Arsenic induces DNA damage in environmentally exposed Mexican children and adults. Influence of GSTO1 and AS3MT Polymorphisms

Toxicological Sciences

Volumn 117, Issue 1, 2010, Pages 63-71

  Sampayo Reyes, Adriana ^a   Hernández, Alba ^b,c   El Yamani, Naouale ^b   López Campos, Celsa ^a,d   Mayet Machado, Eduardo ^d   Rincón Castañeda, Cuauhtémoc B ^d,e   Limones Aguilar, María de L ^a,d   López Campos, Jesús E ^a,d,f   de león, Mario B ^a   González Hernández, Silvia ^a   Hinojosa Garza, Diana ^a   Marcos, Ricardo ^b,c  

^a INSTITUTO MEXICANO DEL SEGURO SOCIAL   (Mexico)

^b UNIVERSITAT AUTÒNOMA DE BARCELONA   (Spain)

^c INSTITUTO DE SALUD CARLOS III   (Spain)

^d Salud Integral Multidisciplinaria   (Mexico)

^e Hospital General del Intituto de Servicios y Seguridad Social para los Trabajadores del Estado   (Mexico)

^f SECRETARÍA DE SALUD   (Mexico)

Author keywords

Arsenic; AS3MT and GSTO1 polymorphisms; Children; Comet assay; Cytogenetic damage; Mexico

Indexed keywords

ALANINE; ARSENIC; AS3MT PROTEIN; CREATININE; DNA; DRINKING WATER; GLUTAMIC ACID; GLUTATHIONE S TRANSFERASE OMEGA 1; GLUTATHIONE TRANSFERASE; METHIONINE; METHYLTRANSFERASE; THREONINE; UNCLASSIFIED DRUG; VALINE;

ADULT; ALLELE; ARTICLE; CHILD; COMET ASSAY; CONTROLLED STUDY; DNA DAMAGE; ENVIRONMENTAL EXPOSURE; ENVIRONMENTAL MONITORING; FEMALE; GENE DELETION; GENETIC DAMAGE; GENETIC POLYMORPHISM; GENETIC VARIABILITY; GENOTOXICITY; HUMAN; HUMAN EXPERIMENT; MALE; MEXICO; OXIDATION; SCHOOL CHILD; URINE LEVEL;

ADULT; ARSENIC; BASE SEQUENCE; CHILD; DNA DAMAGE; DNA PRIMERS; ENVIRONMENTAL EXPOSURE; GLUTATHIONE TRANSFERASE; HUMANS; METHYLTRANSFERASES; MEXICO; POLYMERASE CHAIN REACTION; POLYMORPHISM, GENETIC;

EID: 77955914888     PISSN: 10966080     EISSN: 10960929     Source Type: Journal    
DOI: 10.1093/toxsci/kfq173     Document Type: Article

References (43)

1. Basu, A., Mahata, J., Gupta, S., and Giri, A. K. (2001). Genetic toxicology of a paradoxical human carcinogen, arsenic: a review. Mutat. Res. 488, 171-194.
2. Carrizales, L., Razo, I., Tellez-Hernández, J. I., Torres-Nerio, R., Torres, A., Batres, L. E., Cubillas, A. C., and Diaz-Barriga, F. (2006). Exposure to arsenic and lead of children living near a copper-smelter in San Luis Potosi, Mexico: importance of soil contamination for exposure of children. Environ. Res. 101(2006), 1-10.
3. De Vizcaya-Ruiz, A., Barbier, O., Ruiz-Ramos, R., and Cebrian, M. E. (2009). Biomarkers of oxidative stress and damage in human populations exposed to arsenic. Mutat. Res. 674, 85-92.
4. Drobna, Z., Xing, W., Thomas, D. J., and Styblo, M. (2006). shRNA silencing of AS3MT expression minimizes arsenic methylation capacity of HepG2 cells. Chem. Res. Toxicol. 19, 894-898.
5. Fry, R. C., Navasumrit, P., Valiathan, C., Svensson, J. P., Hogan, B. J., Luo, M., Bhattacharya, S., Kandjanapa, K., Soontararuks, S., Nookabkaew, S., et al. (2007). Activation of inflammation/NF-kappaB signaling in infants born to arsenic-exposed mothers. PLoS Genet. 3, e207.
6. Gonsebatt, M. E., Vega, L., Salazar, A. M., Montero, R., Guzman, P., Blas, J., Del Razo, L. M., Garcia-Vargas, G., Albores, A., Cebrian, M. E., et al. (1997). Cytogenetic effects in human exposure to arsenic. Mutat. Res. 386, 219-228.
7. Hayes, J. D., Flanagan, J. U., and Jowsey, I. R. (2005). Glutathione transferases. Annu. Rev. Pharmacol. Toxicol. 45, 51-88.
8. Hernández, A., and Marcos, R. (2008). Genetic variations associated with interindividual sensitivity in the response to arsenic exposure. Pharmacogenomics 9, 1113-1132.
9. Hernández, A., Xamena, N., Sekaran, C., Tokunaga, H., Sampayo-Reyes, A., Quinteros, D., Creus, A., and Marcos, R. (2008a). High arsenic metabolic efficiency in AS3MT287Thr allele carriers. Pharmacogenet. Genomics 18, 349-355.
10. Hernández, A., Xamena, N., Surrallés, J., Sekaran, C., Tokunaga, H., Quinteros, D., Creus, A., and Marcos, R. (2008b). Role of the Met(287)Thr polymorphism in the AS3MT gene on the metabolic arsenic profile. Mutat. Res. 637, 80-92.
11. International Agency on Research on Cancer (IARC). (2004). Working Group on the Evaluation of Carcinogenic Risks to Humans. Some drinking-water disinfectants and contaminants, including arsenic. IARC Monogr. Eval. Carcinog. Risks Hum. 84, 1-477.
12. Jasso-Pineda, Y., Espinosa-Reyes, G., Gonzalez-Mille, D., Razo-Soto, I., Carrizales, L., Torres-Dosal, A., Mejia-Saavedra, J., Monroy, M., Ize, A. I., Yarto, M., et al. (2007). An integrated health risk assessment approach to the study of mining sites contaminated with arsenic and lead. Integr. Environ. Assess. Manag. 3, 344-350.
13. Johnson, L. R., and Farmer, J. G. (1991). Use of human metabolic studies and urinary arsenic speciation in assessing arsenic exposure. Bull. Environ. Contam. Toxicol. 46, 53-61.
14. Kligerman, A. D., and Tennant, A. H. (2007). Insights into the carcinogenic mode of action of arsenic. Toxicol. Appl. Pharmacol. 222, 281-288.
15. Li, J., Waters, S. B., Drobna, Z., Devesa, V., Styblo, M., and Thomas, D. J. (2005). Arsenic (+3 oxidation state) methyltransferase and the inorganic arsenic methylation phenotype. Toxicol. Appl. Pharmacol. 204, 164-169.
16. Lindberg, A. L., Rahman, M., Persson, L. A., and Vahter, M. (2008). The risk of arsenic induced skin lesions in Bangladeshi men and women is affected by arsenic metabolism and the age at first exposure. Toxicol. Appl. Pharmacol. 230, 9-16.
17. Mandal, A. K., Das, S., Basu, M. K., Chakrabarti, R. N., and Das, N. (2007). Hepatoprotective activity of liposomal flavonoid against arsenite-induced liver fibrosis. J. Pharmacol. Exp. Ther. 320, 994-1001.
18. Mandal, B. K., and Suzuki, K. T. (2002). Arsenic round the world: a review. Talanta 58, 201-235.
19. Marnell, L. L., Garcia-Vargas, G. G., Chowdhury, U. K., Zakharyan, R. A., Walsh, B., Avram, M. D., Kopplin, M. J., Cebrian, M. E., Silbergeld, E. K., and Aposhian, H. V. (2003). Polymorphisms in the human monomethylarsonic acid (MMA V) reductase/hGSTO1 gene and changes in urinary arsenic profiles. Chem. Res. Toxicol. 16, 1507-1513.
20. Mazumder, D. N. (2007). Effect of drinking arsenic contaminated water in children. Indian Pediatr. 44, 925-927.
21. Mendez-Gomez, J., Garcia-Vargas, G. G., Lopez-Carrillo, L., Calderon-Aranda, E. S., Gomez, A., Vera, E., Valverde, M., Cebrian, M. E., and Rojas, E. (2008). Genotoxic effects of environmental exposure to arsenic and lead on children in Region Lagunera, Mexico. Ann. N. Y. Acad. Sci. 1140, 358-367.
22. Mittal, M., and Flora, S. J. (2007). Vitamin E supplementation protects oxidative stress during arsenic and fluoride antagonism in male mice. Drug Chem. Toxicol. 30, 263-281.
23. Moller, P. (2006). The alkaline comet assay: towards validation in biomonitoring of DNA damaging exposures. Basic Clin. Pharmacol. Toxicol. 98, 336-345.
24. Ostrosky-Wegman, P., Gonsebatt, M. E., Montero, R., Vega, L., Barba, H., Espinosa, J., Palao, A., Cortinas, C., Garcia-Vargas, G., and del Razo, L. M. (1991). Lymphocyte proliferation kinetics and genotoxic findings in a pilot study on individuals chronically exposed to arsenic in Mexico. Mutat. Res. 250, 477-482.
25. Paiva, L., Marcos, R., Creus, A., Coggan, M., Oakley, A. J., and Board, P. G. (2008). Polymorphism of glutathione transferase omega 1 in a population exposed to a high environmental arsenic burden. Pharmacogenet. Genomics 18, 1-10.
26. Pu, Y. S., Yang, S. M., Huang, Y. K., Chung, C. J., Huang, S. K., Chiu, A. W., Yang, M. H., Chen, C. J., and Hsueh, Y. M. (2007). Urinary arsenic profile affects the risk of urothelial carcinoma even at low arsenic exposure. Toxicol. Appl. Pharmacol. 218, 99-106.
27. Rahman, M. M., Ng, J. C., and Naidu, R. (2009). Chronic exposure of arsenic via drinking water and its adverse health impacts on humans. Environ. Geochem. Health 31(Suppl. 1), 189-200.
28. Rosado, J. L., Ronquillo, D., Kordas, K., Rojas, O., Alatorre, J., Lopez, P., Garcia-Vargas, G., Caamano, M., Cebrian, M. E., and Stoltzfus, R. J. (2007). Arsenic exposure and cognitive performance in Mexican schoolchildren. Environ. Health Perspect. 115, 1371-1375.
29. Rossman, T. G. (2003). Mechanism of arsenic carcinogenesis: an integrated approach. Mutat. Res. 533, 37-65.
30. Singh, N. P., McCoy, M. T., Tice, R. R., and Schneider, E. L. (1988). A simple technique for quantitation of low levels of DNA damage in individual cells. Exp. Cell Res. 175, 184-191.
31. Smith, A. H., Marshall, G., Yuan, Y., Ferreccio, C., Liaw, J., von Ehrenstein, O., Steinmaus, C., Bates, M. N., and Selvin, S. (2006). Increased mortality from lung cancer and bronchiectasis in young adults after exposure to arsenic in utero and in early childhood. Environ. Health Perspect. 114, 1293-1296.
32. Styblo, M., Del Razo, L. M., Vega, L., Germolec, D. R., LeCluyse, E. L., Hamilton, G. A., Reed, W., Wang, C., Cullen, W. R., and Thomas, D. J. (2000). Comparative toxicity of trivalent and pentavalent inorganic and methylated arsenicals in rat and human cells. Arch. Toxicol. 74, 289-299.
33. Tapio, S., and Grosche, B. (1996). Arsenic in the aetiology of cancer. Mutat. Res. 612, 215-246.
34. Thomas, D. J. (2007). Molecular processes in cellular arsenic metabolism. Toxicol. Appl. Pharmacol. 222, 365-373.
35. Thomas, D. J., Li, J., Waters, S. B., Xing, W., Adair, B. M., Drobna, Z., Devesa, V., and Styblo, M. (2007). Arsenic (+3 oxidation state) methyltransferase and the methylation of arsenicals. Exp. Biol. Med. (Maywood) 232, 3-13.
36. Trejo-Acevedo, A., Diaz-Barriga, F., Carrizales, L., Dominguez, G., Costilla, R., Ize-Lema, I., Yarto-Ramirez, M., Gavilan-Garcia, A., Mejia-Saavedra, J., and Perez-Maldonado, I. N. (2009). Exposure assessment of persistent organic pollutants and metals in Mexican children. Chemosphere 74, 974-980.
37. Tseng, C. H. (2009). A review on environmental factors regulating arsenic methylation in humans. Toxicol. Appl. Pharmacol. 235, 338-350.
38. Vahter, M. (2002). Mechanisms of arsenic biotransformation. Toxicology 181- 182, 211-217.
39. Vahter, M. (2009). Effects of arsenic on maternal and fetal health. Annu. Rev. Nutr. 29, 381-399.
40. Waalkes, M. P., and Liu, J. (2008). Early-life arsenic exposure: methylation capacity and beyond. Environ. Health Perspect. 116 A, 104.
41. Whitbread, A. K., Masoumi, A., Tetlow, N., Schmuck, E., Coggan, M., and Board, P. G. (2005). Characterization of the omega class of glutathione transferases. Methods Enzymol. 401, 78-99.
42. Yanez, L., Garcia-Nieto, E., Rojas, E., Carrizales, L., Mejia, J., Calderon, J., Razo, I., and Diaz-Barriga, F. (2003). DNA damage in blood cells from children exposed to arsenic and lead in a mining area. Environ. Res. 93, 231-240.
43. Yu, R. C., Hsu, K. H., Chen, C. J., and Froines, J. R. (2000). Arsenic methylation capacity and skin cancer. Cancer Epidemiol. Biomarkers Prev. 9, 1259-1262.