Acceleration of diabetic wound healing by collagen-binding vascular endothelial growth factor in diabetic rat model

Diabetes Research and Clinical Practice

Volumn 90, Issue 1, 2010, Pages 66-72

  Yan, Xin ^a   Chen, Bing ^b   Lin, Yue ^a   Li, Yunjian ^a   Xiao, Zhifeng ^b   Hou, Xianglin ^c   Tan, Qian ^a   Dai, Jianwu ^b  

^a MEDICAL SCHOOL OF NANJING UNIVERSITY   (China)

^b INSTITUTE OF GENETICS AND DEVELOPMENTAL BIOLOGY   (China)

^c Yantai Zhenghai Magnetic Material Co Ltd   (China)

Author keywords

Healing; VEGF; Wounds

Indexed keywords

COLLAGEN BINDING PROTEIN VASCULOTROPIN 165 FUSION PROTEIN; GLUCOSE; STREPTOZOCIN; UNCLASSIFIED DRUG; VASCULOTROPIN 165; WOUND HEALING PROMOTING AGENT;

ANGIOGENESIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BODY MASS; CONTROLLED STUDY; DIABETES MELLITUS; DRUG BLOOD LEVEL; GLUCOSE BLOOD LEVEL; GRANULATION TISSUE; HISTOPATHOLOGY; MALE; NONHUMAN; RAT; SPRAGUE DAWLEY RAT; STREPTOZOCIN DIABETES; TISSUE REGENERATION; VASCULARIZATION; WOUND; WOUND HEALING;

ADMINISTRATION, TOPICAL; ANIMALS; COLLAGEN; DIABETES MELLITUS, TYPE 1; GRANULATION TISSUE; HUMANS; MALE; NEOVASCULARIZATION, PHYSIOLOGIC; PROTEIN INTERACTION DOMAINS AND MOTIFS; RANDOM ALLOCATION; RATS; RATS, SPRAGUE-DAWLEY; RECOMBINANT FUSION PROTEINS; SKIN; TIME FACTORS; VASCULAR ENDOTHELIAL GROWTH FACTOR A; WOUND HEALING;

EID: 77956191981     PISSN: 01688227     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.diabres.2010.07.001     Document Type: Article

References (17)

1. Goodridge D., Trepman E., Sloan J., Guse L., Strain L.A., Mclntyre J., et al. Quality of life of adults with unhealed and healed diabetic foot ulcers. Foot Ankle Int 2006, 27(4):274-280.
2. Lobmann R., Schultz G., Lehnert H. Molecular fundamentals of wound healing in diabetic foot syndrome. Med Klin (Munich) 2003, 98(5):292-301.
3. Galkowska H., Wojewodzka U., Olszewski W.L. Chemokines, cytokines, and growth factors in keratinocytes and dermal endothelial cells in the margin of chronic diabetic foot ulcers. Wound Repair Regen 2006, 14(5):558-565.
4. Pradhan L., Nabzdyk C., Andersen N.D., LoGerfo F.W., Veves A. Inflammation and neuropeptides: the connection in diabetic wound healing. Expert Rev Mol Med 2009, 11:e2.
5. Wang Z., Zhang J., Zhang B. Vascular endothelial growth factor gene expression in patients' ischemic skeletal muscle with diabetic foot. Chin J Surg 2002, 40(7):505-507.
6. Yancopoulos G.D., Davis S., Gale N.W., Rudge J.S., Wiegand S.J., Holash J. Vascular-specific growth factors and blood vessel formation. Nature 2000, 407:242-248.
7. Morykwas M.J., Argenta L.C., Shelton Brown E.I., McGuirt W. Vacuum assisted closure: a new method for wound control and treatment: animal studies and basic foundation [J]. Ann Plast Surg 1997, 38(6):553-562.
8. Lee R.J., Springer M.L., Blanco-Bose W.E., Shaw R., Ursell P.C., Blau H.M. VEGF gene delivery to myocardium: deleterious effects of unregulated expression. Circulation 2000, 102:898-901.
9. Lu S.L., Qin C., Xie T., Sai J. Research on factory mechanism of the cutaneous " underlying disorder" in diabetic rats [J]. Chin J Trauma 2004, 20(8):468-473.
10. Onodera H., Ikeuchi D., Nagayama S., Imamura M. Weakness of anastomotic site in diabetic rats is caused by changes in the integrity of newly formed collagen [J]. Dig Surg 2004, 21(2):146-151.
11. Jing Z., Liang D., Zhao Y.N., Sun W.J., Chen B., Lin H., et al. Collagen-targeting vascular endothelial growth factor improves cardiac performance after myocardial infarction. Circulation 2009, 119:1776-1784.
12. Trousdale R.K., Jacobs S., Simhaee D.A., Wu J.K., Lustbader J.W. Wound closure and metabolic parameter variability in a db/db mouse model for diabetic ulcers. J Surg Res 2009, 151(1):100-107.
13. Frank S., Hubner G., Breier G., Longaker M.T., Greenhalgh D.G., Werner S. Regulation of vascular endothelial growth factor expression in cultured keratinocytes. Implications for normal and impaired wound healing [J]. J Biol Chem 1995, 270(21):12607-12613.
14. Howdieshell T.R., Riegner C., Gupta V., Callaway D., Grembowicz K., Sathyanarayana, et al. Normoxic wound fluid contains high levels of vascular endothelial growth factor[J]. Ann Surg 1998, 228(5):707-715.
15. Zhang F., Liu H., Stile F., Lei M.P., Pang Y., Oswald T.M., et al. Effect of vascular endothelial growth factor on rat Achilles tendon healing[J]. Plast Reconstr Surg 2003, 112(6):1613-1619.
16. Zhu X.D., Zhang Y., Hu C.X., Wang Z.G. Study on the molecular mechanisms involved in the increased collagen synthesis by platelet-derived wound healing factors during wound healing in alloxan-induced diabetic rat[J]. Chin J Reparative Reconstr Surg 2001, 15(4):223-226.
17. Hamed S., Ullmann Y., Masoud M., Hellou E., Khamaysi Z., Teot L., et al. Topical erythropoietin promotes wound repair in diabetic rats[J]. J Invest Dermatol 2010, 130:287-294.