Influence of neuronal cell adhesion molecule (NCAM1) variants on suicidal behaviour and correlated traits

Psychiatry Research

Volumn 179, Issue 2, 2010, Pages 222-225

  Giegling, Ina ^a   Chiesa, Alberto ^b   Mandelli, Laura ^b   Gibiino, Sara ^b   Hartmann, Annette M ^a   Möller, Hans Jürgen ^a   Schneider, Barbara ^c   Schnabel, Axel ^c   Maurer, Konrad ^c   De Ronchi, Diana ^b   Rujescu, Dan ^a   Serretti, Alessandro ^b  

^a LUDWIG MAXIMILIANS UNIVERSITY   (Germany)

^b UNIVERSITY OF BOLOGNA   (Italy)

^c GOETHE UNIVERSITY   (Germany)

Author keywords

Aggression; Genetics; Impulsivity; NCAM1; SNPs; Suicidal behaviour; Suicide

Indexed keywords

NERVE CELL ADHESION MOLECULE; CD56 ANTIGEN; NCAM1 PROTEIN, HUMAN;

ADULT; AGGRESSION; ARTICLE; CONTROLLED STUDY; FEMALE; GENE FREQUENCY; GENE FUNCTION; GENE LINKAGE DISEQUILIBRIUM; GENETIC TRAIT; GENETIC VARIABILITY; GENOTYPE; HAPLOTYPE; HUMAN; MAJOR CLINICAL STUDY; MALE; MEDICAL HISTORY; PREVALENCE; PRIORITY JOURNAL; PSYCHOLOGIC ASSESSMENT; SINGLE NUCLEOTIDE POLYMORPHISM; SUICIDAL BEHAVIOR; SUICIDE ATTEMPT; AUTOMUTILATION; GENETICS; INHIBITION (PSYCHOLOGY); MIDDLE AGED; PHYSIOLOGY; PSYCHOLOGY; SUICIDE;

ADULT; FEMALE; GENE FREQUENCY; GENOTYPE; HUMANS; INHIBITION (PSYCHOLOGY); LINKAGE DISEQUILIBRIUM; MALE; MIDDLE AGED; NEURAL CELL ADHESION MOLECULES; POLYMORPHISM, SINGLE NUCLEOTIDE; SELF-INJURIOUS BEHAVIOR; SUICIDE; ANTIGENS, CD56;

EID: 77956191806     PISSN: 01651781     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.psychres.2009.03.028     Document Type: Article

References (33)

1. Baldessarini R.J., Hennen J. Genetics of suicide: an overview. Harvard Review of Psychiatry 2004, 12:1-13.
2. Barrett J.C., Fry B., Maller J., Daly M.J. Haploview: analysis and visualization of LD and haplotype maps. Bioinformatics 2005, 21:263-265.
3. Brezo J., Klempan T., Turecki G. The genetics of suicide: a critical review of molecular studies. Psychiatric Clinics of North America 2008, 31:179-203.
4. Cavalli Sforza L. The History and Geography of Human Genes 1994, Princeton University Press, Princeton, New Jersey, USA.
5. Doherty P., Fazeli M.S., Walsh F.S. The neural cell adhesion molecule and synaptic plasticity. Journal of Neurobiology 1995, 26:437-446.
6. First M.B., Spitzer R.L., Gibbon M., Williams B.W., Benjamin L. Structured Clinical Interview for DSM-IV Axis II Personality Disorders (SCID-II), New York: Biometrics Research Department, New York State Psychiatric Institute 1990.
7. First M.B., Spitzer R.L., Gibbon M., Williams J.B. Structured Clinical Interview for DSM-IV Axis I Disorders-Patient Edition (SCID-I/P, Version 2.0), New York: Biometrics Research Department, New York State Psychiatric Institute 1995.
8. Fitzgerald M. Impulsivity and suicide. Journal of the American Academy Child Adolescent Psychiatry 1999, 38:939-940.
9. Fujita N., Saito R., Watanabe K., Nagata S. An essential role of the neuronal cell adhesion molecule contactin in development of the Xenopus primary sensory system. Developmental Biology 2000, 221:308-320.
10. Gascon E., Vutskits L., Kiss J.Z. Polysialic acid-neural cell adhesion molecule in brain plasticity: from synapses to integration of new neurons. Brain Research Reviews 2007, 56:101-118.
11. Giegling I., Hartmann A.M., Moller H.J., Rujescu D. Anger- and aggression-related traits are associated with polymorphisms in the 5-HT-2A gene. Journal of Affective Disorders 2006, 96:75-81.
12. Giegling I., Chiesa A., Calati R., Hartmann A.M., Moller H.J., De Ronchi D., Rujescu D., Serretti A. Do the estrogen receptors 1 gene variants influence the temperament and character inventory scores in suicidal attempters and healthy subjects?. American Journal of Medical Genetetics part B Neuropsychiatric Genetics 2009, 150B:434-438.
13. Giegling I., Rujescu D., Mandelli L., Schneider B., Hartmann A.M., Schnabel A., Maurer K., De Ronchi D., Moller H.J., Serretti A. Estrogen receptor gene 1 variants are not associated with suicidal behavior. Psychiatry Research 2008, 160:1-7.
14. Hampel R., Selg H. FAF-Fragebogen zur Erfassung von Aggressivitätsfaktoren 1975, Hogrefe Verlag für Psychologie, Handanweisung, Gottingen.
15. Marui T., Funatogawa I., Koishi S., Yamamoto K., Matsumoto H., Hashimoto O., Nanba E., Nishida H., Sugiyama T., Kasai K., Watanabe K., Kano Y., Kato N. Association of the neuronal cell adhesion molecule (NRCAM) gene variants with autism. International Journal of Neuropsychopharmacology 2008, 1-10.
16. Mathers C.D., Loncar D. Projections of global mortality and burden of disease from 2002 to 2030. PLoS Med 2006, 3:e442.
17. Matzel L.D., Babiarz J., Townsend D.A., Grossman H.C., Grumet M. Neuronal cell adhesion molecule deletion induces a cognitive and behavioral phenotype reflective of impulsivity. Genes Brain and Behaviour 2008, 7:470-480.
18. Nock M.K., Borges G., Bromet E.J., Cha C.B., Kessler R.C., Lee S. Suicide and Suicidal Behavior. Epidemiology Review 2008.
19. Rice J.P., Reich T., Bucholz K.K., Neuman R.J., Fishman R., Rochberg N., Hesselbrock V.M., Nurnberger J.I., Schuckit M.A., Begleiter H. Comparison of direct interview and family history diagnoses of alcohol dependence. Alcohololism Clinical and Experimental Research 1995, 19:1018-1023.
20. Roy A. Family history of suicide and impulsivity. Archives of Suicide Research 2006, 10:347-352.
21. Rujescu D., Giegling I., Gietl A., Hartmann A.M., Moller H.J. A functional single nucleotide polymorphism (V158M) in the COMT gene is associated with aggressive personality traits. Biological Psychiatry 2003, 54:34-39.
22. Serretti A., Calati R., Giegling I., Hartmann A.M., Moller H.J., Colombo C., Rujescu D. 5-HT2A SNPs and the temperament and character inventory. Progress in Neuro-Psychopharmacology and Biological Psychiatry 2007, 31:1275-1281.
23. Spielberger C. State-Trait Anger Expression Inventory. Assessment Resourches, Odessoa FL 1991.
24. StatSoft I. STATISTICA per Windows, StatSoft Italia srl 1995.
25. Stork O., Welzl H., Cremer H., Schachner M. Increased intermale aggression and neuroendocrine response in mice deficient for the neural cell adhesion molecule (NCAM). European Journal of Neuroscience 1997, 9:1117-1125.
26. Sullivan P.F., Keefe R.S., Lange L.A., Lange E.M., Stroup T.S., Lieberman J., Maness P.F. NCAM1 and neurocognition in schizophrenia. Biological Psychiatry 2007, 61:902-910.
27. Swann A.C., Dougherty D.M., Pazzaglia P.J., Pham M., Steinberg J.L., Moeller F.G. Increased impulsivity associated with severity of suicide attempt history in patients with bipolar disorder. American Journal of Psychiatry 2005, 162:1680-1687.
28. Vawter M.P. Dysregulation of the neural cell adhesion molecule and neuropsychiatric disorders. European Journal of Pharmacology 2000, 405:385-395.
29. Wittchen H., Zaudig M., Fydrich T. Strukturiertes Klinisches Interview für DSM-IV, Achse I und II 1997, Hogrefe, Göttingen.
30. World Health Organization Burden of Mental and Behavioural Disorders: suicide 2005, http://www.who.int/whr/2001/chapter2/en/index6.html.
31. World Health Organization Suicide prevention (SUPRE). Geneva, Switzerland 2007.
32. Xu Z., He Z., Huang K., Tang W., Li Z., Tang R., Xu Y., Feng G., He L., Shi Y. No genetic association between NCAM1 gene polymorphisms and schizophrenia in the Chinese population. Progress in Neuropsychopharmacol and Biological Psychiatry 2008, 32:1633-1636.
33. Zouk H., Tousignant M., Seguin M., Lesage A., Turecki G. Characterization of impulsivity in suicide completers: clinical, behavioral and psychosocial dimensions. Journal of Affective Disorders 2006, 15:15.