In vivo NMDA receptor activation accelerates motor unit maturation, protects spinal motor neurons, and enhances SMN2 gene expression in severe spinal muscular atrophy mice

Journal of Neuroscience

Volumn 30, Issue 34, 2010, Pages 11288-11299

  Biondi, Olivier ^a   Branchu, Julien ^a   Sanchez, Gabriel ^c   Lancelin, Camille ^a   Deforges, Séverine ^a   Lopes, Philippe ^a,b   Pariset, Claude ^a   Lécolle, Sylvie ^a   Côté, Jocelyn ^c   Chanoine, Christophe ^a   Charbonnier, Frédéric ^a  

^a UNIVERSITÉ PARIS DESCARTES   (France)

^b UNIVERSITÉ D EVRY VAL D ESSONNE   (France)

^c UNIVERSITY OF OTTAWA   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM CALMODULIN DEPENDENT PROTEIN KINASE II; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; N METHYL DEXTRO ASPARTIC ACID; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; SURVIVAL MOTOR NEURON PROTEIN 2;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CELL MATURATION; CONTROLLED STUDY; DISEASE SEVERITY; ENZYME PHOSPHORYLATION; FEMALE; GENE EXPRESSION; GENETIC TRANSCRIPTION; IN VIVO STUDY; MALE; MOTOR PERFORMANCE; MOTOR UNIT; MOUSE; MUSCLE DEVELOPMENT; MUSCLE FUNCTION; NERVE CELL NECROSIS; NEUROMUSCULAR SYNAPSE; NEUROPROTECTION; NEWBORN; NONHUMAN; PHENOTYPE; POSTNATAL DEVELOPMENT; PRIORITY JOURNAL; SKELETAL MUSCLE; SPINAL CORD MOTONEURON; SPINAL MUSCULAR ATROPHY; SURVIVAL;

ANIMALS; COCULTURE TECHNIQUES; FEMALE; GENE EXPRESSION REGULATION; HUMANS; MALE; MICE; MICE, KNOCKOUT; MICE, TRANSGENIC; MOTOR NEURONS; MUSCLE FIBERS, SKELETAL; MUSCULAR ATROPHY, SPINAL; N-METHYLASPARTATE; NEUROPROTECTIVE AGENTS; RECEPTORS, N-METHYL-D-ASPARTATE; SEVERITY OF ILLNESS INDEX; SPINAL CORD; SURVIVAL OF MOTOR NEURON 2 PROTEIN;

EID: 77956130809     PISSN: 02706474     EISSN: 15292401     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.1764-10.2010     Document Type: Article

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