Whole-body biodistribution and radiation dosimetry of the human cannabinoid type-1 receptor ligand18F-MK-9470 in healthy subjects

Journal of Nuclear Medicine

Volumn 49, Issue 3, 2008, Pages 439-445

  Van Laere, Koen ^a   Koole, Michel ^a   Bohorquez, Sandra M Sanabria ^b   Goffin, Karolien ^a   Guenther, Ilonka ^b   Belanger, Marie J ^b   Cote, Josee ^b   Rothenberg, Paul ^b   De Lepeleire, Inge ^b   Grachev, Igor D ^b   Hargreaves, Richard J ^b   Bormans, Guy ^c   Burns, H Donald ^b  

^a UNIVERSITY HOSPITALS LEUVEN   (Belgium)

^b MERCK RESEARCH LABORATORIES   (United States)

^c UNIVERSITY OF LEUVEN   (Belgium)

Author keywords

18F MK 9470; Biodistribution; Cannabinoid type 1 receptor; Dosimetry; Healthy subjects; PET

Indexed keywords

CANNABINOID 1 RECEPTOR; MK 9470; N [2 (3 CYANOPHENYL) 3 [4 (FLUORETHOXY)PHENYL] 1 METHYLPROPYL] 2 (5 METHYL 2 PYRIDYLOXY) 2 METHYLPROPONAMIDE F 18; RADIOPHARMACEUTICAL AGENT; UNCLASSIFIED DRUG;

ADULT; AREA UNDER THE CURVE; ARTICLE; CENTRAL NERVOUS SYSTEM; COMPUTER ASSISTED TOMOGRAPHY; CONTROLLED STUDY; DOSIMETRY; DRUG DISTRIBUTION; FEMALE; HEPATOBILIARY SYSTEM; HUMAN; HUMAN EXPERIMENT; MALE; NORMAL HUMAN; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL; RADIATION DOSE; URINARY EXCRETION;

ADULT; BODY BURDEN; BRAIN; FEMALE; HUMANS; MALE; METABOLIC CLEARANCE RATE; MIDDLE AGED; ORGAN SPECIFICITY; PYRIDINES; RADIATION DOSAGE; RADIOPHARMACEUTICALS; RECEPTOR, CANNABINOID, CB1; REFERENCE VALUES; RELATIVE BIOLOGICAL EFFECTIVENESS; TISSUE DISTRIBUTION; WHOLE-BODY COUNTING;

EID: 40449098011     PISSN: 01615505     EISSN: None     Source Type: Journal    
DOI: 10.2967/jnumed.107.047290     Document Type: Article

References (26)