In vitro inhibitory effect of sarpogrelate hydrochloride on serotonin- induced platelet small-aggregate formation

Current Therapeutic Research - Clinical and Experimental

Volumn 60, Issue 2, 2000, Pages 81-86

  Suehiro, Akira ^a   Marumo, Mikio ^a   Yoshimoto, Hiroshi ^a   Higasa, Satoshi ^a   Kakishita, Eizo ^a  

^a HYOGO COLLEGE OF MEDICINE   (Japan)

Author keywords

Light scattering method; Platelet small aggregate; Sarpogrelate; Serotonin

Indexed keywords

ANTITHROMBOCYTIC AGENT; SARPOGRELATE; SEROTONIN; SEROTONIN 2 ANTAGONIST;

ADULT; ARTICLE; DOSE RESPONSE; DRUG EFFECT; HUMAN; HUMAN CELL; LIGHT SCATTERING; MALE; PRIORITY JOURNAL; THROMBOCYTE AGGREGATION; THROMBOCYTE AGGREGATION INHIBITION; THROMBOGENESIS; THROMBOSIS;

EID: 0033006102     PISSN: 0011393X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0011-393X(00)88485-4     Document Type: Article

References (10)

1. Stoltz JF. Uptake and storage of serotonin by platelets. In: Vanhoutte PM, ed. Serotonin and the Cardiovascular System. New York: Raven Press; 1985:37-42.
2. De Clerck F, Herman AG. 5-Hydroxytryptamine and platelet aggregation. Fed Proc. 1983;42:228-232.
3. 2A) receptors. Cardiovasc Drug Rev. 1997;15:102-121.
4. Hara H, Osakabe M, Kitajima A, et al. MCI-9042, a new antiplatelet agent is a selective S2-serotonergic receptor antagonist. Thromb Haemost. 1991;65:415-420.
5. Ozaki Y, Satoh K, Yatomi Y, et al. Detection of platelet aggregates with a particle counting method using light scattering. Anal Biochem. 1994;218:284-294.
6. Qi R, Ozaki Y, Yang L-B, et al. Intracellular levels of cyclic AMP and cyclic GMP differentially modify platelet aggregate size in human platelets activated with epinephrine or ADP. J Cardiovasc Pharmacol. 1996;28:215-222.
7. Qi R, Ozaki Y, Satoh K, et al. Quantitative measurement of various 5-HT receptor antagonists on platelet activation induced by serotonin. Thromb Res. 1996;81:43-54.
8. Tohgi H, Takahashi H, Watanabe K, et al. Development of large platelet aggregates from small aggregates as determined by laser-light scattering: Effects of aggregant concentration and antiplatelet medication. Thromb Haemost. 1996;75:838-843.
9. Emson PC, Gilbert RFT, Martensson H, Nobin A. Elevated concentrations of substance P and 5-HT in plasma in patients with carcinoid tumors. Cancer. 1984;54:715-718.
10. Zeller J, Weissbarth E, Barwth B, et al. Serotonin content of platelets in inflammatory rheumatic diseases. Arthritis Rheum. 1983;26:532-540.