensin II infusion increases plasma erythropoietin levels via an angiotensin II type 1 receptor-dependent pathway Kidney Int 60 2001 83 86
59. S.M. Freudenthaler, T. Schenck, and I. Lucht Fenoterol stimulates human erythropoietin production via activation of the renin angiotensin system J Clin Pharmacol 48 1999 631 634
60. S.M. Freudenthaler, P. Benohr, and A. Grenz Do alterations of endogenous angiotensin II levels regulate erythropoietin production in humans? Br J Clin Pharmacol 56 2003 378 387
61. K. Nakao, T. Shirakura, M. Azuma, and T. Mackawa Studies on erythropoietin action of angiotensin II Blood 29 1967 754 760
62. J.W. Fisher, and A.I. Samuels Relationship between renal blood flow and erythropoietin production in dogs Proc Soc Exp Biol Med 125 1967 482 485
63. - cotransporter by angiotensin II in rabbit renal cortex Am J Physiol 265 1993 F195 F203
64. M. Araki-Taguchi, S. Nomura, and K. Ino Angiotensin II mimics the hypoxic effect on regulating trophoblast proliferation and differentiation in human placental explant cultures Life Sci 82 1-2 2008 59 67
65. K.P. Marathias, B. Agroyannis, T. Mavromoustakos, J. Matsoukas, and D.V. Vlahakos Hematocrit-lowering effect following inactivation of renin-angiotensin system with angiotensin converting enzyme inhibitors and angiotensin receptor blockers Curr Top Med Chem 4 4 2004 483 486