Attempt to treat congenital pseudarthrosis of the tibia with mesenchymal stromal cell transplantation

Cytotherapy

Volumn 12, Issue 5, 2010, Pages 593-604

  Tikkanen, Jonne ^a,b   Leskelä, Hannu Ville ^a   Lehtonen, Siri T ^a   Vähäsarja, Vesa ^a   Melkko, Jukka ^a   Ahvenjärvi, Lauri ^a   Pääkkö, Eija ^a   Väänänen, Kalervo ^c   Lehenkari, Petri ^a,b  

^a OULU UNIVERSITY HOSPITAL   (Finland)

^b UNIVERSITY OF OULU   (Finland)

^c UNIVERSITY OF EASTERN FINLAND   (Finland)

Author keywords

Cell therapy; Cell transplantation; Congenital pseudarthrosis of the tibia; Mesenchymal stromal cell; Neurofibromatosis type 1

Indexed keywords

ARTICLE; BONE DEFECT; BONE REMODELING; CASE REPORT; CELL TRANSPLANTATION; CHILD; CONGENITAL PSEUDARTHROSIS; FOLLOW UP; FRACTURE EXTERNAL FIXATION; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; ILIAC CREST; LEG AMPUTATION; MESENCHYME CELL; MULTIDETECTOR COMPUTED TOMOGRAPHY; NUCLEAR MAGNETIC RESONANCE IMAGING; OSTEOLYSIS; OSTEOTOMY; PRESCHOOL CHILD; PRIORITY JOURNAL; SCHOOL CHILD; STROMA CELL; TIBIA; TREATMENT FAILURE;

EID: 77956053738     PISSN: 14653249     EISSN: 14772566     Source Type: Journal    
DOI: 10.3109/14653249.2010.487898     Document Type: Article

References (45)

1. Gutmann DH, Aylsworth A, Carey JC, Korf B, Marks J, Pyeritz RE, et al. The diagnostic evaluation and multidisciplinary management of neurofibromatosis 1 and neurofibromatosis. JAMA. 1997;278:51-57
2. Crawford AHJ, Bagamery N. Osseous manifestations of neurofibromatosis in childhood. J Pediatr Orthop. 1986;6: 72-88.
3. Lammert M, Kappler M, Mautner V, Lammert K, St ör kel S, Friedman JM, et al. Decreased bone mineral density in patients with neurofibromatosis 1. Osteoporos Int. 2005;16:1161-1166
4. Andersen KS. Congenital pseudarthrosis of the tibia and neurofibromatosis. Acta Orthop Scand. 1976;47:108-111
5. Paterson D. Congenital pseudarthrosis of the tibia. An overview. Clin Orthop Relat Res. 1989;247:44-54.
6. Vitale MG, Guha A, Skaggs DL. Orthopaedic manifestations of neurofibromatosis in children: an update. Clin Orthop Relat Res. 2002;401:107-118
7. Stevenson DA, Birch PH, Friedman JM, Viskochil DH, Balestrazzi P, Boni S, et al. Descriptive analysis of tibial pseudarthrosis in patients with neurofibromatosis 1. Am J Med Genet. 1999;84:413-419
8. Stevenson DA, Zhou H, AshrafiS, Messiaen LM, Carey JC, D ' Astous JL, et al. Double inactivation of NF1 in tibial pseudarthrosis. Am J Hum Genet. 2006;79:143-148
9. Sakamoto A, Yoshida T, Yamamoto H, Oda Y, Tsuneyoshi M, Iwamoto Y. Congenital pseudarthrosis of the tibia: analysis of the histology and the NF1 gene. J Orthop Sci. 2007;12:361-365
10. Anderson DJ, Schoenecker PL, Sheridan JJ, Rich MM. Use of an intramedullary rod for the treatment of congenital pseudarthrosis of the tibia. J Bone Joint Surg Am. 1992;74:161-168
11. Charnley J. Congenital pseudarthrosis of the tibia treated by intramedullary nail. J Bone Joint Surg Am. 1956;38A:283-290
12. Hagan KF, Buncke HJ. Treatment of congenital pseudarthrosis of the tibia with free vascularized bone graft. Clin Orthop Relat Res. 1982;166:34-44.
13. Weiland AJ, Weiss AP, Moore JR, Tolo VT. Vascularized fibular grafts in the treatment of congenital pseudarthrosis of the tibia. J Bone Joint Surg Am. 1990;72:654-662
14. Paley D, Catagni M, Argnani F, Prevot J, Bell D, Armstrong P. Treatment of congenital pseudoarthrosis of the tibia using the Ilizarov technique. Clin Orthop Relat Res. 1992;280: 81-93.
15. McCarthy RE. Amputation for congenital pseudarthrosis of the tibia. Indications and techniques. Clin Orthop Relat Res. 1982;166:58-61.
16. Ito H, Shirai Y, Gembun Y. A case of congenital pseudarthrosis of the tibia treated with pulsing electromagnetic fields. 17-year follow-up. J Nippon Med Sch. 2000;67: 198-201.
17. Okada K, Miyakoshi N, Takahashi S, Ishigaki S, Nishida J, Itoi E. Congenital pseudoarthrosis of the tibia treated with low-intensity pulsed ultrasound stimulation (LIPUS). Ultrasound Med Biol. 2003;29:1061-1064
18. Garg NK, Gaur S. Percutaneous autogenous bone-marrow grafting in congenital tibial pseudarthrosis. J Bone Joint Surg Br. 1995;77:830-831
19. Fabeck L, Ghafil D, Gerroudj M, Baillon R, Delincé P. Bone morphogenetic protein 7 in the treatment of congenital pseudarthrosis of the tibia. J Bone Joint Surg Br. 2006;88: 116-118
20. Long MW, Robinson JA, Ashcraft EA, Mann KG. Regulation of human bone marrow-derived osteoprogenitor cells by osteogenic growth factors. J Clin Invest. 1995;95:881-887
21. Urist MR, DeLange RJ, Finerman GA. Bone cell differentiation and growth factors. Science. 1983;220:680-686
22. Sammons J, Ahmed N, El-Sheemy M, Hassan HT. The role of BMP-6, IL-6, and BMP-4 in mesenchymal stem celldependent bone development: effects on osteoblastic differentiation induced by parathyroid hormone and vitamin D(3). Stem Cells Dev. 2004;13:273-280
23. Nakashima K, Zhou X, Kunkel G, Zhang Z, Deng JM, Behringer RR, et al. The novel zinc finger-containing transcription factor osterix is required for osteoblast differentiation and bone formation. Cell. 2002;108:17-29.
24. Long MW. Osteogenesis and bone-marrow-derived cells. Blood Cells Mol Dis. 2001;27:677-690
25. Hong J, Hwang ES, McManus MT, Amsterdam A, Tian Y, Kalmukova R, et al. TAZ, a transcriptional modulator of mesenchymal stem cell differentiation. Science. 2005;309: 1074-1078
26. Cheng SL, Yang JW, Rifas L, Zhang SF, Avioli LV. Differentiation of human bone marrow osteogenic stromal cells in vitro: induction of the osteoblast phenotype by dexamethasone. Endocrinology. 1994;134:277-286
27. Leskel ä H, Risteli J, Niskanen S, Koivunen J, Ivaska KK, Lehenkari P. Osteoblast recruitment from stem cells does not decrease by age at late adulthood. Biochem Biophys Res Commun. 2003;311:1008-1013
28. Bruder SP, Kurth AA, Shea M, Hayes WC, Jaiswal N, Kadiyala S. Bone regeneration by implantation of purified, culture-expanded human mesenchymal stem cells. J Orthop Res. 1998;16:155-162
29. Kitoh H, Kitakoji T, Tsuchiya H, Mitsuyama H, Nakamura H, Katoh M, et al. Transplantation of marrow-derived mesenchymal stem cells and platelet-rich plasma during distraction osteogenesis: a preliminary result of three cases. Bone. 2004;35:892-898
30. Kitoh H, Kitakoji T, Tsuchiya H, Katoh M, Ishiguro N. Transplantation of culture expanded bone marrow cells and platelet rich plasma in distraction osteogenesis of the long bones. Bone. 2007;40:522-528
31. Marcacci M, Kon E, Moukhachev V, Lavroukov A, Kutepov S, Quarto R, et al. Stem cells associated with macroporous bioceramics for long bone repair: 6- to 7-year outcome of a pilot clinical study. Tissue Eng. 2007;13:947-955
32. Vacanti CA, Bonassar LJ, Vacanti MP, Shufflebarger J. Replacement of an avulsed phalanx with tissue-engineered bone. N Engl J Med. 2001;344:1511-1514
33. Leskelä H, Kuorilehto T, Risteli J, Koivunen J, Nissinen M, Peltonen S, et al. Congenital pseudarthrosis of neurofibromatosis type 1: impaired osteoblast differentiation and function and altered NF1 gene expression. Bone. 2009;44:243-250
34. Wang X, Li F, Niyibizi C. Progenitors systemically transplanted into neonatal mice localize to areas of active bone formation in vivo: implications of cell therapy for skeletal diseases. Stem Cells. 2006;24:1869-1878
35. Hernigou P, Poignard A, Beaujean F, Rouard H. Percutaneous autologous bone-marrow grafting for nonunions. Influence of the number and concentration of progenitor cells. J Bone Joint Surg Am. 2005;87:1430-1437
36. Lazennec G, Jorgensen C. Concise review. Adult multipotent stromal cells and cancer: risk or benefit? Stem Cells. 2008; 26:1387-1394
37. Adachi N, Ochi M, Deie M, Ito Y. Transplant of mesenchymal stem cells and hydroxyapatite ceramics to treat severe osteochondral damage after septic arthritis of the knee. J Rheumatol. 2005;32:1615-1618
38. Caplan AI. Adult mesenchymal stem cells for tissue engineering versus regenerative medicine. J Cell Physiol. 2007;213:341-347
39. Mishra PK. Bone marrow-derived mesenchymal stem cells for treatment of heart failure: is it all paracrine actions and immunomodulation? J Cardiovasc Med (Hagerstown). 2008; 9:122-128
40. Boyce BF, Xing L. Biology of RANK, RANKL, and osteoprotegerin. Arthritis Res Ther. 2007;9(Suppl 1):S1.
41. Bielby R, Jones E, McGonagle D. The role of mesenchymal stem cells in maintenance and repair of bone. Injury. 2007; 38(Suppl 1):S26-32.
42. Dobbs MB, Rich MM, Gordon JE, Szymanski DA, Schoenecker PL. Use of an intramedullary rod for treatment of congenital pseudarthrosis of the tibia. A long-term follow-up study. J Bone Joint Surg Am. 2004;86A:1186-1197
43. Heikkinen ES, Poyhonen MH, Kinnunen PK, Seppä n en UI. Congenital pseudarthrosis of the tibia. Treatment and outcome at skeletal maturity in 10 children. Acta Orthop Scand. 1999;70:275-282
44. Johnston CE. Congenital pseudarthrosis of the tibia: results of technical variations in the Charnley-Williams procedure. J Bone Joint Surg Am. 2002;84A:1799-1810
45. Ohnishi I, Sato W, Matsuyama J, Yajima H, Haga N, Kamegaya M, et al. Treatment of congenital pseudarthrosis of the tibia: a multicenter study in Japan. J Pediatr Orthop. 2005;25:219-224