Heterogeneous virulence potential and high antibiotic resistance of Pseudomonas aeruginosa strains isolated from Korean pneumonia patients

Journal of Microbiology

Volumn 48, Issue 4, 2010, Pages 518-525

  Yoon, Mi Young ^a   Lee, Kang Mu ^a   Jeong, Seok Hoon ^a   Kim, Jungmin ^b   Yoon, Sang Sun ^a  

^a Yonsei University College of Medicine   (South Korea)

^b Kyungpook National University School of Medicine   (South Korea)

Author keywords

biofilm; P. aeruginosa; pneumonia; quorum sensing; virulence

Indexed keywords

ANTIINFECTIVE AGENT; PANCREATIC ELASTASE; PLASMINOGEN ACTIVATOR INHIBITOR 1; VIRULENCE FACTOR;

ADULT; AGED; ANTIBIOTIC RESISTANCE; ARTICLE; BIOFILM; CLASSIFICATION; FEMALE; GENETICS; HUMAN; INFANT; ISOLATION AND PURIFICATION; MALE; METABOLISM; MICROBIOLOGY; MIDDLE AGED; PATHOGENICITY; PHYLOGENY; PNEUMONIA; PRESCHOOL CHILD; PSEUDOMONAS AERUGINOSA; PSEUDOMONAS INFECTION; SOUTH KOREA; VIRULENCE;

ADULT; AGED; AGED, 80 AND OVER; ANTI-BACTERIAL AGENTS; BIOFILMS; CHILD, PRESCHOOL; DRUG RESISTANCE, BACTERIAL; FEMALE; HUMANS; INFANT; MALE; MIDDLE AGED; PANCREATIC ELASTASE; PHYLOGENY; PLASMINOGEN ACTIVATOR INHIBITOR 1; PNEUMONIA; PSEUDOMONAS AERUGINOSA; PSEUDOMONAS INFECTIONS; REPUBLIC OF KOREA; VIRULENCE; VIRULENCE FACTORS;

PSEUDOMONAS AERUGINOSA;

EID: 77956112598     PISSN: 12258873     EISSN: 12258873     Source Type: Journal    
DOI: 10.1007/s12275-010-9388-2     Document Type: Article

References (39)

1. Azghani, A. O., T. Bedinghaus, and R. Klein. 2000. Detection of elastase from Pseudomonas aeruginosa in sputum and its potential role in epithelial cell permeability. Lung 178, 181-189.
2. Bratu, S., J. Gupta, and J. Quale. 2006. Expression of the las and rhl quorum-sensing systems in clinical isolates of Pseudomonas aeruginosa does not correlate with efflux pump expression or antimicrobial resistance. J. Antimicrob. Chemother. 58, 1250-1253.
3. Campbell, M., E. Mahenthiralingam, and D. P. Speert. 2000. Evaluation of random amplified polymorphic DNA typing of Pseudomonas aeruginosa. J. Clin. Microbiol. 38, 4614-4615.
4. th ed. Approved standard M7-A8. In C. a. L. S. Institute (ed.). Wayne, PA, USA.
5. de Kievit, T. R. 2009. Quorum sensing in Pseudomonas aeruginosa biofilms. Environ. Microbiol. 11, 279-288.
6. Denervaud, V., P. TuQuoc, D. Blanc, S. Favre-Bonte, V. Krishnapillai, C. Reimmann, D. Haas, and C. van Delden. 2004. Characterization of cell-to-cell signaling-deficient Pseudomonas aeruginosa strains colonizing intubated patients. J. Clin. Microbiol. 42, 554-562.
7. Diebel, L. N., D. M. Liberati, P. B. Amin, and C. A. Diglio. 2009. Cleavage of SIgA by Gram-negative respiratory pathogens enhance neutrophil inflammatory potential. J. Trauma. 66, 1336-1342; discussion 1342.
8. Doring, G. 1987. Significance of Pseudomonas aeruginosa virulence factors in acute and chronic Pseudomonas aeruginosa infections. Infection 15, 47-50.
9. El Solh, A. A. and A. Alhajhusain. 2009. Update on the treatment of Pseudomonas aeruginosa pneumonia. J. Antimicrob. Chemother. 64, 229-238.
10. Hassett, D. J., J. Cuppoletti, B. Trapnell, S. V. Lymar, J. J. Rowe, S. S. Yoon, G. M. Hilliard, and et al. 2002. Anaerobic metabolism and quorum sensing by Pseudomonas aeruginosa biofilms in chronically infected cystic fibrosis airways: rethinking antibiotic treatment strategies and drug targets. Adv. Drug Deliv. Rev. 54, 1425-1443.
11. Heck, L. W., K. Morihara, W. B. McRae, and E. J. Miller. 1986. Specific cleavage of human type III and IV collagens by Pseudomonas aeruginosa elastase. Infect. Immun. 51, 115-118.
12. Hoffman, L. R., H. D. Kulasekara, J. Emerson, L. S. Houston, J. L. Burns, B. W. Ramsey, and S. I. Miller. 2009. Pseudomonas aeruginosa lasR mutants are associated with cystic fibrosis lung disease progression. J. Cyst. Fibros. 8, 66-70.
13. Hoffman, L. R., A. R. Richardson, L. S. Houston, H. D. Kulasekara, W. Martens-Habbena, M. Klausen, J. L. Burns, and et al. 2010. Nutrient availability as a mechanism for selection of antibiotic tolerant Pseudomonas aeruginosa within the CF airway. PLoS Pathog. 6, e1000712.
14. Jacquot, J., J. M. Tournier, and E. Puchelle. 1985. In vitro evidence that human airway lysozyme is cleaved and inactivated by Pseudomonas aeruginosa elastase and not by human leukocyte elastase. Infect. Immun. 47, 555-560.
15. Johnson, D. A., B. Carter-Hamm, and W. M. Dralle. 1982. Inactivation of human bronchial mucosal proteinase inhibitor by Pseudomonas aeruginosa elastase. Am. Rev. Respir. Dis. 126, 1070-1073.
16. Kirisits, M. J., L. Prost, M. Starkey, and M. R. Parsek. 2005. Characterization of colony morphology variants isolated from Pseudomonas aeruginosa biofilms. Appl. Environ. Microbiol. 71, 4809-4821.
17. Kobayashi, H., O. Kobayashi, and S. Kawai. 2009. Pathogenesis and clinical manifestations of chronic colonization by Pseudomonas aeruginosa and its biofilms in the airway tract. J. Infect. Chemother. 15, 125-142.
18. Kurahashi, K., O. Kajikawa, T. Sawa, M. Ohara, M. A. Gropper, D. W. Frank, T. R. Martin, and J. P. Wiener-Kronish. 1999. Pathogenesis of septic shock in Pseudomonas aeruginosa pneumonia. J. Clin. Invest. 104, 743-750.
19. Lee, B., J. A. Haagensen, O. Ciofu, J. B. Andersen, N. Hoiby, and S. Molin. 2005. Heterogeneity of biofilms formed by nonmucoid Pseudomonas aeruginosa isolates from patients with cystic fibrosis. J. Clin. Microbiol. 43, 5247-5255.
20. Leid, J. G., C. J. Willson, M. E. Shirtliff, D. J. Hassett, M. R. Parsek, and A. K. Jeffers. 2005. The exopolysaccharide alginate protects Pseudomonas aeruginosa biofilm bacteria from IFN-gammamediated macrophage killing. J. Immunol. 175, 7512-7518.
21. Mah, T. F., B. Pitts, B. Pellock, G. C. Walker, P. S. Stewart, and G. A. O'Toole. 2003. A genetic basis for Pseudomonas aeruginosa biofilm antibiotic resistance. Nature 426, 306-310.
22. Mahenthiralingam, E., M. E. Campbell, J. Foster, J. S. Lam, and D. P. Speert. 1996. Random amplified polymorphic DNA typing of Pseudomonas aeruginosa isolates recovered from patients with cystic fibrosis. J. Clin. Microbiol. 34, 1129-1135.
23. Mathee, K., O. Ciofu, C. Sternberg, P. W. Lindum, J. I. Campbell, P. Jensen, A. H. Johnsen, and et al. 1999. Mucoid conversion of Pseudomonas aeruginosa by hydrogen peroxide: a mechanism for virulence activation in the cystic fibrosis lung. Microbiology 145, 1349-1357.
24. Moneto de Ledesma, A. M., R. Paraje, and S. Paglini. 1985. Proteolytic and elastase activities of Pseudomonas aeruginosa. Rev. Argent Microbiol. 17, 89-96.
25. O'Toole, G. A. and R. Kolter. 1998. Flagellar and twitching motility are necessary for Pseudomonas aeruginosa biofilm development. Mol. Microbiol. 30, 295-304.
26. Pearson, J. P., K. M. Gray, L. Passador, K. D. Tucker, A. Eberhard, B. H. Iglewski, and E. P. Greenberg. 1994. Structure of the autoinducer required for expression of Pseudomonas aeruginosa virulence genes. Proc. Natl. Acad. Sci. USA 91, 197-201.
27. Pearson, J. P., E. C. Pesci, and B. H. Iglewski. 1997. Roles of Pseudomonas aeruginosa las and rhl quorum-sensing systems in control of elastase and rhamnolipid biosynthesis genes. J. Bacteriol. 179, 5756-5767.
28. Rampioni, G., M. Schuster, E. P. Greenberg, E. Zennaro, and L. Leoni. 2009. Contribution of the RsaL global regulator to Pseudomonas aeruginosa virulence and biofilm formation. FEMS Microbiol. Lett. 301, 210-217.
29. Schultz, D. R. and K. D. Miller. 1974. Elastase of Pseudomonas aeruginosa: inactivation of complement components and complement-derived chemotactic and phagocytic factors. Infect. Immun. 10, 128-135.
30. Tingpej, P., L. Smith, B. Rose, H. Zhu, T. Conibear, K. Al Nassafi, J. Manos, and et al. 2007. Phenotypic characterization of clonal and nonclonal Pseudomonas aeruginosa strains isolated from lungs of adults with cystic fibrosis. J. Clin. Microbiol. 45, 1697-1704.
31. Whiteley, M., M. G. Bangera, R. E. Bumgarner, M. R. Parsek, G. M. Teitzel, S. Lory, and E. P. Greenberg. 2001. Gene expression in Pseudomonas aeruginosa biofilms. Nature 413, 860-864.
32. Winstanley, C. and J. L. Fothergill. 2009. The role of quorum sensing in chronic cystic fibrosis Pseudomonas aeruginosa infections. FEMS Microbiol. Lett. 290, 1-9.
33. Wolter, D. J., J. A. Black, P. D. Lister, and N. D. Hanson. 2009. Multiple genotypic changes in hypersusceptible strains of Pseudomonas aeruginosa isolated from cystic fibrosis patients do not always correlate with the phenotype. J. Antimicrob. Chemother. 64, 294-300.
34. Wong, K. K., K. Poole, N. Gotoh, and R. E. Hancock. 1997. Influence of OprM expression on multiple antibiotic resistance in Pseudomonas aeruginosa. Antimicrob. Agents Chemother. 41, 2009-2012.
35. Woods, D. E., M. S. Schaffer, H. R. Rabin, G. D. Campbell, and P. A. Sokol. 1986. Phenotypic comparison of Pseudomonas aeruginosa strains isolated from a variety of clinical sites. J. Clin. Microbiol. 24, 260-264.
36. Yoon, S. S., R. Coakley, G. W. Lau, S. V. Lymar, B. Gaston, A. C. Karabulut, R. F. Hennigan, and et al. 2006. Anaerobic killing of mucoid Pseudomonas aeruginosa by acidified nitrite derivatives under cystic fibrosis airway conditions. J. Clin. Invest. 116, 436-446.
37. Yoon, S. S. and D. J. Hassett. 2004. Chronic Pseudomonas aeruginosa infection in cystic fibrosis airway disease: metabolic changes that unravel novel drug targets. Expert. Rev. Anti. Infect. Ther. 2, 611-623.
38. Zaborina, O., J. E. Kohler, Y. Wang, C. Bethel, O. Shevchenko, L. Wu, J. R. Turner, and J. C. Alverdy. 2006. Identification of multi-drug resistant Pseudomonas aeruginosa clinical isolates that are highly disruptive to the intestinal epithelial barrier. Ann. Clin. Microbiol. Antimicrob. 5, 14.
39. Zhanel, G. G., J. A. Karlowsky, M. H. Saunders, R. J. Davidson, D. J. Hoban, R. E. Hancock, I. McLean, and L. E. Nicolle. 1995. Development of multiple-antibiotic-resistant (Mar) mutants of Pseudomonas aeruginosa after serial exposure to fluoroquinolones. Antimicrob. Agents Chemother. 39, 489-495.