Evidence for catecholaminergic, neuronlike cells in the adult human testis: Changes associated with testicular pathologies

Journal of Andrology

Volumn 20, Issue 3, 1999, Pages 341-347

  Mayerhofer, Artur ^a   Frungieri, M B ^a,b   Fritz, S ^a   Bulling, A ^a   Jessberger, B ^a   Vogt, H J ^a  

^a TECHNICAL UNIVERSITY OF MUNICH   (Germany)

^b INST DE BIOL Y MED EXPERIMENTAL   (Argentina)

Author keywords

Infertility; Neurofilament; Sodium channel; Testis; TH

Indexed keywords

CATECHOLAMINE; COMPLEMENTARY DNA; SODIUM CHANNEL; TYROSINE 3 MONOOXYGENASE;

ADULT; ARTICLE; CATECHOLAMINE NERVE CELL; CLINICAL ARTICLE; CONTROLLED STUDY; GENE EXPRESSION; GERM CELL; HUMAN; HUMAN TISSUE; IMMUNOCOMPETENT CELL; MALE; MALE INFERTILITY; NERVE CELL EXCITABILITY; PRIORITY JOURNAL; SERTOLI CELL; SPERMATOGENESIS; SYMPATHETIC INNERVATION; TESTIS DISEASE;

ADULT; CARRIER PROTEINS; CATECHOLAMINES; DOPAMINE PLASMA MEMBRANE TRANSPORT PROTEINS; GENE EXPRESSION; GERM CELLS; HUMANS; IMMUNOHISTOCHEMISTRY; MALE; MEMBRANE GLYCOPROTEINS; MEMBRANE TRANSPORT PROTEINS; NERVE TISSUE PROTEINS; NEUROFILAMENT PROTEINS; NEURONS; OLIGOSPERMIA; POLYMERASE CHAIN REACTION; SERTOLI CELLS; SODIUM CHANNELS; TESTIS; TYROSINE 3-MONOOXYGENASE;

EID: 0032999199     PISSN: 01963635     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (41)

1. Amara SG, Kuhar MJ. Neurotransmitter transporters: recent progress. Annu Rev Neurosci 1993;16:73-93.
2. Anakwe OO, Murphy PR, Moger WH. Characterization of beta-adrenergic binding sites on rodent Leydig cells. Biol Reprod 1985;33:815-26.
3. Baumgarten HG, Falck B, Holstein AF, Owman CH, Owman T. Adrenergic innervation of the human testis, epididymis, ductus deferens and prostate: a fluorescence microscopic and fluorimetric study. Z Zellforsch Mikroskop Anat 1968;90:81-95.
4. Baumgarten HG, Holstein AF. Catecholaminhaltige Nervenfasern im Hoden des Menschen. Z Zellforsch Mikrosk Anat 1967;79:389-395.
5. Chen Y, Dicou E, Djakiew D. Characterization of nerve growth factor precursor protein expression in rat round spermatids and the trophic effects of nerve growth factor in the maintenance of Sertoli cell viability. Mol Cell Endocrinol 1997;127:129-136.
6. Davidoff MS, Schulze W, Middendorff R, Holstein AF. The Leydig cell of the human testis - a new member of the diffuse neuroendocrine system. Cell Tissue Res 1993;271:429-439.
7. Dees WL, J K Hiney J K, Schultea TD, Mayerhofer A, Danilchik M, Dissen GA, Ojeda SR. The primate ovary contains a population of catecholaminergic neuron-like cells expressing nerve growth factor receptors. Endocrinology 1995;136:5760-5768.
8. de Kretser DM, Baker HWG. Human infertility: the male factor. In: Adashi EY, Rock JA, Rosenwaks Z, eds. Reproductive Endocrinology, Surgery, and Technology. Vol 2. Philadelphia, Pennsylvania: Lippinscott-Raven; 1996:2031-2062.
9. Grima B, Lamouroux A, Boni C, Julien JF, Javoy-Agid F, Mallet J. A single human gene encoding multiple tyrosine hydroxylases with different predicted functional characteristics. Nature 1987;326:707-711.
10. Heindel JJ, Steinberger A, Strada DJ. Identification and characterization of a beta-1-receptor in the rat Sertoli cells. Mol Cell Endocrinol 1981; 22:349-58.
11. Huang M-H, Friend DS, Sunday ME, Singh K, Haley K, Austen KF, Kelly RA, Smith TW. An intrinsic adrenergic system in mammalian heart. J Clin Investig 1996;98:1298-1303.
12. Klugbauer N, Lacinova L, Flockerzi V, Hofmann F. Structure and functional expression of a new member of the tetrodotoxin-sensitive voltage-activated sodium channel family from human neuroendocrine cells. EMBO J 1995;14:1084-1090.
13. Mayerhofer A. Leydig cell regulation by catecholamines and neuroendocrine messengers. In: Payne AH, Hardy MP, Russell LD, eds. The Leydig Cell. Vienna, Illinois: Cache River Press; 1996:407-417, 428.
14. Mayerhofer A, Amador AG, Steger RW, Bartke, A. Testicular function after local injection of 6-hydroxydopamine or norepinephrine in the golden hamster (Mesocricetus auratus). J Androl 1990;11(3):301-311.
15. Mayerhofer A, Bartke A, Steger RW. Catecholamine effects on testicular testosterone production in the gonadally active and the gonadally regressed adult golden hamster. Biol Reprod 1989;40:752-761.
16. Mayerhofer A, Bartke A, Steger RW, Gow G. Catecholamines stimulate testicular testosterone release in the immature golden hamster via interaction with testicular alpha- and beta-adrenergic receptors. Acta Endocrinol (Copenhagen) 1992;127:526-530.
17. Mayerhofer A, Began T, Bartke A. Catecholamines stimulate testicular steroidogenesis in vitro in the Siberian hamster, Phodopus sungorus. Biol Reprod 1993;48:883-888.
18. Mayerhofer A, Danilchick M, Lara H, Pau F, Russell LD, Ojeda SR. Testis of prepubertal rhesus monkeys receives a dual catecholaminergic input provided by the extrinsic and an intragonadal source of catecholamines. Biol Reprod 1996a;55:509-518.
19. Mayerhofer A, Dissen GA, Costa ME, Ojeda SR. A role for neurotransmitters in early follicular development: induction of functional FSH receptors in newly formed follicles. Endocrinology 1997;38:3320-3329.
20. Mayerhofer A, Lahr G, Seidl K, Eusterschulte B, Christoph A, Gratzl M. The neural cell adhesion molecule (NCAM) provides clues to the development of testicular Leydig cells. J Androl 1996b;17:223-230.
21. Mayerhofer A, Russell LD, Grothe C, Rudolf M, Gratzl M. Presence and localization of a basic fibroblast growth factor-like protein in rodent testes. Endocrinology 1991;129:921-924.
22. Mayerhofer A, Smith GD, Danilchik M, Levine JE, Wolf DP, Dissen GA, Ojeda SR. Oocytes are a source of catecholamines in the primate ovary: evidence for a novel cell-cell regulatory loop in the ovary. Proc Natl Acad Sci USA 1998;95:10990-10995.
23. Moger WH, Murphy PR, Caspar RF. Catecholamine stimultaion of androgen production by mouse interstitial cells in primary culture. J Androl 1982;3:227-231.
24. Nagai T, Hirabayashi Y, Takaba H, Yamada K, Miyake K. Testicular mast cells heterogeneity in idiopathic male infertility. Fertil Steril 1992;57, 1331-1336.
25. Newton SC, Mayerhofer A, Bartke A. Dopamine and isoproterenol stimulate lactate secretion from Sertoli cell cultures isolated from the immature golden hamster. Neuroendocrinol Lett 1989;11:207-214.
26. Nistal M, Paniagua R, Asuncion-Abaurrea M. Varicose axons bearing "synaptic" vesicles on the basal lamina of the human seminiferous tubules. Cell Tissue Res 1982;226:75-82.
27. Noda M, Ikeda T, Kayano T, Suzuki H, Takeshima H, Kurasaki M, Takahashi H, Numa S. Existence of distinct sodium channel messenger RNAs in rat brain. Nature 1986;320:188-192.
28. Ogilvie K, Rivier C. The intracerebroventricular injection of interleukin-1β blunts the testosterone response to human chorionic gonadotropin: role of prostaglandin- and adrenergic-dependent pathways. Endocrinology 1998;139:3088-3095.
29. Okkels H, Sand K. Morphological relationship between testicular nerves and Leydig cells in man. J Endocrinol 1940;2:38-46.
30. Persson H, Ayer-Le Lievre C, Soder O, Villar MJ, Metsis M, Olson L, Ritzen M, Hokfelt T. Expression of beta-nerve growth factor receptor mRNA in Sertoli cells downregulated by testosterone. Science 1990; 247:704-707.
31. Prince FP. Ultrastructural evidence of indirect and direct autonomic innervation of human Leydig cells: comparison of neonatal, childhood and pubertal ages. Cell Tissue Res 1992;269:383-390.
32. Prince FP. Ultrastructural evidence of adrenergic, as well as cholinergic, nerve varicosities in relation to the lamina propria of the human seminiferous tubules during childhood. Tissue Cell 1996;28:507-513.
33. Rauchenwald M, Steers WD, Desjardins C. Efferent innervation of the rat testis. Biol Reprod 1995;52:1136-1143.
34. Sangameswaran L, Fish LM, Koch BD, Rabert DK, Delgado SG, Ilnicka M, Jakeman LB, Novakovic S, Wong K, Sze P, Tzoumaka E, Stewart GR, Herman RC, Chan H, Eglen RM, Hunter JC. A novel tetrodotoxin-sensitive, voltage-gated sodium channel expressed in rat and human dorsal root ganglia. J Biol Chem 1997;272:14805-14809.
35. Schütze K, Lahr G. Identification of expressed genes by laser-mediated manipulation of single cells. Nature Biotech 1998;16:737-742.
36. Seidl K, Buchberger A, Erck C. Expression of nerve growth factor and neurotrophin receptors in testicular cells suggest novel roles for neurotrophins outside the nervous system. Reprod Fertil Dev 1996;8: 1075-1087.
37. Seidl K, Holstein AF. Evidence for the presence of nerve growth factor (NGF) and NGF receptors in human testis. Cell Tissue Res 1990;261: 549-554.
38. Setchell BP. Nerves of the testis and scrotum. In: Finn CA, ed. The Mammalian Testis. Reproductive Biology Handbooks. Ithaca, New York: Cornell University Press; 1978:77-89.
39. Setchell BP, Maddocks S, Brooks DE. Anatomy, vasculature, innervation, and fluids of the male reproductive tract. In: Knobil E, Neill JD, eds. The Physiology of Reproduction. 2nd ed. New York: Raven Press; 1994:1063-1175.
40. Skinner MK. Cell-cell interactions in the testis. Endocr Rev 1991;12:45-77.
41. Toledo-Aral JJ, Moss BL, He ZJ, Koszowski AG, Whisenand T, Levinson SR, Wolf JJ, Silos-Santiago I, Halegoua S, Mandel G. Identification of PN1, a predominant voltage-dependent sodium channel expressed principally in peripheral neurons. Proc Natl Acad Sci USA 1997;94: 1527-1532.