Structural insight into methyl-coenzyme M reductase chemistry using coenzyme B analogues

Biochemistry

Volumn 49, Issue 35, 2010, Pages 7683-7693

  Cedervall, Peder E ^a   Dey, Mishtu ^b,c   Pearson, Arwen R ^a,d   Ragsdale, Stephen W ^b   Wilmot, Carrie M ^a  

^a UNIVERSITY OF MINNESOTA   (United States)

^b UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^c MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

^d UNIVERSITY OF LEEDS   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CATALYSIS; CHEMICAL BONDS; CONFORMATIONS; HYDROPHOBICITY; METHANE; SUBSTRATES;

ACTIVE SITE; AS SPECIES; CATALYTIC INTERMEDIATES; CONFORMATIONAL CHANGE; CRYSTALLOGRAPHIC STUDIES; MCR MECHANISM; METHANOGENESIS; METHYL-COENZYME M REDUCTASE; PROTEIN SURFACE; RATE-LIMITING STEPS; SENSITIVE INDICATOR; SLOW SUBSTRATE; STRUCTURAL CHANGE; STRUCTURAL INSIGHTS; TETRAPYRROLES; THIOLATES;

NICKEL;

COENZYME B; DISULFIDE; ENZYME; METHANE; METHYL COENZYME M; METHYL COENZYME M REDUCTASE; OXIDOREDUCTASE; THIOL DERIVATIVE; UNCLASSIFIED DRUG; 7-MERCAPTOHEPTANOYLTHREONINE PHOSPHATE; MESNA; PHOSPHOTHREONINE;

ARTICLE; BACTERIAL GROWTH; CATALYSIS; COENZYME; CONFORMATIONAL TRANSITION; CRYSTAL STRUCTURE; CRYSTALLIZATION; ELECTRON NUCLEAR DOUBLE RESONANCE; ELECTRON SPIN RESONANCE; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME CHEMISTRY; ENZYME STRUCTURE; ENZYME SUBSTRATE; HYDROPHOBICITY; METHANOGENIC BACTERIUM; METHANOTHEMOBACTER MARBURGENSIS; NONHUMAN; PRIORITY JOURNAL; REDUCTION; STRUCTURE ANALYSIS; SYNTHESIS; ULTRAVIOLET SPECTROSCOPY; X RAY CRYSTALLOGRAPHY; X RAY DIFFRACTION; ANALOGS AND DERIVATIVES; CHEMICAL STRUCTURE; CHEMISTRY; ENZYMOLOGY; METABOLISM; METHANOBACTERIACEAE; PROTEIN CONFORMATION;

CATALYSIS; CATALYTIC DOMAIN; CRYSTALLOGRAPHY, X-RAY; MESNA; METHANE; METHANOBACTERIACEAE; MODELS, MOLECULAR; OXIDOREDUCTASES; PHOSPHOTHREONINE; PROTEIN CONFORMATION;

EID: 77956134458     PISSN: 00062960     EISSN: 15204995     Source Type: Journal    
DOI: 10.1021/bi100458d     Document Type: Article

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