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Volumn 18, Issue 16, 2008, Pages 4678-4681

Substituted 3-((Z)-2-(4-nitrophenyl)-2-(1H-tetrazol-5-yl) vinyl)-4H-chromen-4-ones as novel anti-MRSA agents: Synthesis, SAR, and in-vitro assessment

Author keywords

Anti MRSA; Chromones; Convergent; E. faecalis; Tetrazole

Indexed keywords

ANTIINFECTIVE AGENT; CHROMENE DERIVATIVE; TETRAZOLE DERIVATIVE;

EID: 49049098838     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2008.07.007     Document Type: Article
Times cited : (65)

References (39)
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    • note
    • 2), 7.50 (d, 2H, ArH, J = 8.0 Hz), 8.16 (d, 2H, ArH, J = 8.0 Hz); ESI(-ve): 204.5.
  • 27
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    • note
    • 3)
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    • note
    • NOE experiment is performed on 7b. Irradiation of the methylene proton at C-2 of the chromone ring (δ = 9.75) showed no effect on other protons, whereas irradiation of the vinyl proton (δ = 8.46) showed an increase of aromatic protons (δ = 8.43-8.84). Thus, structure as well as regiochemistry (Z) of the double bond is confirmed.
  • 36
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    • note
    • Clinical and Laboratory Standard Institute (Formerly NCCLS). Methods for dilution for antimicrobial susceptibility tests for bacteria that grow aerobically: Approved Standard M7-A6. NCCLS, Villanova, PA, USA, 2003.


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.