Cytotoxicity and antitumoral activity of dichloromethane extract and its fractions from Pothomorphe umbellata

Brazilian Journal of Medical and Biological Research

Volumn 41, Issue 5, 2008, Pages 411-415

  Sacoman, Juliana L ^a   Monteiro, K M ^a   Possenti, A ^a   Figueira, G M ^a   Foglio, M A ^a   Carvalho, J E ^a  

^a UNIVERSITY OF CAMPINAS   (Brazil)

Author keywords

Antitumor activity; Ehrlich ascites tumor; Piperaceae; Pothomorphe umbellata

Indexed keywords

4 NEROLIDYLCATHECOL; CAMPESTEROL; DICHLOROMETHANE; DOXORUBICIN; OXALIC ACID DERIVATIVE; PLANT EXTRACT; PLANT MEDICINAL PRODUCT; POTHOMORPHE UMBELLATA EXTRACT; SITOSTEROL; SODIUM CHLORIDE; STIGMASTEROL;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL CULTURE; CANCER INHIBITION; CANCER SURVIVAL; CELL PROLIFERATION; CELL VIABILITY; COLUMN CHROMATOGRAPHY; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOTOXICITY; DOSE RESPONSE; DRUG DOSE COMPARISON; DRUG SELECTIVITY; EHRLICH ASCITES TUMOR; HUMAN; HUMAN CELL; LD 50; MALE; MOUSE; NONHUMAN; PIPERACEAE; POTHOMORPHE UMBELLATA; PROTEIN CONTENT; SOLVENT EXTRACTION;

ANIMALIA; LEPIANTHES PELTATA; PIPERACEAE;

EID: 48249095974     PISSN: 0100879X     EISSN: 1414431X     Source Type: Journal    
DOI: 10.1590/S0100-879X2008000500010     Document Type: Article

References (19)

1. Rates SM. Plants as source of drugs. Toxicon 2001: 39: 603-613.
2. Moraes MS. Consideration about official Pariparoba Pothomorphe umbellata (L.). Miq Rev Bras Farmacog 1986; 1: 101-108.
3. Silva RAD. Pharmacopeia dos Estados Unidos do Brasil. 1st edn. São Paulo: Companhia Editora Nacional; 1926.
4. Ropke CD, Sawada TC, da Silva V, Michalany NS, de Moraes Barros SB. Photoprotective effect of Pothomorphe- umbellata root extract against ultraviolet radiation induced chronic skin damage in the hairless mouse. Clin Exp Dermatol 2005; 30: 272-276.
5. Perazzo FF, Souza GH, Lopes W, Cardoso LG, Carvalho JC, Nanayakkara NP, et al. Anti-inflammatory and analgesic properties of water-ethanolic extract from Pothomorphe umbellata (Piperaceae) aerial parts. J Ethnopharmacol 2005; 99: 215-220.
6. Nunez V, Castro V, Murillo R, Ponce-Soto LA, Merfort I, Lomonte B. Inhibitory effects of Piper umbellatum and Piper peltatum extracts towards myotoxic phosphotipases A2 from Bothrops snake venoms: isolation of 4-nerolidylcatechol as active principle. Phytochemistry 2005; 66: 1017-1025.
7. Kijoa A, Glesbrecht AM, Akisue MK, Gottlieb OR, Gottlieb HE. 4-Nerolidylcalechol from Pothomorphe umbellata. Planta Med 1980; 39: 85-87.
8. Mongelli E, Romano A, Desmarchelier C, Coussio J, Ciccia G. Cytotoxic 4-nerolidylcatechol from Pothomorphe peltata inhibits topoisomerase I activity. Planta Med 1999; 65: 376-378.
9. Pinto ACS, Pessoa C, Lotufo LVC, Moraes MOM, Moraes ME, Cavalcanti BC, et al. In vitro cytotoxicity of Pothomorphe peltata (L.) Miquel (Piperaceae) isolated 4-nerolidylcatechol and its semi-synthetic diacetyl derivative. Rev Bras PI Med 2006; 8: 205-211.
10. Skehan P, Storeng R, Scudiero D, Monks A, McMahon J, Vistica D, et al. New colorimetric cytotoxicity assay for anti-cancer-drug screening. J Natl Cancer Inst 1990; 82: 1107-1112.
11. Holbeck SL. Update on NCI in vitro drug screen utilities. Eur J Cancer 2004; 40: 785-793.
12. Litchfield JT Jr, Wilcoxon F. The reliability of graphic estimates of relative potency from dose-per cent effect curves. J Pharmacol Exp Ther 1953; 108: 18-25.
13. Vincent PC, Nicholls A. Comparison of the growth of the Ehrlich ascites tumor in male and female mice. Cancer Res 1967; 27: 1058-1065.
14. Ullman-Cullere MH, Foltz CJ. Body condition scoring: a rapid and accurate method for assessing health status in mice. Lab Anim Sci 1999; 49: 319-323.
15. Adams RP. Identification of essential oil components by gas chromatography/mass spectroscopy. Carol Stream: Allured Publishing Corporation; 1995.
16. Gustafson KR, Cardellina JH, McMahon JB, Pannell LK, Cragg GM, Boyd MR. The peltatols, novel HIV-inhibitory catechol derivatives from Pothomorphe umbellata. J Org Chem 1992; 57: 2809-2811.
17. Awad AB, Fink CS. Phytosterols as anticancer dietary components: evidence and mechanism of action. J Nutr 2000; 130: 2127-2130.
18. Meric JB, Rottey S, Olaussen K, Soria JC, Khayat D, Rixe O, et al. Cyclooxygenase-2 as a target for anticancer drug development. Crit Rev Oncol Hematol 2006; 59: 51-64.
19. Parmar VS, Jain SC, Bisht KS, Jain R, Taneja P, Jha A, et al. Phytochemistry of genus Piper. Phytochemistry 1997; 46: 597-673.