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Volumn 12, Issue 2, 2010, Pages 93-106

Combination therapy with mexiletine and sotalol suppresses inherited ventricular arrhythmias in German shepherd dogs better than mexiletine or sotalol monotherapy: A randomized cross-over study

Author keywords

German shepherd dog; Mexiletine; Sotalol; Spontaneous variability; Ventricular arrhythmia

Indexed keywords

MEXILETINE; SOTALOL;

EID: 77955919159     PISSN: 17602734     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jvc.2010.06.001     Document Type: Article
Times cited : (13)

References (50)
  • 2
    • 0343118126 scopus 로고    scopus 로고
    • Age dependence of the development of ventricular arrhythmias in a canine model of sudden cardiac death
    • N.S. Moïse, M.L. Riccio, B. Kornreich, W.F. Flahive Jr., and R.F. Gilmour Jr. Age dependence of the development of ventricular arrhythmias in a canine model of sudden cardiac death Cardiovasc Res 34 1997 483 492
    • (1997) Cardiovasc Res , vol.34 , pp. 483-492
    • Moïse, N.S.1    Riccio, M.L.2    Kornreich, B.3    Flahive Jr., W.F.4    Gilmour Jr., R.F.5
  • 4
    • 0342960924 scopus 로고    scopus 로고
    • Triggered activity as a mechanism for inherited ventricular arrhythmias in German shepherd dogs
    • R.F. Gilmour Jr., and N.S. Moise Triggered activity as a mechanism for inherited ventricular arrhythmias in German shepherd dogs J Am Coll Cardiol 27 1996 1526 1533
    • (1996) J Am Coll Cardiol , vol.27 , pp. 1526-1533
    • Gilmour Jr., R.F.1    Moise, N.S.2
  • 5
    • 0033860578 scopus 로고    scopus 로고
    • Electropharmacological characterization of cardiac repolarization in German shepherd dogs with an inherited syndrome of sudden death
    • J. Mérot, V. Probst, M. Debailleul, U. Gerlacin, N.S. Moïse, H. LaMarec, and F. Charpentier Electropharmacological characterization of cardiac repolarization in German shepherd dogs with an inherited syndrome of sudden death J Am Coll Cardiol 36 2000 939 947
    • (2000) J Am Coll Cardiol , vol.36 , pp. 939-947
    • Mérot, J.1    Probst, V.2    Debailleul, M.3    Gerlacin, U.4    Moïse, N.S.5    Lamarec, H.6    Charpentier, F.7
  • 9
    • 0348048753 scopus 로고    scopus 로고
    • Effects of class i antiarrhythmic drugs on the digitalis-induced triggered activity arrhythmia model: A rationale for the short-term use of class i drugs against triggered arrhythmias
    • A. Takahara, A. Sugiyama, and K. Hashimoto Effects of class I antiarrhythmic drugs on the digitalis-induced triggered activity arrhythmia model: a rationale for the short-term use of class I drugs against triggered arrhythmias Heart Vessels 191 2004 43 48
    • (2004) Heart Vessels , vol.191 , pp. 43-48
    • Takahara, A.1    Sugiyama, A.2    Hashimoto, K.3
  • 10
    • 0030819433 scopus 로고    scopus 로고
    • Sodium channel block with mexiletine is effective in reducing dispersion of repolarization and preventing torsade de pointes in LQT2 and LQT3 models of the long-QT syndrome
    • W. Shimizu, and C. Antzelevitch Sodium channel block with mexiletine is effective in reducing dispersion of repolarization and preventing torsade de pointes in LQT2 and LQT3 models of the long-QT syndrome Circulation 96 1997 2038 2047
    • (1997) Circulation , vol.96 , pp. 2038-2047
    • Shimizu, W.1    Antzelevitch, C.2
  • 12
    • 0026320633 scopus 로고
    • Mexiletine administration for management of ventricular arrhythmia in 22 dogs
    • J. Lunney, and S. Ettinger Mexiletine administration for management of ventricular arrhythmia in 22 dogs J Am Anim Hosp Assoc 27 1991 597 600
    • (1991) J Am Anim Hosp Assoc , vol.27 , pp. 597-600
    • Lunney, J.1    Ettinger, S.2
  • 13
    • 0025170629 scopus 로고
    • A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic use in the treatment of arrhythmias
    • J.P. Monk, and R.N. Brogden A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic use in the treatment of arrhythmias Drugs 40 1990 374 411
    • (1990) Drugs , vol.40 , pp. 374-411
    • Monk, J.P.1    Brogden, R.N.2
  • 15
    • 0025314155 scopus 로고
    • Comparability of the electrophysiologic responses and plasma and myocardial tissue concentrations of sotalol and its d stereoisomer in the dog
    • A.W. Gomoll, R.F. Lekich, M.J. Bartek, C.R. Comereski, and M.J. Antonaccio Comparability of the electrophysiologic responses and plasma and myocardial tissue concentrations of sotalol and its d stereoisomer in the dog J Cardiovasc Pharmacol 16 1990 204 211
    • (1990) J Cardiovasc Pharmacol , vol.16 , pp. 204-211
    • Gomoll, A.W.1    Lekich, R.F.2    Bartek, M.J.3    Comereski, C.R.4    Antonaccio, M.J.5
  • 16
    • 0033008490 scopus 로고    scopus 로고
    • An important new antiarrhythmic
    • J.L. Anderson, and E.N. Prystowsky An important new antiarrhythmic Am Heart J 137 1999 388 409
    • (1999) Am Heart J , vol.137 , pp. 388-409
    • Anderson, J.L.1    Prystowsky, E.N.2
  • 17
    • 0027256636 scopus 로고
    • Sotalol and type IA drugs in combination prevent recurrence of sustained ventricular tachycardia
    • P. Dorian, D. Newman, N. Berman, J. Hardy, and J. Mitchell Sotalol and type IA drugs in combination prevent recurrence of sustained ventricular tachycardia J Am Coll Cardiol 22 1993 106 113
    • (1993) J Am Coll Cardiol , vol.22 , pp. 106-113
    • Dorian, P.1    Newman, D.2    Berman, N.3    Hardy, J.4    Mitchell, J.5
  • 18
    • 0023680262 scopus 로고
    • A comparison of the cellular electrophysiology of amexiletine and sotalol, singly and combined, in canine Purkinje fibers
    • N. Berman, and J. Loukides A comparison of the cellular electrophysiology of amexiletine and sotalol, singly and combined, in canine Purkinje fibers J Cardiovasc Pharmacol 12 1988 286 292
    • (1988) J Cardiovasc Pharmacol , vol.12 , pp. 286-292
    • Berman, N.1    Loukides, J.2
  • 19
    • 0025072293 scopus 로고
    • Sotalol and mexiletine: Combination of rate-dependent electrophysiological effects
    • A. Varró, and D. Lathrop Sotalol and mexiletine: combination of rate-dependent electrophysiological effects J Cardiovasc Pharmacol 16 1990 557 567
    • (1990) J Cardiovasc Pharmacol , vol.16 , pp. 557-567
    • Varró, A.1    Lathrop, D.2
  • 20
    • 0023239875 scopus 로고
    • Combination of sotalol with the class IB substances mexiletine or tocainide in complex ventricular extrasystole
    • W.L. Wagner, M. Manz, and B. Luderitz Combination of sotalol with the class IB substances mexiletine or tocainide in complex ventricular extrasystole Z Kardiol 76 1987 296 302
    • (1987) Z Kardiol , vol.76 , pp. 296-302
    • Wagner, W.L.1    Manz, M.2    Luderitz, B.3
  • 21
    • 77955925052 scopus 로고    scopus 로고
    • Comparison of sotalol and mexiletine versus stand alone sotalol in treatment of boxer dogs with ventricular arrhythmias
    • R. Prosek, A. Estrada, and D. Adin Comparison of sotalol and mexiletine versus stand alone sotalol in treatment of boxer dogs with ventricular arrhythmias J Vet Intern Med 20 2006
    • (2006) J Vet Intern Med , vol.20
    • Prosek, R.1    Estrada, A.2    Adin, D.3
  • 22
    • 61349133545 scopus 로고    scopus 로고
    • Toxicity in Doberman pinchers with ventricular arrhythmias treated with amiodarone (1996-2005)
    • M.S. Kraus, J.D. Thomasons, T.L. Fallaw, and C.A. Calvert Toxicity in Doberman pinchers with ventricular arrhythmias treated with amiodarone (1996-2005) J Vet Intern Med 23 2009 1 6
    • (2009) J Vet Intern Med , vol.23 , pp. 1-6
    • Kraus, M.S.1    Thomasons, J.D.2    Fallaw, T.L.3    Calvert, C.A.4
  • 23
    • 0033631112 scopus 로고    scopus 로고
    • Association between results of ambulatory electrocardiography and development of cardiomyopathy during long-term follow-up of Doberman pinschers
    • C.A. Calvert, G.J. Jacobs, D.D. Smith, S.L. Rathbun, and C.W. Pickus Association between results of ambulatory electrocardiography and development of cardiomyopathy during long-term follow-up of Doberman pinschers J Am Vet Med Assoc 216 2000 34 39
    • (2000) J Am Vet Med Assoc , vol.216 , pp. 34-39
    • Calvert, C.A.1    Jacobs, G.J.2    Smith, D.D.3    Rathbun, S.L.4    Pickus, C.W.5
  • 24
    • 31844451666 scopus 로고    scopus 로고
    • Influence of antiarrhythmia therapy on survival times of 19 clinically healthy Doberman pinschers with dilated cardiomyopathy that experienced syncope, ventricular tachycardia, and sudden death (1985-1998)
    • C.A. Calvert, and J. Brown Influence of antiarrhythmia therapy on survival times of 19 clinically healthy Doberman pinschers with dilated cardiomyopathy that experienced syncope, ventricular tachycardia, and sudden death (1985-1998) J Am Anim Hosp Assoc 40 2004 24 28
    • (2004) J Am Anim Hosp Assoc , vol.40 , pp. 24-28
    • Calvert, C.A.1    Brown, J.2
  • 25
    • 1142310771 scopus 로고    scopus 로고
    • Evaluation of spontaneous variability in the frequency of ventricular arrhythmias in boxers with arrhythmogenic right ventricular cardiomyopathy
    • A.W. Spier, and K.M. Meurs Evaluation of spontaneous variability in the frequency of ventricular arrhythmias in boxers with arrhythmogenic right ventricular cardiomyopathy J Am Vet Med Assoc 224 2004 538 541
    • (2004) J Am Vet Med Assoc , vol.224 , pp. 538-541
    • Spier, A.W.1    Meurs, K.M.2
  • 27
    • 0018352377 scopus 로고
    • Assessment of long-term antiarrhythmic therapy: Studies on the long-term efficacy and toxicity of tocainide
    • R. Engler, W. Ryan, M. LeWinter, H. Bluestein, and J.S. Karliner Assessment of long-term antiarrhythmic therapy: studies on the long-term efficacy and toxicity of tocainide Am J Cardiol 43 1979 612 618
    • (1979) Am J Cardiol , vol.43 , pp. 612-618
    • Engler, R.1    Ryan, W.2    Lewinter, M.3    Bluestein, H.4    Karliner, J.S.5
  • 30
    • 0035885846 scopus 로고    scopus 로고
    • Results of ambulatory electrocardiography in overtly healthy Doberman Pinschers with equivocal echocardiographic evidence of dilated cardiomyopathy
    • C.A. Calvert, and M. Wall Results of ambulatory electrocardiography in overtly healthy Doberman Pinschers with equivocal echocardiographic evidence of dilated cardiomyopathy J Am Vet Med Assoc 219 2001 782 784
    • (2001) J Am Vet Med Assoc , vol.219 , pp. 782-784
    • Calvert, C.A.1    Wall, M.2
  • 31
    • 33846532323 scopus 로고    scopus 로고
    • Animal models of ventricular arrhythmias
    • R.L. Hamlin Animal models of ventricular arrhythmias Pharmacol Ther 113 2007 276 295
    • (2007) Pharmacol Ther , vol.113 , pp. 276-295
    • Hamlin, R.L.1
  • 32
    • 0021842708 scopus 로고
    • Analysis of the spontaneous variability of ventricular arrhythmias: Consecutive ambulatory electrocardiographic recordings of ventricular tachycardia
    • C.M. Pratt, D.J. Slymen, A.M. Wierman, J.B. Young, M.J. Francis, A.A. Seals, M.A. Qhinones, and R. Roberts Analysis of the spontaneous variability of ventricular arrhythmias: consecutive ambulatory electrocardiographic recordings of ventricular tachycardia Am J Cardiol 56 1985 67 72
    • (1985) Am J Cardiol , vol.56 , pp. 67-72
    • Pratt, C.M.1    Slymen, D.J.2    Wierman, A.M.3    Young, J.B.4    Francis, M.J.5    Seals, A.A.6    Qhinones, M.A.7    Roberts, R.8
  • 33
    • 0023158597 scopus 로고
    • Spontaneous variability of ventricular arrhythmias in patients at increased risk for sudden death after acute myocardial infarction: Consecutive ambulatory electrocardiographic recordings of 88 patients
    • C.M. Pratt, P. Théroux, D. Slymen, A. Riordan-Bennett, C. Morisette, A. Galloway, A.A. Seals, and A. Hallstrom Spontaneous variability of ventricular arrhythmias in patients at increased risk for sudden death after acute myocardial infarction: consecutive ambulatory electrocardiographic recordings of 88 patients Am J Cardiol 59 1987 278 283
    • (1987) Am J Cardiol , vol.59 , pp. 278-283
    • Pratt, C.M.1    Théroux, P.2    Slymen, D.3    Riordan-Bennett, A.4    Morisette, C.5    Galloway, A.6    Seals, A.A.7    Hallstrom, A.8
  • 34
    • 0018905388 scopus 로고    scopus 로고
    • Spontaneous variability of complex ventricular arrhythmias detected by long-term electrocardiographic recording
    • Michelson EL, Morganroth J. Spontaneous variability of complex ventricular arrhythmias detected by long-term electrocardiographic recording. Am J Cardiol 61(4):690-95.
    • Am J Cardiol , vol.61 , Issue.4 , pp. 690-695
    • Michelson, E.L.1    Morganroth, J.2
  • 35
    • 0023198223 scopus 로고
    • Spontaneous variability in the frequency of ventricular premature complexes over prolonged intervals and implications for antiarrhythmic treatment
    • L. Toivonen Spontaneous variability in the frequency of ventricular premature complexes over prolonged intervals and implications for antiarrhythmic treatment Am J Cardiol 60 1987 608 612
    • (1987) Am J Cardiol , vol.60 , pp. 608-612
    • Toivonen, L.1
  • 36
    • 0016623067 scopus 로고
    • Monitoring for serious arrhythmias and high risk of sudden death
    • B. Lown, A.F. Calvert, R. Armington, and M. Ryan Monitoring for serious arrhythmias and high risk of sudden death Circulation 52 1975 189 198
    • (1975) Circulation , vol.52 , pp. 189-198
    • Lown, B.1    Calvert, A.F.2    Armington, R.3    Ryan, M.4
  • 37
    • 0018830089 scopus 로고
    • Combined mexiletine and propranolol treatment of refractory ventricular tachycardia
    • E.B. Leahey, R.H. Heissenbuttel, E.G. Giardina, and J.T. Bigger Jr. Combined mexiletine and propranolol treatment of refractory ventricular tachycardia Br Med J 281 1980 357 358
    • (1980) Br Med J , vol.281 , pp. 357-358
    • Leahey, E.B.1    Heissenbuttel, R.H.2    Giardina, E.G.3    Bigger Jr., J.T.4
  • 38
    • 0031033992 scopus 로고    scopus 로고
    • Electrophysiologic mechanisms of antiarrhythmic efficacy of a sotalol and class Ia drug combination: Elimination of reverse use dependence
    • S.D. Lee, D. Newman, M. Ham, and P. Dorian Electrophysiologic mechanisms of antiarrhythmic efficacy of a sotalol and class Ia drug combination: elimination of reverse use dependence J Am Coll Cardiol 29 1997 100 105
    • (1997) J Am Coll Cardiol , vol.29 , pp. 100-105
    • Lee, S.D.1    Newman, D.2    Ham, M.3    Dorian, P.4
  • 39
    • 33646003589 scopus 로고    scopus 로고
    • The role of late i and antiarrhythmic drugs in EAD formation and termination in Purkinje fibers
    • D. Fedida, P.M. Orth, J.C. Hesketh, and A.M. Ezrin The role of late I and antiarrhythmic drugs in EAD formation and termination in Purkinje fibers J Cardiovasc Electrophysiol 17 2006 S71 S78
    • (2006) J Cardiovasc Electrophysiol , vol.17
    • Fedida, D.1    Orth, P.M.2    Hesketh, J.C.3    Ezrin, A.M.4
  • 40
    • 0030724030 scopus 로고    scopus 로고
    • Effects of sodium channel block with mexiletine to reverse action potential prolongation in in vitro models of the long term QT syndrome
    • S. Sicouri, D. Antzelevitch, C. Heilmann, and C. Antzelevitch Effects of sodium channel block with mexiletine to reverse action potential prolongation in in vitro models of the long term QT syndrome J Cardiovasc Electrophysiol 8 1997 1280 1290
    • (1997) J Cardiovasc Electrophysiol , vol.8 , pp. 1280-1290
    • Sicouri, S.1    Antzelevitch, D.2    Heilmann, C.3    Antzelevitch, C.4
  • 41
    • 0027461376 scopus 로고
    • Cellular mechanism underlying the efficacy of the sotalol-quinidine combination
    • N.D. Berman, and P. Dorian Cellular mechanism underlying the efficacy of the sotalol-quinidine combination J Cardiovasc Pharmacol 21 1993 609 614
    • (1993) J Cardiovasc Pharmacol , vol.21 , pp. 609-614
    • Berman, N.D.1    Dorian, P.2
  • 42
    • 0029125160 scopus 로고
    • Mexiletine antagonizes effects of sotalol on QT interval duration and its proarrhythmic effects in a canine model of torsade de pointes
    • F. Chézalviel, J.M. Davy, J.M. Poirier, and J. Weissenburger Mexiletine antagonizes effects of sotalol on QT interval duration and its proarrhythmic effects in a canine model of torsade de pointes J Am Coll Cardiol 26 1995 787 792
    • (1995) J Am Coll Cardiol , vol.26 , pp. 787-792
    • Chézalviel, F.1    Davy, J.M.2    Poirier, J.M.3    Weissenburger, J.4
  • 45
  • 47
    • 0015581481 scopus 로고
    • The reduction of lidocaine clearance by dl-propranolol: An example of hemogynamic drug interaction
    • R.A. Branch, D.G. Shand, G.R. Wilkinson, and A.S. Nies The reduction of lidocaine clearance by dl-propranolol: an example of hemogynamic drug interaction J Pharmacol Exp Ther 184 1973 515 519
    • (1973) J Pharmacol Exp Ther , vol.184 , pp. 515-519
    • Branch, R.A.1    Shand, D.G.2    Wilkinson, G.R.3    Nies, A.S.4
  • 48
    • 0017703049 scopus 로고
    • Mexiletine in the management of ventricular dysrrhythmias
    • N.P. Campbell, J.F. Pantridge, and A.A. Adgey Mexiletine in the management of ventricular dysrrhythmias Eur J Cardiol 6 1977 245 258
    • (1977) Eur J Cardiol , vol.6 , pp. 245-258
    • Campbell, N.P.1    Pantridge, J.F.2    Adgey, A.A.3
  • 49
    • 0023684127 scopus 로고
    • Changes in spontaneous variability of ventricular ectopic activity as a function of time in patients with chronic arrhythmias
    • M.I. Anastasiou-Nana, R.L. Menlove, J.N. Nanas, and J.L. Anderson Changes in spontaneous variability of ventricular ectopic activity as a function of time in patients with chronic arrhythmias Circulation 78 1988 286 295
    • (1988) Circulation , vol.78 , pp. 286-295
    • Anastasiou-Nana, M.I.1    Menlove, R.L.2    Nanas, J.N.3    Anderson, J.L.4
  • 50
    • 0023786031 scopus 로고
    • Spontaneous variability of simple and complex ventricular premature contractions during long time intervals in patients with severe organic heart disease
    • G. Schmidt, K. Ulm, P. Barthel, L. Goedel-Meinen, G. Jahns, and W. Baedeker Spontaneous variability of simple and complex ventricular premature contractions during long time intervals in patients with severe organic heart disease Circulation 78 1988 296 301
    • (1988) Circulation , vol.78 , pp. 296-301
    • Schmidt, G.1    Ulm, K.2    Barthel, P.3    Goedel-Meinen, L.4    Jahns, G.5    Baedeker, W.6


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