Fibromyalgia and childhood abuse: Exploration of stress reactivity as a developmental mediator

Developmental Review

Volumn 30, Issue 3, 2010, Pages 294-307

  Lee, Yu Rim ^a  

^a UNIVERSITY OF WISCONSIN MADISON   (United States)

Author keywords

Childhood abuse; Developmental mediator; Fibromyalgia; Stress reactivity; The hypothalamic pituitary adrenal axis

Indexed keywords

EID: 77956172930     PISSN: 02732297     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.dr.2010.03.009     Document Type: Review

References (100)

1. Ablin J., Neumann L., Buskila D. Pathogenesis of fibromyalgia - A review. Joint, Bone, Spine: Revue Du Rhumatisme 2008, 75:273-279.
2. Adler G.K., Geenen R. Hypothalamic-pituitary-adrenal and autonomic nervous system functioning in fibromyalgia. Rheumatic Disease Clinics of North America 2005, 31:187-202.
3. Adler G.K., Kinsley B.T., Hurwitz S., Mossey C.J., Goldenberg D.L. Reduced hypothalamic-pituitary and sympathoadrenal responses to hypoglycemia in women with fibromyalgia syndrome. The American Journal of Medicine 1999, 106:534-543.
4. Al-Allaf A.W., Dunbar K.L., Hallum N.S., Nosratzadeh B., Templeton K.D., Pullar T. A case-control study examining the role of physical trauma in the onset of fibromyalgia syndrome. Rheumatology 2002, 41:450-453.
5. Alexander R.W., Bradley L.A., Alarcón G.S., Triana-Alexander M., Aaron L.A., Alberts K.R., et al. Sexual and physical abuse in women with fibromyalgia: Association with outpatient health care utilization and pain medication usage. Arthritis Care and Research 1998, 11:102-115.
6. Altemus M., Cloitre M., Dhabhar F. Enhanced cellular immune response in women with PTSD related to childhood abuse. The American Journal of Psychiatry 2003, 160:1705-1707.
7. Anda R.F., Felitti V.J., Bremner J.D., Walker J.D., Whitfield C., Perry B.D., et al. The enduring effects of abuse and related adverse experiences in childhood: A convergence of evidence from neurobiology and epidemiology. European Archives of Psychiatry and Clinical Neuroscience 2006, 256:174-186.
8. Anderberg U.M., Marteinsdottir I., Theorell T., von Knorring L. The impact of life events in female patients with fibromyalgia and in female healthy controls. European Psychiatry 2000, 15:295-301.
9. Andersen S.L., Tomada A., Vincow E.S., Valente E., Polcari A., Teicher M.H. Preliminary evidence for sensitive periods in the effect of childhood sexual abuse on regional brain development. The Journal of Neuropsychiatry and Clinical Neurosciences 2008, 20:292-301.
10. Anderson C.M., Teicher M.H., Polcari A., Renshaw P.F. Abnormal T2 relaxation time in the cerebellar vermis of adults sexually abused in childhood: Potential role of the vermis in stress-enhanced risk for drug abuse. Psychoneuroendocrinology 2002, 27:231-244.
11. Bigatti S.M., Hernandez A.M., Cronan T.A., Rand K.L. Sleep disturbances in fibromyalgia syndrome: Relationship to pain and depression. Arthritis and Rheumatism 2008, 59:961-967.
12. Boisset-Pioro M.H., Esdaile J.M., Fitzcharles M.A. Sexual and physical abuse in women with fibromyalgia syndrome. Arthritis and Rheumatism 1995, 38:235-241.
13. Bradley L.A. Pathophysiologic mechanisms of fibromyalgia and its related disorders. Journal of Clinical Psychiatry 2008, 69:6-13.
14. Bradley L.A., McKendree-Smith N.L., Alberts K.R., Alarcón G.S., Mountz J.M., Deutsch G. Use of neuroimagining to understand abnormal pain sensitivity in fibromyalgia. Current Rheumatology Reports 2000, 2:141-148.
15. Bradley L.A., Sotolongo A., Alberts K.R., Alarcón G.S., Mountz J.M., Liu H.G., et al. Abnormal regional cerebral blood flow in the caudate nucleus among fibromyalgia patients and non-patients is associated with insidious symptom onset. Journal of Musculoskeletal Pain 1999, 7:285-292.
16. Bremner J.D., Randall P., Vermetten E., Staib L., Bronen R.A., Mazure C., et al. Magnetic resonance imaging-based measurement of hippocampal volume in posttraumatic stress disorder related to childhood physical and sexual abuse - A preliminary report. Biological Psychiatry 1997, 41:23-32.
17. Bremner J.D., Vermetten E., Kelley M.E. Cortisol, dehydroepiandrosterone, and estradiol measured over 24h in women with childhood sexual abuse-related posttraumatic stress disorder. The Journal of Nervous and Mental Disease 2007, 195:919-927.
18. Bremner J.D., Vermetten E., Vythilingam M., Afzal N., Schmahl C., Elzinga B., et al. Neural correlates of the classic color and emotional stroop in women with abuse-related posttraumatic stress disorder. Biological Psychiatry 2004, 55:612-620.
19. Bremner J.D., Vythilingam M., Vermetten E., Adil J., Khan S., Nazeer A., et al. Cortisol response to a cognitive stress challenge in posttraumatic stress disorder (PTSD) related to childhood abuse. Psychoneuroendocrinology 2003, 28:733-750.
20. Burgmer M., Pogatzki-Zahn E., Gaubitz M., Stüber C., Wessoleck E., Heuft G., et al. Fibromyalgia unique temporal brain activation during experimental pain: A controlled fMRI study. Journal of Neural Transmission 2010, 117:123-131.
21. Buskila D., Atzeni F., Sarzi-Puttini P. Etiology of fibromyalgia: The possible role of infection and vaccination. Autoimmunity Reviews 2008, 8:41-43.
22. Buskila D., Neumann L., Vaisberg G., Alkalay D., Wolfe F. Increased rates of fibromyalgia following cervical spine injury: A controlled study of 161 cases of traumatic injury. Arthritis and Rheumatism 1997, 40:446-452.
23. Carpenter L.L., Carvalho J.P., Tyrka A.R., Wier L.M., Mello A.F., Mello M.F., et al. Decreased adrenocorticotropic hormone and cortisol responses to stress in healthy adults reporting significant childhood maltreatment. Biological Psychiatry 2007, 62:1080-1087.
24. Carpenter M.T., Hugler R., Enzenauer R.J., Des Rosier K.F., Kirk J.M., Brehm W.T. Physical and sexual abuse in female patients with fibromyalgia. Journal of Clinical Rheumatology 1998, 4:301-306.
25. Castro I., Barrantes F., Tuna M., Cabrera G., Garcia C., Recinos M., et al. Prevalence of abuse in fibromyalgia and other rheumatic disorders at a specialized clinic in rheumatic diseases in Guatemala city. Journal of Clinical Rheumatology 2005, 11:140-145.
26. Chen J.J.H., Wang J.Y., Chang Y.M., Su S.Y., Chang C.T., Sun S.S., et al. Regional cerebral blood flow between primary and concomitant fibromyalgia patients: A possible way to differentiate concomitant fibromyalgia from the primary disease. Scandinavian Journal of Rheumatology 2007, 36:226-232.
27. Ciccone D.S., Elliott D.K., Chandler H.K., Nayak S., Raphael K.G. Sexual and physical abuse in women with fibromyalgia syndrome: A test of the trauma hypothesis. The Clinical Journal of Pain 2005, 21:378-386.
28. Cook D.B., Lange G., Ciccone D.S., Liu W.C., Steffener J., Natelson B.H. Functional imaging of pain in patients with primary fibromyalgia. The Journal of Rheumatology 2004, 31:364-378.
29. Crofford L.J., Pillemer S.R., Kalogeras K.T., Cash J.M., Michelson D., Kling M.A., et al. Hypothalamic-pituitary-adrenal axis perturbations in patients with fibromyalgia. Arthritis and Rheumatism 1994, 37:1583-1592.
30. Davis S.N., Galassetti P., Wasserman D.H., Tate D. Effects of gender on neuroendocrine and metabolic counterregulatory responses to exercise in normal man. The Journal of Clinical Endocrinology and Metabolism 2000, 85:224-230.
31. De Stefano R., Selvi E., Villanova M., Frati E., Manganelli S., Franceschini E., et al. Image analysis quantification of substance P immunoreactivity in the Trapezius muscle of patients with fibromyalgia and myofascial pain syndrome. Journal of Rheumatology 2000, 27:2906-2910.
32. Duval F., Crocq M., Guillon M., Mokrani M., Monreal J., Bailey P., et al. Increased adrenocorticotropin suppression after dexamethasone administration in sexually abused adolescents with posttraumatic stress disorder. Annals New York Academy of Sciences 2004, 1032:273-275.
33. Emad Y., Ragab Y., Zeinhom F., El-Khouly G., Abou-Zeid A., Rasker J.J. Hippocampus dysfunction may explain symptoms of fibromyalgia syndrome. A study with single-voxel magnetic resonance spectroscopy. Journal of Rheumatology 2008, 35:1371-1377.
34. Germanowicz D., Lumertz M.S., Martinez D., Margarites A.F. Sleep disordered breathing concomitant with fibromyalgia syndrome. Jornal Brasileiro de Pneumologia 2006, 32:333-338.
35. Goldberg D. The aetiology of depression. Psychological Medicine 2006, 36:1341-1347.
36. Gracely R.H., Petzke F., Wolf J.M., Clauw D.J. Functional magnetic resonance imaging evidence of augmented pain processing in fibromyalgia. Arthritis and Rheumatism 2002, 46:1333-1343.
37. Griep E.N., Boersma J.W., Lentjes E.G.W.M., Prins A.P.A., Van Der Korst J.K., De Kloet E.R. Function of the hypothalamic-pituitary-adrenal axis in patients with fibromyalgia and low back pain. The Journal of Rheumatology 1998, 25:1374-1381.
38. Guedj E., Cammilleri S., Niboyet J., Dupont P., Vidal E., Dropinski J.-P., et al. Clinical correlate of brain SPECT perfusion abnormalities in fibromyalgia. Journal of Nuclear Medicine 2008, 49:1798-1803.
39. Guedj E., Taïeb D., Cammilleri S., Lussato D., de Laforte C., Niboyet J., et al. Voxel-by-voxel analysis of brain SPECT perfusion in fibromyalgia. Nuclear Instruments and Methods in Physics Research A 2007, 571:85-88.
40. Gur A., Cevik R., Sarac A.J., Colpan L., Em S. Hypothalamic-pituitary-gonadal axis and cortisol in young women with primary fibromyalgia: The potential roles of depression, fatigue, and sleep disturbance in the occurrence of hypocortisolism. Annals of the Rheumatic Diseases 2004, 63:1504-1506.
41. Gur A., Karakoc M., Erdogan S., Nas K., Cevik R., Sarac A.J. Regional cerebral blood flow and cytokines in young females with fibromyalgia. Clinical and Experimental Rheumatology 2002, 20:753-760.
42. Hamilton N.A., Catley D., Karlson C. Sleep and the affective response to stress and pain. Health Psychology 2007, 26:288-295.
43. Harris R.E., Clauw D.J., Scott D.J., McLean S.A., Gracely R.H., Zubieta J.-K. Decreased central μ-opioid receptor availability in fibromyalgia. The Journal of Neuroscience 2007, 27:10000-10006.
44. Harris R.E., Sundgren P.C., Craig A.D., Kirshenbaum E., Sen A., Napadow V., et al. Elevated insular glutamate in fibromyalgia is associated with experimental pain. Arthritis and Rheumatism 2009, 60:3146-3152.
45. Hawley D.J., Wolfe F. Fibromyalgia. Women and health 2000, 1068-1083. Academic Press, New York. M.B. Goldman, M.C. Hatch (Eds.).
46. Heim C., Newport D.J., Bonsall R., Miller A.H., Nemeroff C.B. Altered pituitary-adrenal axis responses to provocative challenge tests in adult survivors of childhood abuse. The American Journal of Psychiatry 2001, 158:575-581.
47. Heim C., Newport D.J., Heit S., Graham Y.P., Wilcox M., Bonsall R., et al. Pituitary-adrenal and autonomic responses to stress in women after sexual and physical abuse in childhood. The Journal of American Medical Association 2000, 284:592-597.
48. Horrocks P.M., Jones A.F., Ratcliffe W.A., Holder G., White A., Holder R., et al. Patterns of ACTH and cortisol pulsatility over twenty-four hours in normal males and females. Clinical Endocrinology 1990, 32:127-134.
49. Imbierowicz K., Egle U.T. Childhood adversities in patients with fibromyalgia and somatoform pain disorder. European Journal of Pain 2003, 7:113-119.
50. Jensen K.B., Kosek E., Petzke F., Carville S., Fransson P., Marcus H., et al. Evidence of dysfunctional pain inhibition in fibromyalgia reflected in rACC during provoked pain. Pain 2009, 144:95-100.
51. King J.A., Mandansky D., King S., Fletcher K.E., Bremner J. Early sexual abuse and low cortisol. Psychiatry and Clinical Neurosciences 2001, 55:71-74.
52. Kirschbaum C., Kudielka B.M., Gaab J., Schommer N.C., Hellhammer D.H. Impact of gender, menstrual cycle phase, and oral contraceptives on the activity of the hypothalamus-pituitary-adrenal axis. Psychosomatic Medicine 1999, 61:154-162.
53. Kirschbaum C., Wüst S., Hellhammer D. Consistent sex differences in cortisol responses to psychological stress. Psychosomatic Medicine 1992, 54:648-657.
54. Klerman E.B., Goldenberg D.L., Brown E.N., Maliszewski A.M., Adler G.K. Circadian rhythms of women with fibromyalgia. The Journal of Clinical Endocrinology and Metabolism 2001, 86:1034-1039.
55. Kwiatek R., Barnden L., Tedman R., Jarrett R., Chew J., Rowe C., et al. Regional cerebral blood flow in fibromyalgia: Single-photon-emission computed tomography evidence of reduction in the pontine tegmentum and thalami. Arthritis and Rheumatism 2000, 43:2823-2833.
56. Lawrence R.C., Felson D.T., Helmick C.G., Arnold L.M., Choi H., Deyo R.A., et al. Estimates of the prevalence of arthritis and other rheumatic conditions in the United States. Part II. Arthritis and Rheumatism 2008, 58:26-35.
57. Lentjes E.G.W.M., Griep E.N., Boersma J.W., Romijn F.P.T.H.M., De Kloet E.R. Glucocorticoid receptors, fibromyalgia and low back pain. Psychoneuroendocrinology 1997, 22:603-614.
58. Lineberger M.D., Means M.K., Edinger J.D. Sleep disturbance in fibromyalgia. Sleep Medicine Clinics 2007, 2:31-39.
59. Macedo J.A., Hesse J., Turner J.D., Meyer J., Hellhammer D.H., Muller C.P. Glucocorticoid sensitivity in fibromyalgia patients: Decreased expression of corticosteroid receptors and glucocorticoid-induced leucine zipper. Psychoneuroendocrinology 2008, 33:799-809.
60. Mahowald M.L., Mahowald M.W. Nighttime sleep and daytime functioning (sleepiness and fatigue) in less well-defined chronic rheumatic diseases with particular reference to the 'alpha-delta NREM sleep anomaly. Sleep Medicine 2000, 1:195-207.
61. McCauley J., Kern D., Kolodner K., Dill L., Schroeder A. Clinical characteristics of women with a history of childhood abuse: Unhealed wounds. JAMA: Journal of the American Medical Association 1997, 277:1362-1368.
62. McLean S.A., Clauw D.J. Biomedical models of fibromyalgia. Disability and Rehabilitation 2005, 27:659-665.
63. McLean S.A., Clauw D.J., Abelson J.L., Liberzon I. The development of persistent pain and psychological morbidity after motor vehicle collision: Integrating the potential role of stress response systems into a biopsychosocial model. Psychosomatic Medicine 2005, 67:783-790.
64. McLean S.A., Williams D.A., Harris R.E., Kop W.J., Groner K.H., Ambrose K., et al. Momentary relationship between cortisol secretion and symptoms in patients with fibromyalgia. Arthritis and Rheumatism 2005, 52:3660-3669.
65. McLean S.A., Williams D.A., Stein P.K., Harris R.E., Lyden A.K., Whalen G., et al. Cerebrospinal fluid corticotropin-releasing factor concentration is associated with pain but not fatigue symptoms in patients with fibromyalgia. Neuropsychopharmacology 2006, 31:2776-2782.
66. Mease P. Fibromyalgia syndrome: Review of clinical presentation, pathogenesis, outcome measures, and treatment. The Journal of Rheumatology 2005, 32(Suppl. 75):6-21.
67. Moldofsky H. The significance, assessment, and management of nonrestorative sleep in fibromyalgia syndrome. CNS Spectrum 2008, 13(Suppl. 5):22-26.
68. Moreno M., López-Crespo G., Flores P. Etiology of anxiety. Antidepressants, Antipsychotics, Anxiolytics: From Chemistry and Pharmacology to Clinical Application 2007, 667-683.
69. Mountz J.M., Bradley L.A., Modell J.G., Alexander R.W., Triana-Alexander M., Aaron L.A. Fibromyalgia in women: Abnormalities of regional cerebral blood flow in the thalamus and the caudate nucleus are associated with low pain threshold levels. Arthritis and Rheumatism 1995, 38:926-938.
70. Nemeroff C.B. Neurobiological consequences of childhood trauma. Journal of Clinical Psychiatry 2004, 65(Suppl. 1):18-28.
71. Nielson W.R., Merskey H. Psychosocial aspects of fibromyalgia. Current Pain and Headache Reports 2001, 5:330-337.
72. Pae C.U., Luyten P., Marks D.M., Han C., Park S.H., Patkar A.A., et al. The relationship between fibromyalgia and major depressive disorder: A comprehensive review. Current Medical Research and Opinion 2008, 24:2359-2371.
73. Pujol J., López-Solà M., Ortiz H., Vilanova J.C., Harrison B.J., Yücel M., et al. Mapping brain response to pain in fibromyalgia patients using temporal analysis of fMRI. PloS One 2009, 4:e5224.
74. Rains J.C., Penzien D.B. Sleep and chronic pain: Challenges to the α-EEG sleep pattern as a pain specific sleep anomaly. Journal of Psychosomatic Research 2003, 54:77-83.
75. Roelfsema F., van den Berg G., Frölich M., Veldhuis J.D., van Eijk A., Buurman M.M., et al. Sex-dependent alteration in cortisol response to endogenous adrenocorticotropin. The Journal of Clinical Endocrinology and Metabolism 1993, 77:234-240.
76. Russell I.J., Orr M.D., Littman B., Vipraio G.A., Alboukrek D., Michalek J.E., et al. Elevated cerebrospinal fluid levels of substance P in patients with the fibromyalgia syndrome. Arthritis and Rheumatism 1994, 37:1593-1601.
77. Sarzi-Puttini P., Atzeni F., Diana A., Doria A., Furlan R. Increased neural sympathetic activation in fibromyalgia syndrome. Annals New York Academy of Sciences 2006, 1069:109-117.
78. Sprott H., Bradley L.A., Oh S.J., Wintersberger W., Alarcón G.S., Mussell H.G., et al. Immunohistochemical and molecular studies of serotonin, substance P, galanin, pituitary adenylyl cyclase-activating polypeptide, and secretoneurin in fibromyalgic muscle tissue. Arthritis and Rheumatism 1998, 41:1689-1694.
79. Staud R. Treatment of fibromyalgia and its symptoms. Expert Opinion on Pharmacotherapy 2007, 8:1629-1642.
80. Staud R., Craggs J.G., Perlstein W.M., Robinson M.E., Price D.D. Brain activity associated with slow temporal summation of C-fiber evoked pain in fibromyalgia patients and healthy controls. European Journal of Pain 2008, 12:1078-1089.
81. Stein M.B., Yehuda R., Koverola C., Hanna C. Enhanced dexamethasone suppression of plasma cortisol in adult women traumatized by childhood sexual abuse. Biological Psychiatry 1997, 42:680-686.
82. Tarullo A.R., Gunnar M.R. Child maltreatment and the developing HPA axis. Hormones and Behavior 2006, 50:632-639.
83. Taylor M.L., Trotter D.R., Csuka M.E. The prevalence of sexual abuse in women with fibromyalgia. Arthritis and Rheumatism 1995, 38:229-234.
84. Thieme K., Turk D.C., Flor H. Comorbid depression and anxiety in fibromyalgia syndrome: Relationship to somatic and psychosocial variables. Psychosomatic Medicine 2004, 66:837-844.
85. Tishler M., Levy O., Maslakov I., Bar-Chaim S., Amit-Vazina M. Neck injury and fibromyalgia-are they really associated?. The Journal of Rheumatology 2006, 33:1183-1185.
86. Torpy D.J., Papanicolaou D.A., Lotsikas A.J., Wilder R.L., Chrousos G.P., Pillemer S.R. Responses of the sympathetic nervous system and the hypothalamic-pituitary-adrenal axis to interleukin-6: A pilot study in fibromyalgia. Arthritis and Rheumatism 2000, 43:872-880.
87. Van Houdenhove B., Egle U.T. Fibromyalgia: A stress disorder? Piecing the biopsychosocial puzzle together. Psychotherapy and Psychosomatics 2004, 73:267-275.
88. Van Houdenhove B., Egle U.T., Luyten P. The role of life stress in fibromyalgia. Current Rheumatology Reports 2005, 7:365-370.
89. Van Houdenhove B., Luyten P. Stress, depression, and fibromyalgia. Acta Neurologica Belgica 2006, 106:149-156.
90. Van Houdenhove B., Luyten P., Egle U.T. Stress as a key concept in chronic widespread pain and fatigue disorders. Journal of Musculoskeletal Pain 2009, 17:390-399.
91. Vythilingam M., Heim C., Newport J., Miller A.H., Anderson E., Bronen R., et al. Childhood trauma associated with smaller hippocampal volume in women with major depression. The American Journal of Psychiatry 2002, 159:2072-2080.
92. Walker E.A., Keegan D., Gardner G., Sullivan M., Bernstein D., Katon W.J. Psychosocial factors in fibromyalgia compared with rheumatoid arthritis: II. Sexual, physical, and emotional abuse and neglect. Psychosomatic Medicine 1997, 59:572-577.
93. Weissbecker I., Floyd A., Dedert E., Salmon P., Sephton S. Childhood trauma and diurnal cortisol disruption in fibromyalgia syndrome. Psychoneuroendocrinology 2006, 31:312-324.
94. Weniger G., Lange C., Sachsse U., Irle E. Amygdala and hippocampal volumes and cognition in adult survivors of childhood abuse with dissociative disorders. Acta Psychiatrica Scandinavica 2008, 118:281-290.
95. White K.P., Carette S., Harth M., Teasell R.W. Trauma and fibromyalgia: Is there an association and what does it mean?. Seminars in Arthritis and Rheumatism 2000, 29:200-216.
96. Wik G., Fischer H., Bragée B., Kristianson M., Fredrikson M. Retrosplenial cortical activation in the fibromyalgia syndrome. Neuroreport 2003, 14:619-621.
97. Wolfe F., Ross K., Anderson J., Russell I.J., Hebert L. The prevalence and characteristics of fibromyalgia in the general population. Arthritis and Rheumatism 1995, 38:19-28.
98. Wolfe F., Smythe H.A., Yunus M.B., Bennett R.M., Bombardier C., Goldenberg D.L., et al. The American College of Rheumatology 1990 criteria for the classification of fibromyalgia. Arthritis and Rheumatism 1990, 33:160-172.
99. Wood P.B. Fibromyalgia syndrome: A central role for the hippocampus - A theoretical construct. Journal of Musculoskeletal Pain 2004, 12:19-26.
100. Wood P.B., Ledbetter C.R., Glabus M.F., Broadwell L.K., Patterson J.C. Hippocampal metabolite abnormalities in fibromyalgia: Correlation with clinical features. The Journal of Pain 2009, 10:47-52.