PCM1 and schizophrenia: A replication study in the northern Swedish population

American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics

Volumn 153, Issue 6, 2010, Pages 1240-1243

  Moens, Lotte N ^a,b   Ceulemans, Shana ^a,b   Alaerts, Maaike ^a,b   Van Den Bossche, Maarten J A ^a,b   Lenaerts, An Sofie ^a,b   De Zutter, Sonia ^a,b   Norrback, Karl Fredrik ^c   Adolfsson, Rolf ^c   Del Favero, Jurgen ^a,b  

^a DEPARTMENT OF PLANT SYSTEMS BIOLOGY   (Belgium)

^b UNIVERSITY OF ANTWERP   (Belgium)

^c UMEÅ UNIVERSITY   (Sweden)

Author keywords

Association; DISC1 pathway; PCM1; Replication; Schizophrenia

Indexed keywords

DISRUPTED IN SCHIZOPHRENIA 1 PROTEIN; PERICENTRIOLAR MATERIAL 1; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; GENE FREQUENCY; GENE MUTATION; GENETIC ASSOCIATION; GENETIC VARIABILITY; GENOTYPE; HAPLOTYPE; HUMAN; MAJOR CLINICAL STUDY; META ANALYSIS; POPULATION; PRIORITY JOURNAL; REPLICATION STUDY; RISK FACTOR; SCHIZOPHRENIA; SINGLE NUCLEOTIDE POLYMORPHISM; SWEDEN;

ALLELES; AUTOANTIGENS; CELL CYCLE PROTEINS; EUROPEAN CONTINENTAL ANCESTRY GROUP; GENE FREQUENCY; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; HAPLOTYPES; HUMANS; POLYMORPHISM, SINGLE NUCLEOTIDE; SCHIZOPHRENIA; SWEDEN;

EID: 77956128853     PISSN: 15524841     EISSN: 1552485X     Source Type: Journal    
DOI: 10.1002/ajmg.b.31088     Document Type: Article

References (11)

1. Alaerts M, Ceulemans S, Forero D, Moens LN, De Zutter S, Heyrman L, Lenaerts A-S, Norrback K-F, Goossens D, De Rijk P, Nilsson L-G, Adolfsson R, Del-Favero J. 2009. NRG1 confirmed as a susceptibility factor for schizophrenia in the Northern Swedish population. Arch Gen Pscyhiatry 66:828-837.
2. Anitha A, Nakamura K, Yamada K, Iwayama Y, Toyota T, Takei N, Iwata Y, Suzuki K, Sekine Y, Matsuzaki H, Kawai M, Thanseem I, Miyoshi K, Katayama T, Matsuzaki S, Baba K, Honda A, Hattori T, Shimizu S, Kumamoto N, Kikuchi M, Tohyama M, Yoshikawa T, Mori N. 2009. Association studies and gene expression analyses of the DISC1-interacting molecules, pericentrin 2 (PCNT2) and DISC1-binding zinc finger protein (DBZ), with schizophrenia and with bipolar disorder. Am J Med Genet Part B 150B:967-976.
3. Blouin JL, Dombroski BA, Nath SK, Lasseter VK, Wolyniec PS, Nestadt G, Thornquist M, Ullrich G, McGrath J, Kasch L, Lamacz M, Thomas MG, Gehrig C, Radhakrishna U, Snyder SE, Balk KG, Neufeld K, Swartz KL, DeMarchi N, Papadimitriou GN, Dikeos DG, Stefanis CN, Chakravarti A, Childs B, Housman DE, Kazazian HH, Antonarakis S, Pulver AE. 1998. Schizophrenia susceptibility loci on chromosomes 13q32 and 8p21. Nat Genet 20: 70-73.
4. Brzustowicz LM, Honer WG, Chow EW, Little D, Hogan J, Hodgkinson K, Bassett A. 1999. Linkage of familial schizophrenia to chromosome 13q32. Am J Hum Genet 65:1096-1103.
5. Datta SR, McQuillin A, Rizig M, Blaveri E, Thirumalai S, Kalsi G, Lawrence J, Bass NJ, Puri V, Choudhury K, Pimm J, Crombie C, Fraser G, Walker N, Curtis D, Zvelebil M, Pereira A, Kandaswamy R, St Clair D, Gurling HM. 2008. A threonine to isoleucine missense mutation in the pericentriolar material 1 gene is strongly associated with schizophrenia. Mol Psychiatry. Advance online publication, 2 December 2008. 10.1038/mp.2008.128.
6. Greene CS, Penrod NM, Williams SM, Moore JH. 2009. Failure to replicate a genetic association may provide important clues about genetic architecture. PLoS ONE 4:e56.
7. Gurling HM, Kalsi G, Brynjolfson J, Sigmundsson T, Sherrington R, Mankoo BS, Read T, Murphy P, Blaveri E, McQuillin A, Petursson H, Curtis D. 2001. Genomewide genetic linkage analysis confirms the presence of susceptibility loci for schizophrenia, on chromosomes 1q32.2, 5q33.2, and 8p21-22 and provides support for linkage to schizophrenia, on chromosomes 11q23.3-24 and 20q12.1-11.23. Am J Hum Genet 68:661-673.
8. Gurling HM, Critchley H, Datta SR, McQuillin A, Blaveri E, Thirumalai S, Pimm J, Krasucki R, Kalsi G, Quested D, Lawrence J, Bass N, Choudhury K, Puri V, O'Daly O, Curtis D, Blackwood D, Muir W, Malhotra AK, Buchanan RW, Good CD, Frackowiak RS, Dolan RJ. 2006. Genetic association and brain morphology studies and the chromosome 8p22 pericentriolar material 1 (PCM1) gene in susceptibility to schizophrenia. Arch Gen Psychiatry 63:844-854. (Pubitemid 44188477)
9. Hennah W, Tomppo L, Hiekkalinna T, Palo OM, Kilpinen H, Ekelund J, Tuulio-Henriksson A, Silander K, Partonen T, Paunio T, Terwilliger JD, Lönnqvist J, Peltonen L. 2007. Families with the risk allele of DISC1 reveal a link between schizophrenia and another component of the same molecular pathway, NDE1. Hum Mol Genet 16:453-462.
10. Kamiya A, Tan PL, Kubo K, Engelhard C, Ishizuka K, Kubo A, Tsukita S, Pulver AE, Nakajima K, Cascella NG, Katsanis N, Sawa A. 2008. Recruitment of PCM1 to the centrosome by the cooperative action of DISC1 and BBS4: A candidate for psychiatric illnesses. Arch Gen Psychiatry 65:996-1006.
11. Souza RP, Romano-Silva MA, Lieberman JA, Meltzer HY, Wong AH, Kennedy JL. 2008. Association study of GSK3 gene polymorphisms with schizophrenia and clozapine response. Psychopharmacology (Berl) 200:177-186.