메뉴 건너뛰기




Volumn 71, Issue 5, 2010, Pages 285-293

Structure-activity relationships of isoeugenol-based chlorophenylpiperazine derivatives on serotonergic/adrenergic receptor, platelet aggregation, and lipid peroxidation

Author keywords

Adrenoceptor; Anti aggregation; Antioxidant; Serotonergic receptor

Indexed keywords

(3 CHLOROPHENYL)PIPERAZINE; 5 NONYLOXYTRYPTAMINE; ADRENALIN; ADRENERGIC RECEPTOR; ALPHA 1 ADRENERGIC RECEPTOR; ALPHA 2 ADRENERGIC RECEPTOR; ASCORBIC ACID; CLONIDINE; EUGENOSEDIN A; EUGENOSEDIN B; EUGENOSEDIN C; ISOEUGENOL; KETANSERIN; METHYSERGIDE; NORADRENALIN; SEROTONIN; SEROTONIN 1B RECEPTOR; SEROTONIN 2A RECEPTOR; SEROTONIN RECEPTOR; TRYPTAMINE; UNCLASSIFIED DRUG; YOHIMBINE;

EID: 77955988103     PISSN: 02724391     EISSN: 10982299     Source Type: Journal    
DOI: 10.1002/ddr.20373     Document Type: Article
Times cited : (3)

References (23)
  • 1
    • 0023882386 scopus 로고
    • Alpha-2A and alpha-2B adrenergic receptor subtypes: Antagonist binding in tissues and cell lines containing only one subtype
    • Bylund DB, Blaxall HS, Murphy TJ. 1988. Alpha-2A and alpha-2B adrenergic receptor subtypes: antagonist binding in tissues and cell lines containing only one subtype. J Pharmacol Exp Ther 245:600-607.
    • (1988) J Pharmacol Exp Ther , vol.245 , pp. 600-607
    • Bylund, D.B.1    Blaxall, H.S.2    Murphy, T.J.3
  • 4
    • 0034945604 scopus 로고    scopus 로고
    • A new aspect of view in synthesizing new type beta-adrenoceptor blockers with ancillary antioxidant activities
    • Huang YC, Wu BN, Yeh JL, Chen SJ, Liang JC, Lo YC, Chen IJ. 2001. A new aspect of view in synthesizing new type beta-adrenoceptor blockers with ancillary antioxidant activities. Bioorg Med Chem 9:1739-1746.
    • (2001) Bioorg Med Chem , vol.9 , pp. 1739-1746
    • Huang, Y.C.1    Wu, B.N.2    Yeh, J.L.3    Chen, S.J.4    Liang, J.C.5    Lo, Y.C.6    Chen, I.J.7
  • 6
    • 0034011690 scopus 로고    scopus 로고
    • Affinity of trazodone for human penile alpha1- and alpha2-adrenoceptors
    • Krege S, Goepel M, Sperling H, Michel MC. 2000. Affinity of trazodone for human penile alpha1- and alpha2-adrenoceptors. BJU Int 85:959-961.
    • (2000) BJU Int , vol.85 , pp. 959-961
    • Krege, S.1    Goepel, M.2    Sperling, H.3    Michel, M.C.4
  • 7
    • 0024443085 scopus 로고
    • The effect of ketanserin on serotonin-induced vascular responses in the isolated perfused rat lung
    • Le Roux MGJ, Syce JA. 1989. The effect of ketanserin on serotonin-induced vascular responses in the isolated perfused rat lung. Eur J Pharmacol 169:269-273.
    • (1989) Eur J Pharmacol , vol.169 , pp. 269-273
    • Le Roux, M.G.J.1    Syce, J.A.2
  • 8
    • 0030273912 scopus 로고    scopus 로고
    • The alpha 2-adrenoceptor antagonist idazoxan is an agonist at 5-HT1A autoreceptors modulating serotonin synthesis in the rat brain in vivo
    • Llado J, Esteban S, Garcia-Sevilla JA. 1996. The alpha 2-adrenoceptor antagonist idazoxan is an agonist at 5-HT1A autoreceptors modulating serotonin synthesis in the rat brain in vivo. Neurosci Lett 218:111-114.
    • (1996) Neurosci Lett , vol.218 , pp. 111-114
    • Llado, J.1    Esteban, S.2    Garcia-Sevilla, J.A.3
  • 10
    • 0034209633 scopus 로고    scopus 로고
    • 2-adrenoceptor inhibitor, binds to human platelets and inhibits their epinephrine-induced aggregation more effectively than yohimbine
    • 2-adrenoceptor inhibitor, binds to human platelets and inhibits their epinephrine-induced aggregation more effectively than yohimbine. Thromb Res 99:231-237.
    • (2000) Thromb Res , vol.99 , pp. 231-237
    • Mustonen, P.1    Savola, J.M.2    Lassila, R.3
  • 12
    • 4644316413 scopus 로고    scopus 로고
    • Metipranolol blunts nitric oxide-induced lipid peroxidation and death of retinal photoreceptors: A comparison with other anti-glaucoma drugs
    • Osborne NN, Wood JP. 2004. Metipranolol blunts nitric oxide-induced lipid peroxidation and death of retinal photoreceptors: a comparison with other anti-glaucoma drugs. Invest Ophthalmol Vis Sci 45:3787-3795.
    • (2004) Invest Ophthalmol Vis Sci , vol.45 , pp. 3787-3795
    • Osborne, N.N.1    Wood, J.P.2
  • 14
    • 2342597853 scopus 로고    scopus 로고
    • Hypotensive effects of eugenosedin-A with serotonin, alpha- and beta-adrenoceptor antagonistic activities in spontaneously hypertensive and normotensive rats
    • Shen KP, Chiu CC, Chen SJ, Chen IJ, Wu BN. 2004. Hypotensive effects of eugenosedin-A with serotonin, alpha- and beta-adrenoceptor antagonistic activities in spontaneously hypertensive and normotensive rats. Pharmacology 71:91-101.
    • (2004) Pharmacology , vol.71 , pp. 91-101
    • Shen, K.P.1    Chiu, C.C.2    Chen, S.J.3    Chen, I.J.4    Wu, B.N.5
  • 15
    • 11144348137 scopus 로고    scopus 로고
    • Antioxidant eugenosedin-A protects against lipopolysaccharide-induced hypotension, hyperglycaemia and cytokine immunoreactivity in rats and mice
    • Shen KP, Lo YC, Yang RC, Liu HW, Chen IJ, Wu BN. 2005. Antioxidant eugenosedin-A protects against lipopolysaccharide- induced hypotension, hyperglycaemia and cytokine immunoreactivity in rats and mice. J Pharm Pharmacol 57:117-125.
    • (2005) J Pharm Pharmacol , vol.57 , pp. 117-125
    • Shen, K.P.1    Lo, Y.C.2    Yang, R.C.3    Liu, H.W.4    Chen, I.J.5    Wu, B.N.6
  • 16
    • 34447328488 scopus 로고    scopus 로고
    • Eugenosedin-A amelioration of lipopolysaccharide-induced up-regulation of p38 MAPK, inducible nitric oxide synthase and cyclooxygenase-2
    • DOI 10.1211/jpp.59.6.0015
    • Shen KP, Liou SF, Hsieh SL, Chen IJ, Wu BN. 2007. Eugenosedin-A amelioration of lipopolysaccharide-induced up-regulation of p38 MAPK, inducible nitric oxide synthase and cyclooxygenase-2. J Pharm Pharmacol 59:879-889. (Pubitemid 47051101)
    • (2007) Journal of Pharmacy and Pharmacology , vol.59 , Issue.6 , pp. 879-889
    • Shen, K.-P.1    Liou, S.-F.2    Hsieh, S.-L.3    Chen, I.-J.4    Wu, B.-N.5
  • 17
    • 39749155191 scopus 로고    scopus 로고
    • Hypotensive and antiaggregative effects of eugenosedin-B with serotonin and alpha/beta-adrenoceptor antagonistic activities in rats and human platelets
    • Shen KP, Chu LW, Hsieh SL, An LM, Chen IJ, Wu BN. 2008. Hypotensive and antiaggregative effects of eugenosedin-B with serotonin and alpha/beta- adrenoceptor antagonistic activities in rats and human platelets. J Cardiovasc Pharmacol 51:154-161.
    • (2008) J Cardiovasc Pharmacol , vol.51 , pp. 154-161
    • Shen, K.P.1    Chu, L.W.2    Hsieh, S.L.3    An, L.M.4    Chen, I.J.5    Wu, B.N.6
  • 19
    • 0033006102 scopus 로고    scopus 로고
    • In vitro inhibitory effect of sarpogrelate hydrochloride on serotonin-induced platelet small-aggregate formation
    • Suehiro A, Marumo M, Yoshimoto H, Higasa S, Kakishita E. 1999. In vitro inhibitory effect of sarpogrelate hydrochloride on serotonin-induced platelet small-aggregate formation. Curr Ther Res 60:81-86.
    • (1999) Curr Ther Res , vol.60 , pp. 81-86
    • Suehiro, A.1    Marumo, M.2    Yoshimoto, H.3    Higasa, S.4    Kakishita, E.5
  • 21
    • 0029124690 scopus 로고
    • 2-adrenoceptors in the cardiovascular effects of monoxidine
    • 2- adrenoceptors in the cardiovascular effects of monoxidine. Eur J Pharmacol 282:19-28.
    • (1995) Eur J Pharmacol , vol.282 , pp. 19-28
    • Urban, R.1    Szabo, B.2    Starke, K.3
  • 22
    • 34848814533 scopus 로고    scopus 로고
    • Activation of BKCa channels via cyclic AMP- and cyclic GMP-dependent protein kinases by eugenosedin-A in rat basilar artery myocytes
    • Wu BN, Chen CF, Hong YR, Howng SL, Lin YL, Chen IJ. 2007. Activation of BKCa channels via cyclic AMP- and cyclic GMP-dependent protein kinases by eugenosedin-A in rat basilar artery myocytes. Br J Pharmacol 152:374-385.
    • (2007) Br J Pharmacol , vol.152 , pp. 374-385
    • Wu, B.N.1    Chen, C.F.2    Hong, Y.R.3    Howng, S.L.4    Lin, Y.L.5    Chen, I.J.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.