Transfusional hemochromatosis: Quantitative relation of MR imaging pituitary signal intensity reduction to intensity reduction to hypogonadotropic hypogonadism

Radiology

Volumn 215, Issue 3, 2000, Pages 818-823

  Sparacia, Gianvincenzo ^c   Iaia, Alberto ^a   Banco, Aurelia ^c   D'Angelo, Paolo ^b   Lagalla, Roberto ^c  

^a BRIGHAM AND WOMEN S HOSPITAL   (United States)

^b Ospedale Villa Sofia   (Italy)

^c NONE

Author keywords

Anemia; Hemochromatosis; Hormones; Pituitary, diseases; Pituitary, MR

Indexed keywords

FERRITIN;

ARTICLE; CORRELATION FUNCTION; DISEASE SEVERITY; HEMOCHROMATOSIS; HUMAN; HYPOGONADISM; HYPOPHYSIS; IMAGE ANALYSIS; NUCLEAR MAGNETIC RESONANCE IMAGING; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; QUANTITATIVE ASSAY; SIGNAL PROCESSING;

EID: 0034044329     PISSN: 00338419     EISSN: None     Source Type: Journal    
DOI: 10.1148/radiology.215.3.r00jn10818     Document Type: Article

References (30)

1. Brasch RC, Wesbey GE, Gooding CA, Koerper MA. Magnetic resonance imaging of transfusional hemosiderosis complicating thalassemia major. Radiology 1984; 150: 767-771.
2. Siegelman ES, Mitchell DG, Outwater E, Munoz SJ, Rubin R. Idiopathic hemochromatosis: MR imaging findings in cirrhotic and precirrhotic patients. Radiology 1993; 188:637-641.
3. Siegelman ES, Mitchell DG, Rubin R, et al. Parenchymal versus reticuloendothelial iron overload in the liver: distinction with MR imaging. Radiology 1991; 179:361-366.
4. Siegelman ES, Mitchell DG, Semelka R. Abdominal iron deposition: metabolism, MR findings, and clinical importance. Radiology 1996; 199:13-22.
5. Jandl JH. Blood: textbook of hematology. Boston, Mass: Little Brown, 1987; 201-207.
6. Housman JF, Chezmar JL, Nelson RC. Magnetic resonance imaging in hemochromatosis: extrahepatic iron deposition. Gastrointest Radiol 1989; 14:59-60.
7. Merkel PA, Simonson DC, Amiel SA, et al. Insulin resistance and hyperinsulinemia in patients with thalassemia major treated by hypertransfusion. N Engl J Med 1988; 318:809-814.
8. Bergeron C, Kovacs K. Pituitary siderosis: a histologic, immunocytologic and ultrastructural study. Am J Pathol 1978; 93:295-310.
9. Roth C, Pekrun A, Bartz M, et al. Short stature and failure of pubertal development in thalassaemia major: evidence for hypothalamic neurosecretory dysfunction of growth hormone secretion and defective pituitary gonadotropin secretion. EurJ Pediatr 1997; 156:777-783.
10. Johnston DL, Rice I., Vick GW III, Hedrick TD, Rokey R. Assessment of tissue iron overload by nuclear magnetic resonance imaging. Am J Med 1989; 87:40-47.
11. Ernst O, Sergent G, Bonvarlet P, et al. Hepatic iron overload: diagnosis and quantification with MR imaging. AJR Am J Roentgenol 1997; 168:1205-1208.
12. Miaux Y, Daurelle P, Zagdanski AM, et al. MRI in haemachromatosis: pituitary versus testicular iron deposition in five patients with hypogonadism. Eur Radiol 1995; 5:165-171.
13. Fujisawa I, Morikawa M, Nakano Y, et al. Hemochromatosis of the pituitary gland: MR imaging. Radiology 1988; 168:213-214.
14. Ambrosetto P, Zucchini S, Cicognani A, Cacciari E. MR findings in pituitary haemosiderosis. Pediatr Radiol 1998; 28:288-299.
15. Kucharzyck W, Olivieri NF, Liu P, et al. MRI of the anterior pituitary gland in thalassemia major: correlation of T2 relaxation with clinical and hormonal status (abstr). In: Proceedings of the 29th Annual Meeting of the American Society of Neuroradiology. Washington, DC: American Society of Neuroradiology, 1991; 102.
16. Sparacia G, Banco A, Midiri M, Iaia A. MR imaging technique for the diagnosis of pituitary iron overload in patients with transfusion-dependent β-thalassemia major. AJNR Am J Neuroradiol 1998; 19:1905-1907.
17. Guyader D, Gandon Y, Deugnier Y, et al. Evaluation of computed assisted tomography in the assessment of liver iron overload. Gastroentorology 1989; 97:737-743.
18. Vymazal J, Hajek M, Patronas N, et al. The quantitative relation between T1-weighted and T2-weighted MRI of normal gray matter and iron concentration. J Magn Reson Imaging 1995; 5:554-560.
19. Stark DD. Hepatic iron overload: paramagnetic pathology. Radiology 1991; 179:333-335.
20. Gandon Y, Guyader D, Heautot JF, et al. Hemochromatosis: diagnosis and quantification of liver iron with gradient-echo MR imaging. Radiology 1994; 193:533-538.
21. Torrance JD, Charlton RW, Schmaman A, Lynch SR, Bothwell TH. Storage iron in "muscle." J Clin Pathol 1968; 21:495-500.
22. Quencer RM, Hinks RS, Pattany PH, Horen M, Donovan Post MJ. Improved MR imaging of the brain by using compensating gradients to suppress motion-induced artifacts. AJR Am J Roentgenol 1988; 151: 163-170.
23. Wang C, Tso S, Todd D. Hypogonadotropic hypogonadism in severe beta-thalassemia: effect of chelation and pulsatile gonadotropin-releasing hormone therapy. J Clin Endocrinol Metab 1989; 68:511-516.
24. Brittenam GM, Cohen AR, McLaren C, et al. Hepatic iron stores and plasma ferritin concentration in patients with sickle cell anemia and thalassemia major. Am J Hematol 1993; 42:81-85.
25. Angelucci A, Giovagnoni A, Valeri G, et al. Limitations of magnetic resonance imaging in measurement of hepatic iron. Blood 1997; 90:4736-4742.
26. Lufkin EG, Baldus WP, Bergstrath EJ, Kao PC. Influence of phlebotomy treatment on abnormal hypothalamic-pituitary function in genetic hemochromatosis. Mayo Clin Proc 1987; 62:473-479.
27. Piperno A, Rivolta MR, D'Alba R, et al. Preclinical hypogonadism in genetic hemochromatosis in the early stage of the disease: evidence of hypothalamic dysfunction. J Endocrinol Invest 1992; 15: 423-428.
28. Kelly TM, Edwards C, Wayne Maikle A, KushnerJP. Hypogonadism in hemochromatosis: reversal with iron deposition. Ann Intern Med 1984; 101:629-632.
29. Cundy T, ButlerJ, Bomford A, Williams R. Reversibility of hypogonadotrophic hypogonadism associated with genetic hemochromatosis. Clin Endocrinol 1993; 38: 617-620.
30. Bronspiegel-Weintrob N, Olivieri NF, Tyler B, Andrews DF, Freedman MH, Holland FJ. Effect of age at the start of iron chelation therapy on gonadal function in betathalassemia major. N Engl J Med 1990; 323:713-719.