A putative role for hypothalamic glucocorticoid receptors in hypertension induced by prenatal undernutrition in the rat

Neuroscience Letters

Volumn 483, Issue 1, 2010, Pages 41-46

  Pérez, Hernán ^a   Soto Moyano, Rubén ^a   Ruiz, Samuel ^b   Hernández, Alejandro ^c   Sierralta, Walter ^a   Olivares, Ricardo ^a   Núñez, Héctor ^a   Flores, Osvaldo ^a   Morgan, Carlos ^a   Valladares, Luis ^a   Gatica, Arnaldo ^a   Flores, Francisco J ^a  

^a UNIVERSITY OF CHILE   (Chile)

^b UNIVERSIDAD DIEGO PORTALES   (Chile)

^c UNIVERSIDAD DE SANTIAGO DE CHILE   (Chile)

Author keywords

Fetal programming; Glucocorticoids; Hypertension; Maternal undernutrition; Paraventricular nucleus

Indexed keywords

CORTICOSTERONE; DEXAMETHASONE; GLUCOCORTICOID RECEPTOR; MIFEPRISTONE;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; CORTICOSTERONE BLOOD LEVEL; FEMALE; HEART RATE; HYPERTENSION; HYPOTHALAMUS; HYPOTHALAMUS HYPOPHYSIS ADRENAL SYSTEM; MALE; MALNUTRITION; MATERNAL NUTRITION; NONHUMAN; PRIORITY JOURNAL; RAT; SYSTOLIC BLOOD PRESSURE;

ANIMALS; AREA UNDER CURVE; CORTICOSTERONE; FEMALE; HEART RATE; HYPERTENSION; HYPOTHALAMO-HYPOPHYSEAL SYSTEM; HYPOTHALAMUS; MALE; MALNUTRITION; NEURONS; PITUITARY-ADRENAL SYSTEM; PREGNANCY; PRENATAL NUTRITIONAL PHYSIOLOGICAL PHENOMENA; RATS; RATS, WISTAR; RECEPTORS, GLUCOCORTICOID;

EID: 77956171802     PISSN: 03043940     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neulet.2010.07.057     Document Type: Article

References (22)

1. Barker D.J. In utero programming of chronic disease. Clin. Sci. 1998, 95:115-128.
2. Bertram C, Trowern A.R., Copin N., Jackson A.A., Whorwood C.B. The maternal diet during pregnancy programs altered expression of the glucocorticoid receptor and type 2 11beta-hydroxysteroid dehydrogenase: potential molecular mechanisms underlying the programming of hypertension in utero. Endocrinology 2001, 142:2841-2853.
3. Chakravarthy M.V., Zhu Y., López M., Yin L., Wozniak D.F., Coleman T., Hu Z., Wolfgang M., Vidal-Puig A., Lane M.D., Semenkovich C.F. Brain fatty acid synthase activates PPARalpha to maintain energy homeostasis. J. Clin. Invest. 2007, 117:2539-2552.
4. Coote J.H., Yang Z., Pyner S., Deering J. Control of sympathetic outflows by the hypothalamic paraventricular nucleus. Clin. Exp. Pharmacol. Physiol. 1998, 25:461-463.
5. Dampney R.A., Horiuchi J., Killinger S., Sheriff M.J., Tan P.S., Mc Dowall L.M. Long-term regulation of arterial blood pressure by hypothalamic nuclei: some critical questions. Clin. Exp. Pharmacol. Physiol. 2005, 32:419-425.
6. Elmes M.J., Gardner D.S., Langley-Evans S.C. Fetal exposure to a maternal low-protein diet is associated with altered left ventricular pressure response to ischaemia-reperfusion injury. Br. J. Nutr. 2007, 98:93-100.
7. Hawkins P., Hanson M.A., Matthews S.G. Maternal undernutrition in early gestation alters molecular regulation of the hypothalamic-pituitary-adrenal axis in the ovine fetus. J. Neuroendocrinol. 2001, 13:855-861.
8. Langley-Evans S.C., Phillips G.J., Jackson A.A. In utero exposure to maternal low protein diets induces hypertension in weanling rats, independently of maternal blood pressure changes. Clin. Nutr. 1994, 13:319-324.
9. Lesage J., Blondeau B., Grino M., Breant B., Dupouy J.P. Maternal undernutrition during late gestation induces fetal overexposure to glucocorticoids and intrauterine growth retardation, and disturbs the hypothalamo-pituitary-adrenal axis in the newborn rat. Endocrinology 2001, 142:1692-1702.
10. Mahgoub A., Hirsch P.F., Munson P.L. Calcium-lowering action of glucocorticoids in adrenalectomized-parathyroidectomized rats. Specificity and relative potency of natural and synthetic glucocorticoids. Endocrine 1997, 6:279-283.
11. National Research Council Guide for the Care and Use of Laboratory Animals (Publication 80-23 rev) 1996, National Institutes of Health, Bethesda.
12. Navarrete M., Nuñez H., Ruiz S., Soto-Moyano R., Valladares L., White A., Perez H. Prenatal undernutrition decreases the sensitivity of the hypothalamo-pituitary-adrenal axis in rat, as revealed by subcutaneous and intraparaventricular dexamethasone challenges. Neurosci. Lett. 2007, 419:99-103.
13. Nuñez H., Ruiz S., Soto-Moyano R., Navarrete M., Valladares L., White A., Perez H. Fetal undernutrition induces overexpression of CRH mRNA and CRH protein in hypothalamus and increases CRH and corticosterone in plasma during postnatal life in the rat. Neurosci. Lett. 2008, 448:115-119.
14. Palkovits M. Interconnections between the neuroendocrine hypothalamus and the central autonomic system. Front. Neuroendocrinol. 1999, 20:270-295.
15. Pellegrino L.J., Pellegrino A.S., Cushman A.J. A Stereotaxic Atlas of the Rat Brain 1979, Plenum Press, New York, 122 pp. 2nd ed.
16. Pérez H., Ruiz S., Núñez H., White A., Gotteland M., Hernández A. Paraventricular-coerulear interactions. Role in hypertension induced by prenatal undernutrition in the rat. Eur. J. Neurosci. 2006, 24:1209-1219.
17. Perez H., Ruiz S., Soto-Moyano R. Prenatal malnutrition-induced hypertension in young rats is prevented by neonatal capsaicin treatment. Neurosci. Lett. 2002, 328:253-256.
18. Rexhepaj R., Boini K.M., Huang D.Y., Amann K., Artunc F., Wang K., Brosens J.J., Kuhl D., Lang F. Role of maternal glucocorticoid inducible kinase SGK1 in fetal programming of blood pressure in response to prenatal diet. Am. J. Physiol. Regul. Integr. Comp. Physiol. 2008, 294:R2008-R2013.
19. Seckl J.R. Glucocorticoid programming of the fetus; adult phenotypes and molecular mechanisms. Mol. Cell. Endocrinol. 2001, 185:61-71.
20. Tonolo G., Soro A., Madeddu P., Troffa C., Melis M.G., Patteri G., Pinna Parpaglia P., Sabino G., Maioli M., Glorios N. Effect of chronic intracerebroventricular dexamethasone on blood pressure in normotensive rats. Am. J. Physiol. 1993, 264:E843-E847.
21. van den Berg D.T.W., de Kloet E.R., van Dijken H.H., de Jong W. Differential central effects of mineraloid and glucocorticoid agonists and antagonists on blood pressure. Endocrinology 1990, 126:118-124.
22. van der Laan S., Lachize S.B., Vreugdenhil E., de Kloet E.R., Meijer O.C. Nuclear receptor coregulators differentially modulate induction and GR-mediated repression of the corticotrophin-releasing hormone gene. Endocrinology 2008, 149:725-732.