Use of alteplase in childhood arterial ischaemic stroke: a multicentre, observational, cohort study

The Lancet Neurology

Volumn 8, Issue 6, 2009, Pages 530-536

  Amlie Lefond, Catherine ^a   deVeber, Gabrielle ^b   Chan, Anthony K ^c   Benedict, Susan ^d   Bernard, Timothy ^e   Carpenter, Jessica ^f   Dowling, Michael M ^g   Fullerton, Heather ^h   Hovinga, Collin ⁱ   Kirton, Adam ^j   Lo, Warren ^k   Zamel, Khaled ^k   Ichord, Rebecca ^l  

^a MEDICAL COLLEGE OF WISCONSIN   (United States)

^b HOSPITAL FOR SICK CHILDREN   (Canada)

^c HAMILTON HEALTH SCIENCES   (Canada)

^d UNIVERSITY OF UTAH SCHOOL OF MEDICINE   (United States)

^e Mountain States Regional Hemophilia and Thrombosis Center   (United States)

^f GEORGE WASHINGTON UNIVERSITY MEDICAL CENTER   (United States)

^g UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^h UNIVERSITY OF CALIFORNIA   (United States)

ⁱ UNIVERSITY OF TENNESSEE HEALTH SCIENCE CENTER   (United States)

^j UNIVERSITY OF CALGARY   (Canada)

^k OHIO STATE UNIVERSITY   (United States)

^l UNIVERSITY OF PENNSYLVANIA   (United States)

more..

Author keywords

[No Author keywords available]

Indexed keywords

ALTEPLASE;

ADOLESCENT; ARTERY DISEASE; ARTICLE; BRAIN HEMORRHAGE; BRAIN HERNIA; BRAIN INFARCTION; BRAIN STEM INFARCTION; CEREBROVASCULAR ACCIDENT; CEREBROVASCULAR DISEASE; CHILD; CLINICAL FEATURE; CLINICAL TRIAL; COHORT ANALYSIS; CONTROLLED STUDY; DISEASE REGISTRY; FEMALE; HOSPITAL DISCHARGE; HUMAN; INFANT; MAJOR CLINICAL STUDY; MALE; MULTICENTER STUDY; NEUROLOGIC DISEASE; OBSERVATIONAL STUDY; PATIENT COMPLIANCE; PRACTICE GUIDELINE; PRESCHOOL CHILD; PRIORITY JOURNAL; PUBLISHING; SCHOOL CHILD; TREATMENT OUTCOME;

ADOLESCENT; BRAIN ISCHEMIA; CHILD; CHILD, PRESCHOOL; COHORT STUDIES; FEMALE; FIBRINOLYTIC AGENTS; HUMANS; INFANT; INTERNATIONAL COOPERATION; INTRACRANIAL HEMORRHAGES; MALE; OBSERVATION; PEDIATRICS; RETROSPECTIVE STUDIES; STROKE; TIME FACTORS; TISSUE PLASMINOGEN ACTIVATOR; TREATMENT OUTCOME;

EID: 65549095487     PISSN: 14744422     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1474-4422(09)70106-1     Document Type: Article

References (41)

1. Lynch J.K., Hirtz D.G., deVeber G., and Nelson K.B. Report of the National Institute of Neurological Disorders and Stroke workshop on perinatal and childhood stroke. Pediatrics 109 (2002) 116-123
2. deVeber G.A., MacGregor D., Curtis R., and Mayank S. Neurologic outcome in survivors of childhood arterial ischemic stroke and sinovenous thrombosis. J Child Neurol 15 (2000) 316-324
3. Fullerton H.J., Chetkovich D.M., Wu Y.W., Smith W.S., and Johnston S.C. Deaths from stroke in US children, 1979 to 1998. Neurology 59 (2002) 34-39
4. Ganesan V., Prengler M., McShane M.A., Wade A.M., and Kirkham F.J. Investigation of risk factors in children with arterial ischemic stroke. Ann Neurol 53 (2003) 167-173
5. The National Institute of Neurological Disorders and Stroke rt-PA Stroke Study Group. Tissue plasminogen activator for acute ischemic stroke. N Engl J Med 333 (1995) 1581-1587
6. Furlan A., Higashida R., Wechsler L., et al. Intra-arterial prourokinase for acute ischemic stroke. The PROACT II study: a randomized controlled trial. Prolyse in Acute Cerebral Thromboembolism. JAMA 282 (1999) 2003-2011
7. Adams Jr. H.P., del Zoppo G., Alberts M.J., et al. Guidelines for the early management of adults with ischemic stroke: a guideline from the American Heart Association/American Stroke Association Stroke Council, Clinical Cardiology Council, Cardiovascular Radiology and Intervention Council, and the Atherosclerotic Peripheral Vascular Disease and Quality of Care Outcomes in Research Interdisciplinary Working Groups: The American Academy of Neurology affirms the value of this guideline as an educational tool for neurologists. Circulation 115 (2007) e478-e534
8. Kwiatkowski T.G., Libman R.B., Frankel M., et al. Effects of tissue plasminogen activator for acute ischemic stroke at one year. National Institute of Neurological Disorders and Stroke Recombinant Tissue Plasminogen Activator Stroke Study Group. N Engl J Med 340 (1999) 1781-1787
9. The NINDS t-PA Stroke Study Group. Intracerebral hemorrhage after intravenous t-PA therapy for ischemic stroke. Stroke 28 (1997) 2109-2118
10. Siegbahn A., and Ruusuvaara L. Age dependence of blood fibrinolytic components and the effects of low-dose oral contraceptives on coagulation and fibrinolysis in teenagers. Thromb Haemost 60 (1988) 361-364
11. Andrew M., Vegh P., Johnston M., Bowker J., Ofosu F., and Mitchell L. Maturation of the hemostatic system during childhood. Blood 80 (1992) 1998-2005
12. Monagle P., Chalmers E., Chan A., et al. Antithrombotic therapy in children: the American College of Chest Physicians Evidence-Based Clinical Practice Guidelines (8th edn). Chest 133 (2008) 887S-968S
13. Roach E.S., Golomb M.R., Adams R., et al. Management of stroke in infants and children: a scientific statement from a Special Writing Group of the American Heart Association Stroke Council and the Council on Cardiovascular Disease in the Young. Stroke 39 (2008) 2644-2691
14. Golomb M.R., Fullerton H.J., Nowak-Gottl U., and deVeber G. Male predominance in childhood ischemic stroke. Findings from the International Pediatric Stroke Study. Stroke 40 (2009) 52-57
15. Sebire G., Fullerton H., Riou E., and deVeber G. Toward the definition of cerebral arteriopathies of childhood. Curr Opin Pediatr 16 (2004) 617-622
16. Bourdial H., Sassolas F., Ville D., and Di F.S. [Intravenous thrombolysis in pediatric arterial ischemic stroke: a case report and a review of the literature]. Arch Pediatr 15 (2008) 1541-1546
17. Heil J.W., Malinowski L., Rinderknecht A., Broderick J.P., and Franz D. Use of intravenous tissue plasminogen activator in a 16-year-old patient with basilar occlusion. J Child Neurol 23 (2008) 1049-1053
18. Jain S.V., and Morton L.D. Ischemic stroke and excellent recovery after administration of intravenous tissue plasminogen activator. Pediatr Neurol 38 (2008) 126-129
19. Benedict S.L., Ni O.K., Schloesser P., White K.S., and Bale Jr. J.F. Intra-arterial thrombolysis in a 2-year-old with cardioembolic stroke. J Child Neurol 22 (2007) 225-227
20. Ortiz G.A., Koch S., Wallace D.M., and Lopez-Alberola R. Successful intravenous thrombolysis for acute stroke in a child. J Child Neurol 22 (2007) 749-752
21. Losurdo G., Giacchino R., Castagnola E., et al. Cerebrovascular disease and varicella in children. Brain Dev 28 (2006) 366-370
22. Shuayto M.I., Lopez J.I., and Greiner F. Administration of intravenous tissue plasminogen activator in a pediatric patient with acute ischemic stroke. J Child Neurol 21 (2006) 604-606
23. Golomb M.R., Rafay M., Armstrong D., et al. Intra-arterial tissue plasminogen activator for thrombosis complicating cerebral angiography in a 17-year-old girl. J Child Neurol 18 (2003) 420-423
24. Kirton A., Wong J.H., Mah J., et al. Successful endovascular therapy for acute basilar thrombosis in an adolescent. Pediatrics 112 (2003) e248-e251
25. Cannon B.C., Kertesz N.J., Friedman R.A., and Fenrich A.L. Use of tissue plasminogen activator in a stroke after radiofrequency ablation of a left-sided accessory pathway. J Cardiovasc Electrophysiol 12 (2001) 723-725
26. Carlson M.D., Leber S., Deveikis J., and Silverstein F.S. Successful use of rt-PA in pediatric stroke. Neurology 57 (2001) 157-158
27. Noser E.A., Felberg R.A., and Alexandrov A.V. Thrombolytic therapy in an adolescent ischemic stroke. J Child Neurol 16 (2001) 286-288
28. Gruber A., Nasel C., Lang W., Kitzmuller E., Bavinzski G., and Czech T. Intra-arterial thrombolysis for the treatment of perioperative childhood cardioembolic stroke. Neurology 54 (2000) 1684-1686
29. Thirumalai S.S., and Shubin R.A. Successful treatment for stroke in a child using recombinant tissue plasminogen activator. J Child Neurol 15 (2000) 558
30. Janjua N., Nasar A., Lynch J.K., and Qureshi A.I. Thrombolysis for ischemic stroke in children: data from the nationwide inpatient sample. Stroke 38 (2007) 1850-1854
31. Golomb M.R., Garg B.P., Saha C., and Williams L.S. Accuracy and yield of ICD-9 codes for identifying children with ischemic stroke. Neurology 67 (2006) 2053-2055
32. Broadley S.A., and Thompson P.D. Time to hospital admission for acute stroke: an observational study. Med J Aust 178 (2003) 329-331
33. Mayer-Reichenauer M., Dachenhausen A., Bosak P., et al. [Time delays in admission to a stroke unit and emergency treatment of patients with ischemic stroke]. Dtsch Med Wochenschr 124 (1999) 1226-1229
34. Pittock S.J., Meldrum D., Hardiman O., et al. Patient and hospital delays in acute ischaemic stroke in a Dublin teaching hospital. Ir Med J 96 (2003) 167-261
35. Gabis L.V., Yangala R., and Lenn N.J. Time lag to diagnosis of stroke in children. Pediatrics 110 (2002) 924-928
36. Rafay M.F., Pontigan A.M., Chiang J., et al. Diagnostic delays in acute pediatric arterial ischemic stroke. Neuropediatrics 37 suppl 1 (2006) s83
37. Shellhaas R.A., Smith S.E., O'Tool E., Licht D.J., and Ichord R.N. Mimics of childhood stroke: characteristics of a prospective cohort. Pediatrics 118 (2006) 704-709
38. Amlie-Lefond C., Chan A.K., Kirton A., et al., for the Thrombolysis in Pediatric Stroke (TIPS) Investigators. Thrombolysis in acute childhood stroke: design and challenges of the thrombolysis in pediatric stroke clinical trial. Neuroepidemiology 32 (2009) 279-286
39. Whelan H.T., Cook J.D., Amlie-Lefond C.M., et al. Practical model-based dose finding in early-phase clinical trials: optimizing tissue plasminogen activator dose for treatment of ischemic stroke in children. Stroke 39 (2008) 2627-2636
40. Vickers A.J., and Scardino P.T. The clinically-integrated randomized trial: proposed novel method for conducting large trials at low cost. Trials 10 (2009) 14
41. Hacke W., Kaste M., Bluhmki E., et al., for the ECASS Investigators. Thrombolysis with alteplase 3 to 4.5 hours after acute ischemic stroke. N Engl J Med 359 (2008) 1317-1329