Altered Mechanical Properties of the Nucleus in Disease

Methods in Cell Biology

Volumn 98, Issue C, 2010, Pages 121-141

  Lombardi, Maria Lucia ^a   Lammerding, Jan ^a  

^a BRIGHAM AND WOMEN S HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADAPTATION; ANIMAL; ATOMIC FORCE MICROSCOPY; BIOLOGICAL MODEL; BIOMECHANICS; BOOK; CELL FRACTIONATION; CELL NUCLEUS; FLOW KINETICS; GENERAL ASPECTS OF DISEASE; HUMAN; INSTRUMENTATION; MECHANICAL STRESS; METHODOLOGY; PHYSIOLOGY; ULTRASTRUCTURE;

ADAPTATION, PHYSIOLOGICAL; ANIMALS; BIOMECHANICS; CELL FRACTIONATION; CELL NUCLEUS; DISEASE; HUMANS; MICROSCOPY, ATOMIC FORCE; MODELS, BIOLOGICAL; RHEOLOGY; STRESS, MECHANICAL;

EID: 77956208262     PISSN: 0091679X     EISSN: None     Source Type: Book Series    
DOI: 10.1016/S0091-679X(10)98006-0     Document Type: Book

References (69)

1. Bione S., et al. Identification of a novel X-linked gene responsible for Emery-Dreifuss muscular dystrophy. Nat. Genet. 1994, 8:323-327.
2. Bonne G., et al. Mutations in the gene encoding lamin A/C cause autosomal dominant Emery-Dreifuss muscular dystrophy. Nat. Genet. 1999, 21:285-288.
3. Broers J.L., et al. A- and B-type lamins are differentially expressed in normal human tissues. Histochem. Cell Biol. 1997, 107:505-517.
4. -/- cells is caused by defective nucleo-cytoskeletal integrity: Implications for the development of laminopathies. Hum. Mol. Genet. 2004, 13:2567-2580.
5. Caille N., et al. Assessment of strain field in endothelial cells subjected to uniaxial deformation of their substrate. Ann. Biomed. Eng. 1998, 26:409-416.
6. Caille N., et al. Contribution of the nucleus to the mechanical properties of endothelial cells. J. Biomech. 2002, 35:177-187.
7. Cao H., Hegele R.A. Nuclear lamin A/C R482Q mutation in canadian kindreds with Dunnigan-type familial partial lipodystrophy. Hum. Mol. Genet. 2000, 9:109-112.
8. Constantinescu D., et al. Lamin A/C expression is a marker of mouse and human embryonic stem cell differentiation. Stem Cells 2006, 24:177-185.
9. Couzon C., et al. Critical stresses for cancer cell detachment in microchannels. Eur. Biophys. J. 2009, 38:1035-1347.
10. Crisp M., et al. Coupling of the nucleus and cytoplasm: Role of the LINC complex. J. Cell Biol. 2006, 172:41-53.
11. Dahl K.N., et al. Power-law rheology of isolated nuclei with deformation mapping of nuclear substructures. Biophys. J. 2005, 89:2855-2864.
12. Dahl K.N., et al. Distinct structural and mechanical properties of the nuclear lamina in Hutchinson-Gilford progeria syndrome. Proc. Natl. Acad. Sci. USA 2006, 103:10271-10276.
13. De Sandre-Giovannoli A., et al. Homozygous defects in LMNA, encoding lamin A/C nuclear-envelope proteins, cause autosomal recessive axonal neuropathy in human (Charcot-Marie-Tooth disorder type 2) and mouse. Am. J. Hum. Genet. 2002, 70:726-736.
14. de Vries A.H., et al. Direct observation of nanomechanical properties of chromatin in living cells. Nano Lett. 2007, 7:1424-1427.
15. Deguchi S., et al. Flow-induced hardening of endothelial nucleus as an intracellular stress-bearing organelle. J. Biomech. 2005, 38:1751-1759.
16. Evans E.A. Structure and deformation properties of red blood cells: Concepts and quantitative methods. Methods Enzymol. 1989, 173:3-35.
17. Fatkin D., et al. Missense mutations in the rod domain of the lamin A/C gene as causes of dilated cardiomyopathy and conduction-system disease. N. Engl. J. Med. 1999, 341:1715-1724.
18. Friedl P., Wolf K. Proteolytic interstitial cell migration: A five-step process. Cancer Metastasis Rev. 2009, 28:129-135.
19. Goldman R.D., et al. Nuclear lamins: Building blocks of nuclear architecture. Genes Dev. 2002, 16:533-547.
20. Gotzmann J., Foisner R. A-type lamin complexes and regenerative potential: A step towards understanding laminopathic diseases?. Histochem. Cell Biol. 2006, 125:33-41.
21. Guilak F. Compression-induced changes in the shape and volume of the chondrocyte nucleus. J. Biomech. 1995, 28:1529-1541.
22. Guilak F., et al. Viscoelastic properties of intervertebral disc cells. Identification of two biomechanically distinct cell populations. Spine (Phila Pa 1976) 1999, 24:2475-2483.
23. Guilak F., et al. Viscoelastic properties of the cell nucleus. Biochem. Biophys. Res. Commun. 2000, 269:781-786.
24. Hale C.M., et al. Dysfunctional connections between the nucleus and the actin and microtubule networks in laminopathic models. Biophys. J. 2008, 95:5462-5475.
25. Hategan A., et al. Adhesively-tensed cell membranes: Lysis kinetics and atomic force microscopy probing. Biophys. J. 2003, 85:2746-2759.
26. Henriksen J.R., Ipsen J.H. Measurement of membrane elasticity by micro-pipette aspiration. Eur. Phys. J. E Soft Matter 2004, 14:149-167.
27. Hou H.W., et al. Deformability study of breast cancer cells using microfluidics. Biomed. Microdevices 2009, 11:557-564.
28. Houben F., et al. Disturbed nuclear orientation and cellular migration in A-type lamin deficient cells. Biochim. Biophys. Acta 2009, 1793:312-324.
29. Houtsmuller A.B. Fluorescence recovery after photobleaching: Application to nuclear proteins. Adv. Biochem. Eng. Biotechnol. 2005, 95:177-199.
30. Hudson M.E., et al. Identification of differentially expressed proteins in ovarian cancer using high-density protein microarrays. Proc. Natl. Acad. Sci. USA 2007, 104:17494-17499.
31. Konety B.R., Getzenberg R.H. Nuclear structural proteins as biomarkers of cancer. J. Cell Biochem 1999, Suppl. 32-33:183-191.
32. Lammerding J., et al. Quantitative measurements of active and passive mechanical properties of adult cardiac myocytes. IEEE Eng. Med. Biol. Mag. 2003, 22:124-127.
33. Lammerding J., et al. Lamin A/C deficiency causes defective nuclear mechanics and mechanotransduction. J. Clin. Invest. 2004, 113:370-378.
34. Lammerding J., et al. Abnormal nuclear shape and impaired mechanotransduction in emerin-deficient cells. J. Cell Biol. 2005, 170:781-791.
35. Lammerding J., et al. Lamins A and C but not lamin B1 regulate nuclear mechanics. J. Biol. Chem. 2006, 281:25768-25780.
36. Lee J.S., et al. Nuclear lamin A/C deficiency induces defects in cell mechanics, polarization, and migration. Biophys. J. 2007, 93:2542-2552.
37. Li Y., et al. Intracellular particle tracking as a tool for tumor cell characterization. J. Biomed. Opt 2009, 14:064005.
38. Liu J., et al. Essential roles for Caenorhabditis elegans lamin gene in nuclear organization, cell cycle progression, and spatial organization of nuclear pore complexes. Mol. Biol. Cell 2000, 11:3937-3947.
39. Maniotis A.J., et al. Demonstration of mechanical connections between integrins, cytoskeletal filaments, and nucleoplasm that stabilize nuclear structure. Proc. Natl. Acad. Sci. USA 1997, 94:849-854.
40. Muchir A., et al. Identification of mutations in the gene encoding lamins A/C in autosomal dominant limb girdle muscular dystrophy with atrioventricular conduction disturbances (LGMD1B). Hum. Mol. Genet. 2000, 9:1453-1459.
41. Newport J.W., et al. A lamin-independent pathway for nuclear envelope assembly. J. Cell Biol. 1990, 111:2247-2259.
42. Novelli G., et al. Mandibuloacral dysplasia is caused by a mutation in LMNA-encoding lamin A/C. Am. J. Hum. Genet. 2002, 71:426-431.
43. Olins A.L., et al. The human granulocyte nucleus: Unusual nuclear envelope and heterochromatin composition. Eur. J. Cell Biol. 2008, 87:279-290..
44. Olins A.L., et al. The LINC-less granulocyte nucleus. Eur. J. Cell Biol. 2009, 88:203-214.
45. Pajerowski J.D., et al. Physical plasticity of the nucleus in stem cell differentiation. Proc. Natl. Acad Sci. USA 2007, 104:15619-15624.
46. Peeters E.A., et al. Monitoring the biomechanical response of individual cells under compression: A new compression device. Med. Biol. Eng. Comput. 2003, 41:498-503.
47. Philip J.T., Dahl K.N. Nuclear mechanotransduction: Response of the lamina to extracellular stress with implications in aging. J. Biomech. 2008, 41:3164-3170.
48. Rowat A., et al. Characterization of the elastic properties of the nuclear envelope. J. R. Soc. Interface 2005, 2:63-69.
49. Rowat A.C., et al. Mechanical properties of the cell nucleus and the effect of emerin deficiency. Biophys. J. 2006, 91:4649-4664.
50. Sanchez J.A., Wangh L.J. New insights into the mechanisms of nuclear segmentation in human neutrophils. J. Cell Biochem. 1999, 73:1-10.
51. Scaffidi P., Misteli T. Lamin A-dependent misregulation of adult stem cells associated with accelerated ageing. Nat. Cell Biol. 2008, 10:452-459.
52. Schape J., et al. Influence of lamin A on the mechanical properties of amphibian oocyte nuclei measured by atomic force microscopy. Biophys. J. 2009, 96:4319-4325.
53. Schirmer E.C., Gerace L. The stability of the nuclear lamina polymer changes with the composition of lamin subtypes according to their individual binding strengths. J. Biol. Chem. 2004, 279:42811-42817.
54. Schirmer E.C., et al. Nuclear membrane proteins with potential disease links found by subtractive proteomics. Science 2003, 301:1380-1382.
55. Schmiedeberg L., et al. High- and low-mobility populations of HP1 in heterochromatin of mammalian cells. Mol. Biol. Cell 2004, 15:2819-2833.
56. Shackleton S., et al. LMNA, encoding lamin A/C, is mutated in partial lipodystrophy. Nat. Genet. 2000, 24:153-156.
57. Shimi T., et al. The A- and B-type nuclear lamin networks: Microdomains involved in chromatin organization and transcription. Genes Dev. 2008, 22:3409-3421.
58. Spencer V.A., et al. Altered profiles in nuclear matrix proteins associated with DNA in situ during progression of breast cancer cells. Cancer Res 2001, 61:1362-1366.
59. Stewart C., Burke B. Teratocarcinoma stem cells and early mouse embryos contain only a single major lamin polypeptide closely resembling lamin B. Cell 1987, 51:383-392.
60. Theret D.P., et al. The application of a homogeneous half-space model in the analysis of endothelial cell micropipette measurements. J. Biomech. Eng. 1988, 110:190-199.
61. Thoumine O., Ott A. Time scale dependent viscoelastic and contractile regimes in fibroblasts probed by microplate manipulation. J. Cell Sci. 1997, 110(Pt 17):2109-2116.
62. Tseng Y., et al. Micromechanical mapping of live cells by multiple-particle-tracking microrheology. Biophys. J. 2002, 83:3162-3176.
63. Tseng Y., et al. Micro-organization and visco-elasticity of the interphase nucleus revealed by particle nanotracking. J. Cell Sci. 2004, 117:2159-2167.
64. Verstraeten V.L., et al. Increased mechanosensitivity and nuclear stiffness in Hutchinson-Gilford progeria cells: Effects of farnesyltransferase inhibitors. Aging Cell 2008, 7:383-393.
65. Weidtkamp-Peters S., et al. Fluorescence correlation spectroscopy to assess the mobility of nuclear proteins. Methods Mol. Biol. 2009, 464:321-341.
66. Wiesmeijer K., et al. Chromatin movement visualized with photoactivable GFP-labeled histone H4. Differentiation 2008, 76:83-90.
67. Wolf K., Friedl P. Molecular mechanisms of cancer cell invasion and plasticity. Br. J. Dermatol. 2006, 154:11-15.
68. Wolf K., et al. Multi-step pericellular proteolysis controls the transition from individual to collective cancer cell invasion. Nat. Cell Biol. 2007, 9:893-904.
69. Zink D., et al. Nuclear structure in cancer cells. Nat. Rev. Cancer 2004, 4:677-687.