Effect of long-term heart rate reduction by If current inhibition on pressure overload-induced heart failure in rats

Journal of Pharmacology and Experimental Therapeutics

Volumn 324, Issue 1, 2008, Pages 43-49

  Ciobotaru, Vlad ^a   Heimburger, Michèle ^a   Louedec, Liliane ^a   Heymes, Christophe ^b   Ventura Clapier, René E ^c   Bedossa, Pierre ^d   Escoubet, Brigitte ^a   Michel, Jean Baptiste ^a   Mercadier, Jean Jacques ^a   Logeart, Damien ^a,b  

^a BICHAT HOSPITAL   (France)

^b HÔPITAL LARIBOISIÈRE   (France)

^c Universite Paris Sud   (France)

^d BEAUJON HOSPITAL   (France)

Author keywords

[No Author keywords available]

Indexed keywords

IVABRADINE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASCENDING AORTA; CONTROLLED STUDY; DIASTOLIC BLOOD PRESSURE; DOSE RESPONSE; HEART FAILURE; HEART INDEX; HEART LEFT VENTRICLE HYPERTROPHY; HEART LEFT VENTRICLE OUTFLOW TRACT; HEART LEFT VENTRICLE OUTFLOW TRACT OBSTRUCTION; HEART MUSCLE FIBROSIS; HEART RATE; HEART STROKE VOLUME; HEART VENTRICLE OVERLOAD; HEART VENTRICLE PRESSURE; INHIBITION KINETICS; ION CURRENT; LONG TERM CARE; NONHUMAN; PRIORITY JOURNAL; RAT;

EID: 37349099373     PISSN: 00223565     EISSN: 15210103     Source Type: Journal    
DOI: 10.1124/jpet.107.130237     Document Type: Article

References (37)

1. Albaladejo P, Carusi A, Apartian A, Lacolley P, Safar ME, and Benetos A (2003) Effect of chronic heart rate reduction with ivabradine on carotid and aortic structure and function in normotensive and hypertensive rats. J Vasc Res 40:320-328.
2. Borer JS, Fox K, Jaillon P, and Lerebours G (2003) Antianginal and antiischemic effects of ivabradine, an I(f) inhibitor, in stable angina: a randomized, double-blind, multicentered, placebo-controlled trial. Circulation 107:817-823.
3. 2+-ATPase delays myocardial failure after myocardial infarction in rats at a cost of increased acute arrhythmias. Circulation 109:1898-1903.
4. Colin P, Ghaleh B, Hittinger L, Monnet X, Slama M, Giudicelli JF, and Berdeaux A (2002) Differential effects of heart rate reduction and beta-blockade on left ventricular relaxation during exercise Am J Physiol Heart Circ Physiol 282:H672-H679.
5. Colin P, Ghaleh B, Monnet X, Su J, Hittinger L, Giudicelli JF, and Berdeaux A (2003) Contributions of heart rate and contractility to myocardial oxygen balance during exercise. Am J Physiol Heart Circ Physiol 284:H676-H682.
6. Dangas G and Gorlin R (1997) Changing concepts in the determination of valvular stenosis Prog Cardiovasc Dis 40:55-64.
7. De Sousa E, Veksler V, Minajeva A, Kaasik A, Mateo P, Mayoux E, Hoerter J, Bigard X, Serrurier B, and Ventura-Clapier R (1999) Subcellular creatine kinase alterations. Implications in heart failure. Circ Res 85:68-76.
8. Dedkov EI, Zheng W, Christensen LP, Weiss RM, Mahlberg-Gaudin F, and Tomanek RJ (2007) Preservation of coronary reserve by ivabradine-induced reduction in heart rate in infracted rats is associated with decrease in perivascular collagen. Am J Physiol Heart Circ Physiol 293:H590-H598.
9. Feldman AM, Weinberg EO, Ray PE, and Lorell BH (1993) Selective changes in cardiac gene expression during compensated hypertrophy and the transition to cardiac decompensation in rats with chronic aortic banding. Circ Res 73:184-192.
10. Grimm D, Huber M, Jabusch HC, Shakibaei M, Fredersdorf S, Paul M, Riegger GA, and Kromer EP (2001) Extracellular matrix proteins in cardiac fibroblasts derived from rat hearts with chronic pressure overload: effects of beta-receptor blockade. J Mol Cell Cardiol 33:487-501.
11. Gullestad L, Wikstrand J, Deedwania P, Hjalmarson A, Egstrup K, Elkayam U, Gottlieb S, Rashkow A, Wedel H, Bermann G, et al. (2005) What resting heart rate should one aim for when treating patients with heart failure with a beta-blocker? Experiences from the Metoprolol Controlled Release/Extended Release Randomized Intervention Trial in Chronic Heart Failure (MERIT-HF). J Am Coll Cardiol 45:252-259.
12. Hittinger L, Mirsky I, Shen YT, Patrick TA, Bishop SP, Vatner SF, Shannon RP, Gelpi RJ, and Pfeffer JM (1995) Hemodynamic mechanisms responsible for reduced subendocardial coronary reserve in dogs with severe left ventricular hypertrophy Circulation 92:978-986.
13. Hittinger L, Shannon RP, Bishop SP, Gelpi RJ, Vatner SF, and Pfeffer JM (1989) Subendomyocardial exhaustion of blood flow reserve and increased fibrosis in conscious dogs with heart failure Circ Res 65:971-980.
14. Hu K, Naumann A, Fraccarallo D, Gaudron P, Kaden JJ, Neubauer S, and Ertl G (2004) Heart rate reduction by zatebradine reduces infarct size and promotes remodelling in rats with experimental myocardial infarction. Am J Physiol Heart Circ Physiol 286:H1281-H1288.
15. Indolfi C, Di Lorenzo E, Perrino C, Stingone AM, Curcio A, Torella D, Cittadini A, Cardone L, Coppola C, Cavuto L, et al. (2002) Hydroxymethylglutaryl coenzyme A reductase inhibitor simvastatin prevents cardiac hypertrophy induced by pressure overload and inhibits p21ras activation Circulation 106:2118-2124.
16. 2+ in myocytes from aortic-banded rats. Circulation 94:2915-2922.
17. Laperche T, Logeart D, Cohen-Solal A, and Gourgon R (1999) Potential interests of heart rate lowering drugs. Heart 81:336-341.
18. Lechat P, Hulot JS, Escolano S, Mallet A, Leizorovicz A, Werhlen-Grandjean M, Pochmalicki G, and Dargie H (2001) Heart rate and cardiac rhythm relationships with bisoprolol benefit in chronic heart failure in CIBIS II Trial Circulation 103:1428-1433.
19. Lei L, Zhou R, Zheng W, Christensen LP, Weiss RM, and Tomanek RJ (2004) Bradycardia induces angiogenesis, increases coronary reserve, and preserves function of the postinfarcted heart. Circulation 110:796-802.
20. Leite-Moreira AF, Correia-Pinto J, and Gillebert TC (1999) Afterload induced changes in myocardial relaxation: a mechanism for diastolic dysfunction Cardiovasc Res 43:344-353.
21. Litwin SE, Katz SE, Weinberg EO, Lorell BH, Aurigemma GP, and Douglas PS (1995) Serial echocardiographic-Doppler assessment of left ventricular geometry and function in rats with pressure-overload hypertrophy. Chronic angiotensin-converting enzyme inhibition attenuates the transition to heart failure. Circulation 91:2642-2654.
22. Marano G, Palazzesi S, Fadda A, Vergari A, and Ferrari AU (2002) Attenuation of aortic banding-induced cardiac hypertrophy by propranolol is independent of beta-adrenoceptor blockade. J Hypertens 20:763-769.
23. Mercadier JJ (2007) Determinants of cardiac remodeling and progression to heart failure, in Congestive Heart Failure (Hosenpud J and Greenberg B eds) pp 30-51, Lippincott Williams & Wilkins, Philadelphia, PA.
24. Mulder P, Barbier S, Chagraoui A, Richard V, Henry JP, Lallemand F, Renet S, Lerebours G, Mahlberg-Gaudin F, and Thuillez C (2004) Long-term heart rate reduction induced by the selective I(f) current inhibitor ivabradine improves left ventricular function and intrinsic myocardial structure in congestive heart failure. Circulation 109:1674-1679.
25. Mulieri LA, Hasenfuss G, Leavitt B, Allen PD, and Alpert NR (1992) Altered myocardial force-frequency relation in human heart failure. Circulation 85:1743-1750.
26. Nattel S, Maguy A, Le Bouter S, Yeh YH (2007) Arrhythmogenic ion-channel remodeling in the heart: heart failure, myocardial infarction, and atrial fibrillation. Physiol Rev 87:425-456.
27. Pape D, Goineau S, Guillo P, Ramee MP, and Bellissant E (2002) Early anti-remodeling effect of labetalol in the congestive heart failure model induced by aortic constriction in the guinea pig. J Cardiovasc Pharmacol 39:746-753.
28. Pfeffer JM (1991) Progressive ventricular dilation in experimental myocardial infarction and its attenuation by angiotensin-converting enzyme inhibition. Am J Cardiol 68:17D-25D.
29. Prunier F, Gaertner R, Louedec L, Michel JB, Mercadier JJ, and Escoubet B (2002) Doppler echocardiographic estimation of left ventricular end-diastolic pressure after MI in rats. Am J Physiol Heart Circ Physiol 283:H346-H352.
30. Ross J Jr, Franklin D, and Sasayama S (1976) Preload, afterload, and the role of afterload mismatch in the descending limb of cardiac function. Eur J Cardiol 4 (Suppl):77-86.
31. Shinke T, Takeuchi M, Takaoka H, and Yokoyama M (1999) Beneficial effects of heart rate reduction on cardiac mechanics and energetics in patients with left ventricular dysfunction. Jpn Circ J 63:957-964.
32. Simon L, Ghaleh B, Puybasset L, Giudicelli JF, and Berdeaux A (1995) Coronary and hemodynamic effects of S 16257, a new bradycardic agent, in resting and exercising conscious dogs. J Pharmacol Exp Ther 275:659-666.
33. Slama M, Ahn J, Peltier M, Maizel J, Chemla D, Varagic J, Susic D, Tribouilloy C, and Frohlich ED (2005) Validation of echocardiographic and Doppler indexes of left ventricular relaxation in adult hypertensive and normotensive rats. Am J Physiol Heart Circ Physiol 289:H1131- H1136.
34. Thackray SDR, Ghosh JM, Wright GA, Witte KKA, Nikitin NP, Kaye GC, Clark AL, Tweddel A, and Cleland JGF (2006) The effect of altering heart rate on ventricular function in patients with heart failure treated with β-blockers. Am Heart J 152:713.e9-713.e13.
35. Vilaine JP (2006) The discovery of the selective I(f) current inhibitor ivabradine. A new therapeutic approach to ischemic heart disease. Pharmacol Res 53:424-434.
36. Weinberg EO, Schoen FJ, George D, Kagaya Y, Douglas PS, Litwin SE, Schunkert H, Benedict CR, and Lorell BH (1994) Angiotensin-converting enzyme inhibition prolongs survival and modifies the transition to heart failure in rats with pressure overload hypertrophy due to ascending aortic stenosis. Circulation 90:1410-1422.
37. Yamakawa H, Takeuchi M, Takaoka H, Hata K, Mori M, and Yokoyama M (1996) Negative chronotropic effect of beta-blockade therapy reduces myocardial oxygen expenditure for nonmechanical work. Circulation 94:340-345.