메뉴 건너뛰기




Volumn 17, Issue 5, 2010, Pages 444-449

Bridging therapy and oral anticoagulation: Current and future prospects

Author keywords

bridging therapy; low molecular weight heparin; oral anticoagulation; periprocedural management; unfractionated heparin

Indexed keywords

ACENOCOUMAROL; ANTIVITAMIN K; ARDEPARIN; DABIGATRAN ETEXILATE; DALTEPARIN; ENOXAPARIN; FLUINDIONE; HEPARIN; LOW MOLECULAR WEIGHT HEPARIN; RIVAROXABAN; WARFARIN;

EID: 77955918007     PISSN: 10656251     EISSN: 15317048     Source Type: Journal    
DOI: 10.1097/MOH.0b013e32833c077b     Document Type: Review
Times cited : (34)

References (44)
  • 1
    • 0035125568 scopus 로고    scopus 로고
    • Antithrombotic therapy for venous thromboembolic disease
    • Hyers TM, Agnelli G, Hull RD, et al. Antithrombotic therapy for venous thromboembolic disease. Chest 2001; 119 (1 Suppl):176S-193S.
    • (2001) Chest , vol.119 , Issue.1 SUPPL.
    • Hyers, T.M.1    Agnelli, G.2    Hull, R.D.3
  • 3
    • 77949913050 scopus 로고    scopus 로고
    • To bridge or not to bridge: That is the question. The argument for bridging therapy in patients on oral anticoagulants requiring temporary interruption for elective procedures
    • Spyropoulos AC. To bridge or not to bridge: that is the question. The argument FOR bridging therapy in patients on oral anticoagulants requiring temporary interruption for elective procedures. J Thromb Thrombolysis 2010; 29:192-198.
    • (2010) J Thromb Thrombolysis , vol.29 , pp. 192-198
    • Spyropoulos, A.C.1
  • 4
    • 44949254299 scopus 로고    scopus 로고
    • Perioperative management of warfarin therapy: To bridge or not to bridge, that is the question
    • Douketis JD. Perioperative management of warfarin therapy: to bridge or not to bridge, that is the question. Mayo Clin Proc 2008; 83:628-629.
    • (2008) Mayo Clin Proc , vol.83 , pp. 628-629
    • Douketis, J.D.1
  • 5
    • 74349125442 scopus 로고    scopus 로고
    • Perioperative management of warfarin and antiplatelet therapy
    • Jaffer AK. Perioperative management of warfarin and antiplatelet therapy. Cleve Clin J Med 2009; 76 (Suppl 4):S37-S44.
    • (2009) Cleve Clin J Med , vol.76 , Issue.SUPPL. 4
    • Jaffer, A.K.1
  • 6
    • 46049099373 scopus 로고    scopus 로고
    • The perioperative management of antithrombotic therapy: American College of Chest Physicians evidence-based clinical practice guidelines
    • (8th edition)
    • Douketis JD, Berger PB, Dunn AS, et al. The perioperative management of antithrombotic therapy: American College of Chest Physicians evidence-based clinical practice guidelines (8th edition). Chest 2008; 133 (6 Suppl): 299S-339S.
    • (2008) Chest , vol.133 , Issue.6 SUPPL.
    • Douketis, J.D.1    Berger, P.B.2    Dunn, A.S.3
  • 7
    • 50049120298 scopus 로고    scopus 로고
    • Guidelines for antithrombotic therapy: Peri-procedural management of antithrombotic therapy and use of bridging anticoagulation
    • Spyropoulos AC, Douketis JD. Guidelines for antithrombotic therapy: peri-procedural management of antithrombotic therapy and use of bridging anticoagulation. Int Angiol 2008; 27:333-343.
    • (2008) Int Angiol , vol.27 , pp. 333-343
    • Spyropoulos, A.C.1    Douketis, J.D.2
  • 8
    • 0027957312 scopus 로고
    • Thromboembolic and bleeding complications in patients with mechanical heart valve prostheses
    • Cannegieter SC, Rosendaal FR, Briet E. Thromboembolic and bleeding complications in patients with mechanical heart valve prostheses. Circulation 1994; 89:635-641.
    • (1994) Circulation , vol.89 , pp. 635-641
    • Cannegieter, S.C.1    Rosendaal, F.R.2    Briet, E.3
  • 9
    • 77953753810 scopus 로고    scopus 로고
    • Risk of stroke after surgery in patients with and without chronic atrial fibrillation
    • Kaatz S, Douketis JD, Zhou H, et al. Risk of stroke after surgery in patients with and without chronic atrial fibrillation. J Thromb Haemost 2010; 8:884-890.
    • (2010) J Thromb Haemost , vol.8 , pp. 884-890
    • Kaatz, S.1    Douketis, J.D.2    Zhou, H.3
  • 10
    • 33644878513 scopus 로고    scopus 로고
    • Bridging of oral anticoagulation therapy for invasive procedures
    • Spyropoulos AC. Bridging of oral anticoagulation therapy for invasive procedures. Curr Hematol Rep 2005; 4:405-413.
    • (2005) Curr Hematol Rep , vol.4 , pp. 405-413
    • Spyropoulos, A.C.1
  • 11
    • 56749163376 scopus 로고    scopus 로고
    • Management of surgical patients receiving anticoagulation and antiplatelet agents
    • Thachil J, Gatt A, Martlew V. Management of surgical patients receiving anticoagulation and antiplatelet agents. Br J Surg 2008; 95:1437-1448.
    • (2008) Br J Surg , vol.95 , pp. 1437-1448
    • Thachil, J.1    Gatt, A.2    Martlew, V.3
  • 12
    • 77449099154 scopus 로고    scopus 로고
    • Incidence and predictors of bleeding or thrombosis after polypectomy in patients receiving and not receiving anti-coagulation therapy
    • Witt DM, Delate T, McCool KH, et al. Incidence and predictors of bleeding or thrombosis after polypectomy in patients receiving and not receiving anti-coagulation therapy. J Thromb Haemost 2009; 7:1982-1989.
    • (2009) J Thromb Haemost , vol.7 , pp. 1982-1989
    • Witt, D.M.1    Delate, T.2    McCool, K.H.3
  • 13
    • 0035125403 scopus 로고    scopus 로고
    • Managing oral anticoagulant therapy
    • Ansell J, Hirsh J, Dalen J, et al. Managing oral anticoagulant therapy. Chest 2001; 119 (1 Suppl):22S-38S.
    • (2001) Chest , vol.119 , Issue.1 SUPPL.
    • Ansell, J.1    Hirsh, J.2    Dalen, J.3
  • 14
    • 0017873741 scopus 로고
    • Discontinuing anticoagulant therapy in surgical patients with cardiac valve prostheses. Observations in 180 operations
    • Tinker JH, Tarhan S. Discontinuing anticoagulant therapy in surgical patients with cardiac valve prostheses. Observations in 180 operations. JAMA 1978; 239:738-739.
    • (1978) JAMA , vol.239 , pp. 738-739
    • Tinker, J.H.1    Tarhan, S.2
  • 15
    • 0028809174 scopus 로고
    • Temporary discontinuation of warfarin therapy: Changes in the international normalized ratio
    • White RH, McKittrick T, Hutchinson R, Twitchell J. Temporary discontinuation of warfarin therapy: changes in the international normalized ratio. Ann Intern Med 1995; 122:40-42.
    • (1995) Ann Intern Med , vol.122 , pp. 40-42
    • White, R.H.1    McKittrick, T.2    Hutchinson, R.3    Twitchell, J.4
  • 16
    • 0032962689 scopus 로고    scopus 로고
    • Current clinical concepts in perioperative anticoagulation
    • Hewitt RL, Chun KL, Flint LM. Current clinical concepts in perioperative anticoagulation. Am Surg 1999; 65:270-273.
    • (1999) Am Surg , vol.65 , pp. 270-273
    • Hewitt, R.L.1    Chun, K.L.2    Flint, L.M.3
  • 17
    • 0025305492 scopus 로고
    • Anticoagulation for noncardiac procedures in patients with prosthetic heart valves. Does low risk mean high cost?
    • Eckman MH, Beshansky JR, Durand-Zaleski I, et al. Anticoagulation for noncardiac procedures in patients with prosthetic heart valves. Does low risk mean high cost? JAMA 1990; 263:1513-1521.
    • (1990) JAMA , vol.263 , pp. 1513-1521
    • Eckman, M.H.1    Beshansky, J.R.2    Durand-Zaleski, I.3
  • 18
    • 0017115575 scopus 로고
    • Living with prosthetic heart valves. Subsequent noncardiac operations and the risk of thromboembolism or hemorrhage
    • Katholi RE, Nolan SP, McGuire LB. Living with prosthetic heart valves. Subsequent noncardiac operations and the risk of thromboembolism or hemorrhage. Am Heart J 1976; 92:162-167.
    • (1976) Am Heart J , vol.92 , pp. 162-167
    • Katholi, R.E.1    Nolan, S.P.2    McGuire, L.B.3
  • 19
    • 0034114004 scopus 로고    scopus 로고
    • Perioperative anticoagulation in patients with chronic atrial fibrillation who are undergoing elective surgery: Results of a physician survey
    • Douketis JD, Crowther MA, Cherian SS. Perioperative anticoagulation in patients with chronic atrial fibrillation who are undergoing elective surgery: results of a physician survey. Can J Cardiol 2000; 16:326-330.
    • (2000) Can J Cardiol , vol.16 , pp. 326-330
    • Douketis, J.D.1    Crowther, M.A.2    Cherian, S.S.3
  • 20
    • 0032718911 scopus 로고    scopus 로고
    • Physician preferences for perioperative anticoagulation in patients with a mechanical heart valve who are undergoing elective noncardiac surgery
    • Douketis JD, Crowther MA, Cherian SS, Kearon CB. Physician preferences for perioperative anticoagulation in patients with a mechanical heart valve who are undergoing elective noncardiac surgery. Chest 1999; 116:1240-1246.
    • (1999) Chest , vol.116 , pp. 1240-1246
    • Douketis, J.D.1    Crowther, M.A.2    Cherian, S.S.3    Kearon, C.B.4
  • 21
    • 70349251620 scopus 로고    scopus 로고
    • Chronically anticoagulated' patients who need surgery: Can low-molecular-weight heparins really be used to "bridge" patients instead of intravenous unfractionated heparin?
    • Jaff MR. Chronically anticoagulated' patients who need surgery: can low-molecular-weight heparins really be used to "bridge" patients instead of intravenous unfractionated heparin? Catheter Cardiovasc Interv 2009; 74 (Suppl 1):S17-S21.
    • (2009) Catheter Cardiovasc Interv , vol.74 , Issue.SUPPL. 1
    • Jaff, M.R.1
  • 22
    • 24944565416 scopus 로고    scopus 로고
    • Low-molecular-weight-heparins as periprocedural anticoagulation for patients on long-term warfarin therapy: A standardized bridging therapy protocol
    • Jaffer AK, Ahmed M, Brotman DJ, et al. Low-molecular-weight-heparins as periprocedural anticoagulation for patients on long-term warfarin therapy: a standardized bridging therapy protocol. J Thromb Thrombolysis 2005; 20:11-16.
    • (2005) J Thromb Thrombolysis , vol.20 , pp. 11-16
    • Jaffer, A.K.1    Ahmed, M.2    Brotman, D.J.3
  • 23
    • 2442486457 scopus 로고    scopus 로고
    • Costs and clinical outcomes associated with low-molecular-weight heparin vs. unfractionated heparin for perioperative bridging in patients receiving long-term oral anticoagulant therapy
    • Spyropoulos AC, Frost FJ, Hurley JS, Roberts M. Costs and clinical outcomes associated with low-molecular-weight heparin vs. unfractionated heparin for perioperative bridging in patients receiving long-term oral anticoagulant therapy. Chest 2004; 125:1642-1650.
    • (2004) Chest , vol.125 , pp. 1642-1650
    • Spyropoulos, A.C.1    Frost, F.J.2    Hurley, J.S.3    Roberts, M.4
  • 24
    • 52349113109 scopus 로고    scopus 로고
    • Perioperative bridging therapy with unfractionated heparin or low-molecular-weight heparin in patients with mechanical prosthetic heart valves on long-term oral anticoagulants (from the REGIMEN Registry)
    • Spyropoulos AC, Turpie AG, Dunn AS, et al. Perioperative bridging therapy with unfractionated heparin or low-molecular-weight heparin in patients with mechanical prosthetic heart valves on long-term oral anticoagulants (from the REGIMEN Registry). Am J Cardiol 2008; 102:883-889.
    • (2008) Am J Cardiol , vol.102 , pp. 883-889
    • Spyropoulos, A.C.1    Turpie, A.G.2    Dunn, A.S.3
  • 25
    • 33646764900 scopus 로고    scopus 로고
    • Clinical outcomes with un-fractionated heparin or low-molecular-weight heparin as bridging therapy in patients on long-term oral anticoagulants: The REGIMEN registry
    • Spyropoulos AC, Turpie AG, Dunn AS, et al. Clinical outcomes with un-fractionated heparin or low-molecular-weight heparin as bridging therapy in patients on long-term oral anticoagulants: the REGIMEN registry. J Thromb Haemost 2006; 4:1246-1252.
    • (2006) J Thromb Haemost , vol.4 , pp. 1246-1252
    • Spyropoulos, A.C.1    Turpie, A.G.2    Dunn, A.S.3
  • 26
    • 3042639769 scopus 로고    scopus 로고
    • Low-molecular-weight heparin as bridging anticoagulation during interruption of warfarin: Assessment of a standardized periprocedural anticoagulation regimen
    • Douketis JD, Johnson JA, Turpie AG. Low-molecular-weight heparin as bridging anticoagulation during interruption of warfarin: assessment of a standardized periprocedural anticoagulation regimen. Arch Intern Med 2004; 164:1319-1326.
    • (2004) Arch Intern Med , vol.164 , pp. 1319-1326
    • Douketis, J.D.1    Johnson, J.A.2    Turpie, A.G.3
  • 27
    • 20844440527 scopus 로고    scopus 로고
    • Single-arm study of bridging therapy with low-molecular-weight heparin for patients at risk of arterial embolism who require temporary interruption of warfarin
    • Kovacs MJ, Kearon C, Rodger M, et al. Single-arm study of bridging therapy with low-molecular-weight heparin for patients at risk of arterial embolism who require temporary interruption of warfarin. Circulation 2004; 110:1658-1663.
    • (2004) Circulation , vol.110 , pp. 1658-1663
    • Kovacs, M.J.1    Kearon, C.2    Rodger, M.3
  • 28
    • 44949133339 scopus 로고    scopus 로고
    • Periprocedural anticoagula tion management of patients with nonvalvular atrial fibrillation
    • Wysokinski WE, McBane RD, Daniels PR, et al. Periprocedural anticoagula tion management of patients with nonvalvular atrial fibrillation. Mayo Clin Proc 2008; 83:639-645.
    • (2008) Mayo Clin Proc , vol.83 , pp. 639-645
    • Wysokinski, W.E.1    McBane, R.D.2    Daniels, P.R.3
  • 29
    • 67649497925 scopus 로고    scopus 로고
    • Standardized low-molecular-weight heparin bridging regimen in outpatients on oral anticoagulants undergoing invasive procedure or surgery: An inception cohort management study
    • Pengo V, Cucchini U, Denas G, et al. Standardized low-molecular-weight heparin bridging regimen in outpatients on oral anticoagulants undergoing invasive procedure or surgery: an inception cohort management study. Circulation 2009; 119:2920-2927.
    • (2009) Circulation , vol.119 , pp. 2920-2927
    • Pengo, V.1    Cucchini, U.2    Denas, G.3
  • 30
    • 73049105008 scopus 로고    scopus 로고
    • Patients requiring interruption of long-term oral anticoagulant therapy: The use of fixed sub-therapeutic doses of low-molecular-weight heparin
    • Malato A, Saccullo G, Lo Coco L, et al. Patients requiring interruption of long-term oral anticoagulant therapy: the use of fixed sub-therapeutic doses of low-molecular-weight heparin. J Thromb Haemost 2010; 8:107-113.
    • (2010) J Thromb Haemost , vol.8 , pp. 107-113
    • Malato, A.1    Saccullo, G.2    Lo Coco, L.3
  • 31
    • 1542610717 scopus 로고    scopus 로고
    • Pacemaker and implantable cardioverter defibrillator implantation without reversal of warfarin therapy
    • Giudici MC, Paul DL, Bontu P, Barold SS. Pacemaker and implantable cardioverter defibrillator implantation without reversal of warfarin therapy. Pacing Clin Electrophysiol 2004; 27:358-360.
    • (2004) Pacing Clin Electrophysiol , vol.27 , pp. 358-360
    • Giudici, M.C.1    Paul, D.L.2    Bontu, P.3    Barold, S.S.4
  • 32
    • 77955922128 scopus 로고    scopus 로고
    • Bridge or continue coumadin for device surgery randomized controlled trial (BRUISECONTROL)
    • University of Ottawa Heart Institute Bethesda (MD): National Library of Medicine (US). Available from: [Accessed 20 January 2010]
    • University of Ottawa Heart Institute. Bridge or continue coumadin for device surgery randomized controlled trial (BRUISECONTROL). ClinicalTrialsgov Bethesda (MD): National Library of Medicine (US). Available from: http://clinicaltrialsgov/ct2/show/NCT00800137?term1/4;NCT00800137&rank1/4;1 NLM Identifier: NCT00800137. [Accessed 20 January 2010]
    • ClinicalTrialsgov
  • 33
    • 38349048530 scopus 로고    scopus 로고
    • Risk of thromboembolism with short-term interruption of warfarin therapy
    • Garcia DA, Regan S, Henault LE, et al. Risk of thromboembolism with short-term interruption of warfarin therapy. Arch Intern Med 2008; 168:63-69.
    • (2008) Arch Intern Med , vol.168 , pp. 63-69
    • Garcia, D.A.1    Regan, S.2    Henault, L.E.3
  • 34
    • 33847067931 scopus 로고    scopus 로고
    • Brief communication: Preoperative anticoagulant activity after bridging low-molecular-weight heparin for temporary interruption of warfarin
    • O'Donnell MJ, Kearon C, Johnson J, et al. Brief communication: preoperative anticoagulant activity after bridging low-molecular-weight heparin for temporary interruption of warfarin. Ann Intern Med 2007; 146:184-187.
    • (2007) Ann Intern Med , vol.146 , pp. 184-187
    • O'Donnell, M.J.1    Kearon, C.2    Johnson, J.3
  • 35
    • 77955926784 scopus 로고    scopus 로고
    • Effectiveness of bridging anticoagulation for surgery (The BRIDGE Study)
    • National Heart Lung and Blood Institute Bethesda (MD): National Library of Medicine (US). Available from: [Accessed 20 January 2010]
    • National Heart, Lung and Blood Institute. Effectiveness of bridging anticoagulation for surgery (The BRIDGE Study). ClinicalTrialsgov Bethesda (MD): National Library of Medicine (US). Available from: http://clinicaltrials.gov/ ct2/show/NCT00786474?term1/4;NCT00786474&rank1/4;1 NLM Identifier: NCT00786474. [Accessed 20 January 2010]
    • ClinicalTrialsgov
  • 36
    • 84940415372 scopus 로고    scopus 로고
    • PERIOP 2-A safety and effectiveness study of LMWH bridging therapy versus placebo bridging therapy for patients on long term warfarin and require temporary interruption of their warfarin
    • Lawson Health Research Institute Bethesda (MD): National Library of Medicine (US). Available from: [Accessed 21 January 2010]
    • Lawson Health Research Institute. PERIOP 2-a safety and effectiveness study of LMWH bridging therapy versus placebo bridging therapy for patients on long term warfarin and require temporary interruption of their warfarin. ClinicalTrialsgov Bethesda (MD): National Library of Medicine (US). Available from: http://clinicaltrials.gov/ct2/show/NCT00432796?term1/4; NCT00432796&rank1/4;1 NLM Identifier: NCT00432796. [Accessed 21 January 2010]
    • ClinicalTrialsgov
  • 37
    • 74949139434 scopus 로고    scopus 로고
    • The new oral anticoagulants
    • Garcia D, Libby E, Crowther MA. The new oral anticoagulants. Blood 2010; 115:15-20.
    • (2010) Blood , vol.115 , pp. 15-20
    • Garcia, D.1    Libby, E.2    Crowther, A.3
  • 39
    • 70349306707 scopus 로고    scopus 로고
    • Dabigatran versus warfarin in patients with atrial fibrillation
    • Connolly SJ, Ezekowitz MD, Yusuf S, et al. Dabigatran versus warfarin in patients with atrial fibrillation. N Engl J Med 2009; 361:1139-1151.
    • (2009) N Engl J Med , vol.361 , pp. 1139-1151
    • Connolly, S.J.1    Ezekowitz, M.D.2    Yusuf, S.3
  • 40
    • 77955923939 scopus 로고    scopus 로고
    • Randomized double-blind study comparing once daily oral rivar-oxaban with adjusted-dose oral warfarin for the prevention of stroke in subjects with nonvalvular atrial fibrillation
    • Bayer Bethesda (MD): National Library of Medicine (US) Available from: [Accessed 11 January 2009]
    • Bayer. Randomized, double-blind study comparing once daily oral rivar-oxaban with adjusted-dose oral warfarin for the prevention of stroke in subjects with nonvalvular atrial fibrillation. ClinicalTrialsgov Bethesda (MD): National Library of Medicine (US) Available from: http://clinicaltrials. gov/ct2/show/NCT00403767?term1/4;NCT00403767&rank1/4;1 NLM Identifier: NCT00403767. [Accessed 11 January 2009]
    • ClinicalTrialsgov
  • 41
    • 3442889161 scopus 로고    scopus 로고
    • Will oral antithrombin agents replace warfarin?
    • Sinnaeve PR, Van de Werf FJ. Will oral antithrombin agents replace warfarin? Heart 2004; 90:827-828.
    • (2004) Heart , vol.90 , pp. 827-828
    • Sinnaeve, P.R.1    Van De Werf, F.J.2
  • 42
    • 34548031359 scopus 로고    scopus 로고
    • The pharmacokinetics, pharmacodynamics and tolerability of dabigatran etexilate, a new oral direct thrombin inhibitor, in healthy male subjects
    • Stangier J, Rathgen K, Stahle H, et al. The pharmacokinetics, pharmacodynamics and tolerability of dabigatran etexilate, a new oral direct thrombin inhibitor, in healthy male subjects. Br J Clin Pharmacol 2007; 64:292-303.
    • (2007) Br J Clin Pharmacol , vol.64 , pp. 292-303
    • Stangier, J.1    Rathgen, K.2    Stahle, H.3
  • 43
    • 58949098587 scopus 로고    scopus 로고
    • Rivaroxaban: Clinical pharmacology
    • Mismetti P, Laporte S. Rivaroxaban: clinical pharmacology. Ann Fr Anesth Reanim 2008; 27 (Suppl 3):S16-S21.
    • (2008) Ann Fr Anesth Reanim , vol.27 , Issue.SUPPL. 3
    • Mismetti, P.1    Laporte, S.2
  • 44
    • 77949421739 scopus 로고    scopus 로고
    • Influence of renal impairment on the pharmacokinetics and pharmacodynamics of oral dabigatran etexilate: An open-label, parallel-group, single-centre study
    • Stangier J, Rathgen K, Stahle H, Mazur D. Influence of renal impairment on the pharmacokinetics and pharmacodynamics of oral dabigatran etexilate: an open-label, parallel-group, single-centre study. Clin Pharmacokinet 2010; 49:259-268.
    • (2010) Clin Pharmacokinet , vol.49 , pp. 259-268
    • Stangier, J.1    Rathgen, K.2    Stahle, H.3    Mazur, D.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.