Ethical controversies at end of life after traumatic brain injury: Defining death and organ donation

Critical Care Medicine

Volumn 38, Issue SUPPL. 9, 2010, Pages

  Souter, Michael ^a   Van Norman, Gail ^b  

^a UNIVERSITY OF WASHINGTON   (United States)

^b UNIVERSITY OF WASHINGTON   (United States)

Author keywords

brain death; cardiac arrest; controlled donation after cardiac death; death; declaring death; donation after cardiac death; double effect; end of life; Ethics; organ transplantation

Indexed keywords

ARTIFICIAL VENTILATION; BRAIN DEATH; HEART ARREST; HEART DEATH; HEART GRAFT; HEART TRANSPLANTATION; HUMAN; LIFE SUSTAINING TREATMENT; LIVER GRAFT; LUNG TRANSPLANTATION; MEDICAL ETHICS; ORGAN DONOR; ORGAN TRANSPLANTATION; PRIORITY JOURNAL; REVIEW; TRAUMATIC BRAIN INJURY; BRAIN INJURY; DEATH; ETHICS; TERMINAL CARE; TRANSPLANTATION;

BRAIN DEATH; BRAIN INJURIES; DEATH; HUMANS; TERMINAL CARE; TISSUE AND ORGAN PROCUREMENT;

EID: 77956203744     PISSN: 00903493     EISSN: 15300293     Source Type: Journal    
DOI: 10.1097/CCM.0b013e3181ec5354     Document Type: Article

References (60)

1. Korein J: Brain death: Interrelated medical and social issues. Preface. Ann N Y Acad Sci 1978; 315:1-5
2. Veatch RM: Death, Dying, and the Biological Revolution. Our Last Responsibility. New Haven, Yale University Press, 1989
3. Bartlett E, Youngner SJ: Human death and the Destruction of the Neocortex, Death: Beyond the Whole-Brain Criteria. Zaner R (Ed). New York, Kluwer Academic Press, 1988, pp 199-215
4. Lock M: Twice Dead: Organ Transplants and the Reinvention of Death. Berkeley, CA, University of California Press, 2002
5. Puccetti R: The conquest of death. Monist 1976; 59:249-263
6. Wijdicks EFM, Wijdicks CA: The portrayal of coma in contemporary motion pictures. Neurology 2006; 66:1300-1303
7. Machado C, Kerein J, Ferrer Y, et al: The concept of brain death did not evolve to benefit organ transplants. J Med Ethics 2007; 33:197-200
8. Wertheimer P, Jouvet M, Descotes J: [Diagnosis of death of the nervous system in comas with respiratory arrest treated by artificial respiration.] [Article in French] Presse Med 1959; 67:87-88
9. Cushing H: Some experimental and clinical observations concerning states of increased intracranial tension. Am J Med Sci 1902; 124:375-400
10. Mollaret P, Goulon M: Le coma dépassé. Rev Neurol (Paris) 1959; 101:3-15
11. What and when is death? JAMA 1968; 204: 539-540
12. Machado C: The first organ transplant from a brain-dead donor. Neurology 2005; 64: 1938-1942
13. A definition of irreversible coma Report of the Ad Hoc Committee of the Harvard Medical School to Examine the Definition of Brain Death. JAMA 1968; 205:337-340
14. Wijdicks EFM: The neurologist and Harvard criteria for brain death. Neurology 2003; 61: 970-976
15. Gilder SSB: Twenty-Second World Medical Assembly. BMJ 1968; 3:493-494
16. An appraisal of the criteria of cerebral death. A summary statement. A collaborative study. JAMA 1977; 237:982-986
17. President's Commission for the Study of Ethical Problems in Medicine and Biomedical and Behavioral Research Guidelines for the determination of death: Report of the medical consultants on the diagnosis of death. JAMA 1981; 246:2184-2186
18. Uniform Determination of Death Act. Available at http://www.law.upenn. edu/bll/archives/ulc/fnact99/1980s/udda80.htm. Accessed July 1, 2010
19. Van Norman G: A matter of life and death: What every anesthesiologist should know about the medical, legal, and ethical aspects of declaring brain death. Anesthesiology 1999; 91:275-287
20. Wijdicks EF: The diagnosis of brain death. N Engl J Med 2001; 344:1215-1221
21. Greer DM, Varelas PN, Haque S, et al: Variability of brain death determination guidelines in leading US neurologic institutions. Neurology 2008; 70:284-289
22. Practice parameters for determining brain death in adults (summary statement). The Quality Standards Subcommittee of the American Academy of Neurology. Neurology 1995; 45:1012-1014
23. Truog RD: Brain death\Too flawed to endure, too ingrained to abandon. J Law Med Ethics 2007; 35:273-281
24. Siminoff LA, Mercer MB, Arnold R: Families' understanding of brain death. Prog Transplant 2003; 13:218-224
25. Whetstine LM: Bench-to-bedside review: when is dead really dead\On the legitimacy of using neurologic criteria to determine death. Crit Care 2007; 11:208-210
26. Kinney HC, Samuels MA: Neuropathology of the persistent vegetative state. A review. J Neuropathol Exp Neurol 1994; 53:548-558
27. Plum F, Posner J: The Diagnosis of Stupor and Coma. Third Edition. New York, Oxford University Press, 1982
28. Machado C: Death on neurological grounds. J Neurosurg Sci 1994; 38:209-222
29. Yamamoto T, Kobayashi K, Kasai M, et al: DBS therapy for the vegetative state and minimally conscious state. Acta Neurochir Suppl 2005; 93:101-104
30. Owen AM, Coleman MR, Boly M, et al: Detecting awareness in the vegetative state. Science 2006; 313:1402
31. Andrews K, Murphy L, Munday R, et al: Mis-diagnosis of the vegetative state: Retrospective study in a rehabilitation unit. BMJ 1996; 313:13-16
32. Charter D: Man in "coma" for 23 years was awake all along. The Times [Brussels], No vember 24, 2009. Available at http://www.timesonline.co.uk/ tol/news/world/europe/article6928353.ece. Accessed January 18, 2010
33. Turgeon A, Lauzier F, Zarychanski R, et al: Determining neurological prognosis in ICU patients with severe traumatic brain injury: A survey of Canadian neurosurgeons. Crit Care Med 2010; 37(Suppl): A314
34. Pallis C: Brain stem death\The evolution of a concept. Med Leg J 1987; 55:84-107
35. Shewmon DA: Chronic "brain death": Meta-analysis and conceptual consequences. Neurology 1998; 51:1538-1545
36. Bernat J: Ethical Issues in Neurology. Third edition. Philadelphia, Lippincott Williams & Wilkins, 2008
37. Goldenberg E, Frank J, Ardelt A, et al: Can death by neurological criteria be pronounced even if preceded by cardiac death: An ethical dilemma or simply a rhetorical question? Crit Care Med 2010; 37(Suppl): A395
38. Martins ET, Linhares MN, Sousa DS, et al: Mortality in severe traumatic brain injury: A multivariated analysis of 748 Brazilian patients from Florianópolis City. J Trauma 2009; 67:85-90
39. Marini AM, Choi J, Labutte R: Synaptic deprivation and age-related vulnerability to hy-poxic-ischemic neuronal injury. Ann N Y Acad Sci 2001; 939:238-253
40. Berger RP: The use of serum biomarkers to predict outcome after traumatic brain injury in adults and children. J Head Trauma Re-habil 2006; 21:315-333
41. Kothari S, Flanagan SR, Kwasnica C, et al: Congenital and acquired brain injury. 5. Emerging concepts in prognostication, evaluation, and treatment. Arch Phys Med Reha-bil 2008; 89(3 Suppl 1):S27-S31
42. Jacobsson LJ, Westerberg M, Söderberg S, et al: Functioning and disability 6-15 years after traumatic brain injuries in northern Sweden. Acta Neurol Scand 2009; 120:389-395
43. United Network for Organ Sharing. Available at http://www.unos.org/. Accessed December 14, 2007
44. Sanz A, Boni RC, Ghirardini A, et al: IRODaT: Comparison of worldwide growth rates from 2000 to 2004. Organs and Tissue 2005; 3:151-154
45. The American public's attitudes toward organ donation and transplantation. Boston, The Partnership for Organ Donation 1993. Available at http://www.transweb.org/reference/articles/gallup-survey/gallup-index.html/. Accessed July 1, 2010
46. Mandell MS, Zamudio S, Seem D, et al: National evaluation of healthcare provider attitudes toward organ donation after cardiac death. Crit Care Med 2006; 34:2952-2958
47. Koostra G, Daemen JH, Oomen AP: Categories of non-heart-beating donors. Transplant Proc 1995; 27:2893-2894
48. Institute of Medicine: Non-Heart-Beating Organ Transplantation: Medical and Ethical Issues in Procurement. Washington, DC, National Academy Press, 1997
49. Non-Heart-Beating Organ Transplantation: Practices and Protocols. Washington, Institute of Medicine National Academy Press, 2000
50. Speilman B, McCarthy CS: Beyond Pittsburgh: Protocols for controlled non-heart-beating cadaver organ recovery. Kennedy Inst Ethics J 1995; 5:323-333
51. Doig CJ, Rocker G: Retrieving organs from non-heart-beating organ donors: A review of medical and ethical issues. Can J Anesth 2003; 50:1069-1076
52. Deciding to forgo life-sustaining treatment: ethical, medical, and legal issues in treatment decisions. In: Source Book in Bioeth-ics. Jonsen AR, Veatch RM, Walters L (Eds). Washington, Georgetown University Press, 1998, pp 159-219
53. Sadler AM, Sadler BL, Stason EB: The uniform anatomic gift act. JAMA 1968; 206: 2501-2506
54. Hawryluck LA, Harvey WR: Analgesia, virtue, and the principle of double effect. J Pall Care 2000; 16(Suppl):S24-S30
55. Van der Heide A, Onwuteaka-Phillipsen BD, Rurup ML, et al: End-of-life practices in the Netherlands under the Euthanasia Act. N Engl J Med 2007; 356:1957-1965
56. Koostra G: The asystolic, or non-heart-beating, donor. Transplantation 1997; 63: 917-921
57. A United Methodist definition of death for use by organ procurement organizations. Journal of the Pacific Northwest. Annual Conference of the United Methodist Church, 134th Annual Session, Tacoma, WA, June 15, 2007
58. Menikoff J: The importance of being dead: Non-heart-beating organ donation. Issues Law Med 2002; 18:3-20
59. Joffe AR: The ethics of donation and transplantation: Are definitions of death being distorted for organ transplantation? Philos Ethics Humanit Med 2007; 2:28-34
60. Youngner S, Arnold R, DeVita ML When is "dead"? Hastings Ctr Rep 1999; 29:14-21