Keratin variants predispose to acute liver failure and adverse outcome: Race and ethnic associations

Gastroenterology

Volumn 139, Issue 3, 2010, Pages

  Strnad, Pavel ^b   Zhou, Qin ^c   Hanada, Shinichiro ^d   Lazzeroni, Laura C ^c   Zhong, Bi Hui ^e   So, Phillip ^c   Davern, Timothy J ^f   Lee, William M ^g   Omary, M Bishr ^a  

^a UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^b UNIVERSITY HOSPITAL ULM   (Germany)

^c STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d KURUME UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^e SUN YAT SEN UNIVERSITY   (China)

^f CALIFORNIA PACIFIC MEDICAL CENTER   (United States)

^g UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

Author keywords

Acetaminophen Toxicity; Acute Hepatitis; Intermediate Filaments; Keratin Mutations; Keratins 8 and 18

Indexed keywords

CYTOKERATIN 18; CYTOKERATIN 8; PARACETAMOL; ANALGESIC AGENT; KRT18 PROTEIN, HUMAN; KRT8 PROTEIN, HUMAN;

ADULT; ADVERSE OUTCOME; AFRICAN AMERICAN; ARTICLE; CAUCASIAN; CONTROLLED STUDY; DISEASE PREDISPOSITION; ETHNIC DIFFERENCE; FEMALE; GENE FREQUENCY; GENE OVEREXPRESSION; GENETIC VARIABILITY; HUMAN; LIVER FAILURE; LIVER TRANSPLANTATION; MAJOR CLINICAL STUDY; MALE; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; SURVIVAL RATE; ACUTE LIVER FAILURE; AMERICAN INDIAN; ASIAN AMERICAN; CHEMICALLY INDUCED; CHI SQUARE DISTRIBUTION; CLINICAL TRIAL; COMPARATIVE STUDY; EPIDEMIOLOGY; ETHNOLOGY; GENETIC PREDISPOSITION; GENETICS; HISPANIC; MIDDLE AGED; MORTALITY; MULTICENTER STUDY; PHENOTYPE; PROGNOSIS; PROSPECTIVE STUDY; RISK; RISK ASSESSMENT; RISK FACTOR; STATISTICAL MODEL; TOXIC HEPATITIS; UNITED STATES; YOUNG ADULT;

ACETAMINOPHEN; ADULT; AFRICAN AMERICANS; ANALGESICS, NON-NARCOTIC; ASIAN AMERICANS; CHI-SQUARE DISTRIBUTION; DRUG-INDUCED LIVER INJURY; EUROPEAN CONTINENTAL ANCESTRY GROUP; FEMALE; GENE FREQUENCY; GENETIC PREDISPOSITION TO DISEASE; HISPANIC AMERICANS; HUMANS; INDIANS, NORTH AMERICAN; KERATIN-18; KERATIN-8; LIVER FAILURE, ACUTE; LOGISTIC MODELS; MALE; MIDDLE AGED; ODDS RATIO; PHENOTYPE; PROGNOSIS; PROSPECTIVE STUDIES; RISK ASSESSMENT; RISK FACTORS; UNITED STATES; YOUNG ADULT;

EID: 77956157619     PISSN: 00165085     EISSN: None     Source Type: Journal    
DOI: 10.1053/j.gastro.2010.06.007     Document Type: Article

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