Knockdown of clock in the ventral tegmental area through RNA interference results in a mixed state of mania and depression-like behavior

Biological Psychiatry

Volumn 68, Issue 6, 2010, Pages 503-511

  Mukherjee, Shibani ^a   Coque, Laurent ^a   Cao, Jun Li ^a   Kumar, Jaswinder ^a   Chakravarty, Sumana ^a   Asaithamby, Aroumougame ^b   Graham, Ami ^a   Gordon, Elizabeth ^a   Enwright III, John F ^c   Dileone, Ralph J ^d   Birnbaum, Shari G ^a   Cooper, Donald C ^a   McClung, Colleen A ^a  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^b UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^c AUSTIN COLLEGE   (United States)

^d YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Anxiety; bipolar disorder; depression; dopamine; RNAi; VTA

Indexed keywords

ADENOVIRUS VECTOR; SHORT HAIRPIN RNA; TRANSCRIPTION FACTOR CLOCK;

ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANXIETY; ARTICLE; CIRCADIAN RHYTHM; CONTROLLED STUDY; DEPRESSION; DOPAMINERGIC NERVE CELL; GENE EXPRESSION; GENE TRANSFER; LOCOMOTION; MALE; MANIA; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; RNA INTERFERENCE; VENTRAL TEGMENTUM;

ACTION POTENTIALS; ANIMALS; ANIMALS, GENETICALLY MODIFIED; ANXIETY; BIPOLAR DISORDER; CIRCADIAN RHYTHM; CLOCK PROTEINS; DEPENDOVIRUS; DEPRESSION; DOPAMINE; GENE EXPRESSION; GENE KNOCKDOWN TECHNIQUES; GENE TRANSFER TECHNIQUES; GENETIC VECTORS; MALE; MICE; MICE, INBRED C57BL; NEURONS; RNA INTERFERENCE; VENTRAL TEGMENTAL AREA;

EID: 77956101152     PISSN: 00063223     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.biopsych.2010.04.031     Document Type: Article

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