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Volumn 8, Issue 2, 2010, Pages 68-76

Thrombospondins and novel TSR-containing proteins, R-spondins, regulate bone formation and remodeling

Author keywords

Bone regeneration; Osteoblast; R spondins; Thrombospondins

Indexed keywords

CARTILAGE OLIGOMERIC MATRIX PROTEIN; REGULATOR PROTEIN; ROOF PLATE SPECIFIC SPONDIN; ROOF PLATE SPECIFIC SPONDIN 1; ROOF PLATE SPECIFIC SPONDIN 2; ROOF PLATE SPECIFIC SPONDIN 3; ROOF PLATE SPECIFIC SPONDIN 4; SCLEROPROTEIN; SECRETORY PROTEIN; THROMBOSPONDIN; THROMBOSPONDIN 1; THROMBOSPONDIN 2; THROMBOSPONDIN 3; THROMBOSPONDIN 4; UNCLASSIFIED DRUG; RSPO4 PROTEIN, HUMAN;

EID: 77955984390     PISSN: 15441873     EISSN: 15442241     Source Type: Journal    
DOI: 10.1007/s11914-010-0017-0     Document Type: Review
Times cited : (37)

References (56)
  • 1
    • 33746561028 scopus 로고    scopus 로고
    • Matricellular proteins: Extracellular modulators of bone development, remodeling, and regeneration
    • Alford AI, Hankenson KD: Matricellular proteins: extracellular modulators of bone development, remodeling, and regeneration. Bone 206, 38:749-757.
    • Bone , vol.206 , Issue.38 , pp. 749-757
    • Alford, A.I.1    Hankenson, K.D.2
  • 2
    • 0035049231 scopus 로고    scopus 로고
    • Thrombospondins as matricellular modulators of cell function
    • Bornstein P: Thrombospondins as matricellular modulators of cell function. J Clin Invest 2001, 107:929-934.
    • (2001) J Clin Invest , vol.107 , pp. 929-934
    • Bornstein, P.1
  • 3
    • 0027198824 scopus 로고
    • The evolution of thethrombospondin gene family
    • Lawler J, Duquette M, Urry L, et al.: The evolution of thethrombospondin gene family. J Mol Evol 1993, 36:509-516.
    • (1993) J Mol Evol , vol.36 , pp. 509-516
    • Lawler, J.1    Duquette, M.2    Urry, L.3
  • 5
    • 0035178990 scopus 로고    scopus 로고
    • Thrombospondins: Multifunctional regulators of cell interactions
    • Adams JC: Thrombospondins: multifunctional regulators of cell interactions. Annu Rev Cell Dev Biol 2001, 17:25-51.
    • (2001) Annu Rev Cell Dev Biol , vol.17 , pp. 25-51
    • Adams, J.C.1
  • 6
    • 0033734115 scopus 로고    scopus 로고
    • Thrombospondin 2, a matricellular protein with diverse functions
    • Bornstein P, Armstrong LC, Hankenson KD, et al.: Thrombospondin 2, a matricellular protein with diverse functions. Matrix Biol 2000, 19:557-568.
    • (2000) Matrix Biol , vol.19 , pp. 557-568
    • Bornstein, P.1    Armstrong, L.C.2    Hankenson, K.D.3
  • 7
    • 0033818794 scopus 로고    scopus 로고
    • The functions of thrombospondin-1 and-2. Curr Opin
    • Lawler J: The functions of thrombospondin-1 and-2. Curr Opin Cell Biol 2000, 12:634-640.
    • (2000) Cell Biol , vol.12 , pp. 634-640
    • Lawler, J.1
  • 8
    • 3242772439 scopus 로고    scopus 로고
    • The thrombospondin type 1 repeat superfamily
    • Tucker RP: The thrombospondin type 1 repeat superfamily. Int J Biochem Cell Biol 2004, 36:969-974.
    • (2004) Int J Biochem Cell Biol , vol.36 , pp. 969-974
    • Tucker, R.P.1
  • 9
    • 0037191047 scopus 로고    scopus 로고
    • Crystal structure of the TSP-1 type 1 repeats: A novel layered fold and its biological implication
    • Tan K, Duquette M, Liu JH, et al.: Crystal structure of the TSP-1 type 1 repeats: a novel layered fold and its biological implication. J Cell Biol 2002, 159:373-382.
    • (2002) J Cell Biol , vol.159 , pp. 373-382
    • Tan, K.1    Duquette, M.2    Liu, J.H.3
  • 10
    • 12344320716 scopus 로고    scopus 로고
    • Thrombospondin-1 is a major activator of TGF-beta1 in vivo
    • Crawford SE, Stellmach V, Murphy-Ullrich JE, et al.: Thrombospondin-1 is a major activator of TGF-beta1 in vivo. Cell 1998, 93:1159-1170.
    • (1998) Cell , vol.93 , pp. 1159-1170
    • Crawford, S.E.1    Stellmach, V.2    Murphy-Ullrich, J.E.3
  • 11
    • 65849384082 scopus 로고    scopus 로고
    • The role of cartilage oligomeric matrix protein (COMP) in skeletal disease
    • Posey KL, Hecht JT: The role of cartilage oligomeric matrix protein (COMP) in skeletal disease. Curr Drug Targets 2008, 9:869-877.
    • (2008) Curr Drug Targets , vol.9 , pp. 869-877
    • Posey, K.L.1    Hecht, J.T.2
  • 12
    • 0032545314 scopus 로고    scopus 로고
    • Identification of twelve mutations in cartilage oligomeric matrix protein (COMP) in patients with pseudoachondroplasia
    • Deere M, Sanford T, Ferguson HL, et al.: Identification of twelve mutations in cartilage oligomeric matrix protein (COMP) in patients with pseudoachondroplasia. Am J Med Genet 1998, 80:510-513.
    • (1998) Am J Med Genet , vol.80 , pp. 510-513
    • Deere, M.1    Sanford, T.2    Ferguson, H.L.3
  • 13
    • 33645318206 scopus 로고    scopus 로고
    • R-Spondin proteins: A novel link to beta-catenin activation
    • Kim KA, Zhao J, Andarmani S, et al.: R-Spondin proteins: a novel link to beta-catenin activation. Cell Cycle 2006, 5:23-26.
    • (2006) Cell Cycle , vol.5 , pp. 23-26
    • Kim, K.A.1    Zhao, J.2    Andarmani, S.3
  • 14
    • 0027199292 scopus 로고
    • Differential expression of thrombospondin 1, 2, and 3 during murine development
    • Iruela-Arispe ML, Liska DJ, Sage EH, et al.: Differential expression of thrombospondin 1, 2, and 3 during murine development. Dev Dyn 1993, 197:40-56.
    • (1993) Dev Dyn , vol.197 , pp. 40-56
    • Iruela-Arispe, M.L.1    Liska, D.J.2    Sage, E.H.3
  • 15
    • 0031668289 scopus 로고    scopus 로고
    • The distribution of the matricellular protein, thrombospondin 2, in tissues of embryonic and adult mice
    • Kyriakides TR, Zhu YH, Yang Z, et al.: The distribution of the matricellular protein, thrombospondin 2, in tissues of embryonic and adult mice. J Histochem Cytochem 1998, 46:1007-1015.
    • (1998) J Histochem Cytochem , vol.46 , pp. 1007-1015
    • Kyriakides, T.R.1    Zhu, Y.H.2    Yang, Z.3
  • 16
    • 66349123284 scopus 로고    scopus 로고
    • Thrombospondin-2 influences the proportion of cartilage and bone during fracture healing
    • This study shows that the absence of TSP2 results in alterations in cartilage and bone content in fracture healing
    • Taylor DK, Meganck JA, Terkhorn S, et al.: Thrombospondin-2 influences the proportion of cartilage and bone during fracture healing. J Bone Miner Res 2009, 24:1043-1054. This study shows that the absence of TSP2 results in alterations in cartilage and bone content in fracture healing.
    • (2009) J Bone Miner Res , vol.24 , pp. 1043-1054
    • Taylor, D.K.1    Meganck, J.A.2    Terkhorn, S.3
  • 17
    • 74249111900 scopus 로고    scopus 로고
    • Thrombospondin-2 regulates matrix mineralization in MC3T3- E1 pre-osteoblasts
    • This study shows that TSP2 regulates osteoblastogenesis independent of effects on proliferation
    • Alford AI, Terkhorn SP, Reddy AB, Hankenson KD: Thrombospondin-2 regulates matrix mineralization in MC3T3- E1 pre-osteoblasts. Bone 2010, 46:464-471. This study shows that TSP2 regulates osteoblastogenesis independent of effects on proliferation.
    • (2010) Bone , vol.46 , pp. 464-471
    • Alford, A.I.1    Terkhorn, S.P.2    Reddy, A.B.3    Hankenson, K.D.4
  • 18
    • 72449157009 scopus 로고    scopus 로고
    • Thrombospondin-2 and SPARC/osteonectin are critical regulators of bone remodeling
    • Delany A, Hankenson K: Thrombospondin-2 and SPARC/osteonectin are critical regulators of bone remodeling. J Cell Commun Signal 2009, 3:227-238.
    • (2009) J Cell Commun Signal , vol.3 , pp. 227-238
    • Delany, A.1    Hankenson, K.2
  • 19
    • 67349123805 scopus 로고    scopus 로고
    • Role of hypoxia-inducible factor-1α in angiogenic-osteogenic coupling
    • Riddle R, Khatri R, Schipani E, et al.: Role of hypoxia-inducible factor-1α in angiogenic-osteogenic coupling. J Mol Med 2009, 87:583-590.
    • (2009) J Mol Med , vol.87 , pp. 583-590
    • Riddle, R.1    Khatri, R.2    Schipani, E.3
  • 20
    • 65549162693 scopus 로고    scopus 로고
    • Thrombospondin2 potentiates notch3/jagged1 signaling
    • Meng H, Zhang X, Hankenson KD, et al.: Thrombospondin2 potentiates notch3/jagged1 signaling. J Biol Chem 2009, 284: 7866-7874.
    • (2009) J Biol Chem , vol.284 , pp. 7866-7874
    • Meng, H.1    Zhang, X.2    Hankenson, K.D.3
  • 21
    • 74249112642 scopus 로고    scopus 로고
    • NOTCHing the bone: Insights into multifunctionality
    • Engin F, Lee B: NOTCHing the bone: insights into multifunctionality. Bone 2010, 46:274-280.
    • (2010) Bone , vol.46 , pp. 274-280
    • Engin, F.1    Lee, B.2
  • 22
    • 33749261278 scopus 로고    scopus 로고
    • Constitutive expression of thrombospondin 1 in MC3T3-E1 osteoblastic cells inhibits mineralization
    • Akemichi U, Yoshihiro M, Keiko M, et al.: Constitutive expression of thrombospondin 1 in MC3T3-E1 osteoblastic cells inhibits mineralization. J Cell Physiol 2006, 209:322-332.
    • (2006) J Cell Physiol , vol.209 , pp. 322-332
    • Akemichi, U.1    Yoshihiro, M.2    Keiko, M.3
  • 23
    • 33750230190 scopus 로고    scopus 로고
    • Effects of THBS3, SPARC and SPP1 expression on biological behavior and survival in patients with osteosarcoma
    • Dalla-Torre C, Yoshimoto M, Lee CH, et al.: Effects of THBS3, SPARC and SPP1 expression on biological behavior and survival in patients with osteosarcoma. BMC Cancer 2006, 6:237.
    • (2006) BMC Cancer , vol.6 , pp. 237
    • Dalla-Torre, C.1    Yoshimoto, M.2    Lee, C.H.3
  • 24
    • 20744460867 scopus 로고    scopus 로고
    • Mice with a disruption of the thrombospondin 3 gene differ in geometric and biomechanical properties of bone and have accelerated development of the femoral head
    • Hankenson KD, Hormuzdi SG, Meganck JA, et al.: Mice with a disruption of the thrombospondin 3 gene differ in geometric and biomechanical properties of bone and have accelerated development of the femoral head. Mol Cell Biol 2005, 25:5599-5606.
    • (2005) Mol Cell Biol , vol.25 , pp. 5599-5606
    • Hankenson, K.D.1    Hormuzdi, S.G.2    Meganck, J.A.3
  • 25
    • 44849140776 scopus 로고    scopus 로고
    • Skeletal abnormalities in mice lacking extracellular matrix proteins, thrombospondin-1, thrombospondin-3, thrombospondin-5, and type IX collagen
    • This study showed significant defects in growth cartilage in compound TSP1/ 3/5 knockout mice
    • Posey KL, Hankenson K, Veerisetty AC, et al.: Skeletal abnormalities in mice lacking extracellular matrix proteins, thrombospondin-1, thrombospondin-3, thrombospondin-5, and type IX collagen. Am J Pathol 2008, 172:1664-1674. This study showed significant defects in growth cartilage in compound TSP1/ 3/5 knockout mice.
    • (2008) Am J Pathol , vol.172 , pp. 1664-1674
    • Posey, K.L.1    Hankenson, K.2    Veerisetty, A.C.3
  • 26
    • 0034232653 scopus 로고    scopus 로고
    • Molecular cloning, sequencing, and tissue and developmental expression of mouse cartilage oligomeric matrix protein (COMP)
    • Fang C, Carlson CS, Leslie MP, et al.: Molecular cloning, sequencing, and tissue and developmental expression of mouse cartilage oligomeric matrix protein (COMP). J Orthop Res 2000, 18:593-603.
    • (2000) J Orthop Res , vol.18 , pp. 593-603
    • Fang, C.1    Carlson, C.S.2    Leslie, M.P.3
  • 27
    • 28244435801 scopus 로고    scopus 로고
    • In vivo human Cartilage oligomeric matrix protein (COMP) promoter activity
    • Posey KL, Davies S, Bales ES, et al.: In vivo human Cartilage oligomeric matrix protein (COMP) promoter activity. Matrix Biol 2005, 24:539-549.
    • (2005) Matrix Biol , vol.24 , pp. 539-549
    • Posey, K.L.1    Davies, S.2    Bales, E.S.3
  • 28
    • 33646443505 scopus 로고    scopus 로고
    • Clinical significance of decreased serum concentration of cartilage oligomeric matrix protein in systemic juvenile idiopathic arthritis
    • Urakami T, Manki A, Inoue T, et al.: Clinical significance of decreased serum concentration of cartilage oligomeric matrix protein in systemic juvenile idiopathic arthritis. J. Rheumatol 2006, 33:996-1000.
    • (2006) J. Rheumatol , vol.33 , pp. 996-1000
    • Urakami, T.1    Manki, A.2    Inoue, T.3
  • 29
    • 70449586524 scopus 로고    scopus 로고
    • Cartilage oligomeric matrix protein is involved in human limb development and in the pathogenesis of osteoarthritis
    • Koelling S, Clauditz TS, Kaste M, et al.: Cartilage oligomeric matrix protein is involved in human limb development and in the pathogenesis of osteoarthritis. Arthritis Res Ther 2006, 8:R56.
    • (2006) Arthritis Res Ther , vol.8
    • Koelling, S.1    Clauditz, T.S.2    Kaste, M.3
  • 30
    • 2942597560 scopus 로고    scopus 로고
    • Interactions between the cartilage oligomeric matrix protein and matrilins. Implications for matrix assembly and the pathogenesis of chondrodysplasias
    • Mann HH, Ozbek S, Engel J, et al.: Interactions between the cartilage oligomeric matrix protein and matrilins. Implications for matrix assembly and the pathogenesis of chondrodysplasias. J Biol Chem 2004, 279:25294-25298.
    • (2004) J Biol Chem , vol.279 , pp. 25294-25298
    • Mann, H.H.1    Ozbek, S.2    Engel, J.3
  • 31
    • 0029035708 scopus 로고
    • Mutations in exon 17B of cartilage oligomeric matrix protein (COMP) cause pseudoachondroplasia
    • Hecht JT, Nelson LD, Crowder E, et al.: Mutations in exon 17B of cartilage oligomeric matrix protein (COMP) cause pseudoachondroplasia. Nat Genet 1995, 10:325-329.
    • (1995) Nat Genet , vol.10 , pp. 325-329
    • Hecht, J.T.1    Nelson, L.D.2    Crowder, E.3
  • 33
    • 0032432979 scopus 로고    scopus 로고
    • Retention of cartilage oligomeric matrix protein (COMP) and cell death in redifferentiated pseudoachondroplasia chondrocytes
    • Hecht JT, Montufar-Solis D, Decker G, et al.: Retention of cartilage oligomeric matrix protein (COMP) and cell death in redifferentiated pseudoachondroplasia chondrocytes. Matrix Biol 1998, 17:625-633.
    • (1998) Matrix Biol , vol.17 , pp. 625-633
    • Hecht, J.T.1    Montufar-Solis, D.2    Decker, G.3
  • 34
  • 35
    • 33847030829 scopus 로고    scopus 로고
    • Unique matrix structurein the rough endoplasmic reticulum cisternae of pseudoachondroplasia chondrocytes
    • Merritt TM, Bick R, Poindexter BJ, et al.: Unique matrix structurein the rough endoplasmic reticulum cisternae of pseudoachondroplasia chondrocytes. Am J Pathol 2007, 170:293-300
    • (2007) Am J Pathol , vol.170 , pp. 293-300
    • Merritt, T.M.1    Bick, R.2    Poindexter, B.J.3
  • 36
    • 0036264997 scopus 로고    scopus 로고
    • Cartilage oligomeric matrix protein-deficient mice have normal skeletal development
    • Svensson L, Aszodi A, Heinegard D, et al.: Cartilage oligomeric matrix protein-deficient mice have normal skeletal development. Mol Cell Biol 2002, 22:4366-4371.
    • (2002) Mol Cell Biol , vol.22 , pp. 4366-4371
    • Svensson, L.1    Aszodi, A.2    Heinegard, D.3
  • 37
    • 73549096658 scopus 로고    scopus 로고
    • An inducible cartilage oligomeric matrix protein mouse model recapitulates humanpseudoachondroplasia phenotype
    • This seminal study shows that a mouse model of a TSP5 mutation recapitulates the human PSACH condition
    • Posey KL, Veerisetty AC, Liu P, et al.: An inducible cartilage oligomeric matrix protein mouse model recapitulates humanpseudoachondroplasia phenotype. Am J Pathol 2009, 175:1555-1563. This seminal study shows that a mouse model of a TSP5 mutation recapitulates the human PSACH condition.
    • (2009) Am J Pathol , vol.175 , pp. 1555-1563
    • Posey, K.L.1    Veerisetty, A.C.2    Liu, P.3
  • 38
    • 34548317505 scopus 로고    scopus 로고
    • Interaction of cartilage oligomeric matrix protein/thrombospondin 5 with aggrecan
    • Chen FH, Herndon ME, Patel N, et al.: Interaction of cartilage oligomeric matrix protein/thrombospondin 5 with aggrecan. J Biol Chem 2007, 282:24591-24598.
    • (2007) J Biol Chem , vol.282 , pp. 24591-24598
    • Chen, F.H.1    Herndon, M.E.2    Patel, N.3
  • 39
    • 0038683221 scopus 로고    scopus 로고
    • Effect of cartilage oligomeric matrix protein on mesenchymal chondrogenesis in vitro
    • Kipnes J, Carlberg AL, Loredo GA, et al.: Effect of cartilage oligomeric matrix protein on mesenchymal chondrogenesis in vitro. Osteoarthritis Cartilage 2003, 11:442-454.
    • (2003) Osteoarthritis Cartilage , vol.11 , pp. 442-454
    • Kipnes, J.1    Carlberg, A.L.2    Loredo, G.A.3
  • 40
    • 34249683186 scopus 로고    scopus 로고
    • Cartilage oligomeric matrix protein associates with granulin-epithelin precursor (GEP) and potentiates GEP-stimulated chondrocyte proliferation
    • Xu K, Zhang Y, Ilalov K, et al.: Cartilage oligomeric matrix protein associates with granulin-epithelin precursor (GEP) and potentiates GEP-stimulated chondrocyte proliferation. J Biol Chem 2007, 282:11347-11355.
    • (2007) J Biol Chem , vol.282 , pp. 11347-11355
    • Xu, K.1    Zhang, Y.2    Ilalov, K.3
  • 41
    • 25444531239 scopus 로고    scopus 로고
    • Cartilage oligomeric matrix protein/thrombospondin 5 supports chondrocyte attachment through interaction with integrins
    • Chen FH, Thomas AO, Hecht JT, et al.: Cartilage oligomeric matrix protein/thrombospondin 5 supports chondrocyte attachment through interaction with integrins. J Biol Chem 2005, 280:32655-32661.
    • (2005) J Biol Chem , vol.280 , pp. 32655-32661
    • Chen, F.H.1    Thomas, A.O.2    Hecht, J.T.3
  • 42
    • 0035937135 scopus 로고    scopus 로고
    • Cartilage oligomeric matrix protein interacts with type IX collagen, and disruptions to these interactions identify a pathogenetic mechanism in a bone dysplasia family
    • Holden P, Meadows RS, Chapman KL, et al.: Cartilage oligomeric matrix protein interacts with type IX collagen, and disruptions to these interactions identify a pathogenetic mechanism in a bone dysplasia family. J Biol Chem 2001, 276:6046-6055.
    • (2001) J Biol Chem , vol.276 , pp. 6046-6055
    • Holden, P.1    Meadows, R.S.2    Chapman, K.L.3
  • 43
    • 0035794206 scopus 로고    scopus 로고
    • Mutations in cartilage oligomeric matrix protein causing pseudoachondroplasia and multiple epiphyseal dysplasia affect binding of calcium and collagen I, II, and IX
    • Thur J, Rosenberg K, Nitsche DP, et al.: Mutations in cartilage oligomeric matrix protein causing pseudoachondroplasia and multiple epiphyseal dysplasia affect binding of calcium and collagen I, II, and IX. J Biol Chem 2001, 276:6083-6092.
    • (2001) J Biol Chem , vol.276 , pp. 6083-6092
    • Thur, J.1    Rosenberg, K.2    Nitsche, D.P.3
  • 44
    • 35748950738 scopus 로고    scopus 로고
    • COMP acts as a catalyst in collagen fibrillogenesis
    • Halasz K, Kassner A, Morgelin M, et al.: COMP acts as a catalyst in collagen fibrillogenesis. J Biol Chem 2007, 282:31166-31173.
    • (2007) J Biol Chem , vol.282 , pp. 31166-31173
    • Halasz, K.1    Kassner, A.2    Morgelin, M.3
  • 45
    • 13444269135 scopus 로고    scopus 로고
    • COMP mutations, chondrocyte function and cartilage matrix
    • Hecht JT, Hayes E, Haynes R, et al.: COMP mutations, chondrocyte function and cartilage matrix. Matrix Biol 2005, 23:525-533.
    • (2005) Matrix Biol , vol.23 , pp. 525-533
    • Hecht, J.T.1    Hayes, E.2    Haynes, R.3
  • 46
    • 1642300426 scopus 로고    scopus 로고
    • R-spondin, a novel gene with thrombospondin type 1 domain, was expressed in the dorsal neural tube and affected in Wnts mutants
    • Kamata T, Katsube K, Michikawa M, et al.: R-spondin, a novel gene with thrombospondin type 1 domain, was expressed in the dorsal neural tube and affected in Wnts mutants. Biochim Biophys Acta 2004, 1676:51-62.
    • (2004) Biochim Biophys Acta , vol.1676 , pp. 51-62
    • Kamata, T.1    Katsube, K.2    Michikawa, M.3
  • 47
    • 48749104088 scopus 로고    scopus 로고
    • R-spondin family members egulate the Wnt pathway by a common mechanism
    • Kim KA, Wagle M, Tran K, et al.: R-spondin family members egulate the Wnt pathway by a common mechanism. Mol Biol ell 2008, 19:2588-2596.
    • (2008) Mol Biol Ell , vol.19 , pp. 2588-2596
    • Kim, K.A.1    Wagle, M.2    Tran, K.3
  • 48
    • 42549128765 scopus 로고    scopus 로고
    • R-spondin 2 is required or normal laryngeal-tracheal, lung and limb morphogenesis
    • Bell SM, Schreiner CM, Wert SE, et al.: R-spondin 2 is required or normal laryngeal-tracheal, lung and limb morphogenesis. evelopment 2008, 135:1049-1058.
    • (2008) Development , vol.135 , pp. 1049-1058
    • Bell, S.M.1    Schreiner, C.M.2    Wert, S.E.3
  • 49
    • 33751547518 scopus 로고    scopus 로고
    • Dynamic expression of R-spondin amily genes in mouse development
    • Nam JS, Turcotte TJ, Yoon JK: Dynamic expression of R-spondin amily genes in mouse development. Gene Expr Patterns 2007, :306-312.
    • (2007) Gene Expr Patterns , pp. 306-312
    • Nam, J.S.1    Turcotte, T.J.2    Yoon, J.K.3
  • 50
    • 62649138786 scopus 로고    scopus 로고
    • Wnt pathway, an essential role in bone egeneration
    • Chen Y, Alman BA: Wnt pathway, an essential role in bone egeneration. J Cell Biochem 2009, 106:353-362.
    • (2009) J Cell Biochem , vol.106 , pp. 353-362
    • Chen, Y.1    Alman, B.A.2
  • 51
    • 38349136218 scopus 로고    scopus 로고
    • R-spondin2 expression in he apical ectodermal ridge is essential for outgrowth and patterning n mouse limb development
    • Aoki M, Kiyonari H, Nakamura H, et al.: R-spondin2 expression in he apical ectodermal ridge is essential for outgrowth and patterning n mouse limb development. Dev Growth Differ 2008, 50:85-95.
    • (2008) Dev Growth Differ , vol.50 , pp. 85-95
    • Aoki, M.1    Kiyonari, H.2    Nakamura, H.3
  • 52
    • 35348913170 scopus 로고    scopus 로고
    • Mouse R-spondin2 is required or apical ectodermal ridge maintenance in the hindlimb
    • Nam JS, Park E, Turcotte TJ, et al.: Mouse R-spondin2 is required or apical ectodermal ridge maintenance in the hindlimb. Dev Biol 2007, 311:124-135.
    • (2007) Dev Biol , Issue.311 , pp. 124-135
    • Nam, J.S.1    Park, E.2    Turcotte, T.J.3
  • 53
    • 62049086203 scopus 로고    scopus 로고
    • Craniofacial malformation n R-spondin2 knockout mice
    • Yamada W, Nagao K, Horikoshi K, et al.: Craniofacial malformation n R-spondin2 knockout mice. Biochem Biophys ResCommun 2009, 381:453-458.
    • (2009) Biochem Biophys ResCommun , vol.381 , pp. 453-458
    • Yamada, W.1    Nagao, K.2    Horikoshi, K.3
  • 54
    • 33750479526 scopus 로고    scopus 로고
    • The gene encoding Rspondin (RSPO4), a secreted protein implicated in Wnt signaling, s mutated in inherited anonychia
    • Blaydon DC, Ishii Y, O'Toole EA, et al.: The gene encoding Rspondin (RSPO4), a secreted protein implicated in Wnt signaling, s mutated in inherited anonychia. Nat Genet 2006, 38:1245-1247.
    • (2006) Nat Genet , vol.38 , pp. 1245-1247
    • Blaydon, D.C.1    Ishii, Y.2    O'toole, E.A.3
  • 55
    • 67649784462 scopus 로고    scopus 로고
    • Wnt11 promotes steoblast maturation and mineralization through R-spondin 2
    • Kriedman MS, Oyserman SM, Hankenson KD: Wnt11 promotes steoblast maturation and mineralization through R-spondin 2. J iol Chem 2009, 284:14117-14125.
    • (2009) J Iol Chem , vol.284 , pp. 14117-14125
    • Kriedman, M.S.1    Oyserman, S.M.2    Hankenson, K.D.3
  • 56
    • 39649102756 scopus 로고    scopus 로고
    • R-spondin1 synergizes withWnt3A ininducing osteoblast differentiation and osteoprotegerin expression
    • This study shows that R-spondin-2 is regulator of BMP-induced osteoblast differentiation
    • Lu W, Kim KA, Liu J, et al.: R-spondin1 synergizes withWnt3A ininducing osteoblast differentiation and osteoprotegerin expression. EBS Lett 2008, 582:643-650. This study shows that R-spondin-2 is regulator of BMP-induced osteoblast differentiation.
    • (2008) EBS Lett , vol.582 , pp. 643-650
    • Lu, W.1    Kim, K.A.2    Liu, J.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.