Perioperative Bridging Therapy With Unfractionated Heparin or Low-Molecular-Weight Heparin in Patients With Mechanical Prosthetic Heart Valves on Long-Term Oral Anticoagulants (from the REGIMEN Registry)

American Journal of Cardiology

Volumn 102, Issue 7, 2008, Pages 883-889

  Spyropoulos, Alex C ^a   Turpie, Alexander G G ^b   Dunn, Andrew S ^c   Kaatz, Scott ^d   Douketis, James ^e   Jacobson, Alan ^f   Petersen, Hans ^g  

^a LOVELACE MEDICAL CENTER   (United States)

^b HAMILTON HEALTH SCIENCES   (Canada)

^c MOUNT SINAI HOSPITAL   (United States)

^d HENRY FORD HOSPITAL   (United States)

^e ST JOSEPH S HOSPITAL   (Canada)

^f VETERANS AFFAIRS MEDICAL CENTER   (United States)

^g LOVELACE RESPIRATORY RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTICOAGULANT AGENT; BEMIPARIN; DALTEPARIN; ENOXAPARIN; FIBRINOLYTIC AGENT; HEPARIN; LOW MOLECULAR WEIGHT HEPARIN; TINZAPARIN;

ADULT; AGED; ANTICOAGULATION; ARTICLE; BLEEDING; COMORBIDITY; DEMOGRAPHY; DRUG SAFETY; FEMALE; HEART VALVE PROSTHESIS; HEART VALVE REPLACEMENT; HOSPITAL DISCHARGE; HUMAN; MAJOR CLINICAL STUDY; MALE; METHODOLOGY; MULTIVARIATE LOGISTIC REGRESSION ANALYSIS; MURAL THROMBUS; OUTPATIENT; PERIOPERATIVE PERIOD; PRIORITY JOURNAL; STROKE; THORAX SURGERY; THROMBOEMBOLISM; THROMBUS; TRANSIENT ISCHEMIC ATTACK; TREATMENT OUTCOME; VALVULAR THROMBUS;

ADMINISTRATION, ORAL; AGED; ANTICOAGULANTS; CANADA; CHI-SQUARE DISTRIBUTION; DISCRIMINANT ANALYSIS; FEMALE; HEART VALVE PROSTHESIS; HEPARIN; HEPARIN, LOW-MOLECULAR-WEIGHT; HUMANS; LOGISTIC MODELS; MALE; PROSPECTIVE STUDIES; REGISTRIES; SURGICAL PROCEDURES, ELECTIVE; UNITED STATES;

EID: 52349113109     PISSN: 00029149     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.amjcard.2008.05.042     Document Type: Article

References (21)

1. Spyropoulos A.C., Jenkins P., and Bornikova L. A disease management protocol for outpatient perioperative bridge therapy with enoxaparin in patients requiring temporary interruption of long-term oral anticoagulation. Pharmacotherapy 24 (2004) 649-658
2. Spandorfer J.M., Lynch S., Weitz H.H., Fertel S., and Merli G.J. Use of enoxaparin for the chronically anticoagulated patient before and after procedures. Am J Cardiol 84 (1999) 478-480 A10.
3. Tinmouth A.H., Morrow B.H., Cruickshank M.K., Moore P.M., and Kovacs M.J. Dalteparin as periprocedure anticoagulation for patients in warfarin and at high risk of thrombosis. Ann Pharmacother 35 (2001) 669-674
4. Ferreira I., Dos L., Tornos P., Nicolau I., Permanyer-Miralda G., and Soler-Soler J. Experience with enoxaparin in patients with mechanical heart valves who must withhold acenocumarol. Heart 89 (2003) 527-530
5. Anticoagulation in Prosthetic Heart Valves and Pregnancy Consensus Report (APPCR)Anticoagulation and enoxaparin use in patients with prosthetic heart valves and/or pregnancy. Clin Cardiol Consens Rep 3 (2002) 1-20
6. Spyropoulos A.C., Turpie A.G., Dunn A.S., Spandorfer J., Douketis J., Jacobson A., Frost F.J., and REGIMEN Investigators. Clinical outcomes with unfractionated heparin or low-molecularweight heparin as bridging therapy in patients on long-term oral anticoagulants: the REGIMEN registry. J Thromb Haemost 4 (2006) 1246-1252
7. Nicolaides A.N., Breddin H.K., Fareed J., Goldhaber S., Haas S., Hull R., Kalodiki E., Myers K., Samama M., Sasahara A., and Cardiovascular Disease Educational and Research Trust and the International Union of Angiology. Prevention of venous thromboembolism. International 14 Consensus Statement: guidelines compiled in accordance with the scientific evidence. Int Angiol 20 (2001) 1-37
8. Charlson M., Szatrowski T.P., Peterson J., and Gold J. Validation of a combined comorbidity index. J Clin Epidemiol 47 (1994) 1245-1251
9. Beyth R.J., Quinn L.M., and Landefeld C.S. Prospective evaluation of an index for predicting the risk of major bleeding in outpatients treated with warfarin. Am J Med 105 (1998) 91-99
10. Katholi R.E., Nolan S.P., and McGuire L.B. The management of anticoagulation during noncardiac operations in patients with prosthetic heart valves: a prospective study. Am Heart J 96 (1978) 163-165
11. Halbritter K.M., Wawer A., Beyer J., Oettler W., and Schellong S.M. Bridging anticoagulation for patients on long-term vitamin-K-antagonists: a prospective 1 year registry of 311 episodes. J Thromb Haemost 3 (2005) 2823-2825
12. Spyropoulos A.C., Frost F.J., Hurley J.S., and Roberts M. Costs and clinical outcomes associated with low-molecular-weight heparin vs unfractionated heparin for perioperative bridging in patients receiving long-term oral anticoagulant therapy. Chest 125 (2004) 1642-1650
13. Montalescot G., Polle V., Collet J.P., Leprince P., Bellanger A., Gandjbakhch I., and Thomas D. Low molecular weight heparin after mechanical heart valve replacement. Circulation 101 (2000) 1083-1086
14. Douketis J.D., Berger P.B., Dunn A.S., Jafer A.K., Spyropoulos A.C., Becker R.C., and Ansell J. The perioperative management of antithrombotic therapy. Chest 133 (2008) 299S-340S
15. Kovacs M.J., Kearon C., Rodger M., Anderson D.R., Turpie A.G., Bates S.M., Desjardins L., Douketis J., Kahn S.R., Solymoss S., and Wells P.S. Single-arm study of bridging therapy with 15 low-molecular-weight heparin for patients at risk of arterial embolism who require temporary interruption of warfarin. Circulation 110 (2004) 1658-1663
16. Douketis J.D., Johnson J.A., and Turpie A.G. Low-molecular-weight heparin as bridging anticoagulation during interruption of warfarin: assessment of a standardized periprocedural anticoagulation regimen. Arch Intern Med 164 (2004) 1319-1326
17. Baudo F., de Cataldo F., Mostarda G., Ghirarduzzi A., Molinatti M., Pengo V., Poli D., Tosetto A., Tiraferri E., and Morra E. Management of patients on long-term oral anticoagulant therapy undergoing elective surgery: survey of the clinical practice in the Italian anticoagulation clinics. Intern Emerg Med 2 (2007) 280-284
18. Hammerstingl C., Tripp C., Schmidt H., von der Recke G., and Omran H. Periprocedural bridging therapy with low-molecular-weight heparin in chronically anticoagulated patients with prosthetic mechanical heart valves: experience in 116 patients from the prospective BRAVE registry. J Heart Valve Dis 16 (2007) 285-292
19. Jaffer A.K., Ahmed M., Brotman D.J., Bragg L., Seshadri N., Qadeer M.A., and Klein A. Low molecular-weight-heparins as periprocedural anticoagulation for patients on long-term warfarin therapy: a standardized bridging therapy protocol. J Thromb Thrombolysis 20 (2005) 11-16
20. Constans M., Santamaria A., Mateo J., Pujol N., Souto J.C., and Fontcuberta J. Low-molecularweight heparin as bridging therapy during interruption of oral anticoagulation in patients undergoing colonoscopy or gastroscopy. Int J Clin Pract 61 (2007) 212-217
21. Spyropoulos A.C., and Turpie A.G. Perioperative bridging interruption with heparin for the patient receiving long-term anticoagulation. Curr Opin Pulm Med 11 (2005) 373-379