Synthesis of new series of quinoxaline based MAO-inhibitors and docking studies

European Journal of Medicinal Chemistry

Volumn 45, Issue 10, 2010, Pages 4479-4489

  Khattab, Sherine N ^a   Hassan, Seham Y ^a   Bekhit, Adnan A ^b   El Massry, Abdel Moneim ^a   Langer, Vratislav ^c   Amer, Adel ^a  

^a Alexandria University Faculty Of Science   (Egypt)

^b Alexandria University Faculty of Pharmacy   (Egypt)

^c CHALMERS UNIVERSITY OF TECHNOLOGY   (Sweden)

Author keywords

1,2,4 Triazolo 4,3 a quinoxalines; Monoamine oxidase inhibitors; Oxidation; Oxidative cyclization; Quinoxalines

Indexed keywords

2 BENZYL 3 (2 ARYLIDENEHYDRAZINYL)QUINOXALINE; 3 BENZYL 2 [2 [1 (4 HYDROXYPHENYL)ETHYLIDENE]HYDRAZINYL]QUINOLINE; 3 BENZYL 2 [2 [4 HYDROXYBENZYLIDENE]HYDRAZINYL]QUINOXALINE; 4 BENZOYL 1 PHENYL [1,2,4]TRIAZOLO[4,3 A]QUINOXALINE; 4 BENZOYL 1[(4 (DIMETHYLAMINO)PHENYL] [1,2,4]TRIAZOLO[4,3 A]QUINOXALINE; 4 BENZYL 1 ARYL [1,2,4]TRIAZOLO[4,3 A]QUINOXALINE; MONOAMINE OXIDASE INHIBITOR; PHENYL(1 ARYL [1,2,4]TRIAZOLO[4,3 A]QUINOXALIN 4 YL)METHANONE; QUINOXALINE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; BIOLOGICAL ACTIVITY; CARBON NUCLEAR MAGNETIC RESONANCE; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME INHIBITION; INFRARED SPECTROMETRY; MOLECULAR DOCKING; OXIDATION; PROTON NUCLEAR MAGNETIC RESONANCE; X RAY CRYSTALLOGRAPHY;

ANIMALS; CATTLE; CRYSTALLOGRAPHY, X-RAY; HUMANS; MALE; MICE; MITOCHONDRIA; MODELS, MOLECULAR; MONOAMINE OXIDASE; MONOAMINE OXIDASE INHIBITORS; PROTEIN BINDING; QUINOXALINES; RATS;

EID: 77956185058     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2010.07.008     Document Type: Article

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