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Volumn 29, Issue 3, 2010, Pages 1-6

The pathogenetic features of cerebral cavernous malformations: A comprehensive review with therapeutic implications

Author keywords

CCM gene; Cerebral cavernous malformation; Signal transduction pathway; Simvastatin

Indexed keywords

APOPTOSIS REGULATORY PROTEIN; CARRIER PROTEIN; CCM2 PROTEIN, HUMAN; KRIT1 PROTEIN, HUMAN; MEMBRANE PROTEIN; MICROTUBULE ASSOCIATED PROTEIN; ONCOPROTEIN; PDCD10 PROTEIN, HUMAN; SIMVASTATIN;

EID: 77956212617     PISSN: None     EISSN: 10920684     Source Type: Journal    
DOI: 10.3171/2010.6.FOCUS10135     Document Type: Article
Times cited : (17)

References (19)
  • 1
    • 1642564595 scopus 로고    scopus 로고
    • Microtubule depolymerization rapidly collapses capillary tube networks in vitro and angiogenic vessels in vivo through the small GTPase Rho
    • Bayless KJ, Davis GE, Microtubule depolymerization rapidly collapses capillary tube networks in vitro and angiogenic vessels in vivo through the small GTPase Rho. J Biol Chem 279:11686-11695, 2004
    • (2004) J Biol Chem , vol.279 , pp. 11686-11695
    • Bayless, K.J.1    Davis, G.E.2
  • 2
    • 19944394831 scopus 로고    scopus 로고
    • Mutations within the programmed cell death 10 gene cause cerebral cavernous malformations
    • Bergametti F, Denier C, Labauge P, Arnoult M, Boetto S, Clanet M, et al, Mutations within the programmed cell death 10 gene cause cerebral cavernous malformations. Am J Hum Genet 76:42-51, 2005
    • (2005) Am J Hum Genet , vol.76 , pp. 42-51
    • Bergametti, F.1    Denier, C.2    Labauge, P.3    Arnoult, M.4    Boetto, S.5    Clanet, M.6
  • 3
    • 77951240109 scopus 로고    scopus 로고
    • Rho kinase inhibition rescues the endothelial cell cerebral cavernous malformation phenotype
    • Borikova AL, Dibble CF, Sciaky N, Welch CM, Abell AN, Bencharit S, et al, Rho kinase inhibition rescues the endothelial cell cerebral cavernous malformation phenotype. J Biol Chem 285:11760-11764, 2010
    • (2010) J Biol Chem , vol.285 , pp. 11760-11764
    • Borikova, A.L.1    Dibble, C.F.2    Sciaky, N.3    Welch, C.M.4    Abell, A.N.5    Bencharit, S.6
  • 4
    • 76349106156 scopus 로고    scopus 로고
    • Recent insights into cerebral cavernous malformations: animal models of CCM and the human phenotype
    • Chan AC, Li DY, Berg MJ, Whitehead KJ, Recent insights into cerebral cavernous malformations: animal models of CCM and the human phenotype. FEBS J 277:1076-1083, 2010
    • (2010) FEBS J , vol.277 , pp. 1076-1083
    • Chan, A.C.1    Li, D.Y.2    Berg, M.J.3    Whitehead, K.J.4
  • 5
    • 76349109226 scopus 로고    scopus 로고
    • Recent insights into cerebral cavernous malformations: a complex jigsaw puzzle under construction
    • Faurobert E, Albiges-Rizo C, Recent insights into cerebral cavernous malformations: a complex jigsaw puzzle under construction. FEBS J 277:1084-1096, 2010
    • (2010) FEBS J , vol.277 , pp. 1084-1096
    • Faurobert, E.1    Albiges-Rizo, C.2
  • 7
    • 9144261692 scopus 로고    scopus 로고
    • Mutations in a gene encoding a novel protein containing a phosphotyrosine-binding domain cause type 2 cerebral cavernous malformations
    • Liquori CL, Berg MJ, Siegel AM, Huang E, Zawistowski JS, Stoffer T, et al, Mutations in a gene encoding a novel protein containing a phosphotyrosine-binding domain cause type 2 cerebral cavernous malformations. Am J Hum Genet 73:1459-1464, 2003
    • (2003) Am J Hum Genet , vol.73 , pp. 1459-1464
    • Liquori, C.L.1    Berg, M.J.2    Siegel, A.M.3    Huang, E.4    Zawistowski, J.S.5    Stoffer, T.6
  • 9
    • 0024384777 scopus 로고
    • 131 cases of cavernous angioma (cavernomas) of the CNS, discovered by retrospective analysis of 24,535 autopsies
    • 128-131 (Fr)
    • Otten P, Pizzolato GP, Rilliet B, Berney J, [131 cases of cavernous angioma (cavernomas) of the CNS, discovered by retrospective analysis of 24,535 autopsies.] Neurochirurgie 35:82-83, 128-131, 1989 (Fr)
    • (1989) Neurochirurgie , vol.35 , pp. 82-83
    • Otten, P.1    Pizzolato, G.P.2    Rilliet, B.3    Berney, J.4
  • 10
    • 33744900611 scopus 로고    scopus 로고
    • Patterns of expression of the three cerebral cavernous malformation (CCM) genes during embryonic and postnatal brain development
    • Petit N, Blécon A, Denier C, Tournier-Lasserve E, Patterns of expression of the three cerebral cavernous malformation (CCM) genes during embryonic and postnatal brain development. Gene Expr Patterns 6:495-503, 2006
    • (2006) Gene Expr Patterns , vol.6 , pp. 495-503
    • Petit, N.1    Blécon, A.2    Denier, C.3    Tournier-Lasserve, E.4
  • 12
    • 0037426448 scopus 로고    scopus 로고
    • Molecular genetic investigations in the CCM1 gene in sporadic cerebral cavernomas
    • Reich P, Winkler J, Straube A, Steiger HJ, Peraud A, Molecular genetic investigations in the CCM1 gene in sporadic cerebral cavernomas. Neurology 60:1135-1138, 2003
    • (2003) Neurology , vol.60 , pp. 1135-1138
    • Reich, P.1    Winkler, J.2    Straube, A.3    Steiger, H.J.4    Peraud, A.5
  • 13
    • 33749263696 scopus 로고    scopus 로고
    • Cerebral cavernous malformation: new molecular and clinical insights
    • Revencu N, Vikkula M, Cerebral cavernous malformation: new molecular and clinical insights. J Med Genet 43:716-721, 2006
    • (2006) J Med Genet , vol.43 , pp. 716-721
    • Revencu, N.1    Vikkula, M.2
  • 14
    • 76349124651 scopus 로고    scopus 로고
    • Recent insights into cerebral cavernous malformations: the molecular genetics of CCM
    • Riant F, Bergametti F, Ayrignac X, Boulday G, Tournier-Lasserve E, Recent insights into cerebral cavernous malformations: the molecular genetics of CCM. FEBS J 277:1070-1075, 2010
    • (2010) FEBS J , vol.277 , pp. 1070-1075
    • Riant, F.1    Bergametti, F.2    Ayrignac, X.3    Boulday, G.4    Tournier-Lasserve, E.5
  • 17
    • 77951044950 scopus 로고    scopus 로고
    • Cerebral cavernous malformations proteins inhibit Rho kinase to stabilize vascular integrity
    • Stockton RA, Shenkar R, Awad IA, Ginsberg MH, Cerebral cavernous malformations proteins inhibit Rho kinase to stabilize vascular integrity. J Exp Med 207:881-896, 2010
    • (2010) J Exp Med , vol.207 , pp. 881-896
    • Stockton, R.A.1    Shenkar, R.2    Awad, I.A.3    Ginsberg, M.H.4
  • 18
    • 59649084619 scopus 로고    scopus 로고
    • The cerebral cavernous malformation signaling pathway promotes vascular integrity via Rho GTPases
    • (Erratum in Nat Med 15:462, 2009)
    • Whitehead KJ, Chan AC, Navankasattusas S, Koh W, London NR, Ling J, et al, The cerebral cavernous malformation signaling pathway promotes vascular integrity via Rho GTPases. Nat Med 15:177-184, 2009 (Erratum in Nat Med 15:462, 2009)
    • (2009) Nat Med , vol.15 , pp. 177-184
    • Whitehead, K.J.1    Chan, A.C.2    Navankasattusas, S.3    Koh, W.4    London, N.R.5    Ling, J.6
  • 19
    • 24144454827 scopus 로고    scopus 로고
    • CCM1 and CCM2 protein interactions in cell signaling: implications for cerebral cavernous malformations pathogenesis
    • Zawistowski JS, Stalheim L, Uhlik MT, Abell AN, Ancrile BB, Johnson GL, et al, CCM1 and CCM2 protein interactions in cell signaling: implications for cerebral cavernous malformations pathogenesis. Hum Mol Genet 14:2521-2531, 2005
    • (2005) Hum Mol Genet , vol.14 , pp. 2521-2531
    • Zawistowski, J.S.1    Stalheim, L.2    Uhlik, M.T.3    Abell, A.N.4    Ancrile, B.B.5    Johnson, G.L.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.