Serotonergic receptor upregulation in cerebral cortex and down regulation in brainstem of streptozotocin induced diabetic rats: Antagonism by pyridoxine and insulin

Neuroscience Letters

Volumn 483, Issue 1, 2010, Pages 23-27

  Abraham, Pretty Mary ^a   Anju, T R ^a   Jayanarayanan, S ^a   Paulose, C S ^a  

^a Department of Physics   (India)

Author keywords

Brainstem; Cerebral cortex; Diabetes; Insulin; Pyridoxine; Serotonin

Indexed keywords

5 HYDROXYINDOLEACETIC ACID; INSULIN; PYRIDOXINE; SEROTONIN; SEROTONIN RECEPTOR;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRAIN CORTEX; BRAIN STEM; CONTROLLED STUDY; DIABETES MELLITUS; DOWN REGULATION; GENE EXPRESSION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; IMMUNOHISTOCHEMISTRY; NONHUMAN; PRIORITY JOURNAL; RAT; REAL TIME POLYMERASE CHAIN REACTION; RECEPTOR BINDING; STREPTOZOCIN DIABETES; UPREGULATION;

ANIMALS; BRAIN STEM; CEREBRAL CORTEX; DIABETES MELLITUS, EXPERIMENTAL; DOWN-REGULATION; GENE EXPRESSION; IMMUNOHISTOCHEMISTRY; INSULIN; MALE; PYRIDOXINE; RATS; RATS, WISTAR; RECEPTORS, SEROTONIN; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; STREPTOZOCIN; UP-REGULATION;

EID: 77956116467     PISSN: 03043940     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neulet.2010.07.042     Document Type: Article

References (18)

1. Aswathy R., Nair P.M., Biju C.S., Paulose Effect of pyridoxine and insulin administration on brain glutamate dehydrogenase activity and blood glucose control in streptozotocin-induced diabetic rats. Biochim. Biophys. Acta 1998, 3:351-354.
2. Buijs R.M., Chun S.J., Niijima A., Romijn H.J., Nagai K. Parasympathetic and sympathetic control of the pancreas: a role for the suprachiasmatic nucleus and other hypothalamic centers that are involved in the regulation of food intake. J. Comp. Neurol. 2001, 431:405-423.
3. Chen A., Shyr M.H., Chen T.Y., Lai H.Y., Lin C.-C., Yen P.S. Dynamic CT perfusion imaging with acetazolamide challenge for evaluation of patients with unilateral cerebrovascular steno-occlusive disease. Am. J. Neuroradiol. 2007, 27:1876-1881.
4. Dakshinamurti K., Sharma S.K., Geiger J.D. Neuroprotective actions of pyridoxine. Biochim. Biophys. Acta 2003, 1647:225-229.
5. Dennis L., Murphy A.L., Gary R., Klaus-Peter L. 5-HT transporter: gene, genetic disorders and pharmacogenetics. Mol. Interv. 2004, 4:109-123.
6. 3H] DOPA in various regions of the brain. J. Neurochem. 1966, 13:655-669.
7. 2A receptors in cerebral cortex and brainstem of streptozotoocin induced diabetic rats. Mol. Cell. Biochem. 1999, 199:81-85.
8. Kim D.K., Tolliver T.J., Huang S.J., Martin B.J., Andrews A.M., Wichems C., Holmes A., Lesch K.P., Murphy D.L. Altered serotonin synthesis, turnover and dynamic regulation in multiple brain regions of mice lacking the serotonin transporter. Neuropharmacology 2005, 49:798-810.
9. Liang K.W, Li J.Y., Wong C.H., Huang K.S., Lin M.Y., Tan P.P., Chen J.C. Morphine tolerance in arthritic rats and serotonergic system. Life Sci. 1999, 64:111-116.
10. Lowry O.H., Roserbrough N.J., Farr A.L., Randall R.J. Protein measurements and folin phenol reagent. J. Biol. Chem. 1951, 193:265-275.
11. Parton L.E., Ye C.P., Coppari R., Enriori P.J., Choi B., Zhang C.Y., Xu C., Vianna C.R., Balthasar N., Lee C.E., Elmquist J.K., Cowley M.A., Lowell B.B. Glucose sensing by POMC neurons regulates glucose homeostasis and is impaired in obesity. Nature 2007, 449:228-232.
12. Paulose C.S., Dakshinamurti K., Packer S., Stephen N.L. Sympathetic stimulation and hypertension in pyridoxine deficient adult rat. Hypertension 1988, 11:387-391.
13. 2A receptor in rat brain. Life Sci. 1997, 60:1393-1397.
14. Scatchard G. The attraction of proteins for small molecules and ions. Ann. N. Y. Acad. Sci. 1949, 51:660-672.
15. TracyAnn P., Harold W.H., Ananda W., Peter R.M., Kara D., Julie A.M., Nigel H.G. Evidence of GLP-1-mediated neuroprotection in an animal model of pyridoxine-induced peripheral sensory neuropathy. Exp. Neurol. 2007, 203:293-301.
16. Turhan C., Klaus-Peter L. Long story short: the serotonin transporter in emotion regulation and social cognition. Nat. Neurosci. 2007, 10:1103-1109.
17. Uzbekov M.N., Murphy S., Rose S.P.R. Ontogenesis of serotonin 'receptors' in different regions of rat brain. Brain Res. 1979, 168:195-199.
18. Zhou L., Sutton G.M., Rochford J.J., Semple R.K., Lam D.D., Oksanen L.J., Thornton-Jones Z.D., Clifton P.G., Yueh C.Y., Evans M.L., McCrimmon R.J., Elmquist J.K., Butler A.A., Heisler L.K. Serotonin 2C receptor agonists improve type 2 diabetes via melanocortin-4 receptor signalling pathways. Cell Metab. 2007, 6:398-405.