Synthesis, crystal structure and pH dependent cytotoxicity of (SP-4-2)-bis(2-aminoethanolato-κ2N,O)platinum(II) - A representative of novel pH sensitive anticancer platinum complexes

Inorganica Chimica Acta

Volumn 357, Issue 11, 2004, Pages 3237-3244

  Galanski, Markus ^a   Baumgartner, Christian ^a   Meelich, Kristof ^a   Arion, Vladimir B ^a   Fremuth, Madeleine ^a   Jakupec, Michael A ^a   Schluga, Petra ^a   Hartinger, Christian G ^a   Keyserlingk, Nikolai Graf V ^b   Keppler, Bernhard K ^a  

^a UNIVERSITY OF VIENNA   (Austria)

^b Faustus Forschungs Co T   (Germany)

Author keywords

Anticancer agents; N,O ligands; pH sensitive cytotoxicity; Platinum complexes

Indexed keywords

CELL CULTURE; CHELATION; CRYSTAL STRUCTURE; DIAGNOSIS; PH; PH SENSORS; PLATINUM COMPOUNDS; SYNTHESIS (CHEMICAL); TUMORS;

ANTI-CANCER AGENTS; CONDITION; CRYSTALS STRUCTURES; N,O-LIGAND; O LIGANDS; PH SENSITIVE; PH-SENSITIVE CYTOTOXICITY; PLATINUM COMPLEXES; SOLID TUMORS; STRUCTURE DEPENDENT;

CYTOTOXICITY;

ANTINEOPLASTIC AGENT; BASE; CISPLATIN; GUANOSINE PHOSPHATE; ORGANIC COMPOUND; PLATINUM COMPLEX;

ACIDIFICATION; ACIDITY; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER THERAPY; CANCER TISSUE; CONTROLLED STUDY; CRYSTAL STRUCTURE; CULTURE MEDIUM; DRUG CYTOTOXICITY; DRUG SCREENING; DRUG SENSITIVITY; DRUG SYNTHESIS; HUMAN; HUMAN CELL; HYPOXIA; LUNG NON SMALL CELL CANCER; OVARY CARCINOMA; OVARY CELL CULTURE; SOLID TUMOR; STANDARD; TUMOR CELL LINE; TUMOR VOLUME;

EID: 3242766909     PISSN: 00201693     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ica.2004.04.003     Document Type: Article

References (27)

1. Rosenberg B., VanCamp L., Krigas T. Nature. 205:1965;698
2. Rosenberg B., VanCamp L., Trosko J.E., Mansour V.H. Nature. 222:1969;385
3. Rosenberg B. Interdiscip. Sci. Rev. 3(2):1978;134
4. Lippert B. Cisplatin: Chemistry and Biochemistry of a Leading Anticancer Drug. 1999;Verlag Helvetica Chimica Acta/WILEY-VCH, Zürich, Switzerland/Weinheim, Germany
5. Jakupec M.A., Galanski M., Keppler B.K. Rev. Physiol. Biochem. Pharmacol. 146:2003;1
6. Jamieson E.R., Lippard S.J. Chem. Rev. 99:1999;2467
7. O'Dwyer P.J., Stevenson J.P., Johnson S.W. Drugs. 59(Suppl. 4):2000;19
8. Kelland L.R. Drugs. 59(Suppl. 4):2000;1
9. Reedijk J., Teuben J.M. Cisplatin: Chemistry and Biochemistry of a Leading Anticancer Drug. Lippert B.:1999;339-362 Verlag Helvetica Chimica Acta/WILEY-VCH, Zürich, Switzerland/Weinheim, Germany
10. Reedijk J. Chem. Rev. 99(9):1999;2499
11. Gerweck L.E. Semin. Radiat. Oncol. 8:1998;176
12. Gerweck L.E., Kozin S.V., Stocks S.J. Br. J. Cancer. 79(5/6):1999;838
13. Volk T., Jaehde E., Fortmeyer H.P., Gluesenkamp K.H., Rajewsky M.F. Br. J. Cancer. 68:1993;492
14. N. Raghunand, R.J. Gillies, Novartis Foundation Symposium 240 (Tumor Microenvironment) (2001) 199
15. Zimmermann W., Galanski M., Giesster G., Keppler B.K. Inorg. Chim. Acta. 292:1999;127
16. G.M. Sheldrick, SHELXS-97, Program for Crystal Structure Solution, University Göttingen, Germany, 1997
17. G.M. Sheldrick, SHELXL-97, Program for Crystal Structure Refinement, University Göttingen, Germany, 1997
18. C.K. Johnson, Rep. ORNL-5138, OAK Ridge National Laboratory, OAK Ridge, TN, 1976
19. International Tables for X-ray Crystallography, Kluwer Academic Press, Dordrecht, The Netherlands, 1992, vol. C, Tables 4.2.6.8 and 6.1.1.4
20. Galanski M., Baumgartner C., Arion V.B., Keppler B.K. Eur. J. Inorg. Chem. 2003;2619
21. Zenker A., Galanski M., Bereuter T.L., Keppler B.K., Lindner W. J. Biol. Inorg. Chem. 5:2000;498
22. Robillard M.S., Galanski M., Zimmermann W., Keppler B.K., Reedijk J. J. Inorg. Biochem. 88:2002;254
23. Küng A., Galanski M., Baumgartner C., Keppler B.K. Inorg. Chim. Acta. 339:2002;9
24. Hartinger C.G., Schluga P., Galanski M., Baumgartner C., Timerbaev A.T., Keppler B.K. Electrophoresis. 24:2003;2038
25. Galanski M., Zimmermann W., Baumgartner C., Keppler B.K. Eur. J. Inorg. Chem. 2001;1145
26. Yilmaz Y.T., Andac O., Topcu Y., Harrison W.T.A. Acta Cryst. C. 57:2001;271
27. Shvelashvilli A.E., Porai-Koshits M.A., Kvitashvili A.I., Shchedrin B.M., Tavberidze M.G. Zh. Strukt. Khim. 15:1974;313