Pro12Ala polymorphism in PPAR-γ2 and dementia in Chinese nonagenarians/centenarians

Age

Volumn 32, Issue 3, 2010, Pages 397-404

  Ji Rong, Yue ^a   Bi Rong, Dong ^a   Chang Quan, Huang ^a   Zhen Chan, Lu ^a   Hong Mei, Wu ^a   Yan Ling, Zhang ^a  

^a SICHUAN UNIVERSITY   (China)

Author keywords

Dementia; Nonagenarians and centenarians; PPAR 2; Pro12Ala polymorphism

Indexed keywords

PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA 2;

AGED; ARTICLE; CHINESE; COGNITIVE DEFECT; CONTROLLED STUDY; DEMENTIA; FEMALE; GENE FREQUENCY; GENETIC ASSOCIATION; GENETIC POLYMORPHISM; GENETIC PREDISPOSITION; HUMAN; LINKAGE ANALYSIS; MAJOR CLINICAL STUDY; MALE; MINI MENTAL STATE EXAMINATION; POLYMERASE CHAIN REACTION; RESTRICTION FRAGMENT LENGTH POLYMORPHISM; SEX DIFFERENCE;

AGED, 80 AND OVER; CHINA; DEMENTIA; FEMALE; HUMANS; MALE; POLYMORPHISM, GENETIC; POLYMORPHISM, RESTRICTION FRAGMENT LENGTH; PPAR GAMMA;

EID: 77956187816     PISSN: 01619152     EISSN: 15744647     Source Type: Journal    
DOI: 10.1007/s11357-010-9132-1     Document Type: Article

References (28)

1. M Barbieri M Bonafe MR Rizzo E Ragno F Olivieri F Marchegiani C Franceschi G Paolisso 2004 Gender specific association of genetic variation in peroxisome proliferator-activated receptor (PPAR)gamma-2 with longevity Exp Gerontol 39 1095 1100 10.1016/j.exger.2004.03.034 1:CAS:528:DC%2BD2cXltl2gu7w%3D 15236769
2. J Berger DE Moller 2002 The mechanisms of action of PPARs Annu Rev Med 53 409 435 10.1146/annurev.med.53.082901.104018 1:CAS:528:DC%2BD38Xitl2mt7s%3D 11818483
3. LM Chuang CA Hsiung YDI Chen LT Ho WHH Sheu D Pei CH Nakatsuka D Cox RE Pratt HH Lei TY Tai 2001 Sibling-based association study of the PPAR gamma(2) Pro12Ala polymorphism and metabolic variables in Chinese and Japanese hypertension families: a SAPPHIRe study J Mol Med 79 656 664 10.1007/s001090100255 1:CAS:528:DC%2BD38Xjsl2itg%3D%3D 11715069
4. MM Corrada R Brookmeyer D Berlau A Paganini-Hill CH Kawas 2008 Prevalence of dementia after age 90: results from the 90+ study Neurology 71 337 343 10.1212/01.wnl.0000310773.65918.cd 1:STN:280:DC%2BD1cvotFyjsw%3D%3D 18596243
5. I Dahlman P Arner 2007 Obesity and polymorphisms in genes regulating human adipose tissue Int J Obes 31 1629 1641 10.1038/sj.ijo.0803657 1:CAS:528:DC%2BD2sXht1ejtrfL
6. BM Forman J Chen RM Evans 1997 Hypolipidemic drugs, polyunsaturated fatty acids, and eicosanoids are ligands for peroxisome proliferator-activated receptors alpha and delta Proc Natl Acad Sci U S A 94 4312 4317 10.1073/pnas.94.9.4312 1:CAS:528:DyaK2sXjtVyhsbs%3D 9113986
7. I Issemann S Green 1990 Activation of a member of the steroid hormone receptor superfamily by peroxisome proliferators Nature 347 645 650 10.1038/347645a0 1:CAS:528:DyaK3MXhsl2gs7g%3D 2129546
8. JW Jama LJ Launer JC Witteman JH den Breeijen MM Breteler DE Grobbee A Hofman 1996 Dietary antioxidants and cognitive function in a population-based sample of older persons. The Rotterdam study Am J Epidemiol 144 275 280 1:STN:280:DyaK28zgt1WntQ%3D%3D 8686696
9. W Johnson SE Harris JM Starr LJ Whalley IJ Deary 2008 PPARG Pro12Ala genotype and risk of cognitive decline in elders? Maybe with diabetes Neurosci Lett 434 50 55 10.1016/j.neulet.2008.01.027 1:CAS:528:DC%2BD1cXjtlygsr0%3D 18280041
10. P Katsel C Li V Haroutunian 2007 Gene expression alterations in the sphingolipid metabolism pathways during progression of dementia and Alzheimer's disease: a shift toward ceramide accumulation at the earliest recognizable stages of Alzheimer's disease? Neurochem Res 32 845 856 10.1007/s11064-007-9297- x 1:CAS:528:DC%2BD2sXjtlymtL4%3D 17342407
11. SA Kliewer JM Lenhard TM Willson I Patel DC Morris JM Lehmann 1995 A prostaglandin J2 metabolite binds peroxisome proliferator-activated receptor gamma and promotes adipocyte differentiation Cell 83 813 819 10.1016/0092-8674(95)90194-9 1:CAS:528:DyaK2MXpvVehtb4%3D 8521498
12. Langley LK (2000) Cognitive assessment of older adults. In: Kane RL (ed) Assessing older persons. Oxford University Press, Oxford, pp 65-128
13. S Masud S Ye SAS Group 2003 Effect of the peroxisome proliferator activated receptor-gamma gene Pro12Ala variant on body mass index: a meta-analysis J Med Genet 40 773 780 10.1136/jmg.40.10.773 1:CAS:528: DC%2BD3sXpsFyqt7w%3D 14569127
14. RS McIntyre JK Soczynska HO Woldeyohannes GF Lewis LA Leiter GM MacQueen A Miranda D Fulgosi JZ Konarski SH Kennedy 2007 Thiazolidinediones: novel treatments for cognitive deficits in mood disorders? Expert Opin Pharmacother 8 1615 1628 10.1517/14656566.8.11.1615 1:CAS:528:DC%2BD2sXoslagtrc%3D 17685880
15. A Meirhaeghe CA Boreham LJ Murray F Richard G Davey Smith IS Young P Amouyel 2007 A possible role for the PPARG Pro12Ala polymorphism in preterm birth Diabetes 56 494 498 10.2337/db06-0915 1:CAS:528:DC%2BD2sXhs1ajsbY%3D 17259396
16. P Poorkaj M Grossman E Steinbart H Payami A Sadovnick D Nochlin T Tabira JQ Trojanowski S Borson D Galasko S Reich B Quinn G Schellenberg TD Bird 2001 Frequency of tau gene mutations in familial and sporadic cases of non-Alzheimer dementia Arch Neurol 58 383 387 10.1001/archneur.58.3.383 1:STN:280: DC%2BD3M7pvVCisg%3D%3D 11255441
17. MJ Santos RA Quintanilla A Toro R Grandy MC Dinamarca JA Godoy NC Inestrosa 2005 Peroxisomal proliferation protects from beta-amyloid neurodegeneration J Biol Chem 280 41057 41068 10.1074/jbc.M505160200 1:CAS:528:DC%2BD2MXht1Oqt73E 16204253
18. R Scacchi A Pinto G Gambina A Rosano RM Corbo 2007 The peroxisome proliferator-activated receptor gamma (PPAR-gamma2) Pro12Ala polymorphism is associated with higher risk for Alzheimer's disease in octogenarians Brain Res 1139 1 5 10.1016/j.brainres.2006.12.078 1:CAS:528:DC%2BD2sXisVWhur4%3D 17270153
19. M Silberfeld S Rueda M Krahn G Naglie 2002 Content validity for dementia of three generic preference based health related quality of life instruments Qual Life Res 11 71 79 10.1023/A:1014406429385 12003057
20. BM Spiegelman 1998 PPAR-gamma: adipogenic regulator and thiazolidinedione receptor Diabetes 47 507 514 10.2337/diabetes.47.4.507 1:CAS:528: DyaK1cXit1Gnsrk%3D 9568680
21. ES Tai D Corella M Deurenberg-Yap X Adiconis SK Chew CE Tan JM Ordovas 2004 Differential effects of the C1431T and Pro12Ala PPARgamma gene variants on plasma lipids and diabetes risk in an Asian population J Lipid Res 45 674 685 10.1194/jlr.M300363-JLR200 1:CAS:528:DC%2BD2cXjtFWmsb4%3D 14729856
22. TN Tombaugh NJ McIntyre 1992 The mini-mental state exam: a comprehensive review J Am Geriatr Soc 40 922 935 1:STN:280:DyaK38zotFanug%3D%3D 1512391
23. P Tontonoz E Hu BM Spiegelman 1994 Stimulation of adipogenesis in fibroblasts by PPAR gamma 2, a lipid-activated transcription factor Cell 79 1147 1156 10.1016/0092-8674(94)90006-X 1:STN:280:DyaK2M%2FpsVaqsg%3D%3D 8001151
24. GS Watson S Craft 2003 The role of insulin resistance in the pathogenesis of Alzheimer's disease: implications for treatment CNS Drugs 17 27 45 10.2165/00023210-200317010-00003 1:CAS:528:DC%2BD3sXms1Sjtw%3D%3D 12467491
25. GS Watson BA Cholerton MA Reger LD Baker SR Plymate S Asthana MA Fishel JJ Kulstad PS Green DG Cook SE Kahn ML Keeling S Craft 2005 Preserved cognition in patients with early Alzheimer disease and amnestic mild cognitive impairment during treatment with rosiglitazone: a preliminary study Am J Geriatr Psychiatry 13 950 958 16286438
26. West NA, Haan MN, Morgenstern H (2008) The PPAR-gamma Pro12Ala polymorphism and risk of cognitive impairment in a longitudinal study. Neurobiol Aging. doi: 10.1016/j.neurobiolaging.2008.06.005
27. K Yaffe AM Kanaya K Lindquist WC Hsueh SR Cummings B Beamer A Newman C Rosano R Li T Harris 2008 PPAR-gamma Pro12Ala genotype and risk of cognitive decline in elders Neurobiol Aging 29 78 83 10.1016/j.neurobiolaging.2006.09.010 1:CAS:528:DC%2BD2sXhtlaksrfM 17052804
28. CJ Yen BA Beamer C Negri K Silver KA Brown DP Yarnall DK Burns J Roth AR Shuldiner 1997 Molecular scanning of the human peroxisome proliferator activated receptor gamma (hPPAR gamma) gene in diabetic Caucasians: identification of a Pro12Ala PPAR gamma 2 missense mutation Biochem Biophys Res Commun 241 270 274 10.1006/bbrc.1997.7798 1:CAS:528:DyaK1cXhtlCgtg%3D%3D 9425261