Oncogenic Ras-mediated downregulation of Clast1/LR8 is involved in Ras-mediated neoplastic transformation and tumorigenesis in NIH3T3 cells

Cancer Science

Volumn 101, Issue 9, 2010, Pages 1990-1996

  Ryu, Sun Hyo ^a   Kim, Ki Hwan ^b   Kim, Hong Beum ^a   Kim, Mi Hwa ^a   Kim, Na Hee ^a   Kang, Yoonsung ^a   Hyun, Jin Won ^c   Seo, Hong Joo ^d   Jun, Jae Yeul ^a   You, Ho Jin ^a  

^a Chosun University   (South Korea)

^b Seoul National University   (South Korea)

^c Jeju National University School of Medicine   (South Korea)

^d Department of Thoracic and Cardiovascular Surgery ^*  (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

K RAS PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; PROTEIN KINASE B; RAS PROTEIN; SMALL INTERFERING RNA;

ANIMAL CELL; ARTICLE; CARCINOGENESIS; CELL INVASION; CELL PROLIFERATION; CELL STRAIN 3T3; CELL TRANSFORMATION; CLAST1 GENE; CONTROLLED STUDY; DEACETYLATION; DNA METHYLATION; DOWN REGULATION; FEMALE; FIBROBLAST; GENE; GENE EXPRESSION; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; ONCOGENE H RAS; PRIORITY JOURNAL;

ACETYLATION; ANIMALS; BASE SEQUENCE; BLOTTING, WESTERN; CELL LINE; CELL LINE, TUMOR; CELL MOVEMENT; CELL PROLIFERATION; CELL TRANSFORMATION, NEOPLASTIC; DNA METHYLATION; DOWN-REGULATION; FEMALE; HISTONES; HUMANS; MICE; MICE, NUDE; MOLECULAR SEQUENCE DATA; NEOPLASMS, EXPERIMENTAL; NIH 3T3 CELLS; RAS PROTEINS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA INTERFERENCE; TRANSFECTION;

EID: 77955973442     PISSN: 13479032     EISSN: 13497006     Source Type: Journal    
DOI: 10.1111/j.1349-7006.2010.01626.x     Document Type: Article

References (33)

1. Lowy DR, Willumsen BM. Function and regulation of ras. Annu Rev Biochem 1993, 62:851-91.
2. Campbell SL, Khosravi-Far R, Rossman KL, Clark GJ, Der CJ. Increasing complexity of Ras signaling. Oncogene 1998, 17:1395-413.
3. White MA, Nicolette C, Minden A. Multiple Ras functions can contribute to mammalian cell transformation. Cell 1995, 80:533-41.
4. Schubbert S, Shannon K, Bollag G. Hyperactive Ras in developmental disorders and cancer. Nat Rev Cancer 2007, 7:295-308.
5. Bardeesy N, DePinho RA. Pancreatic cancer biology and genetics. Nat Rev Cancer 2002, 2:897-909.
6. Bos JL. ras oncogenes in human cancer: a review. Cancer Res 1989, 49:4682-9.
7. Huang E, Ishida S, Pittman J. Gene expression phenotypic models that predict the activity of oncogenic pathways. Nat Genet 2003, 34:226-30.
8. Bild AH, Yao G, Chang JT. Oncogenic pathway signatures in human cancers as a guide to targeted therapies. Nature 2006, 439:353-7.
9. Ulku AS, Der CJ. Ras signaling, deregulation of gene expression and oncogenesis. Cancer Treat Res 2003, 115:189-208.
10. Zuber J, Tchernitsa OI, Hinzmann B. A genome-wide survey of RAS transformation targets. Nat Genet 2000, 24:1441-52.
11. Chang IY, Youn CK, Kim HB. Oncogenic H-Ras up-regulates expression of Ku80 to protect cells from gamma-ray irradiation in NIH3T3 cells. Cancer Res 2005, 65:6811-9.
12. Maeda Y, Fujimura L, O-Wang J. Role of Clast1 in development of cerebellar granule cells. Brain Res 2006, 1104:18-26.
13. Lurton J, Rose TM, Raghu G, Narayanan AS. Isolation of a gene product expressed by a subpopulation of human lung fibroblasts by differential display. Am J Respir Cell Mol Biol 1999, 20:327-31.
14. Rodenhuis S, Slebos RJ, Boot AJ. Incidence and possible clinical significance of K-ras oncogene activation in adenocarcinoma of the human lung. Cancer Res 1988, 48:5738-41.
15. You M, Candrian U, Maronpot RR, Stoner GD, Anderson MW. Activation of the Ki-ras protooncogene in spontaneously occurring and chemically induced lung tumors of the strain A mouse. Proc Natl Acad Sci USA 1989, 86:3070-4.
16. Contente S, Kenyon K, Sriraman P, Subramanyan S, Friedman RM. Epigenetic inhibition of lysyl oxidase transcription after transformation by ras oncogene. Mol Cell Biochem 1999, 194:79-91.
17. Lorentz O, Cadoret A, Duluc I. Downregulation of the colon tumour-suppressor homeobox gene Cdx-2 by oncogenic ras. Oncogene 1999, 18:87-92.
18. Dammann R, Li C, Yoon JH, Chin PL, Bates S, Pfeifer GP. Epigenetic inactivation of a RAS association domain family protein from the lung tumour suppressor locus 3p21.3. Nat Genet 2000, 25:315-9.
19. Chang HC, Cho CY, Hung WC. Silencing of the metastasis suppressor RECK by RAS oncogene is mediated by DNA methyltransferase 3b-induced promoter methylation. Cancer Res 2006, 66:8413-20.
20. Akino K, Toyota M, Suzuki H. The Ras effector RASSF2 is a novel tumor-suppressor gene in human colorectal cancer. Gastroenterology 2005, 129:156-69.
21. Chang HC, Liu LT, Hung WC. Involvement of histone deacetylation in ras-induced down-regulation of the metastasis suppressor RECK. Cell Signal 2004, 16:675-9.
22. Soejima K, Fang W, Rollins BJ. DNA methyltransferase 3b contributes to oncogenic transformation induced by SV40T antigen and activated Ras. Oncogene 2003, 22:4723-33.
23. Ordway JM, Williams K, Curran T. Transcription repression in oncogenic transformation: common targets of epigenetic repression in cells transformed by Fos, Ras or Dnmt1. Oncogene 2004, 23:3737-48.
24. Pruitt K, Ulku AS, Frantz K. Ras-mediated loss of the pro-apoptotic response protein Par-4 is mediated by DNA hypermethylation through Raf-independent and Raf-dependent signaling cascades in epithelial cells. J Biol Chem 2005, 280:23363-70.
25. Malumbres M, Barbacid M. RAS oncogenes: the first 30 years. Nat Rev Cancer 2003, 3:459-65.
26. Downward J. Targeting RAS signalling pathways in cancer therapy. Nat Rev Cancer 2003, 3:11-22.
27. Rodriguez-Viciana P, Warne PH, Khwaja A. Role of phosphoinositide 3-OH kinase in cell transformation and control of the actin cytoskeleton by Ras. Cell 1997, 89:457-67.
28. Cowley S, Paterson H, Kemp P, Marshall CJ. Activation of MAP kinase kinase is necessary and sufficient for PC12 differentiation and for transformation of NIH 3T3 cells. Cell 1994, 77:841-52.
29. Bradley MO, Kraynak AR, Storer RD, Gibbs JB. Experimental metastasis in nude mice of NIH 3T3 cells containing various ras genes. Proc Natl Acad Sci USA 1986, 83:5277-81.
30. Jiang K, Sun J, Cheng J, Djeu JY, Wei S, Sebti S. Akt mediates Ras downregulation of RhoB, a suppressor of transformation, invasion, and metastasis. Mol Cell Biol 2004, 24:5565-76.
31. Rosen K, Rak J, Jin J, Kerbel RS, Newman MJ, Filmus J. Downregulation of the pro-apoptotic protein Bak is required for the ras-induced transformation of intestinal epithelial cells. Curr Biol 1998, 8:1331-4.
32. Barradas M, Monjas A, Diaz-Meco MT, Serrano M, Moscat J. The downregulation of the pro-apoptotic protein Par-4 is critical for Ras-induced survival and tumor progression. EMBO J 1999, 18:6362-9.
33. Rong R, Montalbano J, Jin W. Oncogenic Ras-mediated downregulation of Gadd153/CHOP is required for Ras-induced cellular transformation. Oncogene 2005, 24:4867-72.