One pot synthesis of substituted [1,2,4]-Triazolo [1',2':1,2]pyrimido [6,5-b]-quinoline and its antibacterial activity

Bulletin of the Korean Chemical Society

Volumn 31, Issue 8, 2010, Pages 2341-2344

  Joshi, Ratnadeep S ^a   Mandhane, Priyanka G ^a   Chate, Asha V ^a   Khan, Wajid ^b   Gill, Charansingh H ^a  

^a DR BABASAHEB AMBEDKAR MARATHWADA UNIVERSITY   (India)

^b MAULANA AZAD COLLEGE   (India)

Author keywords

1,2,4 Triazolo 1',2':1,2 pyrimido 6,5 b quinoline; Antibacterial activity; Microwave irradiation; SiO 2 K2CO3

Indexed keywords

[1,2,4]-TRIAZOLO [1',2':1,2]PYRIMIDO[6,5-B]-QUINOLINE; ANTIBACTERIAL ACTIVITY; ONE-POT SYNTHESIS; SIO 2/K2CO3; SOLVENT FREE CONDITIONS;

COMPLEXATION; IRRADIATION; SILICON COMPOUNDS;

MICROWAVE IRRADIATION;

EID: 77956131872     PISSN: 02532964     EISSN: 12295949     Source Type: Journal    
DOI: 10.5012/bkcs.2010.31.8.2341     Document Type: Article

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43. (3a) IR (KBr, cm?1) 2980 (N-H); 1676 (C=N); 962 (C-Cl). 1H NMR (CDCl3, 400 MHz, δ ppm) 7.56 (d, 2H, J = 8.4 Hz, Ar-H), 7.81 (s,1H, Ar-H), 8.12 (d, 2H, J = 8.4 Hz, Ar-H), 7.53 (td, 1H, J = 8.2 & 2.4 Hz, Ar-CH), 8.98 (s, 1H, Ar-H), 10.33 (s, 1H, N-H), MS m/z 258 (m+1) 260 (m+3); (4a) Yellow solid, IR (KBr, cm?1) 1689 (C=N), 1223 (C-C). 1H NMR (CDCl3, 400 MHz, δ ppm) 7.51 (d,1H, J = 9.2 Hz, Ar-H), 7.75 (s, 2H, Ar-H), 7.89 (d, 1H J = 8.8 Hz, Ar-H), 8.13 (d, 1H, Ar-CH), 8.21 (s, 1H, Ar-CH), 8.43 (s, 1H, Ar-H),MS m/z 222 (m+1); (4b) Yellow solid, IR (KBr, cm?1) 1685 (C=N),1221 (C-C). 1H NMR (CDCl3, 400 MHz, δ ppm) 2.43(s, 3H, Ar-CH3), 7.45 (d, 1H, J = 9.4 Hz, Ar-H), 7.65 (d, H, J = 8.8 Hz, Ar-H),7.93 (d, 1H, Ar-H), 8.20 (s, 1H, Ar-CH), 8.25 (s, 1H, Ar-CH), 8.53 (s, 1H, Ar-H), MS m/z 236 (m+1); (4e) Yellow solid, IR (KBr, cm?1) 1690 (C=N), 1229 (C-C). 1H NMR (CDCl3, 400 MHz, δ ppm) 3.80 (s, 3H, Ar-OCH3), 7.35 (d, 1H, J = 9.2 Hz, Ar-H), 7.49 (d, H, J =8.2 Hz, Ar-H), 7.98 (d, 1H, Ar-H), 8.26 (s, 1H, Ar-CH), 8.42 (s, 1H,Ar-CH), 8.65 (s, 1H, Ar-H), MS m/z 251 (m+1); (4g) Yellowsolid IR (KBr, cm?1) 1675 (C=N), 1234 (C-C). 1H NMR (CDCl3,400 MHz, δ ppm) 1.53 (t, 3H, -CH3), 2.98 (q, 2H, -CH2), 7.45 (d,1H, Ar-H), 7.59 (d, 1H, Ar-H), 7.85 (d, 1H, Ar-H), 8.02 (s, 1H,Ar-H), 8.11 (s, 1H, Ar-H), 8.35 (s, 1H, Ar-H), MS m/z 251 (m+1); (4i) Yellow solid, IR (KBr, cm?1) 1678 (C=N), 1232 (C-C). 1HNMR (CDCl3, 400 MHz, δ ppm) 1.41 (t, 3H, -CH3), 3.76 (q, 2H,-CH2), 7.43 (d, 1H, Ar-H), 7.63 (d, 1H, Ar-H), 7.78 (d, 1H, Ar-H),8.09 (s, 1H, Ar-H), 8.34 (s, 1H, Ar-H), 8.53 (s, 1H, Ar-H), MS m/z 266 (m+1).