Long-term β-blocker therapy improves diastolic function even without the therapeutic effect on systolic function in patients with reduced ejection fraction

Journal of Cardiology

Volumn 56, Issue 2, 2010, Pages 176-182

  Tamaki, Shunsuke ^a   Sakata, Yasushi ^a   Mano, Toshiaki ^a   Ohtani, Tomohito ^a,b   Takeda, Yasuharu ^a,b   Kamimura, Daisuke ^c   Omori, Yousuke ^a   Yamamoto, K ^a,b  

^a OSAKA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^b OSAKA UNIVERSITY   (Japan)

^c YOKOHAMA CITY UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

Adrenergic receptor blockers; Diastolic dysfunction; Heart failure

Indexed keywords

ANGIOTENSIN RECEPTOR ANTAGONIST; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; CALCIUM CHANNEL BLOCKING AGENT; DIGITALIS; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; DIURETIC AGENT; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR;

ADULT; ARTICLE; DIASTOLE; DRUG EFFECT; ECHOCARDIOGRAPHY; FEMALE; HEART EJECTION FRACTION; HEART FAILURE; HEART FUNCTION; HEART LEFT VENTRICLE FILLING PRESSURE; HEART LEFT VENTRICLE VOLUME; HEART VENTRICLE REMODELING; HUMAN; LONG TERM CARE; MAJOR CLINICAL STUDY; MALE; RETROSPECTIVE STUDY; SYSTOLE;

ADRENERGIC BETA-ANTAGONISTS; DIASTOLE; ECHOCARDIOGRAPHY; FEMALE; HEART FAILURE; HEART VENTRICLES; HUMANS; MALE; MIDDLE AGED; RETROSPECTIVE STUDIES; STROKE VOLUME; SYSTOLE;

EID: 77956010372     PISSN: 09145087     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jjcc.2010.04.001     Document Type: Article

References (39)

1. Effect of metoprolol CR/XL in chronic heart failure: Metoprolol CR/XL Randomised Intervention Trial in Congestive Heart Failure (MERIT-HF). Lancet 1999, 353:2001-2007. MERIT-HF Study Group.
2. The Cardiac Insufficiency Bisoprolol Study II (CIBIS-II): a randomised trial. Lancet 1999, 353:9-13. CIBIS-II Investigators and Committees.
3. Colucci W.S., Packer M., Bristow M.R., Gilbert E.M., Cohn J.N., Fowler M.B., Krueger S.K., Hershberger R., Uretsky B.F., Bowers J.A., Sackner-Bernstein J.D., Young S.T., Holcslaw T.L., Lukas M.A. Carvedilol inhibits clinical progression in patients with mild symptoms of heart failure. US Carvedilol Heart Failure Study Group. Circulation 1996, 94:2800-2806.
4. Packer M., Bristow M.R., Cohn J.N., Colucci W.S., Fowler M.B., Gilbert E.M., Shusterman N.H. The effect of carvedilol on morbidity and mortality in patients with chronic heart failure. US Carvedilol Heart Failure Study Group. N Engl J Med 1996, 334:1349-1355.
5. Nishiyama M., Park I.S., Yoshikawa T., Hatai Y., Ando M., Takahashi Y., Mori K., Murakami Y. Efficacy and safety of carvedilol for heart failure in children and patients with congenital heart disease. Heart Vessels 2009, 24:187-192.
6. Metra M., Giubbini R., Nodari S., Boldi E., Modena M.G., Cas L.D. Differential effects of ß-blockers in patients with heart failure. Circulation 2000, 102:546-551.
7. Lowes B.D., Gilbert E.M., Abraham W.T., Minobe W., Larrabee P., Ferguson D., Wolfel E., Lindenfeld J., Tsvetkova T., Robertson A.D., Quaife R.A., Bristow M.R. Myocardial gene expression in dilated cardiomyopathy treated with beta-blocking agents. N Engl J Med 2002, 346:1357-1365.
8. Bristow M.R., Gilbert E.M., Abraham W.T., Adams K.F., Fowler M.B., Hershberger R.E., Kubo S.H., Narahara K.A., Ingersoll H., Krueger S., Young S., Shusterman N. Carvedilol produces dose-related improvements in left ventricular function and survival in subjects with chronic heart failure. MOCHA Investigators. Circulation 1996, 94:2807-2816.
9. Bristow M.R., O'Connell J.B., Gilbert E.M., French W.J., Leatherman G., Kantrowitz N.E., Orie J., Smucker M.L., Marshall G., Kelly P. Dose-response of chronic beta-blocker treatment in heart failure from either idiopathic dilated or ischemic cardiomyopathy. Bucindolol Investigators. Circulation 1994, 89:1632-1642.
10. Cohn J.N., Ferrari R., Sharpe N. Cardiac remodeling-concepts and clinical implications: a consensus paper from an international forum on cardiac remodeling. J Am Coll Cardiol 2000, 35:569-582.
11. Hori M., Sasayama S., Kitabatake A., Toyo-oka T., Handa S., Yokoyama M., Matsuzaki M., Takeshita A., Origasa H., Matsui K., Hosoda S. Low-dose carvedilol improves left ventricular function and reduces cardiovascular hospitalization in Japanese patients with chronic heart failure: the Multicenter Carvedilol Heart Failure Dose Assessment (MUCHA) trial. Am Heart J 2004, 147:324-330.
12. Rihal C.S., Nishimura R.A., Hatle L.K., Bailey K.R., Tajik A.J. Systolic and diastolic dysfunction in patients with clinical diagnosis of dilated cardiomyopathy. Relation to symptoms and prognosis. Circulation 1994, 90:2772-2779.
13. Pinamonti B., Di Lenarda A., Sinagra G., Camerini F. Restrictive left ventricular filling pattern in dilated cardiomyopathy assessed by Doppler echocardiography: clinical, echocardiographic and hemodynamic correlations and prognostic implications. Heart Muscle Disease Study Group. J Am Coll Cardiol 1993, 22:808-815.
14. Chrysohoou C., Pitsavos C., Barbetseas J., Kotroyiannis I., Brili S., Vasiliadou K., Papadimitriou L., Stefanadis C. Chronic systemic inflammation accompanies impaired ventricular diastolic function, detected by Doppler imaging, in patients with newly diagnosed systolic heart failure (Hellenic Heart Failure Study). Heart Vessels 2009, 24:22-26.
15. Andersson B., Caidahl K., di Lenarda A., Warren S.E., Goss F., Waldenstrom A., Persson S., Wallentin I., Hjalmarson A., Waagstein F. Changes in early and late diastolic filling patterns induced by long-term adrenergic beta-blockade in patients with idiopathic dilated cardiomyopathy. Circulation 1996, 94:673-682.
16. Kim M.H., Devlin W.H., Das S.K., Petrusha J., Montgomery D., Starling M.R. Effects of beta-adrenergic blocking therapy on left ventricular diastolic relaxation properties in patients with dilated cardiomyopathy. Circulation 1999, 100:729-735.
17. Capomolla S., Febo O., Gnemmi M., Riccardi G., Opasich C., Caporotondi A., Mortara A., Pinna G.D., Cobelli F. Beta-blockade therapy in chronic heart failure: diastolic function and mitral regurgitation improvement by carvedilol. Am Heart J 2000, 139:596-608.
18. Palazzuoli A., Quatrini I., Vecchiato L., Calabria P., Gennari L., Martini G., Nuti R. Left ventricular diastolic function improvement by carvedilol therapy in advanced heart failure. J Cardiovasc Pharmacol 2005, 45:563-568.
19. Palazzuoli A., Carrera A., Calabria P., Puccetti L., Pastrorelli M., Pasqui A.L., Auteri A., Bruni F. Effects of carvedilol therapy on restrictive diastolic filling pattern in chronic heart failure. Am Heart J 2004, 147:73-79.
20. Penicka M., Bartunek J., De Bruyne B., Vanderheyden M., Goethals M., De Zutter M., Brugada P., Geelen P. Improvement of left ventricular function after cardiac resynchronization therapy is predicted by tissue Doppler imaging echocardiography. Circulation 2004, 109:978-983.
21. Kono M., Kisanuki A., Takasaki K., Nakashiki K., Yuasa T., Kuwahara E., Mizukami N., Uemura T., Kubota K., Ueya N., Miyata M., Tei C. Left ventricular systolic function is abnormal in diastolic heart failure: Re-assessment of systolic function using cardiac time interval analysis. J Cardiol 2009, 53:437-446.
22. Takeda Y., Sakata Y., Mano T., Nishio M., Ohtani T., Hori M., Masuyama T., Yamamoto K. Noninvasive assessment of diastolic function in subjects with preserved left ventricular ejection fraction: usefulness of color kinetic imaging. J Card Fail 2008, 14:569-576.
23. Yamaguchi H., Yoshida J., Yamamoto K., Sakata Y., Mano T., Akehi N., Hori M., Lim Y.J., Mishima M., Masuyama T. Elevation of plasma brain natriuretic peptide is a hallmark of diastolic heart failure independent of ventricular hypertrophy. J Am Coll Cardiol 2004, 43:55-60.
24. Yamamoto K., Nishimura R.A., Chaliki H.P., Appleton C.P., Holmes D.R., Redfield M.M. Determination of left ventricular filling pressure by Doppler echocardiography in patients with coronary artery disease: critical role of left ventricular systolic function. J Am Coll Cardiol 1997, 30:1819-1826.
25. Nishimura R.A., Appleton C.P., Redfield M.M., Ilstrup D.M., Holmes D.R., Tajik A.J. Noninvasive Doppler echocardiographic evaluation of left ventricular filling pressures in patients with cardiomyopathies: a simultaneous Doppler echocardiographic and cardiac catheterization study. J Am Coll Cardiol 1996, 28:1226-1233.
26. Eichhorn E.J., Bedotto J.B., Malloy C.R., Hatfield B.A., Deitchman D., Brown M., Willard J.E., Grayburn P.A. Effect of beta-adrenergic blockade on myocardial function and energetics in congestive heart failure. Improvements in hemodynamic, contractile, and diastolic performance with bucindolol. Circulation 1990, 82:473-483.
27. Paraskevaidis I., Farmakis D., Parissis J.T., Dodouras T., Filippatos G., Tsiapras D., Kremastinos D. Carvedilol improves left atrial and left ventricular function and reserve in dilated cardiomyopathy after 1 year of treatment. J Card Fail 2007, 13:108-113.
28. Kobayashi M., Machida N., Mitsuishi M., Yamane Y. Beta-blocker improves survival, left ventricular function and myocardial remodeling in hypertensive rats with diastolic heart failure. Am J Hypertens 2004, 17:1112-1119.
29. Nishio M., Sakata Y., Mano T., Ohtani T., Takeda Y., Miwa T., Hori M., Masuyama T., Kondo T., Yamamoto K. Beneficial effects of bisoprolol on the survival of hypertensive diastolic heart failure model rats. Eur J Heart Fail 2008, 10:446-453.
30. Masuyama T., Yamamoto K., Sakata Y., Doi R., Nishikawa H., Kondo H., Ono K., Kuzuya T., Sugawara M., Hori M. Evolving changes in Doppler mitral flow velocity pattern in rats with hypertensive hypertrophy. J Am Coll Cardiol 2000, 36:2333-2338.
31. Kawaguchi M., Hay I., Fetics B., Kass D.A. Combined ventricular systolic and arterial stiffening in patients with heart failure and preserved ejection fraction: implications for systolic and diastolic reserve limitations. Circulation 2003, 107:714-720.
32. Lechat P., Hulot J.S., Escolano S., Mallet A., Leizorovicz A., Werhlen-Grandjean M., Pochmalicki G., Dargie H. Heart rate and cardiac rhythm relationships with bisoprolol benefit in chronic heart failure in CIBIS II Trial. Circulation 2001, 103:1428-1433.
33. Mulder P., Barbier S., Chagraoui A., Richard V., Henry J.P., Lallemand F., Renet S., Lerebours G., Mahlberg-Gaudin F., Thuillez C. Long-term heart rate reduction induced by the selective I(f) current inhibitor ivabradine improves left ventricular function and intrinsic myocardial structure in congestive heart failure. Circulation 2004, 109:1674-1679.
34. Ciobotaru V., Heimburger M., Louedec L., Heymes C., Ventura-Clapier R., Bedossa P., Escoubet B., Michel J.B., Mercadier J.J., Logeart D. Effect of long-term heart rate reduction by If current inhibition on pressure overload-induced heart failure in rats. J Pharmacol Exp Ther 2008, 324:43-49.
35. Fox K., Ford I., Steg G., Tendra M., Ferrari R. Ivabradine for patients with stable coronary artery disease and left-ventricular systolic dysfunction (BEAUTIFUL): a randomised, double-blind, placebo-controlled trial. Lancet 2008, 372:807-816.
36. Nishio M., Sakata Y., Mano T., Ohtani T., Takeda Y., Hori M., Yamamoto K. Difference of clinical characteristics between hypertensive patients with and without diastolic heart failure: the roles of diastolic dysfunction and renal insufficiency. Hypertens Res 2008, 31:1865-1872.
37. Takeda Y., Sakata Y., Higashimori M., Mano T., Nishio M., Ohtani T., Hori M., Masuyama T., Kaneko M., Yamamoto K. Noninvasive assessment of wall distensibility with the evaluation of diastolic epicardial movement. J Card Fail 2009, 15:68-77.
38. Ommen S.R., Nishimura R.A., Appleton C.P., Miller F.A., Oh J.K., Redfield M.M., Tajik A.J. Clinical utility of Doppler echocardiography and tissue Doppler imaging in the estimation of left ventricular filling pressures: A comparative simultaneous Doppler-catheterization study. Circulation 2000, 102:1788-1794.
39. The J-DHF Program Committee Rationale and design of a randomized trial to assess the effects of beta-blocker in diastolic heart failure: Japanese Diastolic Heart Failure Study (J-DHF). J Card Fail 2005, 11:542-547.