Biodistribution and dosimetry in humans of two inverse agonists to image cannabinoid CB1 receptors using positron emission tomography

European Journal of Nuclear Medicine and Molecular Imaging

Volumn 37, Issue 8, 2010, Pages 1499-1506

  Terry, Garth E ^a,c   Hirvonen, Jussi ^a   Liow, Jeih San ^a   Seneca, Nicholas ^a   Tauscher, Johannes T ^b   Schaus, John M ^b   Phebus, Lee ^b   Felder, Christian C ^b   Morse, Cheryl L ^a   Pike, Victor W ^a   Halldin, Christer ^c   Innis, Robert B ^a  

^a NATIONAL INSTITUTE OF MENTAL HEALTH   (United States)

^b ELI LILLY AND COMPANY   (United States)

^c KAROLINSKA INSTITUTE   (Sweden)

Author keywords

11C MePPEP; 18F FMPEP d 2; Dosimetry; PET

Indexed keywords

5 (3-METHOXY-PHENYL) 3 (1 PHENYL ETHYLAMINO) 1 (4 TRIFLUOROMETHYL PHENYL)PYRROLIDIN 2 ONE C 11; 5 [(3 FLUOROMETHOXY D2)PHENYL] 3 (1 PHENYL ETHYLAMINO) 1 (4 TRIFLUOROMETHYLPHENYL)PYRROLIDIN 2 ONE F 18; CANNABINOID 1 RECEPTOR; RADIOLIGAND; UNCLASSIFIED DRUG;

ADULT; ARTICLE; BONE MARROW; BRAIN; DOSIMETRY; DRUG EXCRETION; FEMALE; HEPATOBILIARY SYSTEM; HUMAN; HUMAN EXPERIMENT; LIVER; LUNG; MALE; NEUROIMAGING; NORMAL HUMAN; POSITRON EMISSION TOMOGRAPHY; RADIOACTIVITY; URINARY EXCRETION;

ADULT; BRAIN; DRUG INVERSE AGONISM; FEMALE; HUMANS; MALE; POSITRON-EMISSION TOMOGRAPHY; PYRROLIDINONES; RADIOMETRY; RECEPTOR, CANNABINOID, CB1;

EID: 77956184378     PISSN: 16197070     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00259-010-1411-7     Document Type: Article

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