Synthesis and properties of triplex-forming oligonucleotides containing 2′-O-(2-methoxyethyl)-5-(3-aminoprop-1-ynyl)-uridine

Bioorganic and Medicinal Chemistry

Volumn 18, Issue 17, 2010, Pages 6389-6397

  Lou, Chenguang ^a   Xiao, Qiang ^a   Brennan, Lavinia ^a   Light, Mark E ^a   Vergara Irigaray, Nuria ^a   Atkinson, Elizabeth M ^a   Holden Dye, Lindy M ^a   Fox, Keith R ^a   Brown, Tom ^a  

^a UNIVERSITY OF SOUTHAMPTON   (United Kingdom)

Author keywords

2 Methoxyethyluridine; Serum nuclease resistance; Stable triplex forming oligonucleotide (TFO)

Indexed keywords

2' O (2 METHOXYETHYL) 5 (3 AMINOPROP 1 YNYL)URIDINE PHOSPHORAMIDITE; DEOXYRIBONUCLEASE; OLIGONUCLEOTIDE; RIBOSE; UNCLASSIFIED DRUG; URIDINE DERIVATIVE;

ARTICLE; DNA FOOTPRINTING; ENZYME DEGRADATION; MELTING POINT; NUCLEOTIDE METABOLISM; SOLID PHASE SYNTHESIS; ULTRAVIOLET RADIATION;

DNA FOOTPRINTING; HUMANS; NUCLEIC ACID CONFORMATION; OLIGODEOXYRIBONUCLEOTIDES; STRUCTURE-ACTIVITY RELATIONSHIP; URIDINE;

EID: 77955982289     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2010.07.005     Document Type: Article

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